Low-density lipoprotein receptor-related protein-1 and nitrative stress in psoriasis vulgaris: a cross-sectional study

Hyperlipidemia is a risk factor for cardiovascular diseases, and low serum lipid levels may play a protective role. Low-density lipoprotein receptor-related protein-1 (LRP1) is a receptor involved in lipid metabolism, cellular signal transduction, and inflammation processes. Nitrosative stress (NO, 3-NT) may also contribute to the pathophysiology of dermatological diseases. To date, no published study has investigated the concentrations of nitrosative stress biomarkers, such as 3-NT and NO, along with LRP1 levels in patients with psoriasis vulgaris. This study aims to assess the relationship between lipid profiles, nitrosative stress markers (NO, 3-NTx), and LRP1 levels with disease severity in psoriasis vulgaris patients. The study included 50 patients with psoriasis vulgaris and 50 healthy individuals. Serum lipid profiles (total cholesterol, triglycerides, LDL, HDL, VLDL) were measured using a colorimetric enzyme method on an autoanalyzer, while NO, 3-NTx, and LRP1 levels were determined via ELISA. The severity of psoriasis was evaluated using the Psoriasis Area Severity Index (PASI). Data on disease duration, medication use, smoking, alcohol consumption, and weight were recorded. Total cholesterol, triglyceride, and LDL levels were significantly higher in psoriasis vulgaris patients compared to healthy controls (p < 0.05). Increased NO and 3-NTx levels were identified as indicators of oxidative stress. A positive correlation was found between LRP1, NO, 3-NTx levels, and PASI scores. Altered lipid profiles and increased oxidative stress in psoriasis vulgaris patients are associated with cardiovascular risk. The correlation between LRP1, NO, and 3-NTx levels and disease severity suggests that these biomarkers may serve as potential monitoring tools in psoriasis management. Further studies are needed to determine their therapeutic and clinical significance.