Archives of Dermatological Research最新文献

{"title":"Exploring the link between inflammatory cytokines and pressure ulcers using Mendelian randomization","authors":"Can Huang, Maowu Cao, Xiangbin Zhu, Na Li, Kunfu Ouyang, Zhen Han, Guiqin Wu","doi":"10.1007/s00403-025-04223-w","DOIUrl":"10.1007/s00403-025-04223-w","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lay public knowledge and perceptions of skincare: a nationwide survey","authors":"Shloka Reddyreddy, Anjali Daniel, Thor S. Stead, Rohan K. Mangal, Latha Ganti","doi":"10.1007/s00403-025-04221-y","DOIUrl":"10.1007/s00403-025-04221-y","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyaluronic acid delayed filler complications: a racial group analysis and call to action","authors":"Andrea Quartey,&nbsp;Udokama Ezekwe,&nbsp;Valerie Callender","doi":"10.1007/s00403-025-04125-x","DOIUrl":"10.1007/s00403-025-04125-x","url":null,"abstract":"<div><p>Injectable cosmetic treatments, especially hyaluronic acid (HA) fillers, constitute over 90% of cosmetic procedures in the U.S. These fillers can cause delayed complications in patients. Given the structural differences in skin of color (SOC) patients compared to those with lighter skin types, this study aims to report the incidence of these complications across different racial and skin types. This study reviewed published literature examining delayed complications of hyaluronic acid fillers occurring across different races, ethnicities, and skin types. A PubMed search in April 2024 identified studies using specific search terms related to HA fillers and delayed complications. A limited number of articles discussed race, ethnic background or skin type when reporting HA delayed filler complications. The literature reflected differences in the rates at which AEs were reported based on patient reported race. However, to determine the true incidence of HA delayed filler complications across race and ethnic backgrounds, efforts should be made to include full demographic information in reporting these events in the literature.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized controlled trial on the efficacy and safety of the combination therapy of topical 0.1% finasteride − 5% Minoxidil in male androgenetic alopecia","authors":"Farah Faulin Lubis,&nbsp;Lili Legiawati,&nbsp;Martha Saulina,&nbsp;Siti R.F. Saldi","doi":"10.1007/s00403-025-04216-9","DOIUrl":"10.1007/s00403-025-04216-9","url":null,"abstract":"<div><p>Current FDA-approved treatments for androgenetic alopecia (AGA) are oral finasteride and topical minoxidil. Topical finasteride offers a potential alternative with similar efficacy and fewer systemic side effects. This study evaluated the effectiveness and safety of combining topical finasteride and minoxidil for male AGA. This 12-week randomized controlled trial divided subjects into two groups which are topical finasteride 0.1%-minoxidil 5% (treatment) and topical minoxidil 5% (control) (NCT05990400, registered 2023-08-04). Hair density, hair diameter, terminal hair rate, and vellus hair rate (assessed using phototrichogram), and the occurrence of side effects (SE) was monitored at four-week intervals. Out of 40 subjects, 2 dropped out in the treatment group. Significant increases in hair density, diameter, and terminal hair rate; and decrease of vellus hair rate were observed at each visit compared to baseline, yet no differences between groups. Systemic SEs included libido reduction (control), mild erectile dysfunction, and chest pain (treatment). Common local SEs (itching, shedding, and dandruff) were similar between groups. One patient (treatment) experienced contact dermatitis. Combining topical finasteride 0.1% with topical minoxidil 5% has similar safety and effectiveness for increasing hair density and diameter in male AGA patients compared to topical minoxidil 5% after 12 weeks of observation.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adalimumab combination with corticosteroid therapy for Stevens–Johnson syndrome/toxic epidermal necrolysis","authors":"Jia Liu,&nbsp;Mengyun Zhou,&nbsp;Taoye Li,&nbsp;Tianhong Xu","doi":"10.1007/s00403-025-04214-x","DOIUrl":"10.1007/s00403-025-04214-x","url":null,"abstract":"<div><p>Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a severe acute mucocutaneous reactions associated with considerable mortality and poor prognosis. Corticosteroids and intravenous immunoglobulin (IVIG), as a traditional remedy, have been widely used in the treatment of SJS/TEN. Recent studies have reported the potential therapeutic benefits of tumor necrosis factor-alpha (TNF-α) antagonists on the disease. However, the optimal treatment remains unknown. This study is to compare the effectiveness and safety of TNF-α antagonist adalimumab conjunction with corticosteroid to traditional remedy on SJS/TEN. In this single-center, retrospective, observational study, we enrolled 53 SJS/TEN patients received either traditional remedy (Corticosteroids and IVIG) or a combination therapy (TNF-α antagonist conjunction with corticosteroid). The primary endpoint was duration of hospitalization and re-epithelization time, and the secondary endpoints including exposure time to high-dose steroids, and major adverse event incidence. 26 patients received traditional remedy and 27 patients received combination remedy. In comparison to traditional remedy, the combination remedy reduced the hospitalization duration (25 ± 4.7 vs. 22 ± 5.2 days; <i>P</i> = 0.032), re-epithelization time (19 ± 2.5 vs.17 ± 3.4 days; <i>P</i> = 0.019), and exposure time to high-dose steroids (18 ± 4 vs. 16 ± 2 days; <i>P</i> = 0.025). Obviously, TNF-α levels in the combination group showed a significant decreased on the discharge day comparing to the traditional group (3.9 ± 1.8 vs. 5.8 ± 2.2, <i>p</i> = 0.001). The major adverse event incidences were no significant statistically difference (<i>P</i> &gt; 0.05) within 6 months of follow-up after hospital discharge, and no death happened between two groups. The combination remedy (adalimumab conjunction with corticosteroid) could be an optimal treatment to promote disease recovery without increasing adverse events and morality in SJS/TEN patients.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04214-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of combined oral isotretinoin and desloratadine vs. isotretinoin alone in acne vulgaris: a comparative study","authors":"Mohamed Ibrahim El-Ghareeb,&nbsp;Abdullah Hassan Kandeel,&nbsp;Naeima Mohammed Khayrullah","doi":"10.1007/s00403-025-04145-7","DOIUrl":"10.1007/s00403-025-04145-7","url":null,"abstract":"<div><p>A combination of desloratadine (DESL) and oral isotretinoin (ISO) may enhance efficacy and reduce the side effects of ISO, particularly those affecting the skin and mucous membranes. We compared the efficacy and safety of this combination versus ISO alone with new dose regimens in the treatment of patients with acne vulgaris. This was a double-blinded, randomized comparative study conducted on 64 patients with acne vulgaris. The severity of acne was scored according to the global acne grading system (GAGS). Serum lipid profile and liver function tests were evaluated before beginning the therapy and repeated monthly for 3 months. Exclusion criteria included hepatic, hyperlipidemic, pregnant, and lactating patients. The patients were divided into the following four groups, with each group including 16 patients treated daily for 3 months: Group I: received a high dose of ISO (0.5 mg/kg) combined with DESL (5 mg), Group II: received a low dose of ISO (0.25 mg/kg) combined with DESL (5 mg), Group III: received a high dose of ISO alone (0.5 mg/kg), and Group IV: received a low dose of ISO alone (0.25 mg/kg). Two patients, each from Group I and Group II, did not complete the treatment course. One patient, each from Group III and Group IV, dropped out of the study. A significant decrease was observed in the GAGS score post-treatment compared to pre-treatment in each group (p &lt; 0.001). In addition, a decrease in the frequency of skin and mucus membrane side effects among Group II, and increased improvement in the GAGS score among Group I were noted; however, no significant differences were observed. Group IV patients were more safe for serum lipids and liver enzymes compared to other groups. Altogether, low-dose ISO, alone or in combination with DESL, is effective for acne vulgaris with fewer side effects compared to high-dose ISO regimens.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of biological agents on lipid profile and hemogram parameters in patients with psoriasis","authors":"Kağan Cingöz,&nbsp;Gülsüm Gençoğlan","doi":"10.1007/s00403-025-04192-0","DOIUrl":"10.1007/s00403-025-04192-0","url":null,"abstract":"<div><p>The effects of biological agents on laboratory parameters in patients with psoriasis remain incompletely characterized, with conflicting data reported. To investigate the effects of five biological agents on lipid profiles, hemogram parameters, inflammatory markers, and their correlation with disease activity in psoriasis patients. This retrospective study analyzed hemogram parameters (<i>n</i> = 153) and lipid profiles (<i>n</i> = 124) in psoriasis patients treated with adalimumab, etanercept, infliximab, ustekinumab, or secukinumab for ≥ 6 months. Parameters were evaluated at baseline, week 12, and week 24. Patients with conditions potentially affecting these parameters were excluded. Platelet counts decreased significantly in etanercept and secukinumab groups (<i>p</i> &lt; 0.001, <i>p</i> &lt; 0.05) and all patients (<i>p</i> &lt; 0.001). Lymphocyte counts increased in adalimumab and etanercept groups (<i>p</i> &lt; 0.001, <i>p</i> &lt; 0.01) and all patients (<i>p</i> &lt; 0.001). Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio decreased significantly in adalimumab, etanercept, secukinumab groups (<i>p</i> &lt; 0.05). Triglyceride levels increased in the ustekinumab group (10.91%) and all patients (3.2%) (<i>p</i> &lt; 0.05). Total cholesterol, LDL, HDL, and atherogenic index showed no significant changes. A strong positive correlation was found between neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio changes (<i>r</i> = 0.646, <i>p</i> &lt; 0.001). Biological agents have specific effects on hematological and lipid parameters in psoriasis patients. The observed changes in inflammatory markers and triglycerides suggest the importance of laboratory monitoring during biological therapy.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of topical 2% carteolol in the treatment of infantile hemangiomas: a dermoscopic and clinical evaluation","authors":"Esranur Ünal,&nbsp;Muhammed Burak Yücel,&nbsp;Saadet Nurşah Gedikli,&nbsp;Yılmaz Ulaş,&nbsp;Fatma Türkan Mutlu,&nbsp;Bengü Nisa Akay","doi":"10.1007/s00403-025-04190-2","DOIUrl":"10.1007/s00403-025-04190-2","url":null,"abstract":"<div><p>Infantile hemangiomas (IH) are the most common benign vascular tumors in infants, often requiring treatment in 10–15% of cases due to complications. While systemic propranolol is the first-line treatment, its potential for systemic side effects raises interest in topical therapies. This study investigates the efficacy of topical 2% carteolol in treating IH and its dermoscopic changes over time. A total of 15 patients with IH were treated with topical 2% carteolol drops applied twice daily for 3 months. Clinical and dermoscopic images were captured at baseline, 1 month, and 3 months. Dermoscopic features such as erythema, clods, coiled vessels, dotted vessels, and others were evaluated. Visual Analog Scale (VAS) scores were used to assess treatment response. The most frequent dermoscopic findings at baseline were coiled vessels, followed by serpentine and dotted vessels. At 1 and 3 months, significant improvements were observed, with reductions in erythema and coiled vessel scores (<i>p</i> &lt; 0.05) and at 3 months with reductions in clod score (<i>p</i> &lt; 0.05). The skin-colored structureless area significantly increased, indicating lesion regression (<i>p</i> &lt; 0.05). VAS scores showed a significant decrease over the 3-month period, with a positive correlation between baseline dotted vessel scores and treatment response (r:0.656, p:0.008). Topical 2% carteolol is an effective and safe treatment for IH. Dermoscopic monitoring provides valuable insights into treatment progression, showing significant changes in erythema, clod, and vascular patterns. The presence of dotted vessels at baseline may serve as a predictor of a favorable treatment response. Further studies with longer follow-up are needed to validate these findings.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LncRNA H19 inhibited dermal papilla cell senescence process through miR-29a by targeting Wnt/β-catenin signaling pathway","authors":"Zhenyu Liu,&nbsp;Yushen Li,&nbsp;Qilin Yang,&nbsp;Guiyuan Cao,&nbsp;Wenjie Yan,&nbsp;Siyuan Jiang,&nbsp;Ruilong Qiao,&nbsp;Bozhi Cai,&nbsp;Zhihao Wu,&nbsp;Changmin Lin,&nbsp;Ningxia Zhu","doi":"10.1007/s00403-025-04128-8","DOIUrl":"10.1007/s00403-025-04128-8","url":null,"abstract":"<div><p>Androgenetic alopecia is a common type of hair loss disease. As the most promising seeder for cell-based therapy, dermal papilla cells are prone to undergo premature senescence during passaging in vitro. Our previous studies revealed high expression of lncRNA H19 in early-passage dermal papilla cells and the maintenance of hair follicle-inducing ability upon prolonged culture. However, the exact mechanism of H19 regulating Wnt signaling pathway related to hair follicle regeneration has not been fully elucidated. Here, a cell senescence model was constructed by continuous cultivation in vitro to investigate the molecular mechanism of H19 in human dermal papilla cells. Animal hair follicle inductivity, cell proliferation and molecular experiments were performed to evaluate the cell inductivity, proliferation, senescence, expression of Wnt signaling key factors in early- and late-passage dermal papilla cells. Ectopic expression and silencing experiments were conducted to estimate effects of H19 on the proliferation and senescence of dermal papilla cells and the possible mechanism. Hair follicles from frontal baldness-prone and occipital non-balding areas of patients with androgenetic alopecia were exploited to detect the expression of H19 and relevant factors. Results showed late-passage DP8 cells exhibited lost hair follicle inductive properties, attenuated cell proliferation, elevated senescent marker and key Wnt factor levels, decreased inducing marker levels. Furthermore, overexpression of H19 inhibited senescence marker expression by binding to SAHH to upregulate miR-29, thus activating the Wnt signaling pathway to maintain inducing ability of DP cells. Knockdown of H19 showed opposite experimental results. Consistently, H19 together with miR-29a levels were lower and the expression levels of miR-29a target genes (DKK1, SFRP2) increased in the dermal papilla cells from frontal baldness-prone and occipital non-balding areas. Conclusively, our data provide a novel insight into the regulation and mechanism of H19 in inhibiting dermal papilla cell senescence, suggesting a potential therapy strategy for androgenetic alopecia.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empathy, expertise, and expeditious communication: identifying how people with hidradenitis suppurativa experience outpatient palliative care","authors":"Alex Soltoff,&nbsp;Sarah Gold,&nbsp;Harika Echuri,&nbsp;Kimberly Curseen,&nbsp;Jesse Soodalter,&nbsp;Dio Kavalieratos,&nbsp;Lauren Orenstein","doi":"10.1007/s00403-025-04121-1","DOIUrl":"10.1007/s00403-025-04121-1","url":null,"abstract":"<div><h3>Background</h3><p>Hidradenitis suppurativa (HS) is a chronic inflammatory condition that significantly impacts quality of life across physical, emotional, and social domains. Palliative care (PC) is specialized care that offers a holistic approach to managing serious illnesses by addressing the multiple dimensions of suffering, yet individuals with chronic dermatologic conditions like HS rarely receive PC. Identifying how individuals with HS experience PC, a medical specialty with an explicit focus on addressing wellbeing holistically, may offer valuable insights for improving broader HS care.</p><h3>Objectives</h3><p>To explore how people with HS experience outpatient PC and to identify specific aspects of care driving this experience.</p><h3>Methods</h3><p>We conducted semi-structured interviews with eleven individuals with HS who had received outpatient PC at a single academic medical center. Eligible participants were referred from a specialty HS clinic, were English-speaking, and were at least 18 years old. Interviews focused on patients’ perceptions of the outpatient PC experience, including aspects of care impacting physical, emotional, and psychosocial wellbeing. Data was analyzed using thematic analysis to identify visit components driving care experiences.</p><h3>Results</h3><p>Four themes emerged as key components driving participants’ experiences in PC: (1) empathy and compassion, (2) expertise in pain and symptom management, (3) psychosocial support through an interdisciplinary team, and (4) effective care coordination and communication. Participants consistently contrasted their PC experiences with past experiences in other healthcare settings.</p><h3>Conclusions</h3><p>Our findings indicate that individuals with HS in this study valued aspects of care that prioritize empathy, symptom management, and effective communication. These care components point to the importance of building clinical structures that support patient-centered care for HS. Adequately resourcing dermatology clinics may enable the translation of valuable elements of palliative care into settings where people with HS traditionally seek care.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}