Rachel K. Lim, Seungmin Woo, Sherif El Raheb, Abrar A. Qureshi, Eunyoung Cho
{"title":"Association of serum vitamin D levels and psoriasis severity: an analysis of the US National health and nutrition examination survey","authors":"Rachel K. Lim, Seungmin Woo, Sherif El Raheb, Abrar A. Qureshi, Eunyoung Cho","doi":"10.1007/s00403-025-03949-x","DOIUrl":"10.1007/s00403-025-03949-x","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Noha E. Mohamed, Doha F. Rabie, Fatma A. Ahmed, Rania Abdelghani, Sara M. Yaseen
{"title":"Evaluation of safety and efficacy of calcipotriol 0.005% cream versus terbinafine hydrochloride 1% cream in treatment of onychomycosis; a randomized split body comparative pilot study","authors":"Noha E. Mohamed, Doha F. Rabie, Fatma A. Ahmed, Rania Abdelghani, Sara M. Yaseen","doi":"10.1007/s00403-025-03932-6","DOIUrl":"10.1007/s00403-025-03932-6","url":null,"abstract":"<div><p>Onychomycosis is a chronic fungal infection of the nails that accounts for10% of the population worldwide and about 50% of the nail diseases in clinical practice. It has negative impact on patient’s quality of life. Multiple treatments are introduced to treat onychomycosis but they are limited by high cost, side effects, drug interaction, and reduced transungual delivery. We aimed to investigate the safety and efficacy of calcipotriol 0.005% cream versus terbinafine hydrochloride 1% cream in treatment of onychomycosis. Twenty adult patients with bilateral onychomycosis were randomized. Twenty adult patients with bilateral onychomycosis were randomized in this study. The patients received calcipotriol 0.005% cream on one side and terbinafine hydrochloride 1% cream on the other side twice/day for 3 months. Outcome was evaluated after treatment by onychomycosis severity index (OSI), mycological evaluation, investigator’s assessment and patient’s satisfaction. Side effects were also evaluated. Study registration number (IRB approval number M602, 30/8/2022). Calcipotriol 0.005% cream had significant higher degree of improvement after 3-month treatment of onychomycosis compared to terbinafine hydrochloride 1% cream (<i>p</i> value = 0.02), while calcipotriol had significantly higher side effects in terms of tolerable irritation compared to terbenafine (<i>p</i> value < 0.05). Insignificant differences between both sides were found regarding post treatment OSI, investigator’s assessment and patient’s satisfaction (<i>p</i> value = 0.12, 0.73, 0.22 respectively). This pilot study provided preliminary data for significant superiority of calcipotriol 0.005% cream in treatment of onychomycosis regarding degree of improvement after 3-month treatment compared to terbinafine hydrochloride 1% cream. Irritation induced by calcipotriol 0.005% cream was tolerable by the patients. Further studies are still needed.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Jak inhibitor intraclass switch in Alopecia Areata patients: a retrospective review of cases at an academic center","authors":"Isabel Silva, Saakshi Khattri","doi":"10.1007/s00403-025-03848-1","DOIUrl":"10.1007/s00403-025-03848-1","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ryan Scheinkman, Sheila Sharifi, Daniel Green, Keyvan Nouri
{"title":"Analyzing the ingredients, SPF, and cost of purported reef safe sunscreens from multiple retailers","authors":"Ryan Scheinkman, Sheila Sharifi, Daniel Green, Keyvan Nouri","doi":"10.1007/s00403-025-03970-0","DOIUrl":"10.1007/s00403-025-03970-0","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Application of multi-needle injector for delivering human adipose stem cells to combat photoaging in nude mice","authors":"Tian Li, Shimeng Wang, Duo Zhang, Haiyue Jiang","doi":"10.1007/s00403-025-03936-2","DOIUrl":"10.1007/s00403-025-03936-2","url":null,"abstract":"<div><p>To assess the efficacy of human adipose stem cells(ADSCs) in treating photo-aged skin using multi-needle injector versus syringe injection methods. Mice were divided into three groups: blank, model, and experimental. Skin photoaging was induced by eight weeks of UVB irradiation in the model and experimental groups. ADSCs (1 × 10<sup>6</sup> cells/120µL) were injected into the experimental group mice thrice over a 30-day period, using a syringe on one side and a multi-needle injector on the other side of the nude mice dorsum. Follow-up assessments one month post-injection included high-definition photography for wrinkle and needle mark analysis, histological evaluation of dermal thickness, collagen and elastic fibers. CD31 and Type I collagen levels were analyzed by immunohistochemistry, while MDA and SOD levels were assessed by ELISA assays. Post-UVB irradiation, significant photoaging signs were observed in the mice, including wrinkles and disordered collagen and elastic fibers. ADSCs treatment led to epidermal thinning, dermal collagen thickening, and improved collagen and elastic fiber organization. CD31 and Type I collagen expression increased, while MDA decreased, and SOD significantly increased. No significant differences were found between the injection methods. Multi-needle injector marks disappeared within 24 h, contrasting with syringe marks, and mass formation was reduced compared to syringe injections. ADSCs effectively ameliorate photoaging in mice. Multi-needle injector injections match the efficacy of syringe injections and offer advantages such as precise depth control and reduced mass formation, suggesting its potential as an effective tool for stem cell-based anti-aging treatments.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nan Zhang, Alyssa L. Stockard, Zachary Leibovit-Reiben, Angelina S. Hwang, Jacob A. Kechter, Caitlin M. Brumfiel, Meera H. Patel, Puneet Bhullar, Colleen Morken, Blake W. Boudreaux, Shams Nassir, Miranda Yousif, Ewoma Ogbaudu, Fangyi Xie, Samantha Zunich, Emily Branch, Amylou Dueck, Julia Lehman, Mark R. Pittelkow, Aaron R. Mangold
{"title":"Repurposing the composite assessment of index lesion severity scoring system in cutaneous lichen planus","authors":"Nan Zhang, Alyssa L. Stockard, Zachary Leibovit-Reiben, Angelina S. Hwang, Jacob A. Kechter, Caitlin M. Brumfiel, Meera H. Patel, Puneet Bhullar, Colleen Morken, Blake W. Boudreaux, Shams Nassir, Miranda Yousif, Ewoma Ogbaudu, Fangyi Xie, Samantha Zunich, Emily Branch, Amylou Dueck, Julia Lehman, Mark R. Pittelkow, Aaron R. Mangold","doi":"10.1007/s00403-025-03996-4","DOIUrl":"10.1007/s00403-025-03996-4","url":null,"abstract":"<div><p>Current validated lichen planus (LP) scoring systems are complicated and optimized for generalized, multi-site disease. There is a need for a validated, simple lesional assessment in LP. Herein, we repurpose and optimize the modified Composite Assessment of Index Lesion Severity (mCAILS) for LP and to validate the optimized lichen planus CAILS (lpCAILS). In this study, cutaneous LP lesions for disease activity and treatment response were prospectively assessed at two single-center, single-arm, open-label clinical trials at Mayo Clinic, Arizona with lpCAILS. Twelve index lesions from the topical ruxolitinib trial in 2018–2021 were used for the development and optimization of lpCAILS, with subsequent internal validation. After, external validation was performed from the oral baricitinib trial in 2021–2023. A total of 24 patients were enrolled in the topical ruxolitinib and oral baricitinib trials. Inclusion criteria is age of at least 18 years with biopsy proven cutaneous LP lesions. Patients were excluded by atypical variants of LP and other active cutaneous conditions. The main outcome was to compare lpCAILS scores’ correlation with Physician Global Assessment (PGA) and area under the curve (AUC) for treatment. The lpCAILS optimized erythema scoring had the highest correlation with PGA (0.63). In the internal validation cohort (<i>N</i> = 87 lesions), among eight (9.2%) measured greater than 4 cm<sup>2</sup>, the optimized composite score demonstrated similar correlation with PGA and comparable AUC to mCAILS. The optimized subscore size had higher correlation with PGA (0.65 vs. 0.61). In external validation (<i>N</i> = 89 lesions), 15 (16.9%) were greater than 4 cm<sup>2</sup> in size. lpCAILS had higher correlations with PGA and (comparable AUCs) to mCAILS for composite score (0.8 vs. 0.78 (93.5% vs. 95.4%)) and subscore domains of erythema (0.79 vs. 0.78 (96.1% vs. 95.5%)), scale (0.76 vs. 0.73 (94.6% vs. 94.2%)), and elevation (0.73 vs. 0.69 (93.8% vs. 92.8%)), except for size (0.75 vs. 0.85 (86.3% vs. 91.9%)). Future studies with larger comparative arms and reliability analyses will be necessary to confirm lpCAILS as a validated disease measurement tool for cutaneous LP that can be used by medical professionals to track LP severity in research studies and clinical practice.</p><p><b>Trial registration</b>: CT03697460, NCT05188521.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of isotretinoin treatment on sleep quality in acne vulgaris patients","authors":"Mehmet Semih Celik, Candan Celik, Nagehan Cepik","doi":"10.1007/s00403-025-03994-6","DOIUrl":"10.1007/s00403-025-03994-6","url":null,"abstract":"<div><p>Isotretinoin is a systemic treatment agent used in patients with severe acne vulgaris. It has been reported to have side effects associated with depression, sleep apnea, and hypersomnia. There are some studies in the literature suggesting that isotretinoin may cause sleep disturbances. The aim of this study was to investigate whether sleep quality is affected in acne vulgaris patients receiving isotretinoin treatment. Fifty patients with acne vulgaris who were receiving isotretinoin treatment and who were referred to the dermatology polyclinic were included in the study. Two Pittsburgh Sleep Quality Index (PSQI) questionnaires, consisting of 7 components and 19 items, were administered to the patients, one during the treatment period and one before the treatment period. Scores ranged from 0 to 21, with scores of 5 and above indicating poor sleep quality. Before isotretinoin treatment, the average PSQI score of male patients was 11.5 ± 4.95, while after treatment it was 18.0 ± 6.69. In female patients, the average PSQI score before treatment was 9.50 ± 4.81, During treatment, it was observed as 14.0 ± 6.28. An increase in scores was observed in both sexes after isotretinoin. The change before and after treatment was considered significant (<i>P</i> < 0.001). In our study, we observed a negative effect of isotretinoin on sleep quality. Some experimental studies have shown that retinoic acids can affect the pathways in the brain that regulate sleep, but further research is needed in this area.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Volatile organic compounds exposure associated with skin cancer among U. S. adults: results from NHANES 2011–2018","authors":"Zhiwen Zhang, Xiaofeng Liang, Kefan Lin, Ying Deng, Yunsheng Liang","doi":"10.1007/s00403-025-03954-0","DOIUrl":"10.1007/s00403-025-03954-0","url":null,"abstract":"<div><p>Skin cancer, including melanoma, squamous cell carcinoma, and basal cell carcinoma, ranks as the fifth most common cancer globally. It exhibits a high incidence rate, with men being more susceptible, particularly as they age, making middle-aged and older men a high-risk group. This study analyzed data from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018 to investigate the relationship between skin cancer and 15 urinary volatile organic compounds (VOC). VOC are a class of gases that are volatile at room temperature and atmospheric pressure, with carbon as the main structural atom. We used binary logistic regression to comprehensively assess the potential association between each urinary VOC exposure and skin cancer, while weighted quantile sum regression was employed to explore the associations of mixed co-exposures. Specific VOC, notably mercapturic acid (MA), showed significant correlations with skin cancer risk, particularly in females. Our research presents a comprehensive assessment of the link between VOC and skin cancer, aiming to provide a scientific basis for understanding the correlation between VOC and skin cancer within human populations.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bancheng Chen, Chenchen Wu, Yan Liao, Hao Hu, Xiaojuan Liu, Chao Chen, Xiaoming Liu, Lin Wu, Xiaofan Chen, Bo Yu
{"title":"Bioinformatic analysis and experimental validation implicate STAT2-mediated angiogenic responses in rosacea pathogenesis","authors":"Bancheng Chen, Chenchen Wu, Yan Liao, Hao Hu, Xiaojuan Liu, Chao Chen, Xiaoming Liu, Lin Wu, Xiaofan Chen, Bo Yu","doi":"10.1007/s00403-025-03915-7","DOIUrl":"10.1007/s00403-025-03915-7","url":null,"abstract":"<div><p>Rosacea is a chronic skin condition characterized by facial erythema, flushing, and telangiectasia. Abnormalities in the vascular responses are associated with the development of rosacea. Our analysis of the GSE65914 dataset revealed differential expression of angiogenesis-related genes in rosacea lesions classified rosacea samples with distinct angiogenic molecular patterns. Further investigation of immune infiltration characteristics across angiogenic patterns identified unique immune signatures associated with VEGFA<sup>high</sup> MMP9<sup>low</sup> and VEGFA<sup>low</sup> MMP9<sup>high</sup> subtypes. Moreover, STAT2 proteins were higher in the VEGFA<sup>high</sup> MMP9<sup>low</sup> pattern group. Increased expression of STAT2 was confirmed in rosacea patients and in the mice model of rosacea induced by LL37. Knockdown of STAT2 suppressed the tube formation ability of human umbilical vein endothelial cells, which implicated STAT2 participated in regulating angiogenic responses. In conclusion, our study characterized rosacea subtypes by distinct angiogenic molecular patterns and found that STAT2 may play a critical role in the regulation of angiogenic responses in rosacea. These insights may provide a promising target of rosacea therapies.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143404267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}