Archives of Dermatological Research最新文献

{"title":"Logistic regression and covariate-balanced matching analysis of lichen planus and inflammatory gastrointestinal disorders","authors":"Amritpal Kooner, Rawle A. Sekhon, Jarett Anderson","doi":"10.1007/s00403-025-04139-5","DOIUrl":"10.1007/s00403-025-04139-5","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is skin thinning a natural consequence of aging or a result of sarcopenia?","authors":"Serpil Tuna,&nbsp;Sevil Alan,&nbsp;Özlem Karataş","doi":"10.1007/s00403-025-03923-7","DOIUrl":"10.1007/s00403-025-03923-7","url":null,"abstract":"<div><p>It is widely known that skin thickness decreases and fragility increases with aging. However, the relationship between sarcopenia, a condition commonly associated with frailty in older adults, and skin thickness remains unclear. This study aimed to evaluate the presence of skin thinning in patients with sarcopenia and investigate the relationship between sarcopenia, age, and skin thickness. This cross-sectional study included 66 participants aged 40 to 80, comprising 20 individuals with pre-sarcopenia, 13 with sarcopenia, and 33 healthy controls. Total skin thickness (epidermal + dermal) was measured using ultrasound (US) at four anatomical regions: leg, hand, forearm, and upper arm. Leg and hand skin thicknesses were significantly lower in patients with pre-sarcopenia compared to the control group (all <i>p</i> &lt; 0.05). Similarly, forearm and upper arm skin thicknesses were significantly lower in patients with sarcopenia compared to the control group (all <i>p</i> = 0.001). After adjusting for confounding factors such as age, sex, and BMI, Sarcopenia remained significantly associated with reduced skin thickness across all regions (all <i>p</i> &lt; 0.05). A moderate-to-high positive correlation exists between HGS and leg skin thickness (all <i>p</i> &lt; 0.01). However, no significant relationships were found between skin thickness and age or sex. Sarcopenia is associated with skin thinning across all examined regions, independent of age, sex, or BMI. Skin thickness measurements may serve as a diagnostic marker for sarcopenia.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"308-nm excimer laser combined with piperine promotes melanin synthesis through PTEN/PDK1/GSK3b regulation of keratinocyte paracrine","authors":"Yifei Wu,&nbsp;Xiaochuan Wang,&nbsp;Jing Liu,&nbsp;Zhiqiong Wang,&nbsp;Jinrong Li,&nbsp;Wenhe Zhang,&nbsp;Jie Xiang,&nbsp;Renfu Li,&nbsp;Sha Du,&nbsp;Chunping Ao","doi":"10.1007/s00403-025-04095-0","DOIUrl":"10.1007/s00403-025-04095-0","url":null,"abstract":"<div><p>Vitiligo is a common skin disorder involving depigmentation. A 308-nm excimer laser and piperine were shown to be useful for the treatment of vitiligo. The aim of this study was to investigate the effect of a 308-nm excimer laser combined with piperine in the treatment of vitiligo and the molecular mechanism by which this treatment promotes melanin synthesis through regulation of the paracrine activity of keratinocytes (KCs). In this study, cells and animals were treated with a 308-nm excimer laser and piperine. ELISA, Western blot analysis, immunofluorescence and RT‒qPCR were used to measure the levels of proteins and genes, and EdU, Transwell, and flow cytometric assays were used to assess cell proliferation and apoptosis. Treatment with the 308-nm excimer laser combined with piperine promoted KCs secretion of cytokines related to melanin production, restrained the secretion of proinflammatory cytokines, elevated the level of PTEN, decreased the level of PDK1, inhibited the phosphorylation of Akt, and facilitated the phosphorylation of GSK3b. After coculture of melanocytes (MCs) with KCs supernatant, the proliferation and migration of MCs increased, the apoptosis of MCs decreased, and the expression of melanin synthesis-related genes increased. Moreover, compared with the 308-nm excimer laser or piperine alone, the combined treatment had a more significant effect. Moreover, inhibiting PTEN weakened the effect of the combined treatment. Animal experiments revealed that a 308-nm excimer laser combined with piperine had a therapeutic effect on vitiligo. After combined treatment, the number of CD8 + T cells decreased, and the PTEN/PDK1/GSK3b pathway was activated, which increased melanin synthesis and alleviated the progression of vitiligo. In conclusion, a 308-nm excimer laser combined with piperine regulates KCs paracrine activity through the PTEN/PDK1/GSK3b molecular axis, promotes MCs proliferation and melanin synthesis, and alleviates the progression of vitiligo, which provides new targets for the clinical treatment of vitiligo.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression among patients with acne vulgaris: does disease severity matter?","authors":"Zeinab Aryanian,&nbsp;Sussan Mouodi,&nbsp;Mohammad Mehdi Asadi,&nbsp;Shima Jahani,&nbsp;Hoda Shirafkan,&nbsp;Azar Shirzadian,&nbsp;Parvaneh Hatami","doi":"10.1007/s00403-025-04129-7","DOIUrl":"10.1007/s00403-025-04129-7","url":null,"abstract":"<div><p>Acne vulgaris has a significant impact on an individual’s mental health and well-being. To investigate the impact of acne vulgaris on mental health of patients. This case-control study was conducted on 93 patients with acne vulgaris and 93 age- and sex- matched healthy volunteers as control group, using the standard Hospital Anxiety and Depression Scale (HADS) questionnaire, from November 2020 to March 2021. The depression score was significantly higher in acne sufferers, and was correlated with disease severity. On the other hand, no significant relationship was found between anxiety score and acne. It can also be seen that depression and anxiety are significantly more common in women and also in younger ages. This study pointed out the importance of evaluating depression signs in patients with acne vulgaris, which could have a significant effect on patients’ quality of life.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the complex roles of immunocyte phenotypes in the pathogenesis of dermatitis: a causal inference Mendelian randomization analysis","authors":"Yi Wang,&nbsp;Yanggang Hong","doi":"10.1007/s00403-025-04072-7","DOIUrl":"10.1007/s00403-025-04072-7","url":null,"abstract":"<div><p>The etiology of dermatitis involves complex interactions between immune cells, genetics, and environmental factors. While immunocyte phenotypes have been linked to various forms of dermatitis, their causal role remains unclear. We conducted a two-sample Mendelian randomization (MR) analysis to investigate the causal effects between 731 immunocyte phenotypes and four types of dermatitis: atopic dermatitis, contact dermatitis, infective dermatitis, and seborrhoeic dermatitis. Genetic variants were used as instrumental variables, and the inverse variance-weighted (IVW) method was employed to assess causality. Sensitivity analyses were performed to ensure robustness. The forward MR analysis identified significant associations between 22 immunocyte phenotypes and atopic dermatitis, 8 phenotypes with contact dermatitis, 5 with infective dermatitis, and 6 with seborrhoeic dermatitis. The reverse MR analysis suggested potential bidirectional interactions of atopic dermatitis and CD3 on CD28 + CD45RA- CD8br (OR = 0.924, <i>P</i> = 0.012). This study revealed causal relationships between specific immunocyte phenotypes and dermatitis subtypes, providing novel insights into the immunopathogenesis of dermatitis and potential therapeutic targets.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in clinical features and risk factors for striae distensae in Black and White women","authors":"Nada Elbuluk,&nbsp;Autumn L. Saizan,&nbsp;Arielle Carolina Mora Hurtado,&nbsp;Ted Hamilton,&nbsp;Sewon Kang","doi":"10.1007/s00403-025-04050-z","DOIUrl":"10.1007/s00403-025-04050-z","url":null,"abstract":"<div><p>Striae distensae (SD) are a common condition, which can appear differently across skin colors and for which effective treatments remain limited. SD have several risk factors, including pregnancy, obesity, growth spurts, and several pathologic conditions. Few studies have examined whether there are skin color differences regarding SD in their clinical presentation, risk factors, and associated comorbidities. To evaluate the clinical features, risk factors, and associated comorbidities of SD among Black and White women. This was a two-part study involving a telephone questionnaire followed by an in-person clinical assessment with standardized photographs. One hundred forty-three women (75 Black, 68 White) completed the survey, and 66 women (33 Black, 33 White) completed the in-person clinical assessment. Black and White women in the study were found to be similar in age, SD duration, parity, pregnancy-associated weight gain, and family history. Black women, on average, had a greater number of SD than White women (118 versus 76, <i>p</i> = 0.01). Striae were typically white and skin-colored among Black women, but white and violaceous among White women (<i>p</i> = 0.02). Black women were more likely to have involvement of the lower legs (<i>p</i> = 0.04), axilla (<i>p</i> = 0.05), and buttocks (<i>p</i> = 0.002) than White women. Compared to Black women, urinary incontinence was more commonly reported among White women, though this did not reach statistical significance (<i>p</i> = 0.07). There was a significant association between smoking and SD in White women (<i>p</i> = 0.003), but not in Black women. Additionally, Black women were more likely to use creams to diminish the appearance of their striae. While the etiology, prevalence, and risk factors of SD may be similar between Black and White women, there may be important skin color differences in SD clinical features and medical comorbidities. Larger studies are needed to further characterize the relationship between SD and medical comorbidities such as urinary incontinence and pelvic floor dysfunction. The study of this relationship may advance understanding of SD pathogenesis and provide pathways for targeted therapies. More studies are needed to determine the role of SD evaluation as a screening tool to help predict the risk of the development of pelvic floor dysfunction.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04050-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antera 3D® skin image analysis system for objective evaluation of clinical treatment efficacy in a patient with facial vitiligo","authors":"Liu Han,&nbsp;Yang Jinzhu,&nbsp;Huang Xiuyun,&nbsp;Yi Zhen,&nbsp;Rao Yinying,&nbsp;Li Jiyu,&nbsp;Qu Miao,&nbsp;Quan Xingping,&nbsp;Chen Mudiao,&nbsp;Feng Jinlian,&nbsp;Qu Yongbin","doi":"10.1007/s00403-025-03941-5","DOIUrl":"10.1007/s00403-025-03941-5","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the changes of skin surface parameters in a patient with vitiligo using Antera 3D^® Skin Image Analysis System, and to observe the clinical efficacy of the treatment of facial vitiligo.</p><h3>Methods</h3><p>A patient with facial vitiligo was treated with intradermal injection of psoralen solution into the lesion combined with 308 nm excimer laser therapy. Vitiligo lesion images were captured using the Antera 3D^® camera before treatment and every 2 weeks after the start of the treatment. The associated software analysis system was used to measure the parameters of melanin level, ultra-low melanin concentration, and L* value as objective indexes for the evaluation of vitiligo treatment efficacy.</p><h3>Results</h3><p>After 10 treatments, the melanin level of the patient’s skin lesions increased from 0.480 to 0.580, while the ultra-low melanin concentration and L* value decreased from 9.360 to 64.10 to 3.032 and 58.10, respectively.</p><h3>Conclusion</h3><p>The Antera 3D^® skin image analysis system provides objective data, which are conducive to improving patients’ treatment compliance and confidence, as well as facilitating the development of treatment plans.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stratified nationwide skin cancer risk in patients with rosacea","authors":"Amritpal Kooner,&nbsp;Rawle A. Sekhon,&nbsp;Mahtab S. Gill,&nbsp;Aditya Dutt","doi":"10.1007/s00403-025-04110-4","DOIUrl":"10.1007/s00403-025-04110-4","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of alcohol consumption, smoking, coffee, and tea intake on cutaneous melanoma: a causal relationship analysis","authors":"Junpeng Li,&nbsp;Lin Cheng,&nbsp;Caiyun Lei","doi":"10.1007/s00403-025-04075-4","DOIUrl":"10.1007/s00403-025-04075-4","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapy resistant hypertrophic lichen planus and its response to oral tofacitinib with a priori tissue cytokine expression: a real-world hospital-based study","authors":"Savitha Sharath,&nbsp;Kabir Sardana,&nbsp;Ananta Khurana,&nbsp;Apeksha Yadav,&nbsp;Archana Singh","doi":"10.1007/s00403-025-04088-z","DOIUrl":"10.1007/s00403-025-04088-z","url":null,"abstract":"<div><h3>Background</h3><p>Although there are several reports on use of tofacitinib in lichen planus (LP), its usage in hypertrophic LP is sparse with no data on tissue cytokine expression.</p><h3>Methods</h3><p>We retrospectively analyzed the records of recalcitrant hypertrophic LP patients treated with tofacitinib monotherapy. Demographic and clinical details were noted. We assessed Th1, Th2, Th17 cytokines in lesional and non-lesional tissue samples using real time PCR. Dose, duration and response to tofacitinib in terms of resolution of lesions and pruritus was noted. Side effects and time after which relapses were seen post treatment were recorded.</p><h3>Results</h3><p>Fifteen hypertrophic LP patients were analysed with a mean age of 34.06years (18-59years, 8 females and 7 males). Previous failed systemic treatments included corticosteroids(<i>n</i> = 1), retinoids(<i>n</i> = 5), cyclosporine(<i>n</i> = 8), methotrexate(<i>n</i> = 8) and thalidomide(<i>n</i> = 3). Tissue cytokine analysis was performed in 3/15 patients which showed upregulation of Th1 and Th17 cytokines [Interferon-γ, Interleukin (IL)-17 and IL-21]. Mean dose of tofacitinib was 11.6 mg (10-15 mg) and was given for a mean duration of 8.8weeks (8-16weeks). Pruritus resolved in a mean duration of 8.6days and mean time to achieve resolution of lesions was 4.69weeks. Two patients failed to show improvement and drug was stopped after 8 weeks. Side effects were noted in 6 patients [dyslipidemia(<i>n</i> = 2), upper respiratory infection(<i>n</i> = 2), fever(<i>n</i> = 1) and folliculitis(<i>n</i> = 1)]. Relapse was noted in 5/13 patients [38.46%, mean time duration: 7.2weeks (4-12weeks)].</p><h3>Conclusion</h3><p>A predominant Th1/Th17 cytokine profile was noted in the subset analysed and was extrapolated to the use of oral tofacitinib in hypertrophic LP patients.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}