Archives of Dermatological Research最新文献

{"title":"Correction to: Abrocitinib as a novel therapeutic approach for refractory prurigo nodularis: real world evidence","authors":"Abdullah Demirbas, Esin Diremsizoglu, Gizem Cınar, Cigdem Vural","doi":"10.1007/s00403-025-04217-8","DOIUrl":"10.1007/s00403-025-04217-8","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143835555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydroxychloroquine is safe and efficacious in oral lichen planus: data from a large outpatient cohort","authors":"Khava Abdusalamova,&nbsp;Margitta Worm,&nbsp;Farzan Solimani","doi":"10.1007/s00403-025-04226-7","DOIUrl":"10.1007/s00403-025-04226-7","url":null,"abstract":"<div><p>Lichen planus (LP) is a chronic inflammatory T-cell mediated disease affecting the skin, mucous membranes and skin appendages. Data on clinical phenotypes and systemic treatment of LP are limited. We analyzed a cohort of LP patients (equal or older than 18 years) regarding their clinical phenotypes (subtype, demographics, comorbidities) and treatment. Patients were selected from 2017 to 2023 who were seen in our outpatient clinic during a treatment period of at least 2 years. We identified 85 patients (62 females, 73% and 76 above 50 years; 89%) who met selection criteria. 33 had oral LP (39%), 23 had cutaneous LP (27%) and 2% had both or other manifestations (32%). Frequent comorbidities were hypertension (n = 40), hypothyroidism (n = 17), asthma (n = 11), diabetes (n = 10) and dyslipidemia (n = 8). 44% were taking a medication known to favor LP onset. 2/85 patients had a malignant transformation. 33 patients were treated topically and 50 required systemic therapy. Hydroxychloroquine (HCQ) (n = 18; 36%) and retinoids (n = 17; 34%) were the most commonly used systemic medications. Both were efficacious as determined by the investigator global response reaching rates 78% and 71%, respectively. The tolerability of retinoids was lower than HCQ (adverse event rate 29% versus 6%). Our results confirm previous data on clinical phenotypes and comorbidity patterns in LP patients. The treatment assessment suggests that HCQ may be an efficacious and safe first-line treatment for mucosal lichen planus. Further data from prospective controlled clinical trials are needed to prove the optimal treatment approach for different clinical phenotypes of LP.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04226-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicinal plants and their derivatives for skin and hair: a Mediterranean perspective of women care","authors":"Latifa Bouissane,&nbsp;Yahya Elfardi,&nbsp;Sohaib Khatib,&nbsp;Ahmed Fatimi,&nbsp;Carla Pereira,&nbsp;Natália Cruz-Martins","doi":"10.1007/s00403-025-04202-1","DOIUrl":"10.1007/s00403-025-04202-1","url":null,"abstract":"<div><p>Since olden days, medicinal and aromatic plants have been consumed due to their well-known therapeutic, ornamental, culinary, and cosmetic properties. Plant-based cosmetics comprise a growing market offering brands of sustainable products with the ultimate goal of responding to the woman needs to boost their natural beauty, such as soothing, toning, moisturizing and protecting skin and hair. The increasing focus on body and beauty care, combined with a better understanding of the diverse biological effects of plants and their derivatives, has revitalized their significance in aesthetic, cosmetic, and dermatological contexts. Concurrently, the increasing prevalence of allergies and hypersensitivity reactions to synthetic additives commonly found in cosmetics and other skin products has spurred interest in seeking healthier and more efficacious natural alternatives. An intense investigation has been stated around the formulation of medicinal plants- and other plant-based cosmetic products for dermatological and aesthetic purposes. Similarly, a raising awareness by cosmetics’ manufacturers and related industries have been progressively stated, culminating with the emergence of a line of plant-based cosmetics increasingly safe and with reliable quality features for multiple purposes. Although a high demand for natural-based products for cosmetic purposes has been stated, further studies are required to deepening knowledge on their beneficial properties, safety and quality features and to identify the main limitations and likelihood of side effects occurrence. In this review, an outlook of the current scenario regarding the use of medicinal and aromatic plants as cosmetic ingredients in the formulation of skin care and other dermatological products traditionally used by the Mediterranean woman for prevention and even cure of skin and hair diseases or for beautification is provided.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04202-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First-in-kind 3D bioprinted human skin model using recombinant human collagen","authors":"Hemanth Gudapati,&nbsp;Rafaela Mayumi Simoes Torigoe,&nbsp;Aydin Tahmasebifar,&nbsp;K-Raman Purushothaman,&nbsp;Saranya Wyles","doi":"10.1007/s00403-025-04236-5","DOIUrl":"10.1007/s00403-025-04236-5","url":null,"abstract":"<div><p>Reliable translational human skin models are lacking for modeling skin diseases and screening effective therapeutics. 3D bioprinting is an emerging technology that enables the fabrication of human skin models that mimic the structure and functions of human skin in a dish (in-vitro). As a prototype, we present a first-in-kind fully humanized 3D bioprinted skin model as an alternative to animal testing for preclinical research. This model utilizes a plant-derived recombinant human collagen and human skin fibroblasts, melanocytes, and keratinocytes. The 3D bioprinted human skin model expresses involucrin and cytokeratin 14, contains melanin granules, and structurally resembles human skin. However, the morphology of keratinocytes is slightly different, containing a thicker layer of proliferative keratinocytes and a thinner layer of differentiated, cornified keratinocytes. Nevertheless, the model shows epidermal stratification, which indicates skin maturation. Further, the model lacks skin appendages such as hair follicles and sweat glands, as current bioprinting technology cannot deliver distinct cells at the single-cell resolution. Recent advances in 3D bioprinting such as spheroid-based bioprinting show potential to address these limitations. Hence, 3D bioprinting of skin using plant-derived recombinant human collagen, presents significant advantages, including high-throughput production of personalized human skin models, reduction of animal testing, and potential applications in regenerative medicine.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A split face study comparing intralesional tranexamic acid versus 1064 nm long pulsed Nd: YAG laser for acne vulgaris treatment","authors":"Heba Hussien Muhammad Eltanany,&nbsp;Faten Abdel Wadoud Abdel Qawy,&nbsp;Mervat Hamdino,&nbsp;Mona S. Ali","doi":"10.1007/s00403-025-04164-4","DOIUrl":"10.1007/s00403-025-04164-4","url":null,"abstract":"<div><p>Acne is among most prevalent skin conditions that adversely impacts patients’ quality of life and self-confidence. Conventional treatment methods face issues with high recurrence rates and unwanted side effects, prompting the need to explore new acceptable treatment options. Comparing the safety and clinical efficacy of intralesional tranexamic acid (TXA) versus 1064 nm long pulsed Nd:YAG laser in the treatment of facial inflammatory acne vulgaris. 30 patients with facial acne vulgaris were involved in a prospective randomized split-face comparative study. Each patient was treated with long-pulsed Nd: YAG laser on one side, and intralesional TXA on the other side at 2-week interval for 4 sessions. Cases were assessed through Investigator Global Assessment of acne (IGA) scale, lesions counting, and erythema score at baseline, after end of treatment, and after follow-up for 3 months. A statistically significant reduction in IGA, lesions count, and erythema score was found in both treated sides (p-value &lt; 0.001). Improvement of IGA and non-inflammatory lesions count was better in laser side more than TXA side after end of treatment and follow-up (p-value &lt; 0.05). Improvement of inflammatory lesions count was non-significant in both sides after end of treatment, while after follow-up it was better on laser side. Improvement of erythema score was non-significant between both therapy modalities after end of treatment and follow-up. 1064 nm long-pulsed Nd: YAG laser and intralesional TXA are effective, and safe treatment modalities for acne. However, Nd-YAG laser has prolonged therapeutic effect over intralesional TXA so, TXA can be considered a promising lunch-time procedure enhancing the outcome.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on recent advances and challenges of microneedle technology for enhanced topical treatment of skin disorders","authors":"Hema,&nbsp;Anu Jindal,&nbsp;Rajni Bala,&nbsp;Amrinder singh","doi":"10.1007/s00403-025-04239-2","DOIUrl":"10.1007/s00403-025-04239-2","url":null,"abstract":"<div><p>Microneedles are tiny, minimally invasive needles that are made to create microchannels over a subcutaneous layer of the skin. These micro-injuries encourage the secretion of growth factors and prompt collagen synthesis. The reasons for using microneedling therapy have increased significantly, leading to its widespread adoption in dermatology. This review article discussed recent advances and challenges of microneedle technology for enhanced topical treatment of skin disorders. It discussed the effective and safe use of microneedles for treating different types of skin conditions like acne, scars, alopecia, melasma, skin rejuvenation, and photo-damage. The drug delivery through the skin was enhanced and rare or permanent adverse effects were not mentioned, while temporary redness and post-inflammatory hyperpigmentation were frequently seen. Microneedling seems to be a generally reliable and secure treatment choice for various skin conditions. More extensive and randomized clinical trials were necessary to ensure their safety and efficacy across diverse populations, conditions, and treatment durations. This trial helps to identify optimal dosages, long-term outcomes, and any adverse effects that may not appear in smaller studies. They also enable comparisons with existing therapies, ensuring the technology’s generalizability and value. Moreover, such trials are essential for regulatory approval and to determine which microneedle technologies work best for specific uses.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychodermatology: a bibliometric perspective on dermatologic and psychiatric intersections","authors":"Waseem Hassan,&nbsp;Antonia Eliene Duarte","doi":"10.1007/s00403-025-04233-8","DOIUrl":"10.1007/s00403-025-04233-8","url":null,"abstract":"","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed regional metastasis from small face/scalp cutaneous squamous carcinoma: outcomes and predictors","authors":"Courtney B. Shires,&nbsp;John D. Boughter,&nbsp;Christopher P. Golembeski,&nbsp;Nicholas M. Sharp,&nbsp;Arabella T. Hall,&nbsp;Merry E. Sebelik","doi":"10.1007/s00403-025-04224-9","DOIUrl":"10.1007/s00403-025-04224-9","url":null,"abstract":"<div><p>Objective: CSCC (cutaneous squamous cell carcinoma) of the face/scalp generally has a favorable outcome. However, patients with delayed regional metastasis from scalp/facial CSCC do very poorly. Historically, prophylactic treatment of the N0 neck for the T1-T2 (as staged in the AJCC 7th edition) face/scalp cancers has not been recommended. This study aims to determine predictors of delayed regional metastases in &lt; 4 cm CSCC of the face and scalp. Methods: We retrospectively analyzed medical records of patients diagnosed regional metastasis of CSCC of the scalp/face at least 6 months after the diagnosis of the primary CSCC at a tertiary academic head and neck clinic during a period between 2012 and 2018. Results: A total of 50 patients with CSCC of the face/scalp were diagnosed and treated for delayed cervical lymph node metastasis during a 6-year period. All patients were male. Areas affected were the scalp, cheeks, and forehead. No patient had neck lymph node metastases at initial presentation for their scalp/face cancer. The presence of perineural invasion in the primary tumor was the only observed predictor of delayed neck lymph node recurrence. We did not observe an association between diameter/depth of the primary skin tumor or lymphovascular invasion and the presence of regional lymph node recurrence. Conclusion: In our review, perineural invasion (PNI) was the one factor predictive of delayed regional lymph node metastasis. This observation confirms the use of PNI to upstage even small CSCC to T3. Prophylactic treatment of the neck in patients with small scalp/face cancers with PNI should be strongly considered, especially in the age of immunotherapy.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04224-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Actigraphy, a valuable tool for objective sleep evaluation in psoriasis: a review","authors":"Katerina Vlami,&nbsp;Kleoniki Pantelidi,&nbsp;Maria Dalamaga,&nbsp;Evangelia Papadavid","doi":"10.1007/s00403-025-04187-x","DOIUrl":"10.1007/s00403-025-04187-x","url":null,"abstract":"<div><p>Psoriasis, a form of chronic inflammatory skin disease, shows wide variations in severity and comorbidities. Considering the relatively clear scientific evidence concerning its great physical and psychological effects, researchers began to use actigraphy as a scientific monitoring tool for its bidirectional relationship with sleep. To evaluate the usefulness of actigraphy as a means to diagnose sleep disturbances in psoriatic patients. We performed a systematic review using PubMed, Scopus and Google Scholar to look at the use of actigraphy in research into psoriasis and sleep disorders. This review covered publications through February 2024. Included records were primary and secondary research papers. Actigraphy consistently revealed strong links between pruritus nighttime arousal, and poorer subjective sleep, although next-day psoriasis symptoms did not always worsen. Systematic analyses emphasized actigraphy’s role in measuring nocturnal scratching, supported by emerging smartwatch apps. Psoriatic arthritis studies likewise reported significant sleep disruptions, though evidence remains limited. From these studies, actigraphy presented as a useful tool in both clinical and research contexts, for diagnosing and monitoring sleep disorders among psoriatic patients. Actigraphy is an important test for psoriatic sleep disorders, providing useful objective data. This way the bridge between psoriasis and sleep be clearly understood, and treatment methods improved.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04187-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of digit ratio (2D:4D) and its relationship with skin sebum level in patients with basal cell carcinoma","authors":"Ismail Can,&nbsp;Fatma Tuncez Akyurek","doi":"10.1007/s00403-025-04225-8","DOIUrl":"10.1007/s00403-025-04225-8","url":null,"abstract":"<div><h3>Introduction</h3><p>The main factor in the development of basal cell carcinoma (BCC) is UV (ultraviolet) exposure. In most cases of BCC there is upregulation of the ‘Sonic Hedgehog’ (SHH) pathway components. Some recent studies have shown that overactivity of the SHH pathway leads to an increase in the number of sebocytes in the skin. Sex differences in tumor formation suggest a possible role of sex hormones in the development of skin cancers.</p><h3>Objective</h3><p>We aimed to evaluate the 2D:4D ratio and its relationship with skin sebum level in patients with BCC.</p><h3>Methods</h3><p>Finger length measurements were made using digital calipers. Skin sebum levels were measured using sebumeter.</p><h3>Results</h3><p>The study included 64 patients with BCC(mean age 67) and 64 healthy subjects(mean age 71) aged 37–92 years. T score (average of sebum levels on forehead, nose and chin) and total sebum score (TSS) were higher in patients with BCC. U score (average of sebum levels of right and left cheeks) was similar in patients and control group. In male subjects, T score, U score and TSS were significantly higher in the patient group. In female subjects, there was no significant difference between the patient and control groups in T score, U score and TSS. The 2D:4D ratio in both hands was similar in the patient and control groups. When evaluated according to the localization of the lesions, the T score and the TSS were found to be higher in male subjects with BCC lesions in the T region than in the control group. In the female patient group, the T score was found to be significantly higher than in the control group.</p><h3>Conclusion</h3><p>There was no correlation between BCC and 2D:4D ratio. We found that skin sebum levels were higher in male patients with BCC compared to the control group. Defining the relationship between BCC and sebum levels may play an important role in the evaluation of the occurrence and prognosis of the disease.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}