Applied physics reviews最新文献

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Efficient shift of ferromagnetic resonance by superconductor gating 超导体门控对铁磁共振的有效移位
IF 15 1区 物理与天体物理
Applied physics reviews Pub Date : 2025-03-05 DOI: 10.1063/5.0231497
Jiaxu Li, Jie Zhang, Guang Yang, Weisheng Zhao
{"title":"Efficient shift of ferromagnetic resonance by superconductor gating","authors":"Jiaxu Li, Jie Zhang, Guang Yang, Weisheng Zhao","doi":"10.1063/5.0231497","DOIUrl":"https://doi.org/10.1063/5.0231497","url":null,"abstract":"The proximity effect has long been recognized as the primary driver of static transport behavior in superconductor/ferromagnetic heterostructures, yet the understanding of magnetic dynamics in this context remains limited. Here, we demonstrate a significant shift of ferromagnetic resonance spectra in ferromagnetic films placed between two superconductor gating layers. Through deliberate modifications of the interface structure using various insertion layers, we have determined that the superconducting proximity effect has a minimal impact on the modulation of ferromagnetic resonance characteristics. Instead, our findings strongly support very recent theoretical predictions that emphasize the phenomenon of ultrastrong coupling between Kittel magnons and Cooper pairs arising from the superconducting magnetoelectric effect. We propose that this ultrastrong coupling not only provides a precise method for determining superconducting parameters like the London penetration depth but also lays the foundation for the manipulation of spin waves through superconductors in future magnonic circuits.","PeriodicalId":8200,"journal":{"name":"Applied physics reviews","volume":"26 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Linear flip-chipped resonant-cavity green μLEDs arrays for low-crosstalk optogenetic probes with low damage 用于低串扰低损伤光遗传探针的线性倒装谐振腔绿色μ led阵列
IF 15 1区 物理与天体物理
Applied physics reviews Pub Date : 2025-03-05 DOI: 10.1063/5.0237052
Binru Zhou, Guohong Wang, Xingfei Zhang, Yulong Tang, Xiaoping Zhou, Jin Lin, Jinpeng Huang, Zhicong Li, Ning Lv, Yuqiu Zhang, Yiyun Zhang, Xiaoyan Yi, Junxi Wang, Jinmin Li
{"title":"Linear flip-chipped resonant-cavity green μLEDs arrays for low-crosstalk optogenetic probes with low damage","authors":"Binru Zhou, Guohong Wang, Xingfei Zhang, Yulong Tang, Xiaoping Zhou, Jin Lin, Jinpeng Huang, Zhicong Li, Ning Lv, Yuqiu Zhang, Yiyun Zhang, Xiaoyan Yi, Junxi Wang, Jinmin Li","doi":"10.1063/5.0237052","DOIUrl":"https://doi.org/10.1063/5.0237052","url":null,"abstract":"Optogenetics with high temporal and spatial resolution hold great potentials to replace the traditional drug and electrical stimulation techniques, which calls for optical probing devices with low crosstalk and organic damages. Here, we report a fabrication method of optoelectrical probes for precise modulation of neurons. A linear array of flip-chipped green resonant-cavity μLEDs (RCLED) with an emitting aperture of 50 μm is integrated on Si platform as the stimulation source. Due to the top/bottom Bragg reflectors, the RCLEDs' output light view-angle is narrowed to <90°. The emission wavelength demonstrates remarkable stability under various injection current densities. Under the 50 A/cm2 driving current density, the RCLEDs' output optical density is 100 mW/mm2 and maximum temperature rise is 0.5 °C, both of which exhibit great improvement compared with those of the optical probes on sapphire substrate. Using these green RCLED probes to stimulate Mac-mCherry photosensitive protein, the analgesia and inhibition effects for medium prefrontal cortex GABAergic neurons are verified. This work provides an effective approach to fabricate integrated microscale light sources for precise stimulation and modulation of neurons, which facilitate the study of complex neural functions.","PeriodicalId":8200,"journal":{"name":"Applied physics reviews","volume":"17 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application and prospect of in situ TEM in wide bandgap semiconductor materials and devices 原位瞬变电磁法在宽禁带半导体材料和器件中的应用与展望
IF 15 1区 物理与天体物理
Applied physics reviews Pub Date : 2025-03-04 DOI: 10.1063/5.0225128
Chao Chen, Tao Zhang, Yimin Lei, Jiatong Fan, Le Zhang, Ge Wang, Luyao Gao, Peixian Li, Qing Zhu, Xiaohua Ma, Yue Hao
{"title":"Application and prospect of in situ TEM in wide bandgap semiconductor materials and devices","authors":"Chao Chen, Tao Zhang, Yimin Lei, Jiatong Fan, Le Zhang, Ge Wang, Luyao Gao, Peixian Li, Qing Zhu, Xiaohua Ma, Yue Hao","doi":"10.1063/5.0225128","DOIUrl":"https://doi.org/10.1063/5.0225128","url":null,"abstract":"Wide bandgap semiconductor (WBS) materials have a wide range of applications in radio frequency and power electronics due to their many advantages such as high saturation drift velocity, breakdown voltage, and excellent thermal/chemical stability. Diamond, Ga2O3, GaN, and SiC are typical WBS materials. Reliability studies for these four materials and devices are crucial for WBS applications. Traditional means of reliability studies include, but are not limited to, x-ray diffraction, atomic force microscopy, Raman spectroscopy, and electron microscopy et al. However, most of these methods are ex situ studies after material or device failure and thus have some limitations. In situ transmission electron microscope (TEM) is a favorable technology to observe the degradation and failure process of materials and devices in real time, which may provide effective guidance in material growth, device structure design, device process optimization, and reliability improvement. In recent years, in situ TEM technology has been gradually used by researchers to study WBS materials and devices. In this review, we present a comprehensive and systematic review of in situ TEM works on diamond, Ga2O3, GaN, and SiC materials and devices, with a particular focus on the progress of the technology in the reliability study of such materials and devices. While summarizing the advantages of in situ TEM in the investigation of WBS materials and devices, the review also looks forward to the future of in situ TEM in promoting the study of WBS materials and devices.","PeriodicalId":8200,"journal":{"name":"Applied physics reviews","volume":"67 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143546502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inorganic semiconducting nanostructures-based printed photodetectors 基于无机半导体纳米结构的印刷光电探测器
IF 15 1区 物理与天体物理
Applied physics reviews Pub Date : 2025-03-04 DOI: 10.1063/5.0236154
Dhayalan Shakthivel, Abhishek Singh Dahiya, Ravinder Dahiya
{"title":"Inorganic semiconducting nanostructures-based printed photodetectors","authors":"Dhayalan Shakthivel, Abhishek Singh Dahiya, Ravinder Dahiya","doi":"10.1063/5.0236154","DOIUrl":"https://doi.org/10.1063/5.0236154","url":null,"abstract":"Optoelectronic devices, such as photodetectors (PDs), are needed in many applications including high-speed optical communications, robotics, healthcare, and biomimetic visual systems, which require detection and interaction using light. As a result, a wide variety of PDs on planar substrates have been reported using various light sensitive materials and traditional micro-/nano-fabrication technologies. In recent years, considerable efforts have been devoted to developing PDs with flexible form factors and using eco-friendly materials and approaches. These efforts have resulted in exploration of degradable materials and printed electronics as a resource-efficient route for manufacturing and to contain end-of-life issues. This paper reviews such new advances, particularly focusing on flexible PDs based on inorganic (e.g., crystalline silicon, compound semiconductors, metal oxides, etc.) semiconductor nanostructures [e.g., Nanowires (NWs), Nanoribbons (NRs), etc.]. The advantages and disadvantages of various bottom-up and top-down methods explored to realize the nanostructures and the wet (solution-processable) and dry printing and assembly methods to print the nanostructures on flexible substrates, are discussed along with their suitability for various applications. This discussion is supported by a comparative analysis of printed PDs in terms of key performance metrics such as responsivity, detectivity, ILight/IDark ratio, response speed, and external quantum efficiency. This comprehensive discussion is expected to benefit researchers and practitioners from academia and industry interested in the field of printed and flexible PDs.","PeriodicalId":8200,"journal":{"name":"Applied physics reviews","volume":"211 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143546501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optical phonons on thermal conduction in advanced materials 光学声子对先进材料热传导的影响
IF 15 1区 物理与天体物理
Applied physics reviews Pub Date : 2025-03-03 DOI: 10.1063/5.0239197
Bin Wei, Xiaotian Zhang, Wang Li, Jiale Li, Yongheng Li, Qilong Gao, Jiawang Hong, Ce-Wen Nan, Yuan-Hua Lin
{"title":"Optical phonons on thermal conduction in advanced materials","authors":"Bin Wei, Xiaotian Zhang, Wang Li, Jiale Li, Yongheng Li, Qilong Gao, Jiawang Hong, Ce-Wen Nan, Yuan-Hua Lin","doi":"10.1063/5.0239197","DOIUrl":"https://doi.org/10.1063/5.0239197","url":null,"abstract":"The requirements for high performance, reliability, and longevity in electronic devices, such as power semiconductors and thermal sensors, make effective thermal management a formidable challenge. Thus, understanding lattice dynamics is crucial for regulating thermal conduction, as the intrinsic limit mainly depends on phonon dispersions. Conventionally, thermal conduction is regulated through heat-carrying acoustic phonon manipulation due to their high group velocities, which are widely utilized in materials such as thermal coatings and thermoelectrics. In recent years, with advancements in thermal transport, optical phonons have been of great interest for tuning thermal conduction, with a particular focus on those with special dispersive behaviors; however, the microscopic mechanisms are significantly different. This review aims to provide a comprehensive understanding of the effect of optical phonons, especially those with high weights on thermal conduction in advanced materials, as well as discuss the fundamental mechanisms, including (i) phonon bandwidth, (ii) phonon gap, (iii) avoided-crossing, (iv) phonon nesting/twinning, (v) optical-acoustic phonon bunching, and (vi) multiple optical phonons.","PeriodicalId":8200,"journal":{"name":"Applied physics reviews","volume":"85 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bulk nonlinear metamaterials for generation of quantum light 用于产生量子光的体非线性超材料
IF 15 1区 物理与天体物理
Applied physics reviews Pub Date : 2025-03-03 DOI: 10.1063/5.0216714
O. Yesharim, I. Hurvitz, J. Foley-Comer, A. Arie
{"title":"Bulk nonlinear metamaterials for generation of quantum light","authors":"O. Yesharim, I. Hurvitz, J. Foley-Comer, A. Arie","doi":"10.1063/5.0216714","DOIUrl":"https://doi.org/10.1063/5.0216714","url":null,"abstract":"Quantum states of light, such as fixed photon number (Fock) states, entangled states, and squeezed states, offer important advantages with respect to classical states of light, such as coherent states and thermal states, in different areas: they enable secure communication and distribution of encryption keys, enable realization of sensors with higher sensitivity and resolution, and are considered candidates for quantum computing and simulation applications. To accommodate these applications, suitable methods for generating the quantum states are needed. Today, the quantum states are often produced by a spontaneous nonlinear process in a standard nonlinear material, followed by a series of optical elements necessary for encoding the desired state on the generated photons. In this review, we consider an alternative approach of structuring the nonlinearity of the crystal so that the desired quantum state will be generated directly at the crystal, without the need for additional elements. Our main focus here is on bulk crystals having structured second-order nonlinearity. The rising interest in these nonlinear metamaterials is fueled by advancements in the ability to efficiently simulate and design spontaneous parametric downconversion (SPDC) processes, as well as by new capabilities of structuring the nonlinearity of ferroelectric crystals, either by electric field poling or by laser-induced writing. As a result, nonlinear metamaterials were recently used to directly shape the spatial and spectral correlations of quantum light that is generated in SPDC. The paper covers the theoretical background and the design and fabrication methods of bulk nonlinear metamaterials for generating quantum light, as well as a series of demonstrations of the use of metamaterials in quantum optical applications.","PeriodicalId":8200,"journal":{"name":"Applied physics reviews","volume":"17 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nonlinear optics at epsilon near zero: From origins to new materials 零附近的非线性光学:从原点到新材料
IF 15 1区 物理与天体物理
Applied physics reviews Pub Date : 2025-02-27 DOI: 10.1063/5.0186961
Dhruv Fomra, Adam Ball, Samprity Saha, Jingwei Wu, Md. Sojib, Amit Agrawal, Henri J. Lezec, Nathaniel Kinsey
{"title":"Nonlinear optics at epsilon near zero: From origins to new materials","authors":"Dhruv Fomra, Adam Ball, Samprity Saha, Jingwei Wu, Md. Sojib, Amit Agrawal, Henri J. Lezec, Nathaniel Kinsey","doi":"10.1063/5.0186961","DOIUrl":"https://doi.org/10.1063/5.0186961","url":null,"abstract":"In the continuously evolving realm of nonlinear optics, epsilon near zero (ENZ) materials have captured significant scientific interest, becoming a compelling focal point over the past decade. During this time, researchers have shown extraordinary demonstrations of nonlinear processes such as unity order index change via intensity dependent refractive index, enhanced second harmonic generation, saturable absorption in ultra-thin films and more recently, frequency shifting via time modulation of permittivity. More recently, remarkable strides have also been made in uncovering the intricacies of ENZ materials' nonlinear optical behavior. This review provides a comprehensive overview of the various types of nonlinearities commonly observed in these systems, with a focus on Drude based homogenous materials. By categorizing the enhancement into intrinsic and extrinsic factors, it provides a framework to compare the nonlinearity of ENZ media with other nonlinear media. The review emphasizes that while ENZ materials may not significantly surpass the nonlinear capabilities of traditional materials, either in terms of fast or slow nonlinearity, they do offer distinct advantages. These advantages encompass an optimal response time, inherent enhancement of slow light effects, and a broadband characteristic, all encapsulated in a thin film that can be purchased off-the shelf. The review further builds upon this framework and not only identifies key properties of transparent conducting oxides that have so far made them ideal test beds for ENZ nonlinearities, but also brings to light alternate material systems, such as perovskite oxides, that could potentially outperform them. We conclude by reviewing the upcoming concepts of time varying physics with ENZ media and outline key points the research community is working toward.","PeriodicalId":8200,"journal":{"name":"Applied physics reviews","volume":"1 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3D printing-based photonic waveguides, fibers, and applications 基于3D打印的光子波导、光纤和应用
IF 15 1区 物理与天体物理
Applied physics reviews Pub Date : 2025-02-27 DOI: 10.1063/5.0238051
Yanhua Luo, Yushi Chu, Jianzhong Zhang, Jianxiang Wen, Gang-Ding Peng
{"title":"3D printing-based photonic waveguides, fibers, and applications","authors":"Yanhua Luo, Yushi Chu, Jianzhong Zhang, Jianxiang Wen, Gang-Ding Peng","doi":"10.1063/5.0238051","DOIUrl":"https://doi.org/10.1063/5.0238051","url":null,"abstract":"Along with the ever expanding frontiers of photonic applications as the world is fast advancing into the information era, there is a growing market for specialty photonic waveguides and fibers requiring sophisticated structures and materials that conventional manufacturing technologies meet great challenges and difficulties to accommodate. Advanced 3D printing or additive manufacturing possesses great flexibility in structure and diversity in material and is emerging as an essential alternative in developing novel specialty photonic waveguides, fibers, and devices for new photonic applications. This paper reviews 3D printing-based photonic waveguides, fibers, and their applications in terms of basic material and processing techniques, fundamental principles and mechanisms, current research and development, and remaining technical problems and challenges.","PeriodicalId":8200,"journal":{"name":"Applied physics reviews","volume":"28 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anomalous thermal transport in semiconductors induced by aliovalent doping 由共价掺杂引起的半导体中的异常热输运
IF 15 1区 物理与天体物理
Applied physics reviews Pub Date : 2025-02-26 DOI: 10.1063/5.0245759
Lankun Wang, Jianbo Zhu, Xingyan Dong, Yu-Ke Zhu, Lei Jiao, Boya Xia, Jiawei Zhou, Fengkai Guo, Mitchell Bordelon, Stephen D. Wilson, Wei Cai, Jiehe Sui, Zihang Liu
{"title":"Anomalous thermal transport in semiconductors induced by aliovalent doping","authors":"Lankun Wang, Jianbo Zhu, Xingyan Dong, Yu-Ke Zhu, Lei Jiao, Boya Xia, Jiawei Zhou, Fengkai Guo, Mitchell Bordelon, Stephen D. Wilson, Wei Cai, Jiehe Sui, Zihang Liu","doi":"10.1063/5.0245759","DOIUrl":"https://doi.org/10.1063/5.0245759","url":null,"abstract":"As an effective method for thermal management technologies, doping or substitution has been extensively utilized to reduce the lattice thermal conductivity of various materials. Intensive studies have been conducted about the phonon mechanism of isoelectronic alloying since the 1950s. Very recently, the specific role of aliovalent doping was elucidated in the half-Heusler NbFeSb system. Here, we have theoretically and experimentally investigated the mechanism of reducing thermal conductivity through aliovalent doping by combining first-principles calculations and neutron diffraction studies for the case study of the TiCoSb half-Heusler system. The softening of the acoustic branches induced by aliovalent doping can effectively reduce the phonon group velocities. Moreover, the introduction of compensating defects, resulting from changes in the Fermi level, plays a vital role in decreasing the relaxation time of phonons, as demonstrated by the analysis of neutron powder diffraction. Due to these two factors, doping with adjacent elements results in a significant reduction in lattice thermal conductivity (for instance, Ni doping at the Co site in the TiCoSb half-Heusler system), especially in the low-temperature range. Our findings provide valuable insight into the phonon scattering mechanism in aliovalent-doped materials and demonstrate the role of compensating defects in heat transport, which is applicable to other doped semiconductor systems.","PeriodicalId":8200,"journal":{"name":"Applied physics reviews","volume":"22 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wireless mechanical and hybrid thrombus fragmentation of ex vivo endovascular thrombosis model in the iliac artery 髂动脉离体血管内血栓形成模型的无线机械和混合血栓碎裂
IF 15 1区 物理与天体物理
Applied physics reviews Pub Date : 2025-02-24 DOI: 10.1063/5.0233677
Marcus C. J. de Boer, Leendert-Jan W. Ligtenberg, Iris Mulder, Constantinos Goulas, Anke Klingner, Roger Lomme, Emily A. M. Klein Rot, Dorothee Wasserberg, Yitong Lu, Remco Liefers, Joep K. van der Mijle Meijer, Gabriëlle J. M. Tuijthof, Doron Ben Ami, Udi Sadeh, Oded Shoseyov, Julien Leclerc, Aaron T. Becker, Pascal Jonkheijm, Michiel Warlé, Islam S. M. Khalil
{"title":"Wireless mechanical and hybrid thrombus fragmentation of ex vivo endovascular thrombosis model in the iliac artery","authors":"Marcus C. J. de Boer, Leendert-Jan W. Ligtenberg, Iris Mulder, Constantinos Goulas, Anke Klingner, Roger Lomme, Emily A. M. Klein Rot, Dorothee Wasserberg, Yitong Lu, Remco Liefers, Joep K. van der Mijle Meijer, Gabriëlle J. M. Tuijthof, Doron Ben Ami, Udi Sadeh, Oded Shoseyov, Julien Leclerc, Aaron T. Becker, Pascal Jonkheijm, Michiel Warlé, Islam S. M. Khalil","doi":"10.1063/5.0233677","DOIUrl":"https://doi.org/10.1063/5.0233677","url":null,"abstract":"This study investigates the efficacy of an untethered magnetic robot (UMR) for wireless mechanical and hybrid blood clot removal in ex vivo tissue environments. By integrating x-ray-guided wireless manipulation with UMRs, we aim to address challenges associated with precise and controlled blood clot intervention. The untethered nature and size of these robots enhance maneuverability and accessibility within complex vascular networks, potentially improving clot removal efficiency. We explore mechanical fragmentation, chemical lysis, and hybrid dissolution techniques that combine mechanical fragmentation with chemical lysis, highlighting their potential for targeted and efficient blood clot removal. Through experimental validation using an ex vivo endovascular thrombosis model within the iliac artery of a sheep, we demonstrate direct revascularization of a 13-mm-long, 1-day-old blood clot positioned inside the left common iliac artery. This was achieved by deploying a UMR into the abdominal aorta within 15 min. Additionally, both mechanical fragmentation and hybrid dissolution achieve a greater volume rate of change compared to no intervention (control) and chemical lysis alone. Mechanical fragmentation exhibits clot removal with a median of 0.87 mm3/min and a range of 2.81 mm3/min, while the hybrid approach demonstrates slower but more consistent clot removal, with a median of 0.45 mm3/min and a range of 0.23 mm3/min.","PeriodicalId":8200,"journal":{"name":"Applied physics reviews","volume":"26 2 1","pages":""},"PeriodicalIF":15.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143486457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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