IF 2.2 4区医学

Apmis Pub Date : 2024-09-09 DOI: 10.1111/apm.13466

Vaijayanthi Saravanan, Vinoj Gopalakrishnan, Maria Infant Majula Shifani Mahendran, Rajan Vaithianathan, Sowmya Srinivasan, Vinoth Boopathy, SriKrishna Krishnamurthy

{"title":"Biofilm mediated integrin activation and directing acceleration of colorectal cancer","authors":"Vaijayanthi Saravanan, Vinoj Gopalakrishnan, Maria Infant Majula Shifani Mahendran, Rajan Vaithianathan, Sowmya Srinivasan, Vinoth Boopathy, SriKrishna Krishnamurthy","doi":"10.1111/apm.13466","DOIUrl":"10.1111/apm.13466","url":null,"abstract":"Bacterial biofilm plays a vital role in influencing several diseases, infections, metabolic pathways and communication channels. Biofilm influence over colorectal cancer (CRC) has been a booming area of research interest. The virulence factors of bacterial pathogen have a high tendency to induce metabolic pathway to accelerate CRC. The bacterial species biofilm may induce cancer through regulating the major signalling pathways responsible for cell proliferation, differentiation, survival and growth. Activation of cancer signals may get initiated from the chronic infections through bacterial biofilm species. Integrin mediates in the activation of major pathway promoting cancer. Integrin-mediated signals are expected to be greatly influenced by biofilm. Integrins are identified as an important dimer, whose dysfunction may alter the signalling cascade specially focusing on TGF-β, PI3K/Akt/mToR, MAPK and Wnt pathway. Along with biofilm shield, the tumour gains greater resistance from radiation, chemotherapy and also from other antibiotics. The biofilm barrier is known to cause challenges for CRC patients undergoing treatment.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"132 10","pages":"688-705"},"PeriodicalIF":2.2,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation with anti-Oma87 antibodies of cytotoxicity, adherence, and internalization of Acinetobacter baumannii in human cervical carcinoma epithelial cells 用抗 Oma87 抗体调节鲍曼不动杆菌在人宫颈癌上皮细胞中的细胞毒性、黏附性和内化。

IF 2.2 4区医学

Apmis Pub Date : 2024-09-02 DOI: 10.1111/apm.13465

Zahra Panji, Mohammadreza Jalali Nadoushan, Zahra Fekrirad, Iraj Rasooli

{"title":"Modulation with anti-Oma87 antibodies of cytotoxicity, adherence, and internalization of Acinetobacter baumannii in human cervical carcinoma epithelial cells","authors":"Zahra Panji, Mohammadreza Jalali Nadoushan, Zahra Fekrirad, Iraj Rasooli","doi":"10.1111/apm.13465","DOIUrl":"10.1111/apm.13465","url":null,"abstract":"BamA, an Omp85 superfamily member, is universally conserved and essential for cell viability. Using anti-Oma87 antibodies, we focus on understanding the effect of Oma87 of Acinetobacter baumannii on pathogenicity. Oma87 was expressed, purified, and used to induce anti-Oma87 antibodies in BALB/c mice. Acute toxicity of the protein was evaluated in mice. HeLa cells were infected with both live and killed A. baumannii 19606 and a clinical isolate. The effects of anti-Oma87 sera on A. baumannii adherence, internalization, and proliferation in HeLa cells were studied. The roles of microfilaments and microtubules in A. baumannii invasion were demonstrated by Actin disruption. Reduced bacterial population and biofilm formation were noted. The ability of A. baumannii to provoke autophagy through Oma87 induction leads to incomplete autophagy and potentially facilitates bacterial replication. Actin-mediated uptake, attachment, and invasion demonstrated A. baumannii survival and multiplication within vacuoles in the host cell. The findings underscore the potential of Oma87 as a therapeutic intervention target in infections caused by A. baumannii. This comprehensive analysis contributes valuable information for understanding the virulence mechanisms of A. baumannii, potentially guiding future strategies to combat infections caused by this pathogen.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"132 11","pages":"843-858"},"PeriodicalIF":2.2,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of TLR4 polymorphisms (Asp299Gly and Thr399Ile) with sepsis: a meta-analysis and trial sequence analysis TLR4 多态性（Asp299Gly 和 Thr399Ile）与败血症的关系：荟萃分析和试验序列分析。

IF 2.2 4区医学

Apmis Pub Date : 2024-09-02 DOI: 10.1111/apm.13463

Jingjing Mu, Yue Shen, Furong Zhu, Qixia Zhang

{"title":"Association of TLR4 polymorphisms (Asp299Gly and Thr399Ile) with sepsis: a meta-analysis and trial sequence analysis","authors":"Jingjing Mu, Yue Shen, Furong Zhu, Qixia Zhang","doi":"10.1111/apm.13463","DOIUrl":"10.1111/apm.13463","url":null,"abstract":"Several investigations have been carried out to explore the genetic association of TLR4 codon variants, specifically Asp299Gly and Thr399Ile, and susceptibility to sepsis, but the results have been contradictory. The present study aimed to conduct a meta-analysis to draw a definitive conclusion regarding the role of TLR4 genetic variants (Asp299Gly and Thr399Ile) in sepsis. A thorough literature search was conducted using the PubMed, Scopus, and Science Direct databases. The inclusion and exclusion criteria were established to ensure the accuracy of the data. The Comprehensive Meta-Analysis Software v4 was utilized to perform the meta-analysis and related analyses. A total of 13 studies were analyzed, including 2328 sepsis cases and 2495 healthy controls for the TLR4 Asp299Gly variant. Eight studies provided genotype data for the rs4986791 polymorphism. The Asp299Gly variant showed a marginal protective effect in the allele (p = 0.08, odds ratio = 0.71) and dominant (p = 0.09, odds ratio = 0.71) genetic models, although it was not statistically significant. The trial sequential analysis indicated that further case–control studies are necessary to draw definitive conclusions about the TLR4 polymorphisms in sepsis. The TLR4 Asp299Gly variant may have a protective effect against sepsis. However, additional research with larger sample sizes across diverse populations is required to validate this finding.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"132 11","pages":"869-880"},"PeriodicalIF":2.2,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HERC5: a comprehensive in silico analysis of its diagnostic, prognostic, and therapeutic potential in cancer HERC5：对其在癌症诊断、预后和治疗方面潜力的全面硅学分析。

IF 2.2 4区医学

Apmis Pub Date : 2024-08-28 DOI: 10.1111/apm.13462

Xianqing Sun, Peng Qiu, Zhennan He, Yuan Zhu, Rui Zhang, Xiang Li, Xiaoyan Wang

{"title":"HERC5: a comprehensive in silico analysis of its diagnostic, prognostic, and therapeutic potential in cancer","authors":"Xianqing Sun, Peng Qiu, Zhennan He, Yuan Zhu, Rui Zhang, Xiang Li, Xiaoyan Wang","doi":"10.1111/apm.13462","DOIUrl":"10.1111/apm.13462","url":null,"abstract":"HERC5, a vital protein in the HERC family, plays crucial roles in immune response, cancer progression, and antiviral defense. This bioinformatic study comprehensively assessed HERC5's significance across various malignancies by analyzing its gene expression, immune and molecular subtype expressions, target proteins, biological functions, and prognostic and diagnostic values in pan-cancer. We further examined its correlation with clinical features, co-expressed and differentially expressed genes, and prognosis in clinical subgroups, focusing on endometrial cancer (UCEC). Our findings showed that HERC5 RNA is expressed at low levels in most cancers and significantly differs across immune and molecular subtypes. HERC5 accurately predicts cancer and correlates with most cancer prognoses. In UCEC, HERC5 was significantly associated with age, hormonal status, clinical stage, treatment status, and metastasis. Elevated HERC5 expression was linked to worse progression-free interval, disease-specific survival, and overall survival in UCEC, particularly in diverse clinical subgroups. Significant differences in HERC5 expression were also observed in various human cancer cell line validations. In summary, HERC5 may be a critical biomarker for pan-cancer prognosis, progression, and diagnosis, as well as a promising new target for cancer therapy.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"132 11","pages":"760-774"},"PeriodicalIF":2.2,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apm.13462","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142091711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Forssman and the staphylococcal hemolysins 福斯曼和葡萄球菌溶血素

IF 2.2 4区医学

Apmis Pub Date : 2024-08-27 DOI: 10.1111/apm.13459

Hanne Ingmer, Jørgen J. Leisner, Stephanie Fulaz

引用次数: 0

Reply to “Comment on micro- and nanorobots for biofilm eradication” 回复 "关于用于消除生物膜的微型和纳米机器人的评论"。

IF 2.2 4区医学

Apmis Pub Date : 2024-08-13 DOI: 10.1111/apm.13460

Naji Naseef Pathoor, Pitchaipillai Sankar Ganesh

引用次数: 0

RE: Aetiological profile of acute encephalitis syndrome in Assam, India, during a 4-year period from 2019 to 2022 RE：2019年至2022年4年间印度阿萨姆邦急性脑炎综合征的病原学概况。

IF 2.2 4区医学

Apmis Pub Date : 2024-08-13 DOI: 10.1111/apm.13461

Hinpetch Daungsupawong, Viroj Wiwanitkit

引用次数: 0

Decreased T-cell response against latent cytomegalovirus infection does not correlate with anti-IFN autoantibodies in patients with APECED 在 APECED 患者中，针对潜伏巨细胞病毒感染的 T 细胞反应降低与抗 IFN 自身抗体无关。

IF 2.2 4区医学

Apmis Pub Date : 2024-08-07 DOI: 10.1111/apm.13458

Iivo Hetemäki, Nelli Heikkilä, Pärt Peterson, Eliisa Kekäläinen, Nick Willcox, Wolff Anette S. B., Hanna Jarva, T Petteri Arstila

{"title":"Decreased T-cell response against latent cytomegalovirus infection does not correlate with anti-IFN autoantibodies in patients with APECED","authors":"Iivo Hetemäki, Nelli Heikkilä, Pärt Peterson, Eliisa Kekäläinen, Nick Willcox, Wolff Anette S. B., Hanna Jarva, T Petteri Arstila","doi":"10.1111/apm.13458","DOIUrl":"10.1111/apm.13458","url":null,"abstract":"Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is an inborn error of immunity affecting both multiple endocrine organs and susceptibility to candidiasis, each with an autoimmune basis. Recently, high titer neutralizing anti-type I interferon (IFN) autoantibodies have been linked with increased severity of SARS-CoV-2 and varicella zoster virus infections in APECED patients. Examining immunity against cytomegalovirus (CMV), we found a higher prevalence of anti-CMV IgG antibodies in patients with APECED (N = 19) than in 44 healthy controls (90% vs 64%, p = 0.04); the similar difference in their IgG levels did not achieve significance (95 ± 74 vs 64 ± 35 IU/mL, ns.). In contrast, the frequency of CMV-specific T cells was lower (804 ± 718/million vs 1591 ± 972/million PBMC p = 0.03). We saw no correlations between levels of anti-CMV IgG and anti-IFN antibodies in APECED patients or in a separate cohort of patients with thymoma (n = 70), over 60% of whom also had anti-IFN antibodies. Our results suggest a dysregulated response to CMV in APECED patients and highlight immunodeficiency to viral infections as part of the disease spectrum.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"132 11","pages":"881-887"},"PeriodicalIF":2.2,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apm.13458","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141900759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world data confirm elexacftor/tezacaftor/ivacaftor modulators halves sweat chloride concentration in eligible people with cystic fibrosis 真实世界的数据证实，elexacftor/tezacaftor/ivacaftor调节剂可将符合条件的囊性纤维化患者的汗液氯化物浓度减半。

IF 2.2 4区医学

Apmis Pub Date : 2024-08-02 DOI: 10.1111/apm.13453

Thomas Bryrup, Daniel Faurholt-Jepsen, Tacjana Pressler, Esben Herborg Henriksen, Christian Leo-Hansen, Bibi Uhre Nielsen, Christine Højte, Inger Hee Mabuza Mathiesen, Terese L. Katzenstein, Majbritt Jeppesen, Søren Jensen-Fangel, Hanne Vebert Olesen, Marianne Skov, Tavs Qvist, Mette Frahm Olsen, the TransformCF Study Group

{"title":"Real-world data confirm elexacftor/tezacaftor/ivacaftor modulators halves sweat chloride concentration in eligible people with cystic fibrosis","authors":"Thomas Bryrup, Daniel Faurholt-Jepsen, Tacjana Pressler, Esben Herborg Henriksen, Christian Leo-Hansen, Bibi Uhre Nielsen, Christine Højte, Inger Hee Mabuza Mathiesen, Terese L. Katzenstein, Majbritt Jeppesen, Søren Jensen-Fangel, Hanne Vebert Olesen, Marianne Skov, Tavs Qvist, Mette Frahm Olsen, the TransformCF Study Group","doi":"10.1111/apm.13453","DOIUrl":"10.1111/apm.13453","url":null,"abstract":"Sweat chloride concentration, a diagnostic feature in cystic fibrosis (CF), reflects CF transmembrane conductance regulator (CFTR) activity. CFTR modulator therapies, especially elexacaftor/tezacaftor/ivacaftor (ETI), has improved CF outcomes. We report nationwide, real-world data on sweat chloride concentration in people with CF (pwCF) with and without modulator therapies. All Danish pwCF with a minimum of one F508del allele were included. Sweat chloride measurements were stratified by genotype and modulator treatment. Differences were assessed using mixed-effects models. We included 977 sweat chloride measurements from 430 pwCF, 71% of which were F508del homozygous. Heterozygous and homozygous ETI-treated pwCF had an estimated mean sweat chloride concentration of 43 mmol/L (95% confidence interval: 39; 48) and 43 mmol/L (39; 47), respectively—48% and 59% lower than those without treatment. High variation in concentrations remained regardless of treatment status. Despite ETI treatment, 27% heterozygous and 23% homozygous pwCF had elevated concentrations (≥60 mmol/L). These real-world data confirm a substantial decrease in sweat chloride concentration during modulator treatment, especially ETI, where mean concentrations halved. However, large variation remained, including persistently high concentrations. These findings emphasize the potential of sweat chloride concentration as a treatment response biomarker and the need to explore its heterogeneity and relationship with clinical outcomes.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"132 10","pages":"728-733"},"PeriodicalIF":2.2,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apm.13453","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141873988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A mathematical description of nonself for biallelic genetic systems in pregnancy, transfusion, and transplantation 妊娠、输血和移植中的双偶联遗传系统的非自我数学描述。

IF 2.2 4区医学

Apmis Pub Date : 2024-07-19 DOI: 10.1111/apm.13457

Klaus Rieneck

引用次数: 0

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