IF 2.2 4区医学

Apmis Pub Date : 2024-09-02 DOI: 10.1111/apm.13463

Jingjing Mu, Yue Shen, Furong Zhu, Qixia Zhang

{"title":"Association of TLR4 polymorphisms (Asp299Gly and Thr399Ile) with sepsis: a meta-analysis and trial sequence analysis","authors":"Jingjing Mu, Yue Shen, Furong Zhu, Qixia Zhang","doi":"10.1111/apm.13463","DOIUrl":"10.1111/apm.13463","url":null,"abstract":"Several investigations have been carried out to explore the genetic association of TLR4 codon variants, specifically Asp299Gly and Thr399Ile, and susceptibility to sepsis, but the results have been contradictory. The present study aimed to conduct a meta-analysis to draw a definitive conclusion regarding the role of TLR4 genetic variants (Asp299Gly and Thr399Ile) in sepsis. A thorough literature search was conducted using the PubMed, Scopus, and Science Direct databases. The inclusion and exclusion criteria were established to ensure the accuracy of the data. The Comprehensive Meta-Analysis Software v4 was utilized to perform the meta-analysis and related analyses. A total of 13 studies were analyzed, including 2328 sepsis cases and 2495 healthy controls for the TLR4 Asp299Gly variant. Eight studies provided genotype data for the rs4986791 polymorphism. The Asp299Gly variant showed a marginal protective effect in the allele (p = 0.08, odds ratio = 0.71) and dominant (p = 0.09, odds ratio = 0.71) genetic models, although it was not statistically significant. The trial sequential analysis indicated that further case–control studies are necessary to draw definitive conclusions about the TLR4 polymorphisms in sepsis. The TLR4 Asp299Gly variant may have a protective effect against sepsis. However, additional research with larger sample sizes across diverse populations is required to validate this finding.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"132 11","pages":"869-880"},"PeriodicalIF":2.2,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HERC5: a comprehensive in silico analysis of its diagnostic, prognostic, and therapeutic potential in cancer HERC5：对其在癌症诊断、预后和治疗方面潜力的全面硅学分析。

IF 2.2 4区医学

Apmis Pub Date : 2024-08-28 DOI: 10.1111/apm.13462

Xianqing Sun, Peng Qiu, Zhennan He, Yuan Zhu, Rui Zhang, Xiang Li, Xiaoyan Wang

{"title":"HERC5: a comprehensive in silico analysis of its diagnostic, prognostic, and therapeutic potential in cancer","authors":"Xianqing Sun, Peng Qiu, Zhennan He, Yuan Zhu, Rui Zhang, Xiang Li, Xiaoyan Wang","doi":"10.1111/apm.13462","DOIUrl":"10.1111/apm.13462","url":null,"abstract":"HERC5, a vital protein in the HERC family, plays crucial roles in immune response, cancer progression, and antiviral defense. This bioinformatic study comprehensively assessed HERC5's significance across various malignancies by analyzing its gene expression, immune and molecular subtype expressions, target proteins, biological functions, and prognostic and diagnostic values in pan-cancer. We further examined its correlation with clinical features, co-expressed and differentially expressed genes, and prognosis in clinical subgroups, focusing on endometrial cancer (UCEC). Our findings showed that HERC5 RNA is expressed at low levels in most cancers and significantly differs across immune and molecular subtypes. HERC5 accurately predicts cancer and correlates with most cancer prognoses. In UCEC, HERC5 was significantly associated with age, hormonal status, clinical stage, treatment status, and metastasis. Elevated HERC5 expression was linked to worse progression-free interval, disease-specific survival, and overall survival in UCEC, particularly in diverse clinical subgroups. Significant differences in HERC5 expression were also observed in various human cancer cell line validations. In summary, HERC5 may be a critical biomarker for pan-cancer prognosis, progression, and diagnosis, as well as a promising new target for cancer therapy.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"132 11","pages":"760-774"},"PeriodicalIF":2.2,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apm.13462","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142091711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Forssman and the staphylococcal hemolysins 福斯曼和葡萄球菌溶血素

IF 2.2 4区医学

Apmis Pub Date : 2024-08-27 DOI: 10.1111/apm.13459

Hanne Ingmer, Jørgen J. Leisner, Stephanie Fulaz

引用次数: 0

Reply to “Comment on micro- and nanorobots for biofilm eradication” 回复 "关于用于消除生物膜的微型和纳米机器人的评论"。

IF 2.2 4区医学

Apmis Pub Date : 2024-08-13 DOI: 10.1111/apm.13460

Naji Naseef Pathoor, Pitchaipillai Sankar Ganesh

引用次数: 0

RE: Aetiological profile of acute encephalitis syndrome in Assam, India, during a 4-year period from 2019 to 2022 RE：2019年至2022年4年间印度阿萨姆邦急性脑炎综合征的病原学概况。

IF 2.2 4区医学

Apmis Pub Date : 2024-08-13 DOI: 10.1111/apm.13461

Hinpetch Daungsupawong, Viroj Wiwanitkit

引用次数: 0

Decreased T-cell response against latent cytomegalovirus infection does not correlate with anti-IFN autoantibodies in patients with APECED 在 APECED 患者中，针对潜伏巨细胞病毒感染的 T 细胞反应降低与抗 IFN 自身抗体无关。

IF 2.2 4区医学

Apmis Pub Date : 2024-08-07 DOI: 10.1111/apm.13458

Iivo Hetemäki, Nelli Heikkilä, Pärt Peterson, Eliisa Kekäläinen, Nick Willcox, Wolff Anette S. B., Hanna Jarva, T Petteri Arstila

{"title":"Decreased T-cell response against latent cytomegalovirus infection does not correlate with anti-IFN autoantibodies in patients with APECED","authors":"Iivo Hetemäki, Nelli Heikkilä, Pärt Peterson, Eliisa Kekäläinen, Nick Willcox, Wolff Anette S. B., Hanna Jarva, T Petteri Arstila","doi":"10.1111/apm.13458","DOIUrl":"10.1111/apm.13458","url":null,"abstract":"Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is an inborn error of immunity affecting both multiple endocrine organs and susceptibility to candidiasis, each with an autoimmune basis. Recently, high titer neutralizing anti-type I interferon (IFN) autoantibodies have been linked with increased severity of SARS-CoV-2 and varicella zoster virus infections in APECED patients. Examining immunity against cytomegalovirus (CMV), we found a higher prevalence of anti-CMV IgG antibodies in patients with APECED (N = 19) than in 44 healthy controls (90% vs 64%, p = 0.04); the similar difference in their IgG levels did not achieve significance (95 ± 74 vs 64 ± 35 IU/mL, ns.). In contrast, the frequency of CMV-specific T cells was lower (804 ± 718/million vs 1591 ± 972/million PBMC p = 0.03). We saw no correlations between levels of anti-CMV IgG and anti-IFN antibodies in APECED patients or in a separate cohort of patients with thymoma (n = 70), over 60% of whom also had anti-IFN antibodies. Our results suggest a dysregulated response to CMV in APECED patients and highlight immunodeficiency to viral infections as part of the disease spectrum.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"132 11","pages":"881-887"},"PeriodicalIF":2.2,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apm.13458","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141900759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world data confirm elexacftor/tezacaftor/ivacaftor modulators halves sweat chloride concentration in eligible people with cystic fibrosis 真实世界的数据证实，elexacftor/tezacaftor/ivacaftor调节剂可将符合条件的囊性纤维化患者的汗液氯化物浓度减半。

IF 2.2 4区医学

Apmis Pub Date : 2024-08-02 DOI: 10.1111/apm.13453

Thomas Bryrup, Daniel Faurholt-Jepsen, Tacjana Pressler, Esben Herborg Henriksen, Christian Leo-Hansen, Bibi Uhre Nielsen, Christine Højte, Inger Hee Mabuza Mathiesen, Terese L. Katzenstein, Majbritt Jeppesen, Søren Jensen-Fangel, Hanne Vebert Olesen, Marianne Skov, Tavs Qvist, Mette Frahm Olsen, the TransformCF Study Group

{"title":"Real-world data confirm elexacftor/tezacaftor/ivacaftor modulators halves sweat chloride concentration in eligible people with cystic fibrosis","authors":"Thomas Bryrup, Daniel Faurholt-Jepsen, Tacjana Pressler, Esben Herborg Henriksen, Christian Leo-Hansen, Bibi Uhre Nielsen, Christine Højte, Inger Hee Mabuza Mathiesen, Terese L. Katzenstein, Majbritt Jeppesen, Søren Jensen-Fangel, Hanne Vebert Olesen, Marianne Skov, Tavs Qvist, Mette Frahm Olsen, the TransformCF Study Group","doi":"10.1111/apm.13453","DOIUrl":"10.1111/apm.13453","url":null,"abstract":"Sweat chloride concentration, a diagnostic feature in cystic fibrosis (CF), reflects CF transmembrane conductance regulator (CFTR) activity. CFTR modulator therapies, especially elexacaftor/tezacaftor/ivacaftor (ETI), has improved CF outcomes. We report nationwide, real-world data on sweat chloride concentration in people with CF (pwCF) with and without modulator therapies. All Danish pwCF with a minimum of one F508del allele were included. Sweat chloride measurements were stratified by genotype and modulator treatment. Differences were assessed using mixed-effects models. We included 977 sweat chloride measurements from 430 pwCF, 71% of which were F508del homozygous. Heterozygous and homozygous ETI-treated pwCF had an estimated mean sweat chloride concentration of 43 mmol/L (95% confidence interval: 39; 48) and 43 mmol/L (39; 47), respectively—48% and 59% lower than those without treatment. High variation in concentrations remained regardless of treatment status. Despite ETI treatment, 27% heterozygous and 23% homozygous pwCF had elevated concentrations (≥60 mmol/L). These real-world data confirm a substantial decrease in sweat chloride concentration during modulator treatment, especially ETI, where mean concentrations halved. However, large variation remained, including persistently high concentrations. These findings emphasize the potential of sweat chloride concentration as a treatment response biomarker and the need to explore its heterogeneity and relationship with clinical outcomes.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"132 10","pages":"728-733"},"PeriodicalIF":2.2,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apm.13453","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141873988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A mathematical description of nonself for biallelic genetic systems in pregnancy, transfusion, and transplantation 妊娠、输血和移植中的双偶联遗传系统的非自我数学描述。

IF 2.2 4区医学

Apmis Pub Date : 2024-07-19 DOI: 10.1111/apm.13457

Klaus Rieneck

引用次数: 0

Exploring the role of mesenchymal stem cells in modulating immune responses via Treg and Th2 cell activation: insights from mouse model of multiple sclerosis 探索间充质干细胞在通过Treg和Th2细胞激活调节免疫反应中的作用：多发性硬化症小鼠模型的启示。

IF 2.2 4区医学

Apmis Pub Date : 2024-07-19 DOI: 10.1111/apm.13456

Abdolvahid Sadeghnejad, Alireza Pazoki, Esmaeil Yazdanpanah, Seyed-Alireza Esmaeili, Bahman Yousefi, Bijan Sadighi-Moghaddam, Rasoul Baharlou, Dariush Haghmorad

{"title":"Exploring the role of mesenchymal stem cells in modulating immune responses via Treg and Th2 cell activation: insights from mouse model of multiple sclerosis","authors":"Abdolvahid Sadeghnejad, Alireza Pazoki, Esmaeil Yazdanpanah, Seyed-Alireza Esmaeili, Bahman Yousefi, Bijan Sadighi-Moghaddam, Rasoul Baharlou, Dariush Haghmorad","doi":"10.1111/apm.13456","DOIUrl":"10.1111/apm.13456","url":null,"abstract":"Multiple sclerosis is a demyelinating neurodegenerative disease, and its animal model, experimental autoimmune encephalomyelitis (EAE), exhibits immunological and clinical similarities. The study aimed to examine mechanisms underlying therapeutic effects of mesenchymal stem cell administration in EAE. C57BL/6 mice were separated into control and treatment groups (T1, T2, and T3); EAE was induced in all animals. Clinical examinations were conducted daily, and on 25th day, animals were sacrificed, and spinal cord was stained for histological analysis. Additionally, spleen cell proliferation assay, assessments of cytokine, and gene expression in both spinal cord and spleen cells were performed. The results indicated a significant reduction in clinical symptoms among treatment groups compared to control group. Histological analyses revealed decreased infiltration of lymphocytes into the spinal cord and reduced demyelinated areas in treatment groups compared to control group. Cytokine production of IL-10, TGF-β, and IL-4 were significantly enhanced and IFN-γ and TNF-α in treatment groups were decreased relative to control group. Also, gene expression of CTLA-4, PD-1, IL-27, and IL-33 indicated a significant increase in treatment groups. The administration of MSCs significantly improved clinical symptoms, attenuated inflammation, and reduced spinal cord demyelination in EAE, suggesting a potential protective effect on disease progression.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"132 11","pages":"888-899"},"PeriodicalIF":2.2,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141730989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unravelling the intricacies of Porphyromonas gingivalis: virulence factors, lifecycle dynamics and phytochemical interventions for periodontal disease management 揭开牙龈卟啉单胞菌的神秘面纱：毒力因子、生命周期动态和牙周病管理的植物化学干预措施。

IF 2.2 4区医学

Apmis Pub Date : 2024-07-19 DOI: 10.1111/apm.13440

Rubeen Nadaf, Vijay M. Kumbar, Shridhar Ghagane

引用次数: 0

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