Viral intruders in the heart: A review of RNA viruses and their role in cardiac disorders.

IF 2.2 4区 医学 Q4 IMMUNOLOGY
Apmis Pub Date : 2024-11-12 DOI:10.1111/apm.13500
Shahram Jalilian, Mona Vasei, Ashkan Garshasbi, Seyed Salaheddin Nabavi, Mohammad-Navid Bastani
{"title":"Viral intruders in the heart: A review of RNA viruses and their role in cardiac disorders.","authors":"Shahram Jalilian, Mona Vasei, Ashkan Garshasbi, Seyed Salaheddin Nabavi, Mohammad-Navid Bastani","doi":"10.1111/apm.13500","DOIUrl":null,"url":null,"abstract":"<p><p>Viral cardiac diseases have a significant impact on global health, and RNA viruses play a crucial role in their pathogenesis. This literature review aims to provide a comprehensive understanding of the complex relationship between RNA viruses and cardiac diseases, focusing on the molecular processes and clinical implications of these interactions. The paper begins by discussing the various RNA viruses that have been linked to cardiac infections. Subsequently, the study explores the mechanisms through which RNA viruses can cause cardiac injury, including direct viral invasion, immune-mediated responses, and molecular mimicry. The review extensively examines the intricate interplay between the host immune system and RNA viruses, shedding light on both protective and harmful immune responses. Additionally, it investigates the role of viral persistence and chronic inflammation in the long-term effects on cardiac health. The thorough analysis presented not only enhances our scientific understanding of how RNA viruses contribute to the development of cardiac diseases but also highlights potential avenues for future research and breakthroughs in this field. Given the significant global health threat posed by viral cardiac disorders, unraveling the molecular foundations of these diseases is essential for advancing diagnostic capabilities and therapeutic interventions.</p>","PeriodicalId":8167,"journal":{"name":"Apmis","volume":" ","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Apmis","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/apm.13500","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Viral cardiac diseases have a significant impact on global health, and RNA viruses play a crucial role in their pathogenesis. This literature review aims to provide a comprehensive understanding of the complex relationship between RNA viruses and cardiac diseases, focusing on the molecular processes and clinical implications of these interactions. The paper begins by discussing the various RNA viruses that have been linked to cardiac infections. Subsequently, the study explores the mechanisms through which RNA viruses can cause cardiac injury, including direct viral invasion, immune-mediated responses, and molecular mimicry. The review extensively examines the intricate interplay between the host immune system and RNA viruses, shedding light on both protective and harmful immune responses. Additionally, it investigates the role of viral persistence and chronic inflammation in the long-term effects on cardiac health. The thorough analysis presented not only enhances our scientific understanding of how RNA viruses contribute to the development of cardiac diseases but also highlights potential avenues for future research and breakthroughs in this field. Given the significant global health threat posed by viral cardiac disorders, unraveling the molecular foundations of these diseases is essential for advancing diagnostic capabilities and therapeutic interventions.

病毒入侵心脏:回顾 RNA 病毒及其在心脏疾病中的作用。
病毒性心脏病对全球健康有着重大影响,而 RNA 病毒在其发病机制中起着至关重要的作用。本文献综述旨在全面了解 RNA 病毒与心脏疾病之间的复杂关系,重点关注这些相互作用的分子过程和临床影响。本文首先讨论了与心脏感染有关的各种 RNA 病毒。随后,研究探讨了 RNA 病毒导致心脏损伤的机制,包括病毒直接入侵、免疫介导反应和分子模拟。综述广泛探讨了宿主免疫系统与 RNA 病毒之间错综复杂的相互作用,揭示了保护性和有害性免疫反应。此外,它还研究了病毒持续存在和慢性炎症对心脏健康的长期影响。所做的详尽分析不仅增强了我们对 RNA 病毒如何导致心脏疾病发展的科学理解,还突出了该领域未来研究和突破的潜在途径。鉴于病毒性心脏疾病对全球健康构成重大威胁,揭示这些疾病的分子基础对于提高诊断能力和治疗干预措施至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Apmis
Apmis 医学-病理学
CiteScore
5.20
自引率
0.00%
发文量
91
审稿时长
2 months
期刊介绍: APMIS, formerly Acta Pathologica, Microbiologica et Immunologica Scandinavica, has been published since 1924 by the Scandinavian Societies for Medical Microbiology and Pathology as a non-profit-making scientific journal.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信