Apmis最新文献 - Book学术

Forssman and the staphylococcal hemolysins. 福斯曼和葡萄球菌溶血素

IF 2.2 4区医学

Apmis Pub Date : 2025-01-01 Epub Date: 2024-08-27 DOI: 10.1111/apm.13459

Hanne Ingmer, Jørgen J Leisner, Stephanie Fulaz

引用次数: 0

Impact of histopathological and serological assessments on early diagnosis of leprosy relapse. 组织病理学和血清学评估对麻风病复发早期诊断的影响。

IF 2.2 4区医学

Apmis Pub Date : 2025-01-01 Epub Date: 2024-11-12 DOI: 10.1111/apm.13497

Bruno de Carvalho Dornelas, Willian Vargas Tenório da Costa, João Pablo Ferraz de Abreu, Juliana Salomão Daud, Felipe Dos Anjos Rodrigues Campos, Deiriene Rodrigues de Oliveira Campos, Douglas Eulálio Antunes, Lúcio Borges de Araújo, Diogo Fernandes Dos Santos, Cleverson Teixeira Soares, Isabela Maria Bernardes Goulart

{"title":"Impact of histopathological and serological assessments on early diagnosis of leprosy relapse.","authors":"Bruno de Carvalho Dornelas, Willian Vargas Tenório da Costa, João Pablo Ferraz de Abreu, Juliana Salomão Daud, Felipe Dos Anjos Rodrigues Campos, Deiriene Rodrigues de Oliveira Campos, Douglas Eulálio Antunes, Lúcio Borges de Araújo, Diogo Fernandes Dos Santos, Cleverson Teixeira Soares, Isabela Maria Bernardes Goulart","doi":"10.1111/apm.13497","DOIUrl":"10.1111/apm.13497","url":null,"abstract":"This study aimed to identify laboratory factors predicting leprosy relapse (LR) after multi-drug therapy (MDT). A case-control study included 80 patients treated with MDT at a national reference center over 12 years. The Relapse Group had 40 patients who relapsed after an average of 89.2 months post-MDT, while the Control Group had 40 patients who remained asymptomatic for an average of 113.1 months. Significant predictors of LR included neural/perineural lymphocytic infiltrate (OR = 4.67; p = 0.0076) and foamy granulomas (OR = 15.55; p = 0.0005), increasing odds by 4.7 and 15.6 times, respectively. The Relapse Group had a mean histological bacillary index (hBI) of 3.23+ compared to 1.8 in the Control Group (p = 0.004). An hBI ≥3+ had 72% sensitivity and 65% specificity for detecting LR (AUC = 0.72; p = 0.0002). Elevated anti-phenolic glycolipid I (anti-PGL-I) IgM antibody levels (ELISA index, EI ≥1) were also associated with LR (OR = 4.67; p = 0.0031). An EI ≥3.6 had 71% sensitivity and 62% specificity (AUC = 0.70; p = 0.0012). Multivariate analysis indicated that neural/perineural infiltrate, foamy granulomas, hBI ≥ 1+, and EI ≥ 1 significantly predicted LR, with up to 94.32% probability. Conclusively, these factors can identify individuals at high probability of LR after MDT.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":" ","pages":"e13497"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Echinacoside attenuates Klebsiella pneumoniae-induced pneumonia via inhibition of the TLR4/NF-κB signaling.

IF 2.2 4区医学

Apmis Pub Date : 2025-01-01 DOI: 10.1111/apm.13507

Mi Zhang, Ming Zhan, Xinyu Song

{"title":"Echinacoside attenuates Klebsiella pneumoniae-induced pneumonia via inhibition of the TLR4/NF-κB signaling.","authors":"Mi Zhang, Ming Zhan, Xinyu Song","doi":"10.1111/apm.13507","DOIUrl":"https://doi.org/10.1111/apm.13507","url":null,"abstract":"The Gram-negative bacterium Klebsiella pneumoniae (K. pneumoniae) is one major causative agent of community- and hospital-acquired pneumonia. Echinacoside (ECH) is a phenylethanoid glycoside isolated from Cistanche deserticola that possesses anti-inflammatory activity. Our research aimed to confirm whether ECH alleviates K. pneumoniae-induced pneumonia and explore the underlying regulatory mechanisms. BEAS-2B cells and BALB/c mice were infected by K. pneumoniae to establish the cellular and animal models, respectively, followed by ECH treatment. Inflammatory cytokine levels were detected by RT-qPCR and ELISA. The lung wet/dry (W/D) weight ratio and the myeloperoxidase (MPO) activity in lung tissues were examined. The pulmonary histopathologic changes were observed through hematoxylin and eosin (H&E) staining. The levels of TLR4/NF-κB pathway-associated molecules were estimated through western blotting, immunohistochemical, and immunohistochemical staining. K. pneumoniae infection caused lung histopathologic damage, enhanced MPO activity, elevated lung W/D weight ratio, and upregulated inflammatory cytokine levels in mice and promoted inflammatory cytokine expression in BEAS-2B cells, which were reversed by ECH treatment. K. pneumoniae infection-induced upregulation in TLR4, phosphorylated (p)-p65, and p-IκBα levels, and downregulation in IκBα levels in BEAS-2B cells and pneumonia mice were overturned by ECH treatment. ECH ameliorates K. pneumoniae-induced pneumonia through suppressing the TLR4/NF-κB pathway.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"133 1","pages":"e13507"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fritz Kauffmann: innovator in microbial classification.

IF 2.2 4区医学

Apmis Pub Date : 2025-01-01 DOI: 10.1111/apm.13504

Rie Jønsson, Mathias Mølbak Ingholt, Karen Angeliki Krogfelt

引用次数: 0

Örjan Ouchterlony and the antigen-antibody double diffusion-in-gel: a survey. Örjan Ouchterlony 和抗原抗体凝胶双重扩散：一项调查。

IF 2.2 4区医学

Apmis Pub Date : 2025-01-01 Epub Date: 2024-10-16 DOI: 10.1111/apm.13480

Niels Høiby

引用次数: 0

Celebrating a century of APMIS: a legacy of pathology, microbiology, and immunology. 庆祝亚太医学信息管理系统一百周年：病理学、微生物学和免疫学的遗产。

IF 2.2 4区医学

Apmis Pub Date : 2025-01-01 Epub Date: 2024-06-30 DOI: 10.1111/apm.13452

Bodil Norrild, Ulrik Ralfkiaer

{"title":"Celebrating a century of APMIS: a legacy of pathology, microbiology, and immunology.","authors":"Bodil Norrild, Ulrik Ralfkiaer","doi":"10.1111/apm.13452","DOIUrl":"10.1111/apm.13452","url":null,"abstract":"This manuscript commemorates the 100th anniversary of APMIS, highlighting its evolution from a regional journal, founded in 1924 as Acta Pathologica et Microbiologica Scandinavica, to an international platform fostering global collaboration in pathology, microbiology, and immunology. The journal's inception was driven by Ulrik Quensel's vision in 1919, leading to the establishment of the Northern Pathological Society and the launch of the journal in 1924. APMIS has consistently published landmark research, including significant contributions from prominent. These studies have advanced understanding in fields such as pathology, microbiology, and immunology. The journal expanded its scope in the 1970s to include immunology, rebranding as APMIS in the mid-1980s. Recent decades have seen a continued commitment to cutting-edge research and an increasing impact factor. As APMIS transitions to an Open Access model under Wiley, it will be renamed the PMI Journal (Pathology, Microbiology, and Immunology) to reflect its global reach and dedication to scientific excellence. This centennial celebration acknowledges the contributions of editors, authors, and readers, looking forward to future advancements in biomedical research.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":" ","pages":"e13452"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beta-cell activity and development of Type 1 diabetes. Beta 细胞活性与 1 型糖尿病的发展。

IF 2.2 4区医学

Apmis Pub Date : 2025-01-01 Epub Date: 2024-05-26 DOI: 10.1111/apm.13441

Rikke Thea, Karsten Buschard

引用次数: 0

Historical concepts and contemporary perspectives of dental caries-a tribute to Henrik Dam (1895-1976). 龋齿的历史概念和当代视角--向亨利克-达姆（1895-1976 年）致敬。

IF 2.2 4区医学

Apmis Pub Date : 2025-01-01 Epub Date: 2024-11-19 DOI: 10.1111/apm.13501

Merete Markvart, Christiane E Sørensen, Kim R Ekstrand, Sebastian Schlafer, Daniel Belstrøm

引用次数: 0

Fungal positivity and other laboratory parameters in HIV- and non-HIV-related cryptococcal meningitis patients upon antifungal treatment

IF 2.2 4区医学

Apmis Pub Date : 2024-12-16 DOI: 10.1111/apm.13476

Chaojuan Liang, Shaoyong Xi, Hanzhen Su, Lida Mo, Liejun Jiang, Huan Lu, Huayi Huang

{"title":"Fungal positivity and other laboratory parameters in HIV- and non-HIV-related cryptococcal meningitis patients upon antifungal treatment","authors":"Chaojuan Liang, Shaoyong Xi, Hanzhen Su, Lida Mo, Liejun Jiang, Huan Lu, Huayi Huang","doi":"10.1111/apm.13476","DOIUrl":"10.1111/apm.13476","url":null,"abstract":"The association between fungal positivity in cerebral spinal fluid (CSF) and other laboratory parameters in cryptococcal meningitis (CM) with or without HIV infection is unclear. India ink staining and culture were used to detect the Cryptococcus in the CSF during the treatment course. Hematology analysis and chemistry analysis of CSF were also performed. Flow cytometry was used to analyze the T lymphocyte subsets in the blood. The positivity of the culture reduced significantly faster than that of the ink staining in both HIV and non-HIV patients between treatment time points. The total protein in the CSF of the HIV-related patients was significantly lower than in the non-HIV-related patients at all time points of treatment (p = 0.009, 0.012, 0.001, and 0.037, respectively). The lactate dehydrogenase (LDH) in the CSF of the HIV-related patients at admission was significantly lower than in the non-HIV-related patients (p = 0.017). There were significant differences in glucose and LDH levels between different time points of treatment (p = 0.000 and 0.016, respectively) in the non-HIV-related patients. For Cryptococcus detection in CSF, the culture method appeared to be more sensitive and reliable than the ink staining method. HIV-related CM patients showed certain hematologic and CSF chemistry features which may help guide the management of patients.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"133 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of toll-like receptors in recurrent pleomorphic adenoma and carcinoma ex pleomorphic adenoma 复发性多形性腺瘤和多形性腺瘤癌的收费样受体表达。

IF 2.2 4区医学

Apmis Pub Date : 2024-12-16 DOI: 10.1111/apm.13505

Maria K. Jauhiainen, Anttoni Markkanen, Timo Atula, Katri Aro, Caj Haglund, Maria Söderlund-Venermo, Antti A. Mäkitie, Saku T. Sinkkonen, Jaana Hagström

{"title":"Expression of toll-like receptors in recurrent pleomorphic adenoma and carcinoma ex pleomorphic adenoma","authors":"Maria K. Jauhiainen, Anttoni Markkanen, Timo Atula, Katri Aro, Caj Haglund, Maria Söderlund-Venermo, Antti A. Mäkitie, Saku T. Sinkkonen, Jaana Hagström","doi":"10.1111/apm.13505","DOIUrl":"10.1111/apm.13505","url":null,"abstract":"Pleomorphic adenoma (PA) is a benign salivary gland tumour that may recur or undergo malignant transformation (CXPA). Toll-like receptors (TLR) mediate immune responses triggered by various agents such as viruses and are related to tumour formation either by stimulating or suppressing their growth, with variation across different tumour entities. We compared TLR immunohistochemical expression in PA, its recurrent counterparts and CXPA and evaluated the effect of virus presence in these tumours. We studied the expression of TLR-2, -3, -5, -7 and -9 in 25 PA, 34 recurrent PA and 15 CXPA tumour samples. In addition, we examined the TLR expression levels in the presence and absence of herpes-, polyoma- and parvovirus DNA in a subset of tumours (n = 20). CXPA expressed significantly more TLR-5 and TLR-9 in the nucleus, cytoplasm and cell membrane compared with benign PA. The presence of virus DNA did not notably affect the TLR expression. TLR expression patterns seem to reflect tumour behaviour but are independent of the presence of viruses tested in this study.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"133 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apm.13505","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0