Apmis最新文献 - Book学术

Microwaves Activate Immune Response and Promote Lymphocytes Proliferation of Wistar Rats

IF 2.2 4区医学

Apmis Pub Date : 2025-03-14 DOI: 10.1111/apm.70017

Ma Lizhen, Cao Shuhua, Zou Yong, Zhi Weijia, Zhao Xuelong, Zhang Mingzhao, Yan Zhifeng, Hu Xiangjun, Wang Lifeng

{"title":"Microwaves Activate Immune Response and Promote Lymphocytes Proliferation of Wistar Rats","authors":"Ma Lizhen, Cao Shuhua, Zou Yong, Zhi Weijia, Zhao Xuelong, Zhang Mingzhao, Yan Zhifeng, Hu Xiangjun, Wang Lifeng","doi":"10.1111/apm.70017","DOIUrl":"https://doi.org/10.1111/apm.70017","url":null,"abstract":"<div>\u0000 \u0000 <p>The potential effects of microwave radiation have gained increasing attention due to its widespread application in daily life. This study aimed to investigate its effects on rat immune function. Male Wistar rats were subjected to 2.856 GHz microwave radiation for 20 min. Cytokine levels in serum were measured by ELISA at 0 and 7 days' post-exposure. HE staining was used to observe the structure of the spleen. Morphology and proliferation of spleen mixed lymphocytes were detected after 24 h of culture, and proliferation was evaluated by the CCK-8 assay. Expression of HSP70 and calreticulin (CRT) was assessed by WB. Rats showed an increased secretion of inflammatory factors in serum. Spleen tissue revealed no significant damage. Compared to the control group, irradiated groups (R-0d and R-7d) showed a significant increase and thickening of the white pulp. The boundary between the red and white medulla in the R-7d group appeared blurred. CCK-8 assay showed that splenic mixed lymphocytes in the irradiated group showed a significant proliferation. There was no significant difference in HSP70 and CRT expression between the exposed and control groups. Microwave exposure might activate the immune system of rats, potentially triggering a T cell-mediated inflammatory response.</p>\u0000 </div>","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"133 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kurarinone Attenuates LPS-Induced Pneumonia by Inhibiting MAPK and NF-κB Signaling Pathways

IF 2.2 4区医学

Apmis Pub Date : 2025-03-13 DOI: 10.1111/apm.70013

Lili Wang, Guoyu Lu, Fangli Wang, Yanyan Tao, Changyuan Dai

{"title":"Kurarinone Attenuates LPS-Induced Pneumonia by Inhibiting MAPK and NF-κB Signaling Pathways","authors":"Lili Wang, Guoyu Lu, Fangli Wang, Yanyan Tao, Changyuan Dai","doi":"10.1111/apm.70013","DOIUrl":"https://doi.org/10.1111/apm.70013","url":null,"abstract":"<div>\u0000 \u0000 <p>Kurarinone is a prenylated flavanone isolated from <i>Sophora flavescens</i> Aiton. This investigation aimed to elucidate whether kurarinone could ameliorate lipopolysaccharide (LPS)-induced pneumonia and explore the underlying mechanism. C57BL/6 mice were treated with LPS (50 μg/20 μL) to establish pneumonia models. Kurarinone (100 mg/kg) or dexamethasone (DEX, 5 mg/kg) was administered for 7 days before LPS inhalation. BEAS-2B cells were incubated with kurarinone at 1, 2, and 5 μM for 2 h before LPS stimulation for 24 h. We found that kurarinone ameliorated lung injury and inflammatory cell infiltration in the mouse lung (<i>p</i> < 0.001). Kurarinone decreased MPO activity (47.6%, <i>p</i> < 0.001) and alleviated the inflammatory response by reducing the levels of IL-1β (34.9%, <i>p</i> < 0.001), TNF-α (55.1%, <i>p</i> < 0.001), and IL-6 (36.2%, <i>p</i> < 0.001) in the lung. Kurarinone reduced the levels of IL-1β, TNF-α, IL-6, iNOS, and COX2 in LPS-treated BEAS-2B cells in a concentration-dependent manner (<i>p</i> < 0.05). Mechanistically, kurarinone restrained LPS-induced activation of MAPK and NF-κB pathways in vivo and in vitro (<i>p</i> < 0.05). Overall, kurarinone alleviates LPS-induced pneumonia in mice by reducing inflammation via MAPK and NF-κB pathways, suggesting that kurarinone might be a potential therapeutic agent for pneumonia. This study provides new research ideas for the discovery of natural flavonoids that can treat pneumonia.</p>\u0000 </div>","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"133 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tunneled Catheter-Related Bloodstream Infections in Chronic Hemodialysis Patients: Frequency, Risk Factors, and Outcomes—A 10-Year Analysis

IF 2.2 4区医学

Apmis Pub Date : 2025-03-13 DOI: 10.1111/apm.70016

Mustafa Arslan, Ercan Kahraman, Elif Menekşe

{"title":"Tunneled Catheter-Related Bloodstream Infections in Chronic Hemodialysis Patients: Frequency, Risk Factors, and Outcomes—A 10-Year Analysis","authors":"Mustafa Arslan, Ercan Kahraman, Elif Menekşe","doi":"10.1111/apm.70016","DOIUrl":"https://doi.org/10.1111/apm.70016","url":null,"abstract":"<div>\u0000 \u0000 <p>The aim of this study is to investigate the rate, risk factors, causative microorganism distribution, and treatment outcomes of catheter-related bloodstream infection (CRBSI) in chronic hemodialysis patients undergoing treatment with a tunneled hemodialysis catheter. Data for all patients who underwent hemodialysis treatment with tunneled catheters at our center between January 2014 and January 2024 were retrospectively analyzed. A total of 171 patients were included in the study. Forty-five patients had 54 CRBSI episodes. The average time between catheter placement and the development of CRBSI was 127.4 days, and the risk of developing CRBSI increased as this duration extended. In the bivariate logistic regression analysis, advanced age (<i>p</i> = 0.03), diabetes (<i>p</i> = 0.005), duration of hemodialysis (<i>p</i> < 0.001), decompensated cirrhosis (<i>p</i> = 0.02), and the femoral vein being the entry site (<i>p</i> = 0.011) were identified as risk factors for CRBSI. In the ROC analysis, the hemoglobin A1c threshold value for the development of CRBSI in diabetic patients was determined to be 9.350 (69% sensitivity, 87% specificity, AUC = 0.755, <i>p</i> < 0.001). We believe that avoiding femoral vein catheterization as much as possible and expediting the transition from catheter to another method for dialysis are important measures to prevent the development of CRBSI.</p>\u0000 </div>","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"133 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143602696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Faecalibacterium prausnitzii Suppresses Mitophagy to Alleviate Muscle Atrophy in Chronic Renal Failure With Protein-Energy Wasting

IF 2.2 4区医学

Apmis Pub Date : 2025-03-11 DOI: 10.1111/apm.70014

Jingwen Ni, Yuting Yin, Pan Liang, Yuanyuan Zheng, Yuying Li, Lvguang Pang, Xiaoshi Zhong, Jianguang Hu

{"title":"Faecalibacterium prausnitzii Suppresses Mitophagy to Alleviate Muscle Atrophy in Chronic Renal Failure With Protein-Energy Wasting","authors":"Jingwen Ni, Yuting Yin, Pan Liang, Yuanyuan Zheng, Yuying Li, Lvguang Pang, Xiaoshi Zhong, Jianguang Hu","doi":"10.1111/apm.70014","DOIUrl":"https://doi.org/10.1111/apm.70014","url":null,"abstract":"<div>\u0000 \u0000 <p>Protein-energy wasting (PEW) facilitates major adverse clinical outcomes in chronic renal failure (CRF), with current therapies not suitable for all patients. <i>Faecalibacterium prausnitzii</i> (<i>F. prausnitzii</i>) can alleviate chronic kidney disease, with unclear effects and mechanisms on CRF with PEW. The CRF rat model was constructed by adenine administration, and PEW was induced by a 4% casein diet. The serum creatinine (SCR), urinary protein (UPR), and blood urea nitrogen (BUN) levels were measured by enzyme-linked immunosorbent assay. Pathology of the gastrocnemius muscle was estimated using hematoxylin and eosin staining. The expression of mitophagy-related markers was detected to assess the mitophagy level. Dexamethasone-induced L6 myotubes established myotube atrophy models. The levels of mitophagy-related markers, muscle RING-finger protein-1 (MuRF1), and atrophy gene 1 (Atrogin1) were detected by quantitative reverse transcription-polymerase chain reaction and western blotting. <i>F. prausnitzii</i> suppressed the SCR, UPR, and BUN expression in serum and gastrocnemius muscle atrophy, which were promoted by CRF with PEW. Dexamethasone-induced expression of MuRF1 and Atrogin1 in L6 myotubes was decreased by <i>F. prausnitzii</i>. Additionally, <i>F. prausnitzii</i> repressed mitophagy in the gastrocnemius muscle and L6 myotubes. In conclusion, <i>F. prausnitzii</i> suppressed renal failure progression and muscle atrophy by inhibiting mitophagy in CRF with PEW.</p>\u0000 </div>","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"133 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143594881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rhinoviral Infection of the Human Lung Vascular Endothelium May Protect From the Secondary Infection With Rhinovirus RV-16

IF 2.2 4区医学

Apmis Pub Date : 2025-03-06 DOI: 10.1111/apm.70011

Izabela Gulbas, Adrian Bekier, Adrian Gajewski, Mateusz Gawrysiak, Sylwia Michlewska, Magdalena Chmiela, Maciej Chałubiński

{"title":"Rhinoviral Infection of the Human Lung Vascular Endothelium May Protect From the Secondary Infection With Rhinovirus RV-16","authors":"Izabela Gulbas, Adrian Bekier, Adrian Gajewski, Mateusz Gawrysiak, Sylwia Michlewska, Magdalena Chmiela, Maciej Chałubiński","doi":"10.1111/apm.70011","DOIUrl":"https://doi.org/10.1111/apm.70011","url":null,"abstract":"<div>\u0000 \u0000 <p>Rhinoviruses are a major cause of respiratory infections, including asthma infectious exacerbations. Human rhinovirus 16 (RV-16) has been widely shown to infect respiratory epithelial cells and the human lung vascular endothelium. RV-16 was also observed to induce an IFN-β-dependent mechanism of antiviral intracellular mechanisms based on OAS-1 and PKR activity. This study aimed to investigate whether the human lung microvascular endothelial cells (HMVEC-L) infected with RV-16 display a resistance to subsequent infections with the same virus, RV-16. HMVEC-L were infected with RV-16 and reinfected with RV-16 on Day 5. IFN-β-dependent responses, antiviral protein expression, inflammatory cytokine levels, and a viral copy numbers were assessed by real-time PCR, flow cytometry, ELISA, and confocal microscopy. RV-16 infection induced a significant IFN-β production and an activation of IFN-β-dependent antiviral proteins in HMVEC-L. On Day 5 post infection, these antiviral mechanisms remained active. In cells reinfected with RV-16, significantly lower replication of RV-16 was observed as compared to cells primarily infected with RV-16 on Day 5. Concomitantly, reinfected HMVEC-L showed a weaker response in IFN-β and inflammatory cytokine production. HMVEC-L infected with RV-16 display a sustained activation of IFN-β-dependent antiviral mechanisms, conferring resistance to subsequent infections with RV-16.</p>\u0000 </div>","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"133 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143564814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Function of B and T Lymphocyte Attenuator and Its Role in Transplantation

IF 2.2 4区医学

Apmis Pub Date : 2025-03-05 DOI: 10.1111/apm.70012

Kai Ma, Heqiao Han, Yuchen Bao, Rongtao Chen, Yixuan Yang, Wenwei Shao

{"title":"The Function of B and T Lymphocyte Attenuator and Its Role in Transplantation","authors":"Kai Ma, Heqiao Han, Yuchen Bao, Rongtao Chen, Yixuan Yang, Wenwei Shao","doi":"10.1111/apm.70012","DOIUrl":"https://doi.org/10.1111/apm.70012","url":null,"abstract":"<div>\u0000 \u0000 <p>Immune checkpoints are important molecules that regulate the immune response, preventing its overactivation from causing tissue damage and autoimmune diseases. B and T lymphocyte attenuator (BTLA) plays an important role in regulating the activation and suppression of the immune response as part of a bidirectional signaling complex. The BTLA and its ligand herpesvirus entry mediator (HVEM) interaction transmits inhibitory signals that suppress the biological activity of T cells, B cells, and DCs. In addition, BTLA–HVEM can affect the induction of Treg cells, further suggesting its important role in immune regulation. Organ transplantation is the ultimate treatment option for many patients with end-stage organ failure. Transplant rejection can cause damage to the transplanted organ, which seriously affects the prognosis of patients. Therefore, we would like to explore the potential application value of the BTLA–HVEM interaction to exert an immunosuppressive function and thus attenuate transplant rejection. We first reviewed the structure and function of BTLA and HVEM, then summarized their research progress in organ transplantation, and further explored the directions of potential future applications and the challenges of current BTLA–HVEM applications.</p>\u0000 </div>","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"133 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the Efficacy of Capreomycin and Levofloxacin Combination Therapy in Multidrug-Resistant Tuberculosis Patients

IF 2.2 4区医学

Apmis Pub Date : 2025-03-04 DOI: 10.1111/apm.70004

Sheng Xu, Guozheng Ding

{"title":"Evaluating the Efficacy of Capreomycin and Levofloxacin Combination Therapy in Multidrug-Resistant Tuberculosis Patients","authors":"Sheng Xu, Guozheng Ding","doi":"10.1111/apm.70004","DOIUrl":"https://doi.org/10.1111/apm.70004","url":null,"abstract":"<div>\u0000 \u0000 <p>Capreomycin (CMN) paired with levofloxacin (LEV) was tested in patients with multidrug-resistant pulmonary tuberculosis (MDR-PTB) for efficacy and immune function. The control group (40 cases) received conventional treatment and the observation group (40 cases) received CMN combined with LEV were established. Three months of intensification therapy and eighteen months of consolidation therapy were performed. The therapeutic effects (sputum negative conversion, lesion absorption, cavity shrinkage, and total effective rates), CD4<sup>+</sup>, CD8<sup>+</sup>, immunoglobulin A (IgA), IgM, IgG, interleukin-6 (IL-6), IL-17, tumor necrosis factor-α (TNF-α), serum alkaline phosphatase (ALP), aspartate aminotransferase (ALT), and alanine aminotransferase (AST) were assessed. Adverse reactions were compared. After treatment, the observation group performed at a higher sputum negative conversion rate, lesion absorption rate, cavity shrinkage rate, and total effective rate than the control group; CD4<sup>+</sup>, IgA, IgM, IgG, and IL-17 were increased and CD8<sup>+</sup>, IL-6, and TNF-α were decreased in both groups, and all of them were improved significantly in the observation group; ALP, ALT, and AST were elevated in both groups, but the differences between the observation and control groups were comparable. CMN combined with LEV is highly effective for MDR-PTB patients, enhancing immune function and reducing inflammation while having minimal effects on liver function.</p>\u0000 </div>","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"133 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and Co-Detection Rates of SARS-CoV-2, Influenza, and Respiratory Syncytial Virus: A Retrospective Analysis

IF 2.2 4区医学

Apmis Pub Date : 2025-02-27 DOI: 10.1111/apm.70010

George W. Pratt, Carlene L. Wong, Lokinendi V. Rao

引用次数: 0

An Evaluation Into the Robustness of Grading of Pleural Mesothelioma Outside of Specialist Centres

IF 2.2 4区医学

Apmis Pub Date : 2025-02-27 DOI: 10.1111/apm.70006

Sarita Prabhakaran, Ashleigh J. Hocking, Yazad Irani, Matthew Hussey, Andrey Alexeyenko, Katalin Dobra, Tamás Micsik, Edwina Duhig, Ann E. Walts, Lieve Vanwalleghem, Vathana Chhut, Anja C. Roden, Victor L. Roggli, Marjan Hertoghs, Francoise Galateau-Salle, Luka Brcic, David Moffat, Sonja Klebe

{"title":"An Evaluation Into the Robustness of Grading of Pleural Mesothelioma Outside of Specialist Centres","authors":"Sarita Prabhakaran, Ashleigh J. Hocking, Yazad Irani, Matthew Hussey, Andrey Alexeyenko, Katalin Dobra, Tamás Micsik, Edwina Duhig, Ann E. Walts, Lieve Vanwalleghem, Vathana Chhut, Anja C. Roden, Victor L. Roggli, Marjan Hertoghs, Francoise Galateau-Salle, Luka Brcic, David Moffat, Sonja Klebe","doi":"10.1111/apm.70006","DOIUrl":"https://doi.org/10.1111/apm.70006","url":null,"abstract":"<p>The 2021 WHO classification of thoracic tumours recommends grading pleural mesothelioma to aid prognostication. Robustness of grading and morphological characterisation is key to its clinical utility, though validation of this grading system has largely been conducted by expert thoracic pathologists. We conducted a survey inviting pathologists across a range of practices and expertise to grade digitised images of 50 epithelioid pleural mesotheliomas that had been graded by an expert in thoracic pathology. We included slides that were considered potentially problematic such as small biopsies, focal necrosis, and rare subtypes that may affect grading (small cell and deciduoid features). Using the Sectra Uniview web viewer, participants were asked to score atypia, mitotic count, and necrosis and choose from a list of cytological and architectural features. Seventy-four pathologists anonymously participated. There was 90% agreement of consensus scores with expert opinion using the WHO 2-tier grade and 72% for the 3-tier nuclear grade but only 70% for nuclear atypia, 56% for mitoses, and 84% for necrosis. Both 3-tier nuclear grade and WHO 2-tier grading systems were significantly associated with survival. Our study affirms the overall robustness and utility of grading for pleural mesothelioma, reveals variances, and suggests the need for dedicated training.</p>","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"133 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apm.70006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pan-Cancer Analysis Reveals SKA3 as a Potential Diagnostic and Prognostic Biomarker 泛癌症分析发现 SKA3 是一种潜在的诊断和预后生物标记物

IF 2.2 4区医学

Apmis Pub Date : 2025-02-25 DOI: 10.1111/apm.70009

Chunlin Li, Min Gao, Hua Huang, Nashunbayaer Zha, Gang Guo

{"title":"Pan-Cancer Analysis Reveals SKA3 as a Potential Diagnostic and Prognostic Biomarker","authors":"Chunlin Li, Min Gao, Hua Huang, Nashunbayaer Zha, Gang Guo","doi":"10.1111/apm.70009","DOIUrl":"https://doi.org/10.1111/apm.70009","url":null,"abstract":"<div>\u0000 \u0000 <p>SKA3, an important factor in cell cycle regulation, is involved in spindle assembly and kinetochore function, playing a critical role in maintaining cancer cell proliferation and division. However, its specific roles and regulatory mechanisms in cancer remain not fully understood. Large-scale datasets from multiple public databases, including The Cancer Genome Atlas and Genotype-Tissue Expression, covering various cancer types, were integrated. Systematic analysis revealed that SKA3 exhibits aberrant expression patterns in multiple cancers and is significantly associated with tumor progression and poor patient prognosis in certain cancers. We explored the status of SKA3 gene mutation, gene amplification and promoter region methylation in various tumors. In the context of immunotherapy, we assessed the value of SKA3 in cancer. Analyzing the correlation between SKA3 expression levels and immune checkpoints and immune cell infiltration, we discovered that SKA3 could serve as a novel immunotherapy biomarker across multiple cancers, guiding clinical immunotherapy decisions. Finally, SKA3 knockdown inhibited lung adenocarcinoma cell proliferation and metastasis. In conclusion, this study provides new insights into the role of SKA3 in cancer and offers significant theoretical and experimental evidence for its development as a diagnostic and prognostic biomarker.</p>\u0000 </div>","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"133 3","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143489744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0