IF 2.2 4区医学

Apmis Pub Date : 2024-06-14 DOI: 10.1111/apm.13446

Rojo-Marcos Gerardo, Hernández-García Guiomar, González-Sarria Ander, Guerrero-Cañar Carlos Andrés, Arévalo-Cañas Coral

{"title":"Dynamics of endemic human coronavirus and SARS-CoV-2 in a hospital of Madrid, Spain. Retrospective study from June 2020 to July 2023","authors":"Rojo-Marcos Gerardo, Hernández-García Guiomar, González-Sarria Ander, Guerrero-Cañar Carlos Andrés, Arévalo-Cañas Coral","doi":"10.1111/apm.13446","DOIUrl":"10.1111/apm.13446","url":null,"abstract":"An observational and retrospective study was carried out to analyse HCoV positivity from a multiplex PCR respiratory panel and RT-PCR for SARS-CoV-2 in respiratory samples from 1 June 2020 to 31 July 2023 at the Príncipe de Asturias University Hospital (HUPA) in Alcalá de Henares, Madrid, Spain. Out of 2802 respiratory panels, 1258 (44.8%) turned out positive. HCoV was detected in 114 (4%) cases (range 0–23; median 1.5; IQR 0–3.75) with positivity rates ranging from 0% to 14%. All four variants of HCoV circulated, and OC-43 was the most common in 62.3% of cases. After the onset of the pandemic, the HCoV season was delayed 22 weeks, with a peak positivity of 9% in the summer of 2021, showing an inverse relationship with the alpha and delta waves of SARS-CoV-2. In the two subsequent autumn–winter seasons, HCoV positivity increased (11–14%) with a reduction in the summer of 2022 and 2023 following the emergence of the omicron variant and the relaxation of social distancing measures. The seasonal spread pattern of endemic HCoV might be returning to normal in our region and likely in other temperate zones of the northern hemisphere after 3 years of the pandemic.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"132 9","pages":"657-662"},"PeriodicalIF":2.2,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apm.13446","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141316639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Routine use of MSI testing in colorectal cancer using a proposed algorithm 使用拟议算法对结直肠癌进行 MSI 常规检测。

IF 2.2 4区医学

Apmis Pub Date : 2024-06-14 DOI: 10.1111/apm.13442

Marie Ley Ringgaard, Torben Steiniche, Søren Palmelund Krag

{"title":"Routine use of MSI testing in colorectal cancer using a proposed algorithm","authors":"Marie Ley Ringgaard, Torben Steiniche, Søren Palmelund Krag","doi":"10.1111/apm.13442","DOIUrl":"10.1111/apm.13442","url":null,"abstract":"Fifteen percent of all colorectal cancers have detectable defects in the mismatch repair system (dMMR). MMR status is used to identify possible Lynch Syndrome (LS) and to determine prognosis and choice of treatment. Two standard techniques for determining MMR status are immunohistochemistry (IHC) and analysis for microsatellite instability (MSI) by PCR. Recently, our department introduced Idylla™ MSI assay as an alternative option to IHC, and as part of this, we introduced a decision algorithm. The purpose of this study was to review the use of the new method and our algorithm and to assess possible false-positive results. Retrospectively, we identified 629 cases of colorectal cancer in which either IHC (336 cases) or Idylla™ MSI (293 cases) was performed. Similar results were obtained by the two methods. IHC detected dMMR in 55 cases (16%) and Idylla™ MSI in 52 cases (18%). In all 52 cases of MSI, subsequent IHC was performed. One case was not confirmed by IHC, but was confirmed by another PCR-based method. Overall, we found that the Idylla™ MSI works well as a screening method for dMMR with no false-positive cases detected. The proposed algorithm was useful and easily applicable.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"132 9","pages":"632-637"},"PeriodicalIF":2.2,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apm.13442","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141316640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in T-cell subsets occur in interstitial lung disease and may contribute to pathology via complicated immune cascade 间质性肺病中的 T 细胞亚群会发生变化，并可能通过复杂的免疫级联导致病理变化。

IF 2.2 4区医学

Apmis Pub Date : 2024-06-11 DOI: 10.1111/apm.13445

Mehmet Ali Karaselek, Tugce Duran, Serkan Kuccukturk, Hulya Vatansev, Pembe Oltulu

{"title":"Changes in T-cell subsets occur in interstitial lung disease and may contribute to pathology via complicated immune cascade","authors":"Mehmet Ali Karaselek, Tugce Duran, Serkan Kuccukturk, Hulya Vatansev, Pembe Oltulu","doi":"10.1111/apm.13445","DOIUrl":"10.1111/apm.13445","url":null,"abstract":"The study aimed to investigate the expression profiles of transcription factors, cytokines, and co-stimulatory molecules in helper T (Th)-cell subsets within bronchoalveolar lavage (BAL) samples of patients with interstitial lung diseases (ILDs). Twenty ILDs patients were included in the study, comprising those with idiopathic pulmonary fibrosis (IPF) (n:8), autoimmune-related ILDs (auto-ILD) (n:4), and orphan diseases (O-ILD) (n:8), alongside five control subjects. Flow cytometry was employed to evaluate the Th to cytotoxic T cell (CTL) ratio in BAL fluid, while cytopathological examination assessed macrophages, lymphocytes, and neutrophils. Quantitative real-time polymerase chain reaction was utilized to investigate the expressions in Th1, Th2, Th17, and regulatory T (Treg) cells. Results revealed elevated Th cell to CTL ratios across all patient groups compared to controls. Furthermore, upregulation of Th1, Th2, Th17, and T-cell factors was observed in all patient groups compared to controls. Interestingly, upregulation of CD28 and downregulation of CTLA-4 and PD-1 gene expression were consistent across all ILDs groups, highlighting potential immune dysregulation. This study provides a comprehensive exploration of molecular immunological mechanisms in ILDs patients, underscoring the dominance of Th2 and Th17 responses and revealing novel findings regarding the dysregulation of CD28, CTLA-4, and PD-1 expressions in ILDs for the first time.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"132 9","pages":"663-671"},"PeriodicalIF":2.2,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apm.13445","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141299888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outer membrane vesicles from X-ray-irradiated Pseudomonas aeruginosa alleviate lung injury caused by P. aeruginosa infection-mediated sepsis 经 X 射线照射的铜绿假单胞菌外膜囊泡可减轻铜绿假单胞菌感染介导的败血症造成的肺损伤

IF 2.2 4区医学

Apmis Pub Date : 2024-06-05 DOI: 10.1111/apm.13444

Hongxia Bi, Jiayuan Qin, Jiaqi Huang, Cejun Zhong, Yanbin Liu

{"title":"Outer membrane vesicles from X-ray-irradiated Pseudomonas aeruginosa alleviate lung injury caused by P. aeruginosa infection-mediated sepsis","authors":"Hongxia Bi, Jiayuan Qin, Jiaqi Huang, Cejun Zhong, Yanbin Liu","doi":"10.1111/apm.13444","DOIUrl":"10.1111/apm.13444","url":null,"abstract":"Pseudomonas aeruginosa infection causes pneumonia and sepsis. Previous research found that X-ray radiation can induce P. aeruginosa to release outer membrane vesicles (OMVs) of relatively consistent sizes. This study found that OMVs derived from X-ray-irradiated P. aeruginosa can significantly inhibit lung leakage, inflammatory cell infiltrating into lung, and the production of pro-inflammatory cytokines, IL-1β and TNFα caused by P. aeruginosa infection under preventive and therapeutic administration conditions. Under the same conditions, OMVs also significantly alleviated pathological characteristics of lung injury, including pulmonary edema, pulmonary hemorrhage, and alveolar wall thickening. OMVs also significantly reduced bacterial burdens in peritoneal cavity, accompanied by a reduction in the number of viable bacteria capable of forming bacterial colonies. Pretreating macrophages and neutrophils with OMVs enhances their bactericidal ability. When bacteria were cocultured with treated cells, the number of viable bacteria capable of forming bacterial colonies was significantly reduced. OMVs themselves have not been shown to cause any lung injury or affect bacterial viability. Therefore, OMVs derived from X-ray-irradiated P. aeruginosa may not only be applied in prevention and treatment of diseases associated with P. aeruginosa infection, but also served as an excellent vaccine development platform.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"132 9","pages":"646-656"},"PeriodicalIF":2.2,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apm.13444","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141257826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aetiological profile of acute encephalitis syndrome in Assam, India, during a 4-year period from 2019 to 2022 2019 年至 2022 年 4 年期间印度阿萨姆邦急性脑炎综合征的病原学概况

IF 2.2 4区医学

Apmis Pub Date : 2024-06-05 DOI: 10.1111/apm.13443

Dharitree Sonowal, Ajanta Sharma, Kimmi Sarmah, Deepak Upadhaya, Sachin Kumar, Harpreet Kaur

{"title":"Aetiological profile of acute encephalitis syndrome in Assam, India, during a 4-year period from 2019 to 2022","authors":"Dharitree Sonowal, Ajanta Sharma, Kimmi Sarmah, Deepak Upadhaya, Sachin Kumar, Harpreet Kaur","doi":"10.1111/apm.13443","DOIUrl":"10.1111/apm.13443","url":null,"abstract":"Acute encephalitis syndrome (AES) is a major public health concern in India as the aetiology remains unknown in the majority of cases with the current testing algorithm. We aimed to study the incidence of Japanese encephalitis (JE) and determine the aetiology of non-JE AES cases to develop an evidence-based testing algorithm. Cerebrospinal fluid (CSF) samples were tested for Japanese encephalitis virus by ELISA and polymerase chain reaction (PCR). Multiplex real-time PCR was done for Dengue, Chikungunya, West Nile, Zika, Enterovirus, Epstein Barr Virus, Herpes Simplex Virus, Adenovirus, Cytomegalovirus, Herpesvirus 6, Parechovirus, Parvovirus B19, Varicella Zoster Virus, Scrub typhus, Rickettsia species, Leptospira, Salmonella species, Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Plasmodium species and by ELISA for Mumps and Measles virus. Of the 3173 CSF samples, 461 (14.5%) were positive for JE. Of the 334 non-JE AES cases, 66.2% viz. Scrub typhus (25.7%), Mumps (19.5%), Measles (4.2%), Parvovirus B19 (3.9%) Plasmodium (2.7%), HSV 1 and 2 (2.4%), EBV and Streptococcus pneumoniae (2.1% each), Salmonella and HHV 6 (1.2% each) were predominant. Hence, an improved surveillance system and our suggested expanded testing algorithm can improve the diagnosis of potentially treatable infectious agents of AES in India.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"132 9","pages":"638-645"},"PeriodicalIF":2.2,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141257920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical characteristics and risk factors of connective tissue disease complicated with bronchiectasis and pulmonary infection 结缔组织病并发支气管扩张和肺部感染的临床特征和风险因素。

IF 2.2 4区医学

Apmis Pub Date : 2024-05-26 DOI: 10.1111/apm.13424

Xuan Qi, Jiaying Yang, Hongtao Jin, Yuran Xiao, Ying Wang, Yiqing Zhang

{"title":"Clinical characteristics and risk factors of connective tissue disease complicated with bronchiectasis and pulmonary infection","authors":"Xuan Qi, Jiaying Yang, Hongtao Jin, Yuran Xiao, Ying Wang, Yiqing Zhang","doi":"10.1111/apm.13424","DOIUrl":"10.1111/apm.13424","url":null,"abstract":"The clinical data from 118 CTD patients with bronchiectasis were collected and categorized into two groups: pulmonary infection present (n = 67) and absent (n = 51), for comparative analysis of characteristics and risk factors. Then, we analyzed and compared their demographics, disease characteristics, and risk factors for infection. Among the whole cohort (n = 118), the incidence of pulmonary infections was 56.78%. The occurrence of rheumatoid arthritis, systemic lupus erythematosus, and vasculitis was found to be associated with an increased risk of pulmonary infection. Sputum culture identified Pseudomonas aeruginosa and Klebsiella pneumoniae as the predominant pathogens in the infected group. Notably, symptoms such as joint pains (p = 0.018) and morning stiffness (p = 0.017) were significantly more common in the infected group compared to the noninfected group. Moreover, our findings revealed that elevated levels of C-reactive protein and complement C3, along with bronchial expansion observed on high-resolution computed tomography (HRCT), were significant independent factors in the infection group. Conversely, pulmonary interstitial changes identified through HRCT (OR: 0.135, 95% CI: 0.030–0.612, p = 0.009) were significantly associated with the non-infection group. Overall, this study provides valuable insights into managing CTD patients with bronchiectasis, emphasizing early detection and tailored approaches to prevent and treat pulmonary infections for better outcomes.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"132 8","pages":"571-580"},"PeriodicalIF":2.2,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beta-cell activity and development of Type 1 diabetes Beta 细胞活性与 1 型糖尿病的发展。

IF 2.2 4区医学

Apmis Pub Date : 2024-05-26 DOI: 10.1111/apm.13441

Rikke Thea, Karsten Buschard

引用次数: 0

Enhanced angiogenesis of human umbilical vein endothelial cells via THP-1-derived M2c-like macrophages and treatment with proteasome inhibitors ‘bortezomib and ixazomib’ 通过 THP-1 衍生的 M2c 样巨噬细胞和蛋白酶体抑制剂 "硼替佐米和伊沙佐米 "的治疗增强人脐静脉内皮细胞的血管生成。

IF 2.2 4区医学

Apmis Pub Date : 2024-05-22 DOI: 10.1111/apm.13426

Selin Engür-Öztürk, Elif Kaya-Tİlkİ, Zerrin Cantürk, Miriş Dİkmen

{"title":"Enhanced angiogenesis of human umbilical vein endothelial cells via THP-1-derived M2c-like macrophages and treatment with proteasome inhibitors ‘bortezomib and ixazomib’","authors":"Selin Engür-Öztürk, Elif Kaya-Tİlkİ, Zerrin Cantürk, Miriş Dİkmen","doi":"10.1111/apm.13426","DOIUrl":"10.1111/apm.13426","url":null,"abstract":"The leading cause of cancer-related death is lung cancer, with metastasis being the most common cause of death. To elucidate the role of macrophages in lung cancer and angiogenesis processes, we established an in vitro co-culture model of A549 or HUVEC with THP-1 cells that polarized to M2c macrophages with hydrocortisone. The proteasome inhibitors bortezomib and ixazomib were investigated for their effects on proliferation, invasion, migration, metastasis, and angiogenesis pathways. The effects of bortezomib and ixazomib on gene expression in gene panels, including crucial genes related to angiogenesis and proteasomes, were investigated after the co-culture model to determine these effects at the molecular level. In conclusion, bortezomib and ixazomib showed antiproliferative effects in both cells, as well as in M2c macrophage co-culture. M2c macrophages also increased invasion in A549 cells and both invasion and migration in HUVEC. mRNA expression upregulation, specifically in the NFKB and VEGF genes, supported the metastatic and angiogenic effects found in A549 and HUVEC with M2c macrophage co-culture. Additionally, bortezomib inhibited the VEGFB pathway in HUVEC and NFKB1 in A549 cells. The significant findings obtained as a result of this study will provide information regarding angiogenesis induced by M2 macrophages.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"132 8","pages":"594-607"},"PeriodicalIF":2.2,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apm.13426","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141074955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fumarate hydratase–deficient renal cell carcinoma: an oncology care institutional experience 富马酸氢化酶缺陷型肾细胞癌：肿瘤护理机构的经验。

IF 2.2 4区医学

Apmis Pub Date : 2024-05-22 DOI: 10.1111/apm.13425

Meenakshi Kamboj, Gurudutt Gupta, Sunil Pasricha, Anurag Mehta, Sudhir Rawal, Amitabh Singh, Anila Sharma, Garima Durga, Divya Bansal, Himanshi Diwan

{"title":"Fumarate hydratase–deficient renal cell carcinoma: an oncology care institutional experience","authors":"Meenakshi Kamboj, Gurudutt Gupta, Sunil Pasricha, Anurag Mehta, Sudhir Rawal, Amitabh Singh, Anila Sharma, Garima Durga, Divya Bansal, Himanshi Diwan","doi":"10.1111/apm.13425","DOIUrl":"10.1111/apm.13425","url":null,"abstract":"Renal cell carcinoma (RCC) accounts for 2% of all cancer cases worldwide, and majority are sporadic. The latest World Health Organization (WHO) classification of renal cell tumors (fifth edition, 2022) has molecularly defined renal tumor entities, which includes fumarate hydratase (FH)–deficient RCC. FH-deficient RCC is an aggressive carcinoma caused by pathogenic alterations in FH gene, seen in 15% of patients with hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC) syndrome. These tumors occur more frequently at a younger age and present at an advanced stage, carrying a dismal prognosis. We report a series of 10 cases of FH-deficient RCC. The mean age was 49.8 years, and all cases presented in advanced stages (III and IV). Morphologically, the cases had varied architectural patterns with characteristic eosinophilic macronucleoli and perinucleolar halo. On immunohistochemistry (IHC), all showed diffuse nucleo-cytoplasmic expression of S-(2-succino)-cysteine (2-SC), with loss of FH in seven cases. FH-deficient RCCs are aggressive neoplasms and can be diagnosed using specific IHC markers (FH and 2-SC). These patients should undergo germline testing for FH gene mutation, genetic counseling, and surveillance of family members.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"132 8","pages":"544-552"},"PeriodicalIF":2.2,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141075006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The criteria for chronic rhinosinusitis in children with cystic fibrosis are rarely fulfilled after initiation of CFTR modulator treatment 囊性纤维化患儿在开始接受 CFTR 调节剂治疗后，很少能达到慢性鼻炎的标准。

IF 2.2 4区医学

Apmis Pub Date : 2024-05-21 DOI: 10.1111/apm.13427

Magne Bech, Marianne Skov, Ida S. B. Andersen, Christian von Buchwald, Kasper Aanæs

{"title":"The criteria for chronic rhinosinusitis in children with cystic fibrosis are rarely fulfilled after initiation of CFTR modulator treatment","authors":"Magne Bech, Marianne Skov, Ida S. B. Andersen, Christian von Buchwald, Kasper Aanæs","doi":"10.1111/apm.13427","DOIUrl":"10.1111/apm.13427","url":null,"abstract":"The vast majority of people with cystic fibrosis (pwCF) have untreated secondary chronic rhinosinusitis (CRS). Whereas the introduction of the cystic fibrosis transmembrane conductance regulator modulator (CFTRm) treatment regime has improved the lung function of pwCF, few studies have been published examining the effect on sinonasal symptoms in children. Our aim was to explore the effect of double CFTRm treatment on CRS and olfaction in children with CF. pwCF were included in this non-randomized cross-sectional study, where an otolaryngologist performed a complete ENT examination before initiating treatment with elaxacaftor/tezacaftor/ivacaftor (ETI). Twenty-three pwCF aged 6–12 years were included. Eighteen of 23 patients were on a double CFTRm treatment, and 5 patients were CFTRm naive, respectively. Altogether, 19 had normal olfaction, 20 had none or mild CRS symptoms according to SNOT-22, and 14 had a normal endoscopy. None of the patients had symptoms of chronic rhinosinusitis lasting for more than 12 weeks, thus none of the patients fulfilled the criteria for CRS. Children with CF treated with double CFTRm have few to no symptoms of CRS and normal olfaction, which is an improvement compared with children following treatment modalities prior to CFTRm.","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"132 9","pages":"625-631"},"PeriodicalIF":2.2,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apm.13427","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141075008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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