慢性炎症性皮肤病中宿主与微生物之间的微环境相互作用

IF 2.2 4区 医学 Q4 IMMUNOLOGY
Apmis Pub Date : 2024-09-13 DOI:10.1111/apm.13464
Lene Bay, Gregor Borut Jemec, Hans Christian Ring
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引用次数: 0

摘要

最近的一些微生物组研究表明,在各种慢性炎症性皮肤病中都存在微生物菌群失调现象,并认为它在发病机制中起着重要作用。虽然皮肤菌群失调在炎症性皮肤病中的作用尚有争议,但局部微环境被认为是皮肤微生物群组成变化和功能改变的关键。事实上,在这些皮肤病中,各种局部营养物质(如脂质)、pH 值、水、氧气和抗菌肽可能会影响皮肤菌群失调的程度。特别是在特应性皮炎和化脓性扁桃体炎中,皮肤菌群失调的显著变化与局部宿主免疫异常变化有关。本综述结合各种慢性炎症性皮肤病的物理、化学和生物微环境,对宿主与微生物群之间的潜在致病串扰进行了综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Microenvironmental host–microbe interactions in chronic inflammatory skin diseases
Several microbiome studies have recently demonstrated microbial dysbiosis in various chronic inflammatory skin diseases, and it is considered an important role in the pathogenesis. Although the role of skin dysbiosis in inflammatory skin diseases is debatable, the local microenvironment is considered essential concerning compositional changes and functional alterations of the skin microbiota. Indeed, various local nutrients (e.g., lipids), pH values, water, oxygen, and antimicrobial peptides may affect the level of skin dysbiosis in these skin diseases. In particular, in atopic dermatitis and hidradenitis suppurativa, significant changes in skin dysbiosis have been associated with local aberrant host immune changes. In this review, the potential pathogenic crosstalk between the host and the microbiota is reviewed in relation to the physical, chemical, and biological microenvironments of various chronic inflammatory skin diseases.
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来源期刊
Apmis
Apmis 医学-病理学
CiteScore
5.20
自引率
0.00%
发文量
91
审稿时长
2 months
期刊介绍: APMIS, formerly Acta Pathologica, Microbiologica et Immunologica Scandinavica, has been published since 1924 by the Scandinavian Societies for Medical Microbiology and Pathology as a non-profit-making scientific journal.
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