Maria K. Jauhiainen, Anttoni Markkanen, Timo Atula, Katri Aro, Caj Haglund, Maria Söderlund-Venermo, Antti A. Mäkitie, Saku T. Sinkkonen, Jaana Hagström
{"title":"复发性多形性腺瘤和多形性腺瘤癌的收费样受体表达。","authors":"Maria K. Jauhiainen, Anttoni Markkanen, Timo Atula, Katri Aro, Caj Haglund, Maria Söderlund-Venermo, Antti A. Mäkitie, Saku T. Sinkkonen, Jaana Hagström","doi":"10.1111/apm.13505","DOIUrl":null,"url":null,"abstract":"<p>Pleomorphic adenoma (PA) is a benign salivary gland tumour that may recur or undergo malignant transformation (CXPA). Toll-like receptors (TLR) mediate immune responses triggered by various agents such as viruses and are related to tumour formation either by stimulating or suppressing their growth, with variation across different tumour entities. We compared TLR immunohistochemical expression in PA, its recurrent counterparts and CXPA and evaluated the effect of virus presence in these tumours. We studied the expression of TLR-2, -3, -5, -7 and -9 in 25 PA, 34 recurrent PA and 15 CXPA tumour samples. In addition, we examined the TLR expression levels in the presence and absence of herpes-, polyoma- and parvovirus DNA in a subset of tumours (n = 20). CXPA expressed significantly more TLR-5 and TLR-9 in the nucleus, cytoplasm and cell membrane compared with benign PA. The presence of virus DNA did not notably affect the TLR expression. TLR expression patterns seem to reflect tumour behaviour but are independent of the presence of viruses tested in this study.</p>","PeriodicalId":8167,"journal":{"name":"Apmis","volume":"133 1","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apm.13505","citationCount":"0","resultStr":"{\"title\":\"Expression of toll-like receptors in recurrent pleomorphic adenoma and carcinoma ex pleomorphic adenoma\",\"authors\":\"Maria K. Jauhiainen, Anttoni Markkanen, Timo Atula, Katri Aro, Caj Haglund, Maria Söderlund-Venermo, Antti A. Mäkitie, Saku T. Sinkkonen, Jaana Hagström\",\"doi\":\"10.1111/apm.13505\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Pleomorphic adenoma (PA) is a benign salivary gland tumour that may recur or undergo malignant transformation (CXPA). Toll-like receptors (TLR) mediate immune responses triggered by various agents such as viruses and are related to tumour formation either by stimulating or suppressing their growth, with variation across different tumour entities. We compared TLR immunohistochemical expression in PA, its recurrent counterparts and CXPA and evaluated the effect of virus presence in these tumours. We studied the expression of TLR-2, -3, -5, -7 and -9 in 25 PA, 34 recurrent PA and 15 CXPA tumour samples. In addition, we examined the TLR expression levels in the presence and absence of herpes-, polyoma- and parvovirus DNA in a subset of tumours (n = 20). CXPA expressed significantly more TLR-5 and TLR-9 in the nucleus, cytoplasm and cell membrane compared with benign PA. The presence of virus DNA did not notably affect the TLR expression. TLR expression patterns seem to reflect tumour behaviour but are independent of the presence of viruses tested in this study.</p>\",\"PeriodicalId\":8167,\"journal\":{\"name\":\"Apmis\",\"volume\":\"133 1\",\"pages\":\"\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-12-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apm.13505\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Apmis\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/apm.13505\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Apmis","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/apm.13505","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
多形性腺瘤(PA)是一种良性唾液腺肿瘤,可能复发或发生恶性转化(CXPA)。Toll样受体(TLR)介导由病毒等各种物质引发的免疫反应,并通过刺激或抑制肿瘤的生长与肿瘤的形成有关,在不同的肿瘤实体中存在差异。我们比较了 TLR 在 PA 及其复发性肿瘤和 CXPA 中的免疫组化表达,并评估了这些肿瘤中病毒存在的影响。我们研究了 25 例 PA、34 例复发性 PA 和 15 例 CXPA 肿瘤样本中 TLR-2、-3、-5、-7 和 -9 的表达。此外,我们还检测了肿瘤子集(n = 20)中存在和不存在疱疹病毒、多瘤病毒和副粘病毒 DNA 时的 TLR 表达水平。与良性 PA 相比,CXPA 在细胞核、细胞质和细胞膜上表达的 TLR-5 和 TLR-9 明显较多。病毒 DNA 的存在并未明显影响 TLR 的表达。TLR的表达模式似乎反映了肿瘤的行为,但与本研究中测试的病毒的存在无关。
Expression of toll-like receptors in recurrent pleomorphic adenoma and carcinoma ex pleomorphic adenoma
Pleomorphic adenoma (PA) is a benign salivary gland tumour that may recur or undergo malignant transformation (CXPA). Toll-like receptors (TLR) mediate immune responses triggered by various agents such as viruses and are related to tumour formation either by stimulating or suppressing their growth, with variation across different tumour entities. We compared TLR immunohistochemical expression in PA, its recurrent counterparts and CXPA and evaluated the effect of virus presence in these tumours. We studied the expression of TLR-2, -3, -5, -7 and -9 in 25 PA, 34 recurrent PA and 15 CXPA tumour samples. In addition, we examined the TLR expression levels in the presence and absence of herpes-, polyoma- and parvovirus DNA in a subset of tumours (n = 20). CXPA expressed significantly more TLR-5 and TLR-9 in the nucleus, cytoplasm and cell membrane compared with benign PA. The presence of virus DNA did not notably affect the TLR expression. TLR expression patterns seem to reflect tumour behaviour but are independent of the presence of viruses tested in this study.
期刊介绍:
APMIS, formerly Acta Pathologica, Microbiologica et Immunologica Scandinavica, has been published since 1924 by the Scandinavian Societies for Medical Microbiology and Pathology as a non-profit-making scientific journal.