Kaixuan Wang , Xingxing Zhu , Yuting Wang , Jikui Xie , Ming Ni , Qiang Xie
{"title":"Optimization of synthesis conditions of [68Ga]Ga-PSMA-D5 and its clinical application in prostate cancer","authors":"Kaixuan Wang , Xingxing Zhu , Yuting Wang , Jikui Xie , Ming Ni , Qiang Xie","doi":"10.1016/j.apradiso.2025.111825","DOIUrl":"10.1016/j.apradiso.2025.111825","url":null,"abstract":"<div><div>Radioisotope-labeled prostate-specific membrane antigen (PSMA) PET tracers have gained popularity in diagnosing prostate cancer (PCa). Recently, a novel biphenyl-containing tracer [<sup>68</sup>Ga]Ga-PSMA-D5 targeting PSMA has been developed for PET imaging of PCa. The advantages of [<sup>68</sup>Ga]Ga-PSMA-D5 include high tumor uptake, simple synthesis, and convenient labeling, making it a promising PSMA PET tracer. In order to facilitate the routine production and clinical application of [<sup>68</sup>Ga]Ga-PSMA-D5, a straightforward and efficient automated synthesis is described. The optimum labeling parameters were determined at laboratory scale, and subsequently incorporated into an automated production process. Further studies have demonstrated that clinical doses of [<sup>68</sup>Ga]Ga-PSMA-D5 can be prepared within 25 min, with excellent radio chemical purity (>99 %) and activity yield (70.8 % ± 2.3 %, non-decay corrected). All the quality control results satisfy the required criteria for release. PET/CT imaging has shown that [<sup>68</sup>Ga]Ga-PSMA-D5 can safely and effectively target prostate cancer-associated lesions with excellent tumor-to-background contrast. This methodology facilitates efficient synthesis of [<sup>68</sup>Ga]Ga-PSMA-D5 in a commercially available synthesis module and shows diagnostic value for PCa in further clinical application.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"221 ","pages":"Article 111825"},"PeriodicalIF":1.6,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohamed A. Hekal , Mohamed H.H. Abbas , Ahmed A. Abdelhafez
{"title":"Enhancing durum wheat growth and productivity in arid soils via seed irradiation with gamma rays and the foliar application of nano Cu","authors":"Mohamed A. Hekal , Mohamed H.H. Abbas , Ahmed A. Abdelhafez","doi":"10.1016/j.apradiso.2025.111821","DOIUrl":"10.1016/j.apradiso.2025.111821","url":null,"abstract":"<div><div>The current study aims at increasing durum wheat productivity under arid-conditions via following two strategies: seed irradiation with γ-rays and spraying plants with nano Cu. Wheat seeds were irradiated in a<sup>60</sup>Co Gamma Irradiation Unit to achieve 0Gy (R<sub>0</sub>), 50Gy (R<sub>50</sub>),100Gy (R<sub>100</sub>), 150Gy (R<sub>150</sub>) and 200Gy (R<sub>200</sub>), while nano Cu-was prepared in lab. A field study of a split-plot design was then conducted for 2-seasons, in which foliar applications with nano-Cu were applied in main plots i.e. 30 (nCu<sub>30</sub>), 60 (nCu<sub>60</sub>) and 90 mg Cu L<sup>−1</sup> (nCu<sub>90</sub>) versus the recommended Cu-mineral dose (Cu<sub>60</sub>) while irradiated seeds were applied in subplots. The obtained results showed that the highest increases in wheat growth and yield were attained for Cu<sub>60</sub>. Comparable increases in grain yield were noticed for nCu<sub>60</sub> foliar application. Likewise, γ-irradiation (≤150Gy) effectively enhanced wheat growth and productivity. Generally, wheat growth parameters and productivity were correlated significantly and positively with plant uptake of Cu, N, Fe, Zn and Mn. Concerning combination between these two factors, the highest increase in grain yield was noted for R<sub>150</sub>nCu<sub>90</sub>, recording 4.7 and 5.5 Mg ha<sup>−1</sup> in the first and second seasons respectively. These yields were over 20 % higher than R<sub>0</sub>Cu<sub>60</sub> treatment in the two seasons of study. We concluded that seed irradiation with γ-rays up to 150 Gy and nano-Cu spray (nCu60) is guaranteed to increase wheat productivity grown on arid soils.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"221 ","pages":"Article 111821"},"PeriodicalIF":1.6,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143820516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Suman , M. Srinivas Reddy , K. Vinay Kumar Reddy , M. Sreenath Reddy , Ch Gopal Reddy , P. Yadagiri Reddy
{"title":"Annual effective dose assessment: Natural background gamma radiation at Kothapally village, Nalgonda district, Telangana, India","authors":"G. Suman , M. Srinivas Reddy , K. Vinay Kumar Reddy , M. Sreenath Reddy , Ch Gopal Reddy , P. Yadagiri Reddy","doi":"10.1016/j.apradiso.2025.111823","DOIUrl":"10.1016/j.apradiso.2025.111823","url":null,"abstract":"<div><div>The annual effective dose due to natural background gamma and radionuclides in soil samples was estimated in the indoors and outdoors of Kothapally village located in the vicinity of proposed Chitrial Uranium mineralized area. In the present study μR-survey meter and Thermoluminescence dosimeters (TLDs) were used for instantaneous and integrated measurements of natural background gamma radiation levels respectively. The annual effective dose to the general public, was found to be vary from 0.92 to 2.26 with an average value of 1.39 ± 0.23 mSv.y<sup>−1</sup> (GM = 1.37 mSv.y<sup>−1</sup>) using μR survey meter, and varied between 0.6 and 1.4 with an average value of 1.0 ± 0.2 mSv.y<sup>−1</sup> (GM = 1.0 mSv.y<sup>−1</sup>) using the TLDs. The annual effective dose is also estimated from the collected soil samples and it is found to be vary between 1.0 and 2.0 mSv.y<sup>−1</sup> with an average value of 1.13 ± 0.12 mSv.y<sup>−1</sup> (GM = 0. 96 mSv.y<sup>−1</sup>). The external and internal hazard index parameters from the radioactive elements subsist in the soil samples of the study area, and the ratio between the indoor and outdoor natural background gamma radiation levels, and their distribution in the indoors and outdoors, also to be discussed in this paper.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"221 ","pages":"Article 111823"},"PeriodicalIF":1.6,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143815572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigation of radioactivity levels in the indoor and beach samples of Kollam, Kerala and the assessment of radiological hazard indices","authors":"M Ramsiya , AK Visnuprasad","doi":"10.1016/j.apradiso.2025.111824","DOIUrl":"10.1016/j.apradiso.2025.111824","url":null,"abstract":"<div><div>The beach sand on the south-west coast of Kerala, India is one of the richest sources of thorium in the world. This causes enhanced natural radioactivity in the nearby locations due to the presence of various radionuclides. Natural radioactivity levels in 48 soil samples collected from houses and 78 samples collected from the beach along the coastal areas of Kollam, Kerala were analyzed using the gamma-ray spectrometer The radium and thorium content in the samples measured from houses is more than that of beach samples and it varies as 54.7 ± 1.0 – 21720.1 ± 19.2 Bq kg<sup>−1</sup> and 110.3 ± 1.1 – 95623 ± 21.8 Bq kg<sup>−1</sup> for radium and thorium respectively. The ambient gamma-ray dose in the outdoor atmosphere was measured using a survey meter and TLDs and the measurements showed a strong positive correlation (R<sup>2</sup> = 0.92). The vertical profile studies in beach sand samples were done for distances in 4 locations at three intervals. The results of vertical profile studies show that the activity concentration of radium and thorium at 30–40 cm depth was greater than that at 0–10 cm and less than that at 60–70 cm.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"221 ","pages":"Article 111824"},"PeriodicalIF":1.6,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143800206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nayton Bruno F. Pessoa , Rogério F. da Costa , Liberato S. dos Santos , Caroline M. Barbosa , Cesar Raitz , Inaya C.B. Lima
{"title":"Comparison between pore size distributions of the fine aggregate matrix obtained by micro-computed X-ray tomography and a set of linear regressions","authors":"Nayton Bruno F. Pessoa , Rogério F. da Costa , Liberato S. dos Santos , Caroline M. Barbosa , Cesar Raitz , Inaya C.B. Lima","doi":"10.1016/j.apradiso.2025.111819","DOIUrl":"10.1016/j.apradiso.2025.111819","url":null,"abstract":"<div><div>The Fine Aggregate Matrix is composed of asphalt binder, fine aggregates, filler materials, and pores. It has been used to understand the behavior of asphalt mixtures since fatigue damage in asphalt mixtures is frequently related to small-scale phenomena with considerable influence off the fine part of the mixture. In addition, several researchers point out the importance of taking into account the pore size distribution in the designs of these samples, as they are related to moisture damage. This research aimed to compare the method of determining pore size distribution of nine Fine Aggregate Matrix samples using X-ray micro-computed tomography to the method of determining pore size distribution by analyzing a set of linear regressions between the pore volume and the density of the samples. The results showed that the pore distribution obtained through linear regression resembles the pore distribution obtained from X-ray computed microtomography and that the average sample density overestimated the linear regression set model by up to 6.1 % of the pore volume. The observed sampling error was less than 0.59 %, which shows that the number of samples was sufficient to estimate the pore volume of the FAM2. Thus, the hypothesis test result confirmed that the difference cannot be considered significant for a 95 % confidence level. Therefore, the linear regression set model can be considered adequate to describe the pore volume obtained by X-ray micro-computed tomography.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"221 ","pages":"Article 111819"},"PeriodicalIF":1.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143808637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eder Queiroz Barbosa , Daniel Marcos Bonotto , Cynthia Romariz Duarte , Luis Henrique Mancini
{"title":"Effects of Compton scattering on radiometric maps from Rio Preto area, Goiás State, Brazil","authors":"Eder Queiroz Barbosa , Daniel Marcos Bonotto , Cynthia Romariz Duarte , Luis Henrique Mancini","doi":"10.1016/j.apradiso.2025.111822","DOIUrl":"10.1016/j.apradiso.2025.111822","url":null,"abstract":"<div><div>Gamma ray spectrometry measurements offer broad utility as a powerful method for identifying and quantifying radionuclides without the need of physicochemical sample preparation. Additionally, <em>in situ</em> readings are non-destructive, preserving the samples integrity. This study aimed to enhance the calibration steps of widely utilized gamma spectrometers based on NaI(Tl) scintillation detectors, involving calculation of combined uncertainties and assessment of systematic effects arising from the interaction of gamma radiation with matter, emphasizing the Compton interference in the gamma spectra. Radiometric data in 272 rock samples from Rio Preto Project developed at Goiás State, Brazil, spanning from 1995 to 2001, were obtained by means of a benchtop gamma spectrometer installed at LABIDRO-Isotopes and Hydrochemistry Laboratory, IGCE-UNESP, Rio Claro (SP), Brazil. The obtained dataset alllowed determine gamma interference factors within the spectral windows of natural radionuclides [K(<sup>40</sup>K), eU(<sup>214</sup>Bi), and eTh(<sup>208</sup>Tl)]. Furthermore, isoline maps were constructed using the geostatistical “minimum curvature” model to data analysis after removal of the Compton interference in spectral windows. Geostatistical models were employed to map their distribution in the study area, contributing to the refinement of procedures adopted for plotting survey/monitoring maps devoted to exploration/environmental purposes, thus, improving the accuracy and comprehension of gamma spectrometric data.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"221 ","pages":"Article 111822"},"PeriodicalIF":1.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143785553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G.S. Sahoo , Sabyasachi Paul , S.P. Tripathy , N. Chaudhary , P. Srinivasan
{"title":"An approach to measure low LET radiation at high dose using CR-39 track detector","authors":"G.S. Sahoo , Sabyasachi Paul , S.P. Tripathy , N. Chaudhary , P. Srinivasan","doi":"10.1016/j.apradiso.2025.111817","DOIUrl":"10.1016/j.apradiso.2025.111817","url":null,"abstract":"<div><div>CR-39 track detectors are commonly used for measuring high LET (linear energy transfer) radiation with LET values above 10 keV/μm. This study proposes a method for using CR-39 to measure low LET radiation, such as photons and electrons, at high doses in the order of kilogray (kGy). CR-39 detectors were irradiated with bremsstrahlung photons generated from 10 MeV electrons striking a tantalum target, resulting in absorbed doses ranging from 6.5 kGy to 261.4 kGy. FLUKA Monte Carlo simulation was performed to estimate the dose deposition in CR-39 due to bremsstrahlung photons and to estimate the primary and secondary electron fluences incident on CR-39. The simulations revealed that the secondary electrons produced by the interactions of primary electron beam were of two orders less magnitude than that of bremsstrahlung photons. The results showed no significant changes in the absorbance values of different functional group vibrations of unetched CR-39 even they were exposed to high dose up to 261.4 kGy. However, after chemical etching, the intensities of two prominent peaks at 1230 cm<sup>−1</sup> (aliphatic ester C–O–C stretching) and 1735 cm<sup>−1</sup> (ester C=O stretching) significantly decreased at doses above 65.3 kGy. The study demonstrates the feasibility of using CR-39 track detectors for measuring low LET radiation at high doses in the range from 46 to 197 kGy by combining FTIR spectroscopy with chemical etching.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"221 ","pages":"Article 111817"},"PeriodicalIF":1.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahdi Shaddoust , Amir Reza Khoshhal , Abbas Bagheri Khatibani , Mohammad Hadi Ahmadi
{"title":"Structural, morphological, and optical properties of sol-gel derived ZnO and ZnO:Cu and its application as a gamma ray attenuator","authors":"Mahdi Shaddoust , Amir Reza Khoshhal , Abbas Bagheri Khatibani , Mohammad Hadi Ahmadi","doi":"10.1016/j.apradiso.2025.111812","DOIUrl":"10.1016/j.apradiso.2025.111812","url":null,"abstract":"<div><div>Pristine and copper doped zinc oxide nanostructures have been afforded by a simple and easy to access sol-gel method. Their common properties were examined through the standard analyzing methods. X-ray diffraction results vouched the hexagonal structure of zinc oxide; even though, the insertion of copper changed the zinc oxide structure to some extent. FESEM achievements illustrated the nanosized quasi-spherical grains and the agglomeration of them. The protection factors against gamma rays, including mean free path (MFP), mass attenuation coefficients (MAC), linear attenuation coefficients (LAC), transmission Factor (TF), tenth value layer (TVL), half value layer (HVL) and radiation protection efficiency (RPE) were calculated. According to these factors, it can be concluded that the use of ZnO, and ZnO-Cu (10 % and 20 %) as a shielding for gamma ray can be valuable. For a more complete review, a simulation survey through GEometry ANd Tracking (GEANT4) code was applied to compare the protecting parameters.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"221 ","pages":"Article 111812"},"PeriodicalIF":1.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hiroshi Watabe , Peter K.N. Yu , Dragana Krstic , Dragoslav Nikezic , Kyeong Min Kim , Taiga Yamaya , Naoki Kawachi , Hiroki Tanaka , Zoran Jovanovic , A.K.F. Haque , M. Rafiqul Islam , Gary Tse , Quinncy Lee , Mehrdad Shahmohammadi Beni
{"title":"RAPTOR-AI: An open-source AI powered radiation protection toolkit for radioisotopes","authors":"Hiroshi Watabe , Peter K.N. Yu , Dragana Krstic , Dragoslav Nikezic , Kyeong Min Kim , Taiga Yamaya , Naoki Kawachi , Hiroki Tanaka , Zoran Jovanovic , A.K.F. Haque , M. Rafiqul Islam , Gary Tse , Quinncy Lee , Mehrdad Shahmohammadi Beni","doi":"10.1016/j.apradiso.2025.111797","DOIUrl":"10.1016/j.apradiso.2025.111797","url":null,"abstract":"<div><div>Artificial intelligence (AI) has gained significant attention in various scientific fields due to its ability to process large datasets. In nuclear radiation physics, while AI presents exciting opportunities, it cannot replace physics-based models essential for explaining radiation interactions with matter. To combine the strengths of both, we have developed and open-sourced the Radiation Protection Toolkit for Radioisotopes with Artificial Intelligence (RAPTOR-AI). This toolkit integrates AI with the Particle and Heavy Ion Transport code System (PHITS) Monte Carlo package, enabling rapid radiation protection analysis for radioisotopes and structural shielding. RAPTOR-AI is particularly valuable for emergency scenarios, allowing quick dose dispersion assessments when a facility’s structural map is available, enhancing safety and response efficiency.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"221 ","pages":"Article 111797"},"PeriodicalIF":1.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}