Applied Radiation and Isotopes最新文献

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Spatial and vertical distribution of uranium and associated hydro-geochemistry, chemometric statistics in groundwater of Mansa and Barnala districts, Punjab, India. 印度旁遮普邦Mansa和Barnala地区地下水中铀的空间和垂直分布及其相关的水文地球化学、化学计量统计。
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2025-07-05 DOI: 10.1016/j.apradiso.2025.112032
Satvir Singh, Tanu Sharma, B S Bajwa, Inderpreet Kaur
{"title":"Spatial and vertical distribution of uranium and associated hydro-geochemistry, chemometric statistics in groundwater of Mansa and Barnala districts, Punjab, India.","authors":"Satvir Singh, Tanu Sharma, B S Bajwa, Inderpreet Kaur","doi":"10.1016/j.apradiso.2025.112032","DOIUrl":"https://doi.org/10.1016/j.apradiso.2025.112032","url":null,"abstract":"<p><p>The current study aimed to elucidate the spatial and vertical distribution of uranium in groundwater of Mansa and Barnala districts of South-West Punjab, along with associated physico-geochemical properties and related pathfinder elements, employing hydro-geochemical methodologies and chemometric statistics. In this study, high prevalence (surpassing WHO limit 30 μg/L in drinking water) of uranium was observed in 67 % and 50 % of groundwater samples from Mansa and Barnala districts, respectively. Substantial fluoride contamination followed by nitrates was found in groundwater of both districts. The groundwater from deeper aquifers was found to be suitable for irrigation purpose in the study area. From the hydro-geochemistry study in Mansa district, it was observed both water-rock interactions and high saline water intrusions were responsible for ionic solubility whereas in Barnala district, the primary source of dissolved ions is water-rock interaction. A strong positive correlation of uranium was observed with its path finder elements (Cr, Mo, Se) in both districts indicated that the geogenic sources are predominantly responsible for the origin of U in groundwater of two districts. This study may provide a foundational dataset for the spatial and vertical distribution of uranium in groundwater across both districts, serving local communities, state and central governments and related organizations in formulating the policies and remediation strategies to address water pollution.</p>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"225 ","pages":"112032"},"PeriodicalIF":1.6,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DHR-Net: Dynamic Harmonized registration network for multimodal medical images DHR-Net:多模态医学图像动态协调配准网络
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2025-07-05 DOI: 10.1016/j.apradiso.2025.112031
Xin Yang , Dongxue Li , Songyu Chen , Liwei Deng , Jing Wang , Sijuan Huang
{"title":"DHR-Net: Dynamic Harmonized registration network for multimodal medical images","authors":"Xin Yang ,&nbsp;Dongxue Li ,&nbsp;Songyu Chen ,&nbsp;Liwei Deng ,&nbsp;Jing Wang ,&nbsp;Sijuan Huang","doi":"10.1016/j.apradiso.2025.112031","DOIUrl":"10.1016/j.apradiso.2025.112031","url":null,"abstract":"<div><div>Although deep learning has driven remarkable advancements in medical image registration, deep neural network-based non-rigid deformation field generation methods demonstrate high accuracy in single-modality scenarios. However, multi-modal medical image registration still faces critical challenges. To address the issues of insufficient anatomical consistency and unstable deformation field optimization in cross-modal registration tasks among existing methods, this paper proposes an end-to-end medical image registration method based on a Dynamic Harmonized Registration framework (DHR-Net). DHR-Net employs a cascaded two-stage architecture, comprising a translation network and a registration network that operate in sequential processing phases. Furthermore, we propose a loss function based on the Noise Contrastive Estimation framework, which enhances anatomical consistency in cross-modal translation by maximizing mutual information between input and transformed image patches. This loss function incorporates a dynamic temperature adjustment mechanism that progressively optimizes feature contrast constraints during training to improve high-frequency detail preservation, thereby better constraining the topological structure of target images. Experiments conducted on the M&amp;M Heart Dataset demonstrate that DHR-Net outperforms existing methods in registration accuracy, deformation field smoothness, and cross-modal robustness. The framework significantly enhances the registration quality of cardiac images while demonstrating exceptional performance in preserving anatomical structures, exhibiting promising potential for clinical applications.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"225 ","pages":"Article 112031"},"PeriodicalIF":1.6,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of alpha induced secondary proton production in natNi-reactor structural material natni反应器结构材料中α诱导二次质子产生的分析
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2025-07-05 DOI: 10.1016/j.apradiso.2025.111986
Swapna Balakrishnan , M.M. Musthafa , Midhun C.V. , Gokul Das H. , Vafiya Thaslim T.T. , F.S. Shana , Najmunnisa T. , Rijin N.T. , S. Ghugre , S. Dasgupta , J. Datta
{"title":"Analysis of alpha induced secondary proton production in natNi-reactor structural material","authors":"Swapna Balakrishnan ,&nbsp;M.M. Musthafa ,&nbsp;Midhun C.V. ,&nbsp;Gokul Das H. ,&nbsp;Vafiya Thaslim T.T. ,&nbsp;F.S. Shana ,&nbsp;Najmunnisa T. ,&nbsp;Rijin N.T. ,&nbsp;S. Ghugre ,&nbsp;S. Dasgupta ,&nbsp;J. Datta","doi":"10.1016/j.apradiso.2025.111986","DOIUrl":"10.1016/j.apradiso.2025.111986","url":null,"abstract":"<div><div>Nickel is a crucial structural material in nuclear reactors due to its excellent thermal properties and corrosion resistance. In the reactor environment, high-energy alpha particles are produced and causing secondary interactions within the structural materials, leading to the formation of hydrogen gas within the structural material. This study explores the extent of hydrogen production due to alpha-induced reactions on natural nickel in the energy range of reactor interest. Experimental measurements of the <span><math><msup><mrow></mrow><mrow><mi>n</mi><mi>a</mi><mi>t</mi></mrow></msup></math></span>Ni(<span><math><mi>α</mi></math></span>, xp)<sup>61</sup>Cu cross-section were conducted using the stack foil activation method, providing new data for reactor gas formation estimation. Reactor material selection and construction rely on theoretical simulations using codes, so the accuracy, precision, and reproducibility of these codes are important. Theoretical predictions generated using TALYS 1.96 and EMPIRE-3.2.3 showed noticeable deviations from the experimental data, even after parameter optimization. Incorporating beta-decay channels in the EMPIRE-3.2.3 code improved the accuracy of gas formation predictions. The results are vital for evaluating reactor safety.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"225 ","pages":"Article 111986"},"PeriodicalIF":1.6,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-resolution alpha-particle spectrometry of 243Am 243Am的高分辨率α粒子光谱分析
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2025-07-05 DOI: 10.1016/j.apradiso.2025.112029
S. Pommé, K. Pelczar
{"title":"High-resolution alpha-particle spectrometry of 243Am","authors":"S. Pommé,&nbsp;K. Pelczar","doi":"10.1016/j.apradiso.2025.112029","DOIUrl":"10.1016/j.apradiso.2025.112029","url":null,"abstract":"<div><div>Alpha particles emitted by a thin <sup>243</sup>Am source were detected with an energy resolution of 9–10 keV in a planar ion-implanted silicon semiconductor detector. A magnet system was installed above the source to deflect conversion electrons emitted quasi-coincidentally with the alpha particles, thus strongly reducing sum peaks from simultaneous detections that would distort the energy spectrum. In addition, measurements were performed at different distances between the source and detector surfaces, to verify whether the energy spectra were insensitive to variations in geometrical efficiency. Peak shapes were fitted to the energy spectrum, the alpha-particle emission probabilities determined, the uncertainty budget calculated, and the results compared with literature values.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"225 ","pages":"Article 112029"},"PeriodicalIF":1.6,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive evaluation of angiography Equipment: Ensuring precision and compliance in high-precision medical procedures 血管造影设备的综合评价:确保高精度医疗程序的准确性和依从性
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2025-07-05 DOI: 10.1016/j.apradiso.2025.112033
Gerardo Antonio Noguera Vega
{"title":"Comprehensive evaluation of angiography Equipment: Ensuring precision and compliance in high-precision medical procedures","authors":"Gerardo Antonio Noguera Vega","doi":"10.1016/j.apradiso.2025.112033","DOIUrl":"10.1016/j.apradiso.2025.112033","url":null,"abstract":"<div><div>This comprehensive study studies the detailed assessment of angiography devices in high-precision medical interventions. Concentrating on geometric parameters, metrology, dosimetry, performance, and image quality, it holds all the requirements and ideals established by the regulatory authority in Costa Rica.</div><div>The verification was meticulously conducted, encompassing geometrical parameters such as the source-to-skin distance, X-ray beam perpendicularity and centering, image detector input field size, geometric distortion, monitor linearity, and alignment of the radiation field with the detector's field of view.The results confirmed that the equipment fully complies with the stringent requirements established by regulatory standards. Operationally, the system was evaluated at different peak kilovoltage (kVp) settings −60 kVp, 80 kVp, 90 kVp, and 110 kVp-in pulsed fluoroscopy mode, with precisely defined pulse durations and frequencies.</div><div>The performance evaluation included analysis of output consistency (μGy·m<sup>2</sup>/mAs), tube current (mA) and time (s), as well as additional non-invasive tests on the generator. The results demonstrated stable performance within permissible limits. The assessment also covered peak kilovoltage accuracy and beam filtration, confirming compliance with applicable regulatory standards. Image quality was critically evaluated, with particular attention to the presence of artifacts and spatial resolution, which remained within the established acceptable thresholds.</div><div>Additionally, a radiometric study was conducted to illustrate the distribution of the radiation field around the examination table and other areas of interest. This complementary analysis reinforces the overall evaluation of the angiography system, providing assurance of its clinical suitability and operational safety.</div><div>The specific findings indicate that the pulse duration and pulse rate were 133.7 ms and 4 pulses per second, respectively. These values will serve as the reference standard for a future angiographic operating under similar conditions, with a beam filtered by 4.9 mm Al. The measured dose output was 49.3 μGy m<sup>2</sup>/mAs, with a maximum deviation of 3.9 %. The peak kilovoltage showed a deviation of only 0.7 %. Image quality was free of artifacts, with a measured spatial resolution (line pairs per millimeter) of 5 lp/mm and a detection threshold of 2.5 lp/mm. Overall image uniformity reached 96 %. A radiation field distribution map accurately depicts the spatial characteristics of the room.</div><div>In summary, the results demonstrate that this equipment not only meets but, in some aspects, exceeds established standards of practice, highlighting the importance of comprehensive evaluation in this field.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"225 ","pages":"Article 112033"},"PeriodicalIF":1.6,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radioactivity and radon exhalation rate of some granite building materials in Türkiye 某些花岗岩建筑材料的放射性和氡释放率
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2025-07-04 DOI: 10.1016/j.apradiso.2025.112024
Ayhan Akkaş
{"title":"Radioactivity and radon exhalation rate of some granite building materials in Türkiye","authors":"Ayhan Akkaş","doi":"10.1016/j.apradiso.2025.112024","DOIUrl":"10.1016/j.apradiso.2025.112024","url":null,"abstract":"<div><div>The presence of elevated concentrations of naturally occurring radionuclides in building materials can lead to the generation of high dose rates within indoor environments, resulting from both internal and external exposure pathways. The internal dose is mainly attributable to radon exhalation from the building materials, whereas the external dose is a consequence of γ-rays emitted from the radionuclides present within the building materials. The principal radioisotopes of interest are potassium (K), thorium (Th) and radium (Ra), in terms of their respective concentrations in the material. The concentration of Ra in the material is also a significant factor in determining the quantity of radioactive radon gas that is released from the material. In the study conducted by Çetin in 2011, the concentration of radionuclides present in selected granite materials used in construction in Türkiye was determined using the gamma spectrometry analysis method. Radionuclide concentrations were used to calculate the annual effective dose values for eight of these materials. The radon exhalation rate is directly affected by the radium concentration in the material. This reports gives natural radioactivity content and radon exhalation rate measurements for some granite building materials using in Türkiye.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"225 ","pages":"Article 112024"},"PeriodicalIF":1.6,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tracking gaseous radioactivity through a spallation neutron source from origin to discharge 跟踪气体放射性通过散裂中子源从起源到放电
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2025-07-04 DOI: 10.1016/j.apradiso.2025.112036
G.P. Škoro, D.J.S. Findlay
{"title":"Tracking gaseous radioactivity through a spallation neutron source from origin to discharge","authors":"G.P. Škoro,&nbsp;D.J.S. Findlay","doi":"10.1016/j.apradiso.2025.112036","DOIUrl":"10.1016/j.apradiso.2025.112036","url":null,"abstract":"<div><div>An exercise has been carried out at the ISIS Spallation Neutron Source to track quantitatively the progress of radioactive air all the way from the machine areas where gaseous radioactivity is generated to the discharge stack from which gaseous radioactivity is vented to atmosphere. Calculations and measurements have been found to agree to within a factor ∼2, which is regarded as satisfactory in view of the many uncertainties involved and the approximations and assumptions that have had to be made in order to make the exercise tractable. A satisfying corollary is that the entire ‘life cycle’ of gaseous activity within ISIS, from generation through to discharge, is well understood.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"225 ","pages":"Article 112036"},"PeriodicalIF":1.6,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An automatic patient-specific quality assurance with a novel DVH scoring algorithm for volumetric modulated arc therapy of cervical cancer 用于子宫颈癌体积调制弧线治疗的新型DVH评分算法的自动患者特异性质量保证
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2025-07-04 DOI: 10.1016/j.apradiso.2025.112030
Ji Zhang , Boda Ning , Xiaotong Jin , Yanting Shen , Yiran Mu , Jinling Yi , Ce Han , Yongqiang Zhou , Yanling Bai , Xiance Jin
{"title":"An automatic patient-specific quality assurance with a novel DVH scoring algorithm for volumetric modulated arc therapy of cervical cancer","authors":"Ji Zhang ,&nbsp;Boda Ning ,&nbsp;Xiaotong Jin ,&nbsp;Yanting Shen ,&nbsp;Yiran Mu ,&nbsp;Jinling Yi ,&nbsp;Ce Han ,&nbsp;Yongqiang Zhou ,&nbsp;Yanling Bai ,&nbsp;Xiance Jin","doi":"10.1016/j.apradiso.2025.112030","DOIUrl":"10.1016/j.apradiso.2025.112030","url":null,"abstract":"<div><h3>Purpose</h3><div>To develop a novel DVH scoring algorithm to predict and classify patient-specific quality assurance (PSQA) results by different DVH metrics automatically and efficiently.</div></div><div><h3>Methods</h3><div>A total of 200 cervical cancer patients who treated by Infinity (109 cases) and Synergy (91 cases) linear accelerators underwent volumetric modulated arc therapy (VMAT) from 2019 to 2022 were enrolled and used as technical testing (TT) and technical validation (TV) datasets, respectively, which was then randomly divided into training, validation and testing set at a ratio of 7:1:2. PSQA dose distributions were predicted using U-shape-like network with skip-connection modules (called T-Net) with the input of CT and plan dose distributions. A novel weight-based DVH scoring (WDS) algorithm was developed and trained to classify “pass” or “fail” (PoF) of PSQA results based on the dose errors (DEs) and volumetric errors (VEs) calculated between predicted and planned DVHs.</div></div><div><h3>Results</h3><div>T-Net achieved a best performance in predicting PSQA dose distributions in comparison with other deep learning models. The WDS method achieved a sensitivity, specificity and accuracy of 100.00 %, 50.00 %, 0.955, and 100.00 %,33.33 %, 0.890 in <span>TT</span> and TV, respectively, which was better than models of random forest (RF) and support vector machines (SVM) with an accuracy of 0.909, 0.833 and 0.864, 0.722 in TT and TV, respectively. The threshold DVH score for 22 and 18 validation patients were 49.62 and 57.62 in the TT and TV with a precision, recall rate and F1 score of 0.952, 1, 0.976 and 0.882, 1, 0.938, respectively.</div></div><div><h3>Conclusions</h3><div>The suggested novel WDS algorithm can improve the accuracy and efficiency of classifying the PoF of PSQA objectively and automatically.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"225 ","pages":"Article 112030"},"PeriodicalIF":1.6,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Observational validation study of dosimetry using radiographic films in breast cancer intraoperative radiotherapy 乳腺癌术中放疗中使用x线片进行剂量测定的观察性验证研究
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2025-07-03 DOI: 10.1016/j.apradiso.2025.112028
Yu-Yun Kao , Jen-Yang Tang , Wen-Hsi Cheng
{"title":"Observational validation study of dosimetry using radiographic films in breast cancer intraoperative radiotherapy","authors":"Yu-Yun Kao ,&nbsp;Jen-Yang Tang ,&nbsp;Wen-Hsi Cheng","doi":"10.1016/j.apradiso.2025.112028","DOIUrl":"10.1016/j.apradiso.2025.112028","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Intraoperative radiotherapy (IORT) for breast cancer offers a promising alternative to conventional external beam radiotherapy by delivering high-dose radiation directly to the tumor bed during surgery. However, accurate dosimetry is critical to ensure the safety and efficacy of this procedure. This study aimed to develop and validate a reliable dosimetry using GAFchromic EBT-3 films for precise <em>in vivo</em> and <em>in vitro</em> dosimetry during IORT. The primary objective was to verify the accuracy of absorbed delivered doses during IORT using GAFchromic EBT-3 films, in comparison with that of Monte Carlo simulations.</div></div><div><h3>Methods</h3><div>This observational study included 38 patients with breast cancer who underwent IORT at Kaohsiung Municipal Ta-Tung Hospital and Kaohsiung Medical University Chung-Ho Memorial Hospital in Taiwan. Patients were selected based on predefined inclusion criteria. Using GAFchromic EBT-3 films during IORT, absorbed doses, including the applicator surface, excision wound, and surrounding breast tissue, were measured at various critical points. Monte Carlo simulations were conducted to validate the accuracy of these manufacturer-provided data.</div></div><div><h3>Results</h3><div>The mean measured dose was 20.37 ± 0.67 Gy, which had a 1.2 % discrepancy from the planned dose of 20 Gy. Dose measurements at other surrounding tissues indicated effective protection, with mean doses of 1.36 ± 0.92 Gy on the excision wound and 1.08 ± 1.18 Gy on the surrounding breast edge. Monte Carlo simulations confirmed a high level of consistency with the manufacturer's data, with an error margin of &lt;3 %.</div></div><div><h3>Conclusions</h3><div>The use of GAFchromic EBT-3 films for dosimetry during IORT was feasible and reliable and provided an independent verification method to ensure accurate dose delivery. This study demonstrates that accurate dosimetric validation supports the clinical optimization of intraoperative radiotherapy (IORT), enabling precise dose delivery while reducing exposure to surrounding healthy tissues. These findings may contribute to enhanced treatment safety, improved local control, and favorable cosmetic outcomes in breast-conserving therapy. Further research is warranted to refine this technique and explore its applicability in other radiotherapy contexts.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"225 ","pages":"Article 112028"},"PeriodicalIF":1.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144563858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiolabeling, quality control, and in vitro cell culture studies of [99mTc]Tc-tamoxifen citrate for estrogen receptor-positive breast cancer imaging [99mTc] tc -柠檬酸他莫昔芬用于雌激素受体阳性乳腺癌成像的放射标记、质量控制和体外细胞培养研究
IF 1.6 3区 工程技术
Applied Radiation and Isotopes Pub Date : 2025-07-03 DOI: 10.1016/j.apradiso.2025.112023
Hayriye Okşaş, Meliha Ekinci
{"title":"Radiolabeling, quality control, and in vitro cell culture studies of [99mTc]Tc-tamoxifen citrate for estrogen receptor-positive breast cancer imaging","authors":"Hayriye Okşaş,&nbsp;Meliha Ekinci","doi":"10.1016/j.apradiso.2025.112023","DOIUrl":"10.1016/j.apradiso.2025.112023","url":null,"abstract":"<div><h3>Background</h3><div>Early and accurate imaging of estrogen receptor-positive (ER<sup>+</sup>) breast cancer remains an unmet need in nuclear medicine. Tamoxifen, a selective estrogen receptor modulator, offers a molecular targeting strategy, yet previous radiolabeling approaches often required elevated temperatures or chelating agents.</div></div><div><h3>Purpose</h3><div>This study aimed to develop and evaluate a simple, chelator-free radiolabeling method for tamoxifen citrate (TC) with technetium-99m ([<sup>99m</sup>Tc]Tc) under mild conditions, without requiring purification, and to assess its physicochemical stability and selective uptake in breast cancer cells.</div></div><div><h3>Methods</h3><div>[<sup>99m</sup>Tc]Tc-TC was synthesized using stannous chloride as a reducing agent at room temperature. Radiochemical purity was assessed by radio thin-layer chromatography (RTLC) and radioelectrophoresis. Stability was examined in saline and cell culture media. Cellular uptake was evaluated in ER<sup>+</sup> (MCF-7) and ER<sup>-</sup> (MCF-10A) cell lines. A theoretical coordination model of [<sup>99m</sup>Tc]Tc-TC was also proposed.</div></div><div><h3>Results</h3><div>The most stable [<sup>99m</sup>Tc]Tc-TC complex was formed using 0.01 mg of stannous chloride as the reducing agent, 37 MBq of activity at pH 7.4, and a 20 min incubation time. The radiolabeled complex showed &gt;97 % radiochemical purity and remained stable for 6 h in saline and 2 h in cell medium. Cellular uptake in MCF-7 cells was approximately 72–77 %, more than double that in MCF-10A cells (around 30 %), demonstrating ER<sup>+</sup> selectivity. Radioelectrophoresis confirmed a distinct migration profile from [<sup>99m</sup>Tc]Tc-citrate, supporting the formation of a [<sup>99m</sup>Tc]Tc-TC complex.</div></div><div><h3>Conclusions</h3><div>[<sup>99m</sup>Tc]Tc-TC was successfully synthesized <em>via</em> a simple room-temperature labeling strategy, showing high stability and ER-specific cell uptake. Although <em>in vivo</em> validation is planned for future studies, this formulation holds promise as a receptor-targeted radiopharmaceutical for breast cancer imaging.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"225 ","pages":"Article 112023"},"PeriodicalIF":1.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144563859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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