Applied Radiation and Isotopes最新文献

{"title":"Studies of structural and trapping parameters of gamma irradiated biochar for dosimetric applications","authors":"Umme Muslima ,&nbsp;Mayeen Uddin Khandaker ,&nbsp;S.N. Mat Nawi ,&nbsp;Md Raghib Rahat ,&nbsp;S.E. Lam ,&nbsp;S.F. Abdul Sani ,&nbsp;D.A. Bradley ,&nbsp;H.J. Woo ,&nbsp;Mohamed Y. Hanfi","doi":"10.1016/j.apradiso.2025.112042","DOIUrl":"10.1016/j.apradiso.2025.112042","url":null,"abstract":"<div><div>Biochar, a low-cost and environment-friendly material, possesses favorable physical and chemical properties towards dosimetric applications. The current investigation concentrated on the structural and thermoluminescence (TL) trapping parameters of biochar influenced by gamma-ray doses ranging from 0 to 200 Gy. The TL glow curves of gamma irradiated biochar samples have been analyzed by several well-established models viz initial rise, peak shape and curve fitting methods for estimating the fundamental trap parameters, i.e., kinetic order (b), activation energy (E) and frequency factor (s). The calculated geometric factor (μ_g) ranges between 0.50 and 0.56, indicating that the kinetic parameters can be appropriately determined using Chen's general-order kinetic model. The measured activation energy range (0.30–0.38 eV), along with the corresponding frequency factor, suggests that the biochar contains moderately stable trapping centers. These features collectively support the material's potential for reliable passive TL dosimetry, combining effective charge retention with efficient carrier release upon thermal stimulation. T_max-T_stop experiment was also performed and six subpeaks under the glow curve were located. The structural and morphological changes brought on by the radiation doses are being observed using SEM-EDX, Raman spectra and X-ray diffraction (XRD). SEM-EDX study validates the dose-dependent microstructural damage of biochar. The dose-dependent structural alterations and self-annealing with increasing gamma doses were clearly indicated by the intensity ratio (I_D/I_G), obtained from raman spectra. The crystallite size obtained from the generalized Tuinstra-Koenig equation is inversely proportional to the intensity ratio (I_D/I_G), confirms the defect generation with the increasing radiation doses. Through the examination of crystallite size (D), dislocation density (δ), lattice strain (ɛ), and FWHM from XRD patterns, additional validation of dose-dependent variation of TL trapping parameters was obtained. Analysis of the structural and trapping attributes reveals the structural alterations induced by gamma irradiation. Consequently, it is evidently noticeable that biochar possesses considerable potential for dosimetric applications.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"225 ","pages":"Article 112042"},"PeriodicalIF":1.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monte Carlo dosimetry of silver-111 in simplified cell geometries in the framework of the ISOLPHARM project","authors":"A. Donzella ,&nbsp;A. Leso ,&nbsp;A. Arzenton ,&nbsp;G. Bonomi ,&nbsp;S. Bortolussi ,&nbsp;D. Chen ,&nbsp;S. Corradetti ,&nbsp;M. Lunardon ,&nbsp;E. Mariotti ,&nbsp;E. Reniero ,&nbsp;D. Serafini ,&nbsp;G.S. Valli ,&nbsp;L. Zangrando ,&nbsp;A. Zenoni ,&nbsp;A. Andrighetto","doi":"10.1016/j.apradiso.2025.111979","DOIUrl":"10.1016/j.apradiso.2025.111979","url":null,"abstract":"<div><div>The ISOLPHARM project of the INFN aims to study the properties of the ¹¹¹Ag <span><math><msup><mrow><mi>β</mi></mrow><mrow><mo>−</mo></mrow></msup></math></span> emitter as a promising core for novel radiopharmaceuticals. ¹¹¹Ag will be produced at the SPES facility of the Legnaro National Laboratories, with high specific activity and remarkable yields, exploiting the ISOL technique. This work presents Monte Carlo dosimetry calculations at cellular level to assess the therapeutic potential of ¹¹¹Ag within the ADMIRAL project. Using the formalism introduced by the MIRD, S-values are calculated for a biological cell exposed to different scenarios of activity distributions of ¹¹¹Ag. The results of dosimetry calculations performed with <span>Geant4</span>, MCNP6 and PHITS Monte Carlo codes are presented and discussed, showing a good mutual agreement and also with the MIRDcell values. These results will be used within the ISOLPHARM project for the planning of in-vitro experiments in 2D cell cultures and 3D tissue-mimicking scaffolds.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"225 ","pages":"Article 111979"},"PeriodicalIF":1.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Setting up a national diagnostic reference level for computed tomography for the public sector in Costa Rica: first step","authors":"Dagoberto Eloy González-López ,&nbsp;Adlin López-Díaz ,&nbsp;Fredys Santos-Gutiérrez ,&nbsp;Lourdes Salvador-Hernández ,&nbsp;Leonel Alberto Torres-Aroche ,&nbsp;Simone Kodlulovich-Renha","doi":"10.1016/j.apradiso.2025.112043","DOIUrl":"10.1016/j.apradiso.2025.112043","url":null,"abstract":"<div><h3>Background and aim</h3><div>Computed Tomography (CT) is a key tool in medical diagnostics but is associated with significant ionizing radiation exposure, highlighting the need to optimize doses through Diagnostic Reference Levels (DRLs). The current study aimed to assess CT radiation dose and propose a National Diagnostic Reference Level (NDRL) for the 5 most frequent adult studies using CT dose parameters such as CT Dose Index Volume (CTDI_vol) and Dose Length Product (DLP) as well as to compare the practices for aforementioned examinations between hospitals in Costa Rica's public sector.</div></div><div><h3>Materials and methods</h3><div>Data from patients and studies developed in 11/12 public hospitals in Costa Rica between January to August 2024 were collected. Procedures performed on adults for five main anatomical regions (head, cervical spine, chest, abdomen-pelvis, and chest-abdomen-pelvis) were analysed, using the 50th and 75th percentiles of dosimetric parameters (CTDI_vol and DLP) as reference exposure values. The NDRL was achieved from the third quartile of median CTDI_vol and DLP for each hospital and examination.</div></div><div><h3>Results</h3><div>The proposed public National Diagnostic Reference Levels (NDRLs) are as follows: for Head examinations, a CTDI_vol of 52 mGy and a DLP of 1239 mGy cm; for Cervical Spine, 22 mGy and 774 mGy cm; for Chest, 10 mGy and 594 mGy cm; for combined Abdomen-Pelvis studies, 14 mGy and 1283 mGy cm; and for combined Chest-Abdomen-Pelvis studies, 12 mGy and 1498 mGy cm. Overall, these values align with international reference levels in terms of CTDI_vol; however, notable discrepancies were observed in DLP values—particularly for Chest-Abdomen-Pelvis exams, where the proposed level exceeded the French NDRL by up to 170 %.</div></div><div><h3>Conclusion</h3><div>While the NDRLs outlined in this study were generally acceptable and consistent with previously published research, optimizing radiation doses remains imperative, particularly for those equipment and hospitals with values above the reference. This analysis represents the first effort to establish DRLs in Costa Rica, providing a robust foundation for optimizing radiological safety.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"225 ","pages":"Article 112043"},"PeriodicalIF":1.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144614199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular and multicellular dosimetry of two copper radioisotopes: 67Cu and 64Cu","authors":"Laura De Nardo ,&nbsp;Lucia De Dominicis ,&nbsp;Juan Esposito ,&nbsp;Antonio Rosato ,&nbsp;Cristina Bolzati ,&nbsp;Laura Meléndez-Alafort","doi":"10.1016/j.apradiso.2025.112041","DOIUrl":"10.1016/j.apradiso.2025.112041","url":null,"abstract":"<div><div>Radioisotopes ⁶⁴Cu/⁶⁷Cu represent a promising theranostic pair for nuclear medicine, offering the potential to achieve PET imaging (⁶⁴Cu) and therapeutic treatment (⁶⁷Cu). Recently, it has been hypothesised that ⁶⁴Cu Auger emissions, if located within the cellular nucleus, could render therapy significantly more advantageous than ⁶⁷Cu. The objective of this study was to evaluate and compare the dosimetric characteristics of ⁶⁷Cu and ⁶⁴Cu using various tumour models. The cell nuclei absorbed dose (D_N) was assessed considering a homogeneous distribution of ⁶⁴Cu or ⁶⁷Cu radioactivity in isolated spheres with radii ranging from 1 μm to 10 mm, and also for spherical cell cluster models with radii ranging from 50 to 1350 μm, assuming various percentages of labelled cells in the cluster and copper radionuclides localisation in one of the three cell compartments (nucleus, cytoplasm, or cell surface). Results obtained with MIRDcell software confirmed that, in spherical cell clusters, D_N of both labelled and unlabelled cells is consistently higher for ⁶⁷Cu than for ⁶⁴Cu when radioactivity is localised in the cytoplasm or the cell surface. However, when ⁶⁴Cu was localised within the nucleus, D_N was higher than for ⁶⁷Cu only when the percentage of labelled cells was low (≤50 %) or the cell clusters were very small. This indicates that, even if the radiopharmaceutical could be localised in the cell nucleus, D_N produced by ⁶⁴Cu would be higher than the one of ⁶⁷Cu only in a limited number of cases. However, the D_N therapeutic effect needs to be corroborated with experimental data.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"225 ","pages":"Article 112041"},"PeriodicalIF":1.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated zirconium-89 and lutetium-177 antibody labeling and formulation using a Trasis MiniAIO module","authors":"Berend van der Wildt ,&nbsp;Stijn A. Spoormans ,&nbsp;Nathalie J. Koorn ,&nbsp;Carlijn A. Vlaswinkel ,&nbsp;Alex J. Poot","doi":"10.1016/j.apradiso.2025.112051","DOIUrl":"10.1016/j.apradiso.2025.112051","url":null,"abstract":"<div><h3>Introduction</h3><div>Radiolabeled antibodies are used to select the right treatment for the right patient by determining antigen expression levels <em>in vivo</em>. In addition, antibodies labeled with therapeutic nuclides can be used for cancer treatment. To efficiently produce these labeled antibodies in constant high quality, automated procedures are desired. This research describes the labeling and formulation of zirconium-89 and lutetium-177 labeled Dinutuximab on the Trasis MiniAIO module, as proof-of-principle antibody to be used for GD2 imaging and therapy in neuroblastoma patients.</div></div><div><h3>Methods</h3><div>Dinutuximab was modified for labeling with a DFO- or DOTA-chelator using isothiocyanate chemistry. Radiolabeling with zirconium-89 and lutetium-177 and subsequent purification and formulation were performed using the Trasis MiniAIO and compared to manual synthesis procedures. Radiochemical purity was assessed by iTLC and HPLC. Immunoreactivity was evaluated using a radioligand binding assay on antigen coated wells.</div></div><div><h3>Results</h3><div>Radiolabeled products were obtained with good radiochemical yield of 76 ± 8 % for [⁸⁹Zr]Dinutuximab 70 ± 8 % for [¹⁷⁷Lu]Dinutuximab. Immunoreactivity was &gt;50 % for zirconium-89 and lutetium-177 labeled constructs, which was similar to immunoreactivity of products obtained by manual synthesis. Manually obtained radiochemical yields were somewhat higher as a result of residual radioactivity in valves and tubings in automated synthesis runs, however losses were minimized through incorporation of several washing steps. Generally, yields were comparable with previously reported automation procedures and importantly, satisfactory for human application.</div></div><div><h3>Conclusion</h3><div>We have developed a reproducible and high-yielding automated method for the synthesis and formulation of radiolabeled diagnostic and therapeutic antibodies on a Trasis MiniAIO module. This method should assist in obtaining labeled products with consistent quality while simultaneously reducing the workers radiation dose.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"225 ","pages":"Article 112051"},"PeriodicalIF":1.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptive digital shaping of nuclear pulse based on real-time tracking of system transfer function and xLSTM","authors":"Zhonglin Wu,&nbsp;Hongquan Huang,&nbsp;Dejie Chen,&nbsp;Xingke Ma","doi":"10.1016/j.apradiso.2025.112048","DOIUrl":"10.1016/j.apradiso.2025.112048","url":null,"abstract":"<div><div>Typically, the radiation signals detected by a nuclear detector are processed through subsequent conditioning circuits and converted into analog pulse signals. Digital shaping techniques are then used to generate standard trapezoidal or Gaussian digital signals for energy spectrum analysis and counting processing. However, detector aging or environmental changes (such as temperature and humidity) can cause variations in the system transfer function. If the digital shaping parameters are not adjusted in a timely and accurate manner, the shaped waveform may become distorted, affecting the accurate extraction of pulse amplitude. To address this issue, this paper proposes a real-time transfer function tracking algorithm based on waveform vector space. This method dynamically captures transfer function variations through a continuously updated mechanism and simultaneously iteratively searches for the optimal pulse signal in a relatively stable state. Furthermore, we innovatively introduce the extended long short-term memory (xLSTM) network into the field of nuclear pulse parameter identification, ensuring adaptive digital shaping optimization in real-time tracking scenarios. Experimental results show that this method can keep the relative error of digital shaping parameters within 0.3 %.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"225 ","pages":"Article 112048"},"PeriodicalIF":1.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macro and microdistribution of boric acid in compact bone","authors":"María Silvina Olivera ,&nbsp;Carlos Ignacio Sallucci ,&nbsp;Marina Carpano ,&nbsp;María Alejandra Dagrosa ,&nbsp;María Sol Espain ,&nbsp;Daniel Brandizzi ,&nbsp;Paula Curotto ,&nbsp;Silvia Inés Thorp ,&nbsp;Emiliano César Cayetano Pozzi ,&nbsp;Gisela Saint Martin ,&nbsp;Agustina Mariana Portu","doi":"10.1016/j.apradiso.2025.112046","DOIUrl":"10.1016/j.apradiso.2025.112046","url":null,"abstract":"<div><div>The biodistribution of boronophenylalanine (BPA), a widely used compound for Boron Neutron Capture Therapy (BNCT), is well characterized. In contrast, data on boric acid (BA) biodistribution remain limited. Given previously observed high boron levels in calcified tissues following BA administration, we conducted a comparative study to evaluate its accumulation and retention in bone. Wistar rats were infused with: (a) BA at 40 ppm boron, (b) BPA at 40 ppm, and (c) BA at 200 ppm. Animals were euthanized under anesthesia at various time points post-injection (15 min–6 h). Boron concentrations in the diaphysis, knee joint, liver, kidney, skin, and blood were quantified using inductively coupled plasma optical emission spectroscopy (ICP-OES). We also optimized neutron autoradiography to study boron microdistribution in compact bone. A novel sample preparation method was developed to prevent boron loss and improve the quality of the tissue sections. Samples from diaphysis, collected 3 h post-infusion, were sliced with a diamond saw and polished to the desired thickness using multiple double-sided diamond disks. Both ICP-OES and neutron autoradiography revealed high boron concentrations in bone regions, suggesting preferential accumulation in the mineral matrix. These findings highlight the potential relevance of BA not only for therapeutic purposes but also in evaluating possible radiotoxic effects during BNCT.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"225 ","pages":"Article 112046"},"PeriodicalIF":1.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144614196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of gamma radiation on optical properties of PVA/PEG/EY blend, and radiochromism","authors":"Yamen A. Alibwaini ,&nbsp;O.M. Hemeda ,&nbsp;Marwan S. Mousa ,&nbsp;T. Sharshar ,&nbsp;Enas A. Arrasheed ,&nbsp;Abdul-Wali Ajlouni ,&nbsp;A.H. Ashour ,&nbsp;R. ElShater ,&nbsp;Magda Elsehly ,&nbsp;Ilya A. Weinstein ,&nbsp;A.M.A. Henaish","doi":"10.1016/j.apradiso.2025.112050","DOIUrl":"10.1016/j.apradiso.2025.112050","url":null,"abstract":"<div><div>PVA/PEG/EY samples were irradiated using of 50 KGy, gamma radiation dose. To investigate the effects of irradiation on the optical properties of the blend, UV–vis spectroscopy is used to study 6 samples of the blend, with different PEG content, 0, 1, 3, 5, 10, 15 percent, before and after irradiation. Radiation effects manifest itself as many changes in the following parameters: The absorption for all sample decreases after irradiation, the direct and indirect energy gap value increases after irradiation, the values of the extinction coefficient decrease after irradiation. The values of the extinction coefficient, k, of the nonirradiated samples are decreased or increased depending on the PEG content, while it increased for all irradiated samples despite of the PEG content. The refractive index, n, increases with increasing PEG concentration for irradiated and nonirradiated samples. The main changes occurred in the optical parameters after irradiation are: an increase in the values of the dispersion energy parameter, Ed, an increase in the single oscillator energy Eo, an immense decrease in the average oscillator strength, So, a large increase in the ratio of the effective number of carrier concentration to the effective mass of the electron (e²/πc²). The values of the real and imaginary parts of the optical permittivity of irradiated samples are less than nonirradiated samples. The optical conductivity, σopt, increase for all irradiated samples. The values of O.D, are changing in four specific regions. The decrease and increase in O.D values depend on the variation in absorbance values which depend on PEG concentrations, and the role of irradiation in changing the absorbance of the blend.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"225 ","pages":"Article 112050"},"PeriodicalIF":1.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment planning of boron neutron capture therapy for superficial head-and-neck cancer","authors":"Yi-Lian Wang ,&nbsp;Yen-Wan Hsueh Liu ,&nbsp;Ling-Wei Wang","doi":"10.1016/j.apradiso.2025.112045","DOIUrl":"10.1016/j.apradiso.2025.112045","url":null,"abstract":"<div><div>This study is a retrospective analysis of the effectiveness of bolus placement for superficial oral cancer treated with boron neutron capture therapy (BNCT) using the THORplan treatment planning system. Three treatment plans were performed: one without bolus, one with the bolus placed directly on the skin surface, and one with the bolus positioned at the collimator exit as an alternative to overcome potential challenges in patient setup using bolus. The results indicate that applying a 1 cm-thick bolus directly on the skin surface significantly increases the mean tumor dose by 60 %, owing to the forward shift of the thermal neutron flux peak into the tumor region. Conversely, this benefit was not observed when the bolus was placed at the collimator exit. The air gap between the bolus and the skin surface reduced the epithermal neutron flux entering the skin by 40 %, diminishing its therapeutic effectiveness.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"225 ","pages":"Article 112045"},"PeriodicalIF":1.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144614198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radioluminescence properties of rare earth doped LiF–MgF2 compounds for fiber optic dosimetry","authors":"Yohanna Fernández ,&nbsp;Pablo Molina ,&nbsp;Julián Marcazzó ,&nbsp;Epifanio Cruz Zaragoza ,&nbsp;Soledad Machello ,&nbsp;Martín Santiago","doi":"10.1016/j.apradiso.2025.112039","DOIUrl":"10.1016/j.apradiso.2025.112039","url":null,"abstract":"<div><div>This work investigates the radioluminescence (RL) properties of LiF–MgF₂ compounds doped with rare earth (RE) ions (Eu, Ce, Lu, Tm) for their potential use in fiber optic dosimetry (FOD). Polycrystalline powders were synthesized via a two-step thermal treatment and tested under beta and clinical LINAC X-ray irradiation. Among all compositions, the Eu-doped sample at 0.4mol% (LiF–MgF₂:Eu) showed the highest RL yield, excellent repeatability, and no significant signal afterglow, making it the most promising candidate. The RL spectrum of LiF–MgF₂:Eu revealed broad emission bands attributed to intrinsic defects and Eu-related transitions. An FOD probe was constructed using this material and evaluated under clinical 6 MV LINAC irradiation. Time-resolved measurements confirmed the feasibility of the time-delayed readout method to suppress the Cherenkov stem effect. Percentage depth dose (PDD) curves obtained with the FOD probe showed good agreement with those measured using a reference ionization chamber and Monte Carlo simulations. These findings suggest that LiF–MgF₂:Eu is a suitable, tissue-equivalent scintillator for real-time dosimetry in LINAC radiotherapy.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"225 ","pages":"Article 112039"},"PeriodicalIF":1.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}