Laura De Nardo , Lucia De Dominicis , Juan Esposito , Antonio Rosato , Cristina Bolzati , Laura Meléndez-Alafort
{"title":"67Cu和64Cu两种铜放射性同位素的细胞和多细胞剂量学","authors":"Laura De Nardo , Lucia De Dominicis , Juan Esposito , Antonio Rosato , Cristina Bolzati , Laura Meléndez-Alafort","doi":"10.1016/j.apradiso.2025.112041","DOIUrl":null,"url":null,"abstract":"<div><div>Radioisotopes <sup>64</sup>Cu/<sup>67</sup>Cu represent a promising theranostic pair for nuclear medicine, offering the potential to achieve PET imaging (<sup>64</sup>Cu) and therapeutic treatment (<sup>67</sup>Cu). Recently, it has been hypothesised that <sup>64</sup>Cu Auger emissions, if located within the cellular nucleus, could render therapy significantly more advantageous than <sup>67</sup>Cu. The objective of this study was to evaluate and compare the dosimetric characteristics of <sup>67</sup>Cu and <sup>64</sup>Cu using various tumour models. The cell nuclei absorbed dose (D<sub>N</sub>) was assessed considering a homogeneous distribution of <sup>64</sup>Cu or <sup>67</sup>Cu radioactivity in isolated spheres with radii ranging from 1 μm to 10 mm, and also for spherical cell cluster models with radii ranging from 50 to 1350 μm, assuming various percentages of labelled cells in the cluster and copper radionuclides localisation in one of the three cell compartments (nucleus, cytoplasm, or cell surface). Results obtained with MIRDcell software confirmed that, in spherical cell clusters, D<sub>N</sub> of both labelled and unlabelled cells is consistently higher for <sup>67</sup>Cu than for <sup>64</sup>Cu when radioactivity is localised in the cytoplasm or the cell surface. However, when <sup>64</sup>Cu was localised within the nucleus, D<sub>N</sub> was higher than for <sup>67</sup>Cu only when the percentage of labelled cells was low (≤50 %) or the cell clusters were very small. This indicates that, even if the radiopharmaceutical could be localised in the cell nucleus, D<sub>N</sub> produced by <sup>64</sup>Cu would be higher than the one of <sup>67</sup>Cu only in a limited number of cases. However, the D<sub>N</sub> therapeutic effect needs to be corroborated with experimental data.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"225 ","pages":"Article 112041"},"PeriodicalIF":1.8000,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cellular and multicellular dosimetry of two copper radioisotopes: 67Cu and 64Cu\",\"authors\":\"Laura De Nardo , Lucia De Dominicis , Juan Esposito , Antonio Rosato , Cristina Bolzati , Laura Meléndez-Alafort\",\"doi\":\"10.1016/j.apradiso.2025.112041\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Radioisotopes <sup>64</sup>Cu/<sup>67</sup>Cu represent a promising theranostic pair for nuclear medicine, offering the potential to achieve PET imaging (<sup>64</sup>Cu) and therapeutic treatment (<sup>67</sup>Cu). Recently, it has been hypothesised that <sup>64</sup>Cu Auger emissions, if located within the cellular nucleus, could render therapy significantly more advantageous than <sup>67</sup>Cu. The objective of this study was to evaluate and compare the dosimetric characteristics of <sup>67</sup>Cu and <sup>64</sup>Cu using various tumour models. The cell nuclei absorbed dose (D<sub>N</sub>) was assessed considering a homogeneous distribution of <sup>64</sup>Cu or <sup>67</sup>Cu radioactivity in isolated spheres with radii ranging from 1 μm to 10 mm, and also for spherical cell cluster models with radii ranging from 50 to 1350 μm, assuming various percentages of labelled cells in the cluster and copper radionuclides localisation in one of the three cell compartments (nucleus, cytoplasm, or cell surface). Results obtained with MIRDcell software confirmed that, in spherical cell clusters, D<sub>N</sub> of both labelled and unlabelled cells is consistently higher for <sup>67</sup>Cu than for <sup>64</sup>Cu when radioactivity is localised in the cytoplasm or the cell surface. However, when <sup>64</sup>Cu was localised within the nucleus, D<sub>N</sub> was higher than for <sup>67</sup>Cu only when the percentage of labelled cells was low (≤50 %) or the cell clusters were very small. This indicates that, even if the radiopharmaceutical could be localised in the cell nucleus, D<sub>N</sub> produced by <sup>64</sup>Cu would be higher than the one of <sup>67</sup>Cu only in a limited number of cases. However, the D<sub>N</sub> therapeutic effect needs to be corroborated with experimental data.</div></div>\",\"PeriodicalId\":8096,\"journal\":{\"name\":\"Applied Radiation and Isotopes\",\"volume\":\"225 \",\"pages\":\"Article 112041\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2025-07-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Applied Radiation and Isotopes\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0969804325003860\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied Radiation and Isotopes","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0969804325003860","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
Cellular and multicellular dosimetry of two copper radioisotopes: 67Cu and 64Cu
Radioisotopes 64Cu/67Cu represent a promising theranostic pair for nuclear medicine, offering the potential to achieve PET imaging (64Cu) and therapeutic treatment (67Cu). Recently, it has been hypothesised that 64Cu Auger emissions, if located within the cellular nucleus, could render therapy significantly more advantageous than 67Cu. The objective of this study was to evaluate and compare the dosimetric characteristics of 67Cu and 64Cu using various tumour models. The cell nuclei absorbed dose (DN) was assessed considering a homogeneous distribution of 64Cu or 67Cu radioactivity in isolated spheres with radii ranging from 1 μm to 10 mm, and also for spherical cell cluster models with radii ranging from 50 to 1350 μm, assuming various percentages of labelled cells in the cluster and copper radionuclides localisation in one of the three cell compartments (nucleus, cytoplasm, or cell surface). Results obtained with MIRDcell software confirmed that, in spherical cell clusters, DN of both labelled and unlabelled cells is consistently higher for 67Cu than for 64Cu when radioactivity is localised in the cytoplasm or the cell surface. However, when 64Cu was localised within the nucleus, DN was higher than for 67Cu only when the percentage of labelled cells was low (≤50 %) or the cell clusters were very small. This indicates that, even if the radiopharmaceutical could be localised in the cell nucleus, DN produced by 64Cu would be higher than the one of 67Cu only in a limited number of cases. However, the DN therapeutic effect needs to be corroborated with experimental data.
期刊介绍:
Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment.
The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria.
Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.