Annual review of pharmacology and toxicology最新文献_第5页

Early Detection of Wellness-to-Disease Transitions in the AI Era: Implications for Pharmacology and Toxicology. 人工智能时代健康到疾病转变的早期检测：对药理学和毒理学的影响。

IF 19 1区医学

Annual review of pharmacology and toxicology Pub Date : 2026-01-01 Epub Date: 2025-09-25 DOI: 10.1146/annurev-pharmtox-062124-013423

Noa Rappaport, Bartek Nogal, Kevin Perrott, Vincenzo Domina, Leroy Hood, Nathan D Price

{"title":"Early Detection of Wellness-to-Disease Transitions in the AI Era: Implications for Pharmacology and Toxicology.","authors":"Noa Rappaport, Bartek Nogal, Kevin Perrott, Vincenzo Domina, Leroy Hood, Nathan D Price","doi":"10.1146/annurev-pharmtox-062124-013423","DOIUrl":"10.1146/annurev-pharmtox-062124-013423","url":null,"abstract":"Precision medicine demands a shift from static, single-analyte diagnostics toward dynamic, systems-level understanding of health and disease. This review explores how the convergence of systems biology, multiomics, and artificial intelligence (AI) redefines biomarker discovery to drive early disease detection and personalized intervention. We highlight pioneering efforts that use longitudinal, multimodal data to map individual health trajectories and uncover early disease signals. Advances in AI, including machine learning and contextualization using knowledge graphs and digital twins, are accelerating clinical translation by enabling predictive, context-aware analyses. Real-world applications, including omics-informed diagnostics and digital health monitoring, demonstrate the potential of this approach to transform health care from reactive treatment to proactive wellness. These technologies also inform the development of targeted therapeutics that intervene earlier, personalize treatment, and potentially halt or reverse disease progression. We outline challenges, emerging solutions, and future directions that position AI-driven systems biology at the center of next-generation precision health.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":" ","pages":"41-64"},"PeriodicalIF":19.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Caenorhabditis elegans as a Model System for Environmental Mitotoxicants. 秀丽隐杆线虫作为环境有丝分裂毒物的模式系统。

IF 19 1区医学

Annual review of pharmacology and toxicology Pub Date : 2026-01-01 Epub Date: 2025-11-21 DOI: 10.1146/annurev-pharmtox-062124-012254

Akinleye Akinrinde, Luis Andres Sanchez, Silvia Maglioni, Natascia Ventura

{"title":"Caenorhabditis elegans as a Model System for Environmental Mitotoxicants.","authors":"Akinleye Akinrinde, Luis Andres Sanchez, Silvia Maglioni, Natascia Ventura","doi":"10.1146/annurev-pharmtox-062124-012254","DOIUrl":"10.1146/annurev-pharmtox-062124-012254","url":null,"abstract":"Environmental pollutants such as heavy metals, pesticides, and plastic nanoparticles pose significant risks to human, animal, and environmental health. New approach methodologies complying with the 3R principles (replace, reduce, refine) are essential for advancing the molecular basis of pollutant-induced toxicity, thus improving risk assessment, disease prevention, and therapies. Thanks to its remarkable features, the multicellular organism Caenorhabditis elegans offers unique opportunities to meet this goal. Mitochondria, central hubs in cellular homeostasis, are particularly vulnerable to pollutants, orchestrating stress responses that progress to toxicity and disease. C. elegans represents a powerful model to study these effects, offering conserved systems with quantifiable end points. While previous studies have mainly focused on environmental stressors inducing DNA damage, this review explores C. elegans's end points of relevance for mitotoxicology, highlighting advantages and limitations of the system as an alternative approach for in vivo environmental-induced mitochondrial toxicology and diseases.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":" ","pages":"261-284"},"PeriodicalIF":19.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145572751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dengue Fever Vaccines: Progress and Challenges. 登革热疫苗：进展和挑战。

IF 19 1区医学

Annual review of pharmacology and toxicology Pub Date : 2026-01-01 Epub Date: 2025-08-19 DOI: 10.1146/annurev-pharmtox-062124-040711

Alan L Rothman, Heather Friberg

引用次数: 0

Lessons from Glucocorticoids, Metformin, and Dimethyl Fumarate: Could Targeting Immunometabolism Lead to Better Anti-Inflammatory Therapies? 糖皮质激素、二甲双胍和富马酸二甲酯的经验教训：靶向免疫代谢能带来更好的抗炎治疗吗？

IF 19 1区医学

Annual review of pharmacology and toxicology Pub Date : 2026-01-01 Epub Date: 2025-07-09 DOI: 10.1146/annurev-pharmtox-062624-013520

Victoria A Evans, Luke A J O'Neill

{"title":"Lessons from Glucocorticoids, Metformin, and Dimethyl Fumarate: Could Targeting Immunometabolism Lead to Better Anti-Inflammatory Therapies?","authors":"Victoria A Evans, Luke A J O'Neill","doi":"10.1146/annurev-pharmtox-062624-013520","DOIUrl":"10.1146/annurev-pharmtox-062624-013520","url":null,"abstract":"Emerging evidence suggests that alterations in immunometabolism contribute to pathogenesis of inflammatory diseases, providing potential therapeutic targets. Anti-inflammatory drugs such as glucocorticoids, metformin, and dimethyl fumarate (DMF) modulate key immunometabolic pathways. Glucocorticoids boost itaconate production, which exerts anti-inflammatory effects via multiple targets, including by modification of cysteines on inflammatory proteins. Metformin, known for inhibiting gluconeogenesis in type 2 diabetes, also blocks mitochondrial Complex I and increases GDF-15, a regulator of food intake with anti-inflammatory properties, which may explain effects of metformin on inflammation. DMF, like itaconate, modifies cysteines on target proteins, notably KEAP1, leading to Nrf2 activation, which induces antioxidant enzymes and suppresses inflammatory gene expression. These immunometabolic actions suggest that targeting immune cell metabolism could provide new strategies for treating autoimmune diseases. This review explores recent advances in itaconate, GDF-15, and Nrf2 signaling and how harnessing these pathways may lead to novel anti-inflammatory therapies for patients with inflammatory diseases.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":" ","pages":"419-440"},"PeriodicalIF":19.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gβγ Signaling: Lessons Across the Cellular Multiverse. Gβγ信号：跨越细胞多元宇宙的经验教训。

IF 19 1区医学

Annual review of pharmacology and toxicology Pub Date : 2026-01-01 Epub Date: 2025-08-25 DOI: 10.1146/annurev-pharmtox-062124-033726

Sana Qayum, Darlaine Pétrin, Jason C Tanny, Terence E Hébert

引用次数: 0

Incretin Signaling Neighborhoods and Adverse Drug Reactions. 肠促胰岛素信号传导与药物不良反应。

IF 19 1区医学

Annual review of pharmacology and toxicology Pub Date : 2026-01-01 Epub Date: 2025-09-10 DOI: 10.1146/annurev-pharmtox-062124-015046

Shane C Wright, Peter Lindquist, Mette M Rosenkilde, Volker M Lauschke

引用次数: 0

Treating Pregnant and Lactating Women: Insights from Clinical Pharmacology. 治疗孕妇和哺乳期妇女：来自临床药理学的见解。

IF 19 1区医学

Annual review of pharmacology and toxicology Pub Date : 2026-01-01 DOI: 10.1146/annurev-pharmtox-071724-014725

Davies Otieno, Francis Williams Ojara, Naomi Richardson, Catriona Waitt, Ping Zhao, Dan Hartman

{"title":"Treating Pregnant and Lactating Women: Insights from Clinical Pharmacology.","authors":"Davies Otieno, Francis Williams Ojara, Naomi Richardson, Catriona Waitt, Ping Zhao, Dan Hartman","doi":"10.1146/annurev-pharmtox-071724-014725","DOIUrl":"10.1146/annurev-pharmtox-071724-014725","url":null,"abstract":"Pregnant and lactating women have historically been excluded from clinical trials, limiting data on drug pharmacokinetics, safety, and efficacy in these populations. This knowledge gap stems from complex ethical, historical, and cultural factors, which previously categorized these women as vulnerable rather than protected participants. Recent legislative frameworks, including the FDA Pregnancy and Lactation Labeling Rule, have catalyzed efforts to include these populations in structured research. Quantitative pharmacology approaches using innovations such as physiologically based pharmacokinetic models support optimized trial designs, safer dosing regimens, and ethical research frameworks. Emerging technologies, including artificial intelligence, novel drug delivery mechanisms, and organ-on-chip models, further enhance insights into maternal-fetal drug exposure and drug exposures in breastfeeding infants. Integrating in vitro, ex vivo, in vivo, and clinical data and modeling approaches improves understanding of pregnancy-related physiological changes and their impact on drug outcomes, ultimately enabling appropriate and equitable pharmacotherapy for pregnant and breastfeeding women.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":"66 1","pages":"191-210"},"PeriodicalIF":19.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multisystem Toxicity of E-Cigarettes in Preclinical and Clinical Studies: Pathophysiologic Effects of E-Cigarette Aerosol Exposures from Head to Toe. 电子烟在临床前和临床研究中的多系统毒性：从头到脚暴露于电子烟气溶胶的病理生理效应。

IF 19 1区医学

Annual review of pharmacology and toxicology Pub Date : 2026-01-01 Epub Date: 2025-08-19 DOI: 10.1146/annurev-pharmtox-062124-022856

Matthew J Mears, Priya Bandaru, Evan W Neczypor, Min Kwang Byun, Michelle Zhang, Matthew W Gorr, Jorge A Masso-Silva, Laura Barnes, Alexia Perryman, Avnee J Kumar, Jeffrey M Hendel, Ana Lucia Fuentes, Loren E Wold, Laura E Crotty Alexander

{"title":"Multisystem Toxicity of E-Cigarettes in Preclinical and Clinical Studies: Pathophysiologic Effects of E-Cigarette Aerosol Exposures from Head to Toe.","authors":"Matthew J Mears, Priya Bandaru, Evan W Neczypor, Min Kwang Byun, Michelle Zhang, Matthew W Gorr, Jorge A Masso-Silva, Laura Barnes, Alexia Perryman, Avnee J Kumar, Jeffrey M Hendel, Ana Lucia Fuentes, Loren E Wold, Laura E Crotty Alexander","doi":"10.1146/annurev-pharmtox-062124-022856","DOIUrl":"10.1146/annurev-pharmtox-062124-022856","url":null,"abstract":"The global population breathes unsafe levels of pollutants. In recent years, electronic cigarettes (e-cigs) have become a significant source of particulate matter (PM), which causes injurious effects across organ systems. E-cig users and bystanders are exposed to concentrated aerosols, commonly called vapor, that we now know can have harmful long-term consequences due to PM and chemicals contained within. E-cigs are diverse in design, and e-liquids vary dramatically, making it difficult to draw broad conclusions from studies of different devices, brands, and flavors. With the rise in popularity of e-cigs, it is important to define the health effects across the body. In this comprehensive review, we dissect and summarize the known organ-specific effects of e-cigs, including underlying molecular mechanisms. Notably, e-cig aerosols broadly cause increased cytokine release and oxidative stress, which are associated with a heightened risk of organ dysfunction. We also highlight ways to minimize harmful e-cig constituents to develop safer products.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":" ","pages":"325-352"},"PeriodicalIF":19.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12965465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RNA Splicing as a Therapeutic Target in Cancer. RNA剪接作为癌症的治疗靶点。

IF 19 1区医学

Annual review of pharmacology and toxicology Pub Date : 2026-01-01 Epub Date: 2025-07-22 DOI: 10.1146/annurev-pharmtox-062124-035809

Alexander M Lewis, Kenyon Weis, Omar Abdel-Wahab

引用次数: 0

From Fundamental Biology to Toxicology by Way of an Accident. 从基础生物学到毒理学的一次意外。

IF 19 1区医学

Annual review of pharmacology and toxicology Pub Date : 2026-01-01 Epub Date: 2025-08-12 DOI: 10.1146/annurev-pharmtox-071724-100915

Ana M Soto

引用次数: 0