Trichloroethylene: An Update on an Environmental Contaminant with Multiple Health Effects.

IF 11.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Lawrence H Lash
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引用次数: 0

Abstract

The halogenated solvent trichloroethylene (TCE) has had many uses in medicine, construction, consumer products, and the military. Many of these uses have been discontinued or restricted due to its toxicity, which affects multiple target organs and includes both acute, high-dose toxicity and chronic, low-dose toxicity that also encompass several cancers. US and international agencies have conducted risk and hazard assessments for TCE, with comprehensive publications coming out in the last 10-15 years. Accordingly, the focus of this article is to review recently published data since that time (i.e., 2014) that clarify unsettled questions or provide additional insights into the metabolism and mechanisms of toxicity of TCE in several target organs. Besides metabolism, the review focuses on the kidneys, liver, immune system, nervous system, cardiovascular and pulmonary systems, the search for biomarkers, and recent analyses of human cancer risk and incidence from TCE exposure.

三氯乙烯:一种对健康有多重影响的环境污染物的最新情况。
卤代溶剂三氯乙烯(TCE)在医药、建筑、消费品和军事领域有许多用途。三氯乙烯的毒性影响多个靶器官,包括急性、高剂量毒性和慢性、低剂量毒性,其中慢性、低剂量毒性还包括多种癌症。美国和国际机构对三氯乙烷进行了风险和危害评估,并在过去 10-15 年间发表了全面的出版物。因此,本文的重点是回顾自那时(即 2014 年)以来最新发表的数据,这些数据澄清了一些悬而未决的问题,或提供了有关三氯乙烷在多个靶器官中的代谢和毒性机制的更多见解。除新陈代谢外,本文还重点关注肾脏、肝脏、免疫系统、神经系统、心血管和肺部系统、生物标志物的寻找,以及最近对接触三氯乙烯导致的人类癌症风险和发病率的分析。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
27.80
自引率
0.00%
发文量
53
期刊介绍: Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.
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