Annual review of pharmacology and toxicology最新文献_第10页

Prenatal and Postnatal Pharmacotherapy in Down Syndrome: The Search to Prevent or Ameliorate Neurodevelopmental and Neurodegenerative Disorders. 唐氏综合症的产前和产后药物治疗:预防或改善神经发育和神经退行性疾病的研究。

IF 12.5 1区医学

Annual review of pharmacology and toxicology Pub Date : 2022-01-06 DOI: 10.1146/annurev-pharmtox-041521-103641

Renata Bartesaghi, Stefano Vicari, William C Mobley

引用次数: 4

Synthetic Retinoids Beyond Cancer Therapy. 合成类维生素a超越癌症治疗。

IF 12.5 1区医学

Annual review of pharmacology and toxicology Pub Date : 2022-01-06 DOI: 10.1146/annurev-pharmtox-052120-104428

Lorraine J Gudas

引用次数: 7

Epigenetic Neuropharmacology: Drugs Affecting the Epigenome in the Brain. 表观遗传神经药理学:影响大脑表观基因组的药物。

IF 12.5 1区医学

Annual review of pharmacology and toxicology Pub Date : 2021-01-06 DOI: 10.1146/annurev-pharmtox-030220-022920

Miklos Toth

引用次数: 8

Inhibin. 抑制素。

IF 12.5 1区医学

Annual review of pharmacology and toxicology Pub Date : 2020-02-07 DOI: 10.32388/5bw2ar

C. Li, K. Ramasharma

引用次数: 0

G Protein-Coupled Receptor Pharmacology at the Single-Molecule Level. 单分子水平的G蛋白偶联受体药理学。

IF 12.5 1区医学

Annual review of pharmacology and toxicology Pub Date : 2020-01-08 DOI: 10.1146/annurev-pharmtox-010919-023348

D. Calebiro, J. Grimes

{"title":"G Protein-Coupled Receptor Pharmacology at the Single-Molecule Level.","authors":"D. Calebiro, J. Grimes","doi":"10.1146/annurev-pharmtox-010919-023348","DOIUrl":"https://doi.org/10.1146/annurev-pharmtox-010919-023348","url":null,"abstract":"G protein-coupled receptors (GPCRs) mediate the effects of numerous hormones and neurotransmitters and are major pharmacological targets. Classical studies with crude cell lysates or membrane preparations have identified the main biochemical steps involved in GPCR signaling. Moreover, recent studies on purified proteins have provided astounding details at the atomic level of the 3-D structures of receptors in multiple conformations, including in complex with G proteins and β-arrestins. However, several fundamental questions remain regarding the highly specific effects and rapid nature of GPCR signaling. Recent developments in single-molecule microscopy are providing important contributions to answering these questions. Overall, single-molecule studies have revealed unexpected levels of complexity, with receptors existing in different conformations and dynamically interacting among themselves, their signaling partners, and structural elements of the plasma membrane to produce highly localized signals in space and time. These findings may provide a new basis to develop innovative strategies to modulate GPCR function for pharmacological purposes. Expected final online publication date for the Annual Review of Pharmacology and Toxicology, Volume 60 is January 6, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2020-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-pharmtox-010919-023348","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42506705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Using What We Already Have: Uncovering New Drug Repurposing Strategies in Existing Omics Data. 利用我们已有的:在现有组学数据中发现新的药物再利用策略。

IF 12.5 1区医学

Annual review of pharmacology and toxicology Pub Date : 2020-01-08 DOI: 10.1146/annurev-pharmtox-010919-023537

J. Pulley, J. Rhoads, Rebecca N. Jerome, A. Challa, K. Erreger, M. M. Joly, R. Lavieri, Kelly E. Perry, Nicole M. Zaleski, J. Shirey-Rice, D. Aronoff

{"title":"Using What We Already Have: Uncovering New Drug Repurposing Strategies in Existing Omics Data.","authors":"J. Pulley, J. Rhoads, Rebecca N. Jerome, A. Challa, K. Erreger, M. M. Joly, R. Lavieri, Kelly E. Perry, Nicole M. Zaleski, J. Shirey-Rice, D. Aronoff","doi":"10.1146/annurev-pharmtox-010919-023537","DOIUrl":"https://doi.org/10.1146/annurev-pharmtox-010919-023537","url":null,"abstract":"The promise of drug repurposing is to accelerate the translation of knowledge to treatment of human disease, bypassing common challenges associated with drug development to be more time- and cost-efficient. Repurposing has an increased chance of success due to the previous validation of drug safety and allows for the incorporation of omics. Hypothesis-generating omics processes inform drug repurposing decision-making methods on drug efficacy and toxicity. This review summarizes drug repurposing strategies and methodologies in the context of the following omics fields: genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiomics, phenomics, pregomics, and personomics. While each omics field has specific strengths and limitations, incorporating omics into the drug repurposing landscape is integral to its success. Expected final online publication date for the Annual Review of Pharmacology and Toxicology Volume 60 is January 9, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2020-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-pharmtox-010919-023537","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45438270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 31

Artificial Intelligence in Drug Treatment. 药物治疗中的人工智能。

IF 12.5 1区医学

Annual review of pharmacology and toxicology Pub Date : 2020-01-08 DOI: 10.1146/annurev-pharmtox-010919-023746

Eden L. Romm, I. Tsigelny

{"title":"Artificial Intelligence in Drug Treatment.","authors":"Eden L. Romm, I. Tsigelny","doi":"10.1146/annurev-pharmtox-010919-023746","DOIUrl":"https://doi.org/10.1146/annurev-pharmtox-010919-023746","url":null,"abstract":"The most common applications of artificial intelligence (AI) in drug treatment have to do with matching patients to their optimal drug or combination of drugs, predicting drug-target or drug-drug interactions, and optimizing treatment protocols. This review outlines some of the recently developed AI methods aiding the drug treatment and administration process. Selection of the best drug(s) for a patient typically requires the integration of patient data, such as genetics or proteomics, with drug data, like compound chemical descriptors, to score the therapeutic efficacy of drugs. The prediction of drug interactions often relies on similarity metrics, assuming that drugs with similar structures or targets will have comparable behavior or may interfere with each other. Optimizing the dosage schedule for administration of drugs is performed using mathematical models to interpret pharmacokinetic and pharmacodynamic data. The recently developed and powerful models for each of these tasks are addressed, explained, and analyzed here. Expected final online publication date for the Annual Review of Pharmacology and Toxicology Volume 60 is January 9, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2020-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-pharmtox-010919-023746","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42626964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Lipid-Dependent Regulation of Ion Channels and G Protein-Coupled Receptors: Insights from Structures and Simulations. 离子通道和G蛋白偶联受体的脂质依赖性调节：结构和模拟的见解。

IF 12.5 1区医学

Annual review of pharmacology and toxicology Pub Date : 2020-01-08 DOI: 10.1146/annurev-pharmtox-010919-023411

Anna L. Duncan, Wanling Song, M. Sansom

{"title":"Lipid-Dependent Regulation of Ion Channels and G Protein-Coupled Receptors: Insights from Structures and Simulations.","authors":"Anna L. Duncan, Wanling Song, M. Sansom","doi":"10.1146/annurev-pharmtox-010919-023411","DOIUrl":"https://doi.org/10.1146/annurev-pharmtox-010919-023411","url":null,"abstract":"Ion channels and G protein-coupled receptors (GPCRs) are regulated by lipids in their membrane environment. Structural studies combined with biophysical and molecular simulation investigations reveal interaction sites for specific lipids on membrane protein structures. For K channels, PIP2 plays a key role in regulating Kv and Kir channels. Likewise, several recent cryo-EM structures of TRP channels have revealed bound lipids, including PIP2 and cholesterol. Among the pentameric ligand-gated ion channel family, structural and biophysical studies suggest the M4 TM helix may act as a lipid sensor, e.g., forming part of the binding sites for neurosteroids on the GABAA receptor. Structures of GPCRs have revealed multiple cholesterol sites, which may modulate both receptor dynamics and receptor oligomerization. PIP2 also interacts with GPCRs and may modulate their interactions with G proteins. Overall, it is evident that multiple lipid-binding sites exist on channels and receptors that modulate their function allosterically and are potential druggable sites. Expected final online publication date for the Annual Review of Pharmacology and Toxicology, Volume 60 is January 6, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2020-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-pharmtox-010919-023411","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46135990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 92

Beyond THC and Endocannabinoids. 除了四氢大麻酚和内源性大麻素。

IF 12.5 1区医学

Annual review of pharmacology and toxicology Pub Date : 2020-01-08 DOI: 10.1146/annurev-pharmtox-010818-021441

P. Pacher, N. Kogan, R. Mechoulam

{"title":"Beyond THC and Endocannabinoids.","authors":"P. Pacher, N. Kogan, R. Mechoulam","doi":"10.1146/annurev-pharmtox-010818-021441","DOIUrl":"https://doi.org/10.1146/annurev-pharmtox-010818-021441","url":null,"abstract":"Research in the cannabinoid field, namely on phytocannabinoids, the endogenous cannabinoids anandamide and 2-arachidonoyl glycerol and their metabolizing and synthetic enzymes, the cannabinoid receptors, and anandamide-like cannabinoid compounds, has expanded tremendously over the last few years. Numerous endocannabinoid-like compounds have been discovered. The Cannabis plant constituent cannabidiol (CBD) was found to exert beneficial effects in many preclinical disease models ranging from epilepsy, cardiovascular disease, inflammation, and autoimmunity to neurodegenerative and kidney diseases and cancer. CBD was recently approved in the United States for the treatment of rare forms of childhood epilepsy. This has triggered the development of many CBD-based products for human use, often with overstated claims regarding their therapeutic effects. In this article, the recently published research on the chemistry and biological effects of plant cannabinoids (specifically CBD), endocannabinoids, certain long-chain fatty acid amides, and the variety of relevant receptors is critically reviewed. Expected final online publication date for the Annual Review of Pharmacology and Toxicology, Volume 60 is January 6, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2020-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-pharmtox-010818-021441","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43674242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 92

Levering Mechanically Activated Piezo Channels for Potential Pharmacological Intervention. 利用机械激活的压电通道进行潜在的药理学干预。

IF 12.5 1区医学

Annual review of pharmacology and toxicology Pub Date : 2020-01-08 DOI: 10.1146/annurev-pharmtox-010919-023703

Bailong Xiao

{"title":"Levering Mechanically Activated Piezo Channels for Potential Pharmacological Intervention.","authors":"Bailong Xiao","doi":"10.1146/annurev-pharmtox-010919-023703","DOIUrl":"https://doi.org/10.1146/annurev-pharmtox-010919-023703","url":null,"abstract":"The mechanically activated Piezo channels, including Piezo1 and Piezo2 in mammals, function as key mechanotransducers for converting mechanical force into electrochemical signals. This review highlights key evidence for the potential of Piezo channel drug discovery. First, both mouse and human genetic studies have unequivocally demonstrated the prominent role of Piezo channels in various mammalian physiologies and pathophysiologies, validating their potential as novel therapeutic targets. Second, the cryo-electron microscopy structure of the 2,547-residue mouse Piezo1 trimer has been determined, providing a solid foundation for studying its structure-function relationship and drug action mechanisms and conducting virtual drug screening. Third, Piezo1 chemical activators, named Yoda1 and Jedi1/2, have been identified through high-throughput screening assays, demonstrating the drugability of Piezo channels. However, the pharmacology of Piezo channels is in its infancy. By establishing an integrated drug discovery platform, we may hopefully discover and develop a fleet of Jedi masters for battling Piezo-related human diseases. Expected final online publication date for the Annual Review of Pharmacology and Toxicology, Volume 60 is January 6, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2020-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-pharmtox-010919-023703","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44481935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 71