Harnessing the Power of Electronic Health Records and Genomics for Drug Discovery.

IF 11.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Kristi Krebs, Lili Milani
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引用次数: 1

Abstract

A long-standing recognition that information from human genetics studies has the potential to accelerate drug discovery has led to decades of research on how to leverage genetic and phenotypic information for drug discovery. Established simple and advanced statistical methods that allow the simultaneous analysis of genotype and clinical phenotype data by genome- and phenome-wide analyses, colocalization analyses with quantitative trait loci data from transcriptomics and proteomics data sets from different tissues, and Mendelian randomization are essential tools for drug development in the postgenomic era. Numerous studies have demonstrated how genomic data provide opportunities for the identification of new drug targets, the repurposing of drugs, and drug safety analyses. With an increase in the number of biobanks that enable linking in-depth omics data with rich repositories of phenotypic traits via electronic health records, more powerful ways for the evaluation and validation of drug targets will continue to expand across different disciplines of clinical research.

利用电子健康记录和基因组学的力量进行药物研发。
长期以来,人们一直认识到人类遗传学研究的信息具有加速药物发现的潜力,因此数十年来一直在研究如何利用基因和表型信息进行药物发现。通过全基因组和全表型分析同时分析基因型和临床表型数据、与来自不同组织的转录组学和蛋白质组学数据集的定量性状位点数据进行共定位分析,以及孟德尔随机化等已建立的简单和先进的统计方法是后基因组时代药物开发的重要工具。大量研究表明,基因组数据为新药靶点的确定、药物的再利用以及药物安全性分析提供了机会。随着生物库数量的增加,可以通过电子健康记录将深度 omics 数据与丰富的表型特征库联系起来,评估和验证药物靶点的更有力方法将继续在临床研究的不同学科中得到推广。
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来源期刊
CiteScore
27.80
自引率
0.00%
发文量
53
期刊介绍: Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.
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