Annual review of pharmacology and toxicology最新文献

Pharmacological Mechanisms of Cellular Nanoparticles in Biological Neutralization. 细胞纳米颗粒在生物中和中的药理学机制。

IF 13.1 1区医学

Annual review of pharmacology and toxicology Pub Date : 2025-07-28 DOI: 10.1146/annurev-pharmtox-062124-015449

Lei Sun, Kailin Feng, Jiayuan Alex Zhang, Wei-Ting Shen, Weiwei Gao, Liangfang Zhang

{"title":"Pharmacological Mechanisms of Cellular Nanoparticles in Biological Neutralization.","authors":"Lei Sun, Kailin Feng, Jiayuan Alex Zhang, Wei-Ting Shen, Weiwei Gao, Liangfang Zhang","doi":"10.1146/annurev-pharmtox-062124-015449","DOIUrl":"https://doi.org/10.1146/annurev-pharmtox-062124-015449","url":null,"abstract":"Biological neutralization refers to the process by which a biological agent, such as an antibody, enzyme, or therapeutic nanoparticle, renders a target molecule or pathogen harmless or inactive. Traditional approaches, such as antibody-based therapies, rely on precise molecular recognition, requiring customized development for each target. Recently, cell membrane-coated nanoparticles (cellular nanoparticles or CNPs), formulated by using natural cell membranes as drug substances, have emerged as a promising alternative. Acting as decoys, CNPs bind harmful agents based on membrane function rather than the molecular specificity, enabling broad-spectrum neutralization. This review examines how this fundamental pharmacological mechanism has guided CNP design to counteract pathological threats, including bacterial toxins, nerve agents, neurotoxins, inflammatory cytokines, autoantibodies, secretory enzymes, and viruses. Furthermore, we discuss strategies to enhance CNP performance through modifying the nanoparticle core or the membrane shell. By highlighting recent advancements, we aim to inspire further research into CNP-based approaches for tackling complex biological threats.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":" ","pages":""},"PeriodicalIF":13.1,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RNA Splicing as a Therapeutic Target in Cancer. RNA剪接作为癌症的治疗靶点。

IF 11.2 1区医学

Annual review of pharmacology and toxicology Pub Date : 2025-07-22 DOI: 10.1146/annurev-pharmtox-062124-035809

Alexander M Lewis, Kenyon Weis, Omar Abdel-Wahab

引用次数: 0

A Common Adverse Outcome Pathway for Metal(loid)s Inducing Nephrotoxicity to Advance Next-Generation Risk Assessment of Chemical Mixtures. 一种常见的金属（样物质）诱导肾毒性的不良后果通路，以推进下一代化学混合物的风险评估。

IF 11.2 1区医学

Annual review of pharmacology and toxicology Pub Date : 2025-07-16 DOI: 10.1146/annurev-pharmtox-062124-011335

Tessa Schillemans, Annick D van den Brand, Agneta Åkesson, Marcel J B Mengelers, Mirjam Luijten

{"title":"A Common Adverse Outcome Pathway for Metal(loid)s Inducing Nephrotoxicity to Advance Next-Generation Risk Assessment of Chemical Mixtures.","authors":"Tessa Schillemans, Annick D van den Brand, Agneta Åkesson, Marcel J B Mengelers, Mirjam Luijten","doi":"10.1146/annurev-pharmtox-062124-011335","DOIUrl":"https://doi.org/10.1146/annurev-pharmtox-062124-011335","url":null,"abstract":"Chronic exposure to the metal(loid)s arsenic, cadmium, lead, and mercury via contaminated food or drinking water may induce kidney toxicity, but there is little consensus on the biological processes involved. Health risk assessment of these substances is further complicated by coexposures and the sometimes unclear causal interpretation of population studies. To address these issues, we developed a common adverse outcome pathway (AOP) describing how these metal(loid)s can induce kidney toxicity. Upon identification of renal dysfunction resulting from proximal tubular damage as a common adverse outcome, we developed the AOP by collecting evidence from relevant (experimental) studies. Evaluation of the weight of evidence revealed a moderate to high confidence in this AOP. It enhances our mechanistic understanding of metal(loid)-induced kidney toxicity and provides scientific evidence for a causal relationship between the adverse effect and effect biomarkers. As such, this is an example of how AOPs can facilitate next-generation risk assessment of combined exposure to different contaminants.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":" ","pages":""},"PeriodicalIF":11.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lessons from Glucocorticoids, Metformin, and Dimethyl Fumarate: Could Targeting Immunometabolism Lead to Better Anti-Inflammatory Therapies? 糖皮质激素、二甲双胍和富马酸二甲酯的经验教训：靶向免疫代谢能带来更好的抗炎治疗吗？

IF 11.2 1区医学

Annual review of pharmacology and toxicology Pub Date : 2025-07-09 DOI: 10.1146/annurev-pharmtox-062624-013520

Victoria A Evans, Luke A J O'Neill

{"title":"Lessons from Glucocorticoids, Metformin, and Dimethyl Fumarate: Could Targeting Immunometabolism Lead to Better Anti-Inflammatory Therapies?","authors":"Victoria A Evans, Luke A J O'Neill","doi":"10.1146/annurev-pharmtox-062624-013520","DOIUrl":"https://doi.org/10.1146/annurev-pharmtox-062624-013520","url":null,"abstract":"Emerging evidence suggests that alterations in immunometabolism contribute to pathogenesis of inflammatory diseases, providing potential therapeutic targets. Anti-inflammatory drugs such as glucocorticoids, metformin, and dimethyl fumarate (DMF) modulate key immunometabolic pathways. Glucocorticoids boost itaconate production, which exerts anti-inflammatory effects via multiple targets, including by modification of cysteines on inflammatory proteins. Metformin, known for inhibiting gluconeogenesis in type 2 diabetes, also blocks mitochondrial Complex I and increases GDF-15, a regulator of food intake with anti-inflammatory properties, which may explain effects of metformin on inflammation. DMF, like itaconate, modifies cysteines on target proteins, notably KEAP1, leading to Nrf2 activation, which induces antioxidant enzymes and suppresses inflammatory gene expression. These immunometabolic actions suggest that targeting immune cell metabolism could provide new strategies for treating autoimmune diseases. This review explores recent advances in itaconate, GDF-15, and Nrf2 signaling and how harnessing these pathways may lead to novel anti-inflammatory therapies for patients with inflammatory diseases.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":" ","pages":""},"PeriodicalIF":11.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human Mutations in the TRPV1 Channel: Implications for Noxious Cold Sensation. 人类TRPV1通道的突变：对有害冷感觉的影响。

IF 11.2 1区医学

Annual review of pharmacology and toxicology Pub Date : 2025-07-09 DOI: 10.1146/annurev-pharmtox-062624-025423

Ben Katz, Rita Gutorov, Channa Maayan, Rachel Zaguri, Baruch Minke

{"title":"Human Mutations in the TRPV1 Channel: Implications for Noxious Cold Sensation.","authors":"Ben Katz, Rita Gutorov, Channa Maayan, Rachel Zaguri, Baruch Minke","doi":"10.1146/annurev-pharmtox-062624-025423","DOIUrl":"https://doi.org/10.1146/annurev-pharmtox-062624-025423","url":null,"abstract":"Sensing specific temperature ranges as noxious is crucial for protecting organisms from tissue damage. While the molecular detectors for noxious heat are well-characterized, those responsible for noxious cold detection remain elusive. The transient receptor potential vanilloid 1 (TRPV1) is a polymodal channel activated by heat, acid, and various animal and plant toxins. Due to its association with inflammatory pain, TRPV1 has become a promising target for analgesic development. A recent study reported on an individual carrying a homozygous TRPV1 mutation (N331K) that led to pronounced functional loss. Examination of the affected individual revealed an expected decrease in sensitivity to noxious heat and an unexpected increase in sensitivity to noxious cold. Furthermore, extensive neurogenic inflammatory, flare, and pain responses were observed following the application of a TRPA1 channel activator. These findings suggest that the combined activity of TRPV1 and TRPA1 is essential for controlling noxious cold sensitivity and should be considered when assessing TRPV1 pharmacology.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":" ","pages":""},"PeriodicalIF":11.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Change of Mind: Targeting Amyloid-β with Better Safety Profile. 想法的改变：靶向淀粉样蛋白β具有更好的安全性。

IF 11.2 1区医学

Annual review of pharmacology and toxicology Pub Date : 2025-06-25 DOI: 10.1146/annurev-pharmtox-062124-113434

Katelynn E Krick, Donna M Wilcock

引用次数: 0

Evolving Approaches for Pharmacological Therapy of Obesity. 肥胖症药物治疗方法的演变。

IF 11.2 1区医学

Annual review of pharmacology and toxicology Pub Date : 2025-01-01 Epub Date: 2024-12-17 DOI: 10.1146/annurev-pharmtox-031124-101146

Ariana M Chao, Simeon Taylor, Molly Moore, Anastassia Amaro, Thomas A Wadden

引用次数: 0

Pharmacogenetic Panel Testing: A Review of Current Practice and Potential for Clinical Implementation. 药物基因组测试：当前实践与临床实施潜力回顾。

IF 11.2 1区医学

Annual review of pharmacology and toxicology Pub Date : 2025-01-01 Epub Date: 2024-12-17 DOI: 10.1146/annurev-pharmtox-061724-080935

R Mosch, M van der Lee, H J Guchelaar, J J Swen

引用次数: 0

Targeting Neuroplasticity in Substance Use Disorders: Implications for Therapeutics. 针对药物使用障碍的神经可塑性：对治疗的影响。

IF 11.2 1区医学

Annual review of pharmacology and toxicology Pub Date : 2025-01-01 Epub Date: 2024-12-17 DOI: 10.1146/annurev-pharmtox-061724-080548

Marina E Wolf

{"title":"Targeting Neuroplasticity in Substance Use Disorders: Implications for Therapeutics.","authors":"Marina E Wolf","doi":"10.1146/annurev-pharmtox-061724-080548","DOIUrl":"10.1146/annurev-pharmtox-061724-080548","url":null,"abstract":"The last two decades have witnessed substantial advances in identifying synaptic plasticity responsible for behavioral changes in animal models of substance use disorder. We have learned the most about cocaine-induced plasticity in the nucleus accumbens and its relationship to cocaine seeking, so that is the focus in this review. Synaptic plasticity pointing to potential therapeutic targets has been identified mainly using two drug self-administration models: extinction-reinstatement and abstinence models. A relationship between cocaine seeking and potentiated AMPAR transmission in nucleus accumbens is indicated by both models. In particular, an atypical subpopulation-Ca2+-permeable or CP-AMPARs-mediates cue-induced seeking that persists even after long periods of abstinence, modeling the persistent vulnerability to relapse that represents a major challenge in treating substance use disorder. We review strategies to reverse CP-AMPAR plasticity; strategies targeting other components of excitatory synapses, including dysregulated glutamate uptake and release; and behavioral interventions that can be augmented by harnessing synaptic plasticity.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":" ","pages":"259-280"},"PeriodicalIF":11.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toluene Toxicity in the Brain: From Cellular Targets to Molecular Mechanisms. 脑中的甲苯毒性：从细胞靶点到分子机制。

IF 11.2 1区医学

Annual review of pharmacology and toxicology Pub Date : 2025-01-01 DOI: 10.1146/annurev-pharmtox-012924-010532

Andrew A Shaw, Jeffery D Steketee, Anna N Bukiya, Alex M Dopico

引用次数: 0