Early Detection of Wellness-to-Disease Transitions in the AI Era: Implications for Pharmacology and Toxicology.

IF 13.1 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Noa Rappaport, Bartek Nogal, Kevin Perrott, Vincenzo Domina, Leroy Hood, Nathan D Price
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引用次数: 0

Abstract

Precision medicine demands a shift from static, single-analyte diagnostics toward dynamic, systems-level understanding of health and disease. This review explores how the convergence of systems biology, multiomics, and artificial intelligence (AI) redefines biomarker discovery to drive early disease detection and personalized intervention. We highlight pioneering efforts that use longitudinal, multimodal data to map individual health trajectories and uncover early disease signals. Advances in AI, including machine learning and contextualization using knowledge graphs and digital twins, are accelerating clinical translation by enabling predictive, context-aware analyses. Real-world applications, including omics-informed diagnostics and digital health monitoring, demonstrate the potential of this approach to transform health care from reactive treatment to proactive wellness. These technologies also inform the development of targeted therapeutics that intervene earlier, personalize treatment, and potentially halt or reverse disease progression. We outline challenges, emerging solutions, and future directions that position AI-driven systems biology at the center of next-generation precision health.

人工智能时代健康到疾病转变的早期检测:对药理学和毒理学的影响。
精准医学要求从静态的、单分析物诊断转向动态的、系统级的健康和疾病理解。这篇综述探讨了系统生物学、多组学和人工智能(AI)的融合如何重新定义生物标志物的发现,以推动早期疾病检测和个性化干预。我们重点介绍了利用纵向、多模式数据绘制个人健康轨迹和发现早期疾病信号的开创性工作。人工智能的进步,包括机器学习和使用知识图谱和数字双胞胎的情境化,通过实现预测性、情境感知分析,正在加速临床翻译。现实世界的应用,包括基于组学的诊断和数字健康监测,证明了这种方法将医疗保健从被动治疗转变为主动健康的潜力。这些技术还为靶向治疗的发展提供了信息,这些治疗可以早期干预,个性化治疗,并有可能阻止或逆转疾病进展。我们概述了挑战、新兴解决方案和未来方向,将人工智能驱动的系统生物学置于下一代精准健康的中心。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
27.80
自引率
0.00%
发文量
53
期刊介绍: Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.
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