代谢和炎症机制驱动心房颤动。

IF 13.1 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Lisa Stoll, Elizabeth E Ha, James C Lo
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引用次数: 0

摘要

心房颤动(AF)是一种常见的心律失常,严重影响患者的生活质量和死亡率。随着肥胖和2型糖尿病的流行,其患病率持续上升,需要改进治疗策略,更好地了解驱动代谢性疾病相关房颤的因素和机制。为此,在观察、临床和实验研究中,房颤和代谢性疾病之间的联系正在越来越多地进行探索。慢性炎症是代谢性疾病的标志,多项研究也证明了房颤与炎症之间的密切关系。在这篇综述中,我们讨论了在代谢和炎症的背景下控制房颤发展机制的最新进展,治疗发展的相关概念,以及降钙素在房颤中的新作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metabolic and Inflammatory Mechanisms Driving Atrial Fibrillation.

Atrial fibrillation (AF) is a common arrhythmia with a tremendous impact on quality of life and mortality. Its prevalence continues to rise alongside the increasing obesity and type 2 diabetes epidemics, raising a need for improved therapeutic strategies and a better understanding of the factors and mechanisms that drive metabolic disease-associated AF. To this end, the link between AF and metabolic disease is being increasingly explored in observational, clinical, and experimental studies. Chronic inflammation is a hallmark of metabolic disease, and multiple studies have also demonstrated a strong relationship between AF and inflammation. In this review, we discuss recent advances in our understanding of the mechanisms governing the development of AF in the context of metabolism and inflammation, related concepts in therapeutic development, and a novel role for calcitonin in AF.

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来源期刊
CiteScore
27.80
自引率
0.00%
发文量
53
期刊介绍: Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.
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