Annual review of pharmacology and toxicology最新文献_第4页

Metabolic and Inflammatory Mechanisms Driving Atrial Fibrillation. 代谢和炎症机制驱动心房颤动。

IF 19 1区医学

Annual review of pharmacology and toxicology Pub Date : 2026-01-01 Epub Date: 2025-09-16 DOI: 10.1146/annurev-pharmtox-062124-025403

Lisa Stoll, Elizabeth E Ha, James C Lo

引用次数: 0

Cross-Organ Mitochondrial Communication in Stress and Disease. 应激和疾病中的跨器官线粒体通讯。

IF 19 1区医学

Annual review of pharmacology and toxicology Pub Date : 2026-01-01 Epub Date: 2025-09-22 DOI: 10.1146/annurev-pharmtox-062124-024150

Koning Shen, Jenni Durieux, Andrew Dillin

引用次数: 0

The Promises and Prospects of Long-Acting Therapeutics for Treatment and Prevention of Infectious Diseases. 治疗和预防传染病的长效疗法的前景与展望。

IF 19 1区医学

Annual review of pharmacology and toxicology Pub Date : 2026-01-01 Epub Date: 2025-09-16 DOI: 10.1146/annurev-pharmtox-071724-100739

Adeniyi Olagunju, Simone Perazzolo, Zachary R Stephen, Mark Ryan, Xiaolin Xu, Prajith Venkatasubramanian, Shakir Atoyebi, Rachele Delle Fratte, Andrew Owen, Charles Flexner, Rodney J Y Ho

{"title":"The Promises and Prospects of Long-Acting Therapeutics for Treatment and Prevention of Infectious Diseases.","authors":"Adeniyi Olagunju, Simone Perazzolo, Zachary R Stephen, Mark Ryan, Xiaolin Xu, Prajith Venkatasubramanian, Shakir Atoyebi, Rachele Delle Fratte, Andrew Owen, Charles Flexner, Rodney J Y Ho","doi":"10.1146/annurev-pharmtox-071724-100739","DOIUrl":"10.1146/annurev-pharmtox-071724-100739","url":null,"abstract":"Long-acting (LA) therapeutics have emerged as a key component of infectious disease treatment and prevention strategies, their uptake fueled by the need to bridge notable gaps with short-acting drug formulations. In this review, we present the key drivers and summarize the enabling technologies. Focusing on infections with significant global disease burden (HIV, hepatitis B and C, tuberculosis, malaria, and COVID-19), the current state of knowledge on approved LA therapeutics and promising innovations currently in development are summarized. The potential role of LA therapeutics as countermeasures for diseases of pandemic potential and new approaches using computational modeling to accelerate their development for pediatric and perinatal health are discussed. Due to complexities in manufacturing, and the diversity of patent-protected technologies, barriers exist for global access to LA products and in upscaling intricate LA formulations. A multipronged strategic framework, including acceleration of equitable access through generic product manufacture, is proposed to realize the full potential of LA therapeutics for global health.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":" ","pages":"87-112"},"PeriodicalIF":19.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7618339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing Large-Scale Pharmacogenetic Studies in African Populations for Clinical Care and Drug Development. 为临床护理和药物开发加强非洲人群的大规模药物遗传学研究。

IF 19 1区医学

Annual review of pharmacology and toxicology Pub Date : 2026-01-01 Epub Date: 2025-09-22 DOI: 10.1146/annurev-pharmtox-071724-014737

Abdoulaye Yalcouyé, Kevin Esoh, Ambroise Wonkam

{"title":"Enhancing Large-Scale Pharmacogenetic Studies in African Populations for Clinical Care and Drug Development.","authors":"Abdoulaye Yalcouyé, Kevin Esoh, Ambroise Wonkam","doi":"10.1146/annurev-pharmtox-071724-014737","DOIUrl":"10.1146/annurev-pharmtox-071724-014737","url":null,"abstract":"African populations remain largely underrepresented in genomic studies despite their high genetic diversity. The significant variability in drug efficacy and toxicity across different ancestry populations should trigger more diversified and inclusive pharmacogenomic (PGx) studies. Non-European populations, especially Africans, remain largely underrepresented in GWASs and other genomic studies despite their high genetic diversity, which holds information critical for better understanding drug-related toxicity and enhancing the development of new drugs. Therefore, studies using population genetic clustering, polygenic risk scores, high-throughput organoid models, and multiomics analysis are urgently needed in African populations to enhance pharmacogenomics and drug development globally. For instance, studies of loss-of-function mutations in PCSK9, commonly found in populations of African descent, have led to the development of PCSK9 inhibitors, which are used globally to reduce hypercholesterolemia and cardiovascular disease risk. More studies on diverse African populations could elevate PGx, drug development, and therapeutics as illustrated by the PCSK9 example.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":" ","pages":"171-190"},"PeriodicalIF":19.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroinflammation and Disease: Pathways and Opportunities. 神经炎症和疾病：途径和机会。

IF 19 1区医学

Annual review of pharmacology and toxicology Pub Date : 2026-01-01 Epub Date: 2025-09-18 DOI: 10.1146/annurev-pharmtox-062124-043519

Olivia Hoffman, Nicholas H Varvel, Avtar S Roopra, Ray Dingledine

{"title":"Neuroinflammation and Disease: Pathways and Opportunities.","authors":"Olivia Hoffman, Nicholas H Varvel, Avtar S Roopra, Ray Dingledine","doi":"10.1146/annurev-pharmtox-062124-043519","DOIUrl":"10.1146/annurev-pharmtox-062124-043519","url":null,"abstract":"We explore three emerging molecular pathways driving neuroinflammation in chronic and acute brain diseases: the EP2 receptor for prostaglandin E2, the CCR2 receptor for chemokine CCL2, and JAK/STAT signaling. Inflammation is now recognized as a causative factor in neurodegenerative disorders, with neuroinflammation preceding symptom onset in Alzheimer's disease and likely heralding the onset of epilepsy and Parkinson's disease. The EP2 receptor modulates immune cell activation and exacerbates inflammatory responses, while CCR2 regulates peripheral immune cell recruitment to sites of brain inflammation. JAK/STAT pathways regulate neuronal and glial function across brain regions and can both amplify and resolve neuroinflammatory processes. These three signaling pathways converge at multiple nodes-immune cell recruitment, cytokine amplification, and transcriptional regulation-establishing feedforward loops that sustain pathology in chronic diseases. Understanding these mechanisms and their complex interactions provides opportunities for novel therapeutic interventions in neurological conditions characterized by inflammation, potentially leading to disease-modifying treatments.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":" ","pages":"541-563"},"PeriodicalIF":19.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Common Adverse Outcome Pathway for Metal(loid)s Inducing Nephrotoxicity to Advance Next-Generation Risk Assessment of Chemical Mixtures. 一种常见的金属（样物质）诱导肾毒性的不良后果通路，以推进下一代化学混合物的风险评估。

IF 19 1区医学

Annual review of pharmacology and toxicology Pub Date : 2026-01-01 Epub Date: 2025-07-16 DOI: 10.1146/annurev-pharmtox-062124-011335

Tessa Schillemans, Annick D van den Brand, Agneta Åkesson, Marcel J B Mengelers, Mirjam Luijten

{"title":"A Common Adverse Outcome Pathway for Metal(loid)s Inducing Nephrotoxicity to Advance Next-Generation Risk Assessment of Chemical Mixtures.","authors":"Tessa Schillemans, Annick D van den Brand, Agneta Åkesson, Marcel J B Mengelers, Mirjam Luijten","doi":"10.1146/annurev-pharmtox-062124-011335","DOIUrl":"10.1146/annurev-pharmtox-062124-011335","url":null,"abstract":"Chronic exposure to the metal(loid)s arsenic, cadmium, lead, and mercury via contaminated food or drinking water may induce kidney toxicity, but there is little consensus on the biological processes involved. Health risk assessment of these substances is further complicated by coexposures and the sometimes unclear causal interpretation of population studies. To address these issues, we developed a common adverse outcome pathway (AOP) describing how these metal(loid)s can induce kidney toxicity. Upon identification of renal dysfunction resulting from proximal tubular damage as a common adverse outcome, we developed the AOP by collecting evidence from relevant (experimental) studies. Evaluation of the weight of evidence revealed a moderate to high confidence in this AOP. It enhances our mechanistic understanding of metal(loid)-induced kidney toxicity and provides scientific evidence for a causal relationship between the adverse effect and effect biomarkers. As such, this is an example of how AOPs can facilitate next-generation risk assessment of combined exposure to different contaminants.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":" ","pages":"305-323"},"PeriodicalIF":19.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacological Mechanisms of Cellular Nanoparticles in Biological Neutralization. 细胞纳米颗粒在生物中和中的药理学机制。

IF 19 1区医学

Annual review of pharmacology and toxicology Pub Date : 2026-01-01 Epub Date: 2025-07-28 DOI: 10.1146/annurev-pharmtox-062124-015449

Lei Sun, Kailin Feng, Jiayuan Alex Zhang, Wei-Ting Shen, Weiwei Gao, Liangfang Zhang

{"title":"Pharmacological Mechanisms of Cellular Nanoparticles in Biological Neutralization.","authors":"Lei Sun, Kailin Feng, Jiayuan Alex Zhang, Wei-Ting Shen, Weiwei Gao, Liangfang Zhang","doi":"10.1146/annurev-pharmtox-062124-015449","DOIUrl":"10.1146/annurev-pharmtox-062124-015449","url":null,"abstract":"Biological neutralization refers to the process by which a biological agent, such as an antibody, enzyme, or therapeutic nanoparticle, renders a target molecule or pathogen harmless or inactive. Traditional approaches, such as antibody-based therapies, rely on precise molecular recognition, requiring customized development for each target. Recently, cell membrane-coated nanoparticles (cellular nanoparticles or CNPs), formulated by using natural cell membranes as drug substances, have emerged as a promising alternative. Acting as decoys, CNPs bind harmful agents based on membrane function rather than the molecular specificity, enabling broad-spectrum neutralization. This review examines how this fundamental pharmacological mechanism has guided CNP design to counteract pathological threats, including bacterial toxins, nerve agents, neurotoxins, inflammatory cytokines, autoantibodies, secretory enzymes, and viruses. Furthermore, we discuss strategies to enhance CNP performance through modifying the nanoparticle core or the membrane shell. By highlighting recent advancements, we aim to inspire further research into CNP-based approaches for tackling complex biological threats.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":" ","pages":"211-225"},"PeriodicalIF":19.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Mechanistic Framework for Repurposing FDA-Approved Drugs to Combat Antimicrobial Resistance: The Case of Staphylococcus aureus. 重新利用fda批准的药物对抗抗菌素耐药性的机制框架：金黄色葡萄球菌的案例。

IF 19 1区医学

Annual review of pharmacology and toxicology Pub Date : 2026-01-01 Epub Date: 2025-09-25 DOI: 10.1146/annurev-pharmtox-062624-014243

Daniel Sun, Victor Nizet

{"title":"A Mechanistic Framework for Repurposing FDA-Approved Drugs to Combat Antimicrobial Resistance: The Case of Staphylococcus aureus.","authors":"Daniel Sun, Victor Nizet","doi":"10.1146/annurev-pharmtox-062624-014243","DOIUrl":"10.1146/annurev-pharmtox-062624-014243","url":null,"abstract":"The global rise of antibiotic-resistant bacteria poses a critical threat to healthcare systems, challenging researchers to stay ahead of evolving pathogens. Among the most concerning are invasive infections caused by Staphylococcus aureus (SA), where morbidity and mortality remain high despite advances in care. Resistance in SA has emerged rapidly after the introduction of new antibiotics, limiting treatment options and prompting an urgent need for alternatives. While developing new antimicrobials remains essential, repurposing FDA-approved drugs-originally developed for noninfectious indications-offers a complementary strategy. These agents have known safety and pharmacokinetic profiles and may impact bacterial virulence, antibiotic susceptibility, or host immunity to improve outcomes. This review highlights recent advances in SA drug repurposing, focusing on six mechanistic categories: inhibition of virulence factors, antibiotic resensitization, enhanced susceptibility to innate immunity, host cell protection, augmentation of immune functions, and modulation of pathological inflammation. Together, these strategies offer a multifaceted framework to improve SA infection outcomes using existing therapeutics.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":" ","pages":"65-85"},"PeriodicalIF":19.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Chemical Toxicology of Ambient Air Pollutants. 环境空气污染物的化学毒理学。

IF 19 1区医学

Annual review of pharmacology and toxicology Pub Date : 2026-01-01 Epub Date: 2025-08-05 DOI: 10.1146/annurev-pharmtox-021025-091036

Arthur K Cho, Yoshito Kumagai, Yumi Abiko

引用次数: 0

From Cell Reprogramming to Tissue Rejuvenation: Countering Aging by Targeting a Gerozyme. 从细胞重编程到组织再生：通过靶向Gerozyme对抗衰老。

IF 19 1区医学

Annual review of pharmacology and toxicology Pub Date : 2026-01-01 Epub Date: 2025-09-19 DOI: 10.1146/annurev-pharmtox-071724-100856

Helen M Blau, Ermelinda Porpiglia

引用次数: 0