Annual review of pharmacology and toxicology最新文献_第4页

Dynamic Multiplex Tissue Imaging in Inflammation Research. 炎症研究中的动态多重组织成像。

IF 12.5 1区医学

Annual review of pharmacology and toxicology Pub Date : 2024-01-24 Epub Date: 2023-09-18 DOI: 10.1146/annurev-pathmechdis-070323-124158

Stefan Uderhardt, Georgiana Neag, Ronald N Germain

{"title":"Dynamic Multiplex Tissue Imaging in Inflammation Research.","authors":"Stefan Uderhardt, Georgiana Neag, Ronald N Germain","doi":"10.1146/annurev-pathmechdis-070323-124158","DOIUrl":"10.1146/annurev-pathmechdis-070323-124158","url":null,"abstract":"Inflammation is a highly dynamic process with immune cells that continuously interact with each other and parenchymal components as they migrate through tissue. The dynamic cellular responses and interaction patterns are a function of the complex tissue environment that cannot be fully reconstructed ex vivo, making it necessary to assess cell dynamics and changing spatial patterning in vivo. These dynamics often play out deep within tissues, requiring the optical focus to be placed far below the surface of an opaque organ. With the emergence of commercially available two-photon excitation lasers that can be combined with existing imaging systems, new avenues for imaging deep tissues over long periods of time have become available. We discuss a selected subset of studies illustrating how two-photon microscopy (2PM) has helped to relate the dynamics of immune cells to their in situ function and to understand the molecular patterns that govern their behavior in vivo. We also review some key practical aspects of 2PM methods and point out issues that can confound the results, so that readers can better evaluate the reliability of conclusions drawn using this technology.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":" ","pages":"43-67"},"PeriodicalIF":12.5,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10673543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating Biomarkers Instead of Genotyping to Establish Metabolizer Phenotypes. 用循环生物标记物代替基因分型来确定代谢物表型。

IF 12.5 1区医学

Annual review of pharmacology and toxicology Pub Date : 2024-01-23 Epub Date: 2023-08-16 DOI: 10.1146/annurev-pharmtox-032023-121106

Roman Tremmel, Ute Hofmann, Mathias Haag, Elke Schaeffeler, Matthias Schwab

{"title":"Circulating Biomarkers Instead of Genotyping to Establish Metabolizer Phenotypes.","authors":"Roman Tremmel, Ute Hofmann, Mathias Haag, Elke Schaeffeler, Matthias Schwab","doi":"10.1146/annurev-pharmtox-032023-121106","DOIUrl":"10.1146/annurev-pharmtox-032023-121106","url":null,"abstract":"Pharmacogenomics (PGx) enables personalized treatment for the prediction of drug response and to avoid adverse drug reactions. Currently, PGx mainly relies on the genetic information of absorption, distribution, metabolism, and excretion (ADME) targets such as drug-metabolizing enzymes or transporters to predict differences in the patient's phenotype. However, there is evidence that the phenotype-genotype concordance is limited. Thus, we discuss different phenotyping strategies using exogenous xenobiotics (e.g., drug cocktails) or endogenous compounds for phenotype prediction. In particular, minimally invasive approaches focusing on liquid biopsies offer great potential to preemptively determine metabolic and transport capacities. Early studies indicate that ADME phenotyping using exosomes released from the liver is reliable. In addition, pharmacometric modeling and artificial intelligence improve phenotype prediction. However, further prospective studies are needed to demonstrate the clinical utility of individualized treatment based on phenotyping strategies, not only relying on genetics. The present review summarizes current knowledge and limitations.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":" ","pages":"65-87"},"PeriodicalIF":12.5,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10013253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mass Spectrometry-Based Proteogenomics: New Therapeutic Opportunities for Precision Medicine. 基于质谱的蛋白质组学：精准医学的新治疗机会。

IF 12.5 1区医学

Annual review of pharmacology and toxicology Pub Date : 2024-01-23 Epub Date: 2023-09-22 DOI: 10.1146/annurev-pharmtox-022723-113921

Sunil K Joshi, Paul Piehowski, Tao Liu, Sara J C Gosline, Jason E McDermott, Brian J Druker, Elie Traer, Jeffrey W Tyner, Anupriya Agarwal, Cristina E Tognon, Karin D Rodland

{"title":"Mass Spectrometry-Based Proteogenomics: New Therapeutic Opportunities for Precision Medicine.","authors":"Sunil K Joshi, Paul Piehowski, Tao Liu, Sara J C Gosline, Jason E McDermott, Brian J Druker, Elie Traer, Jeffrey W Tyner, Anupriya Agarwal, Cristina E Tognon, Karin D Rodland","doi":"10.1146/annurev-pharmtox-022723-113921","DOIUrl":"10.1146/annurev-pharmtox-022723-113921","url":null,"abstract":"Proteogenomics refers to the integration of comprehensive genomic, transcriptomic, and proteomic measurements from the same samples with the goal of fully understanding the regulatory processes converting genotypes to phenotypes, often with an emphasis on gaining a deeper understanding of disease processes. Although specific genetic mutations have long been known to drive the development of multiple cancers, gene mutations alone do not always predict prognosis or response to targeted therapy. The benefit of proteogenomics research is that information obtained from proteins and their corresponding pathways provides insight into therapeutic targets that can complement genomic information by providing an additional dimension regarding the underlying mechanisms and pathophysiology of tumors. This review describes the novel insights into tumor biology and drug resistance derived from proteogenomic analysis while highlighting the clinical potential of proteogenomic observations and advances in technique and analysis tools.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":" ","pages":"455-479"},"PeriodicalIF":12.5,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10950354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41094754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Nocebo Effect. 恐慌效应

IF 11.2 1区医学

Annual review of pharmacology and toxicology Pub Date : 2024-01-23 Epub Date: 2023-08-16 DOI: 10.1146/annurev-pharmtox-022723-112425

Luana Colloca

引用次数: 0

Circadian Regulation of Drug Responses: Toward Sex-Specific and Personalized Chronotherapy. 药物反应的昼夜节律调节：实现性别特异性和个性化的慢性疗法

IF 12.5 1区医学

Annual review of pharmacology and toxicology Pub Date : 2024-01-23 Epub Date: 2023-09-18 DOI: 10.1146/annurev-pharmtox-051920-095416

Francis A Lévi, Alper Okyar, Eva Hadadi, Pasquale F Innominato, Annabelle Ballesta

{"title":"Circadian Regulation of Drug Responses: Toward Sex-Specific and Personalized Chronotherapy.","authors":"Francis A Lévi, Alper Okyar, Eva Hadadi, Pasquale F Innominato, Annabelle Ballesta","doi":"10.1146/annurev-pharmtox-051920-095416","DOIUrl":"10.1146/annurev-pharmtox-051920-095416","url":null,"abstract":"Today's challenge for precision medicine involves the integration of the impact of molecular clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy. Meaningful improvements of tolerability and/or efficacy of medications through proper administration timing have been confirmed over the past decade for immunotherapy and chemotherapy against cancer, as well as for commonly used pharmacological agents in cardiovascular, metabolic, inflammatory, and neurological conditions. Experimental and human studies have recently revealed sexually dimorphic circadian drug responses. Dedicated randomized clinical trials should now aim to issue personalized circadian timing recommendations for daily medical practice, integrating innovative technologies for remote longitudinal monitoring of circadian metrics, statistical prediction of molecular clock function from single-timepoint biopsies, and multiscale biorhythmic mathematical modelling. Importantly, chronofit patients with a robust circadian function, who would benefit most from personalized chronotherapy, need to be identified. Conversely, nonchronofit patients could benefit from the emerging pharmacological class of chronobiotics targeting the circadian clock.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":" ","pages":"89-114"},"PeriodicalIF":12.5,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10311547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apathy and Motivation: Biological Basis and Drug Treatment. 冷漠与动机：生物基础与药物治疗

IF 12.5 1区医学

Annual review of pharmacology and toxicology Pub Date : 2024-01-23 Epub Date: 2023-08-16 DOI: 10.1146/annurev-pharmtox-022423-014645

Harry Costello, Masud Husain, Jonathan P Roiser

引用次数: 0

From Thalidomide to Rational Molecular Glue Design for Targeted Protein Degradation. 从沙利度胺到靶向蛋白质降解的合理分子胶设计

IF 12.5 1区医学

Annual review of pharmacology and toxicology Pub Date : 2024-01-23 Epub Date: 2023-08-16 DOI: 10.1146/annurev-pharmtox-022123-104147

Vladas Oleinikovas, Pablo Gainza, Thomas Ryckmans, Bernhard Fasching, Nicolas H Thomä

引用次数: 0

Oral Anticoagulants Beyond Warfarin. 华法林之外的口服抗凝剂。

IF 12.5 1区医学

Annual review of pharmacology and toxicology Pub Date : 2024-01-23 Epub Date: 2023-09-27 DOI: 10.1146/annurev-pharmtox-032823-122811

Renske H Olie, Kristien Winckers, Bianca Rocca, Hugo Ten Cate

{"title":"Oral Anticoagulants Beyond Warfarin.","authors":"Renske H Olie, Kristien Winckers, Bianca Rocca, Hugo Ten Cate","doi":"10.1146/annurev-pharmtox-032823-122811","DOIUrl":"10.1146/annurev-pharmtox-032823-122811","url":null,"abstract":"Direct oral anticoagulants (DOACs) have largely replaced vitamin K antagonists, mostly warfarin, for the main indications for oral anticoagulation, prevention and treatment of venous thromboembolism, and prevention of embolic stroke in atrial fibrillation. While DOACs offer practical, fixed-dose anticoagulation in many patients, specific restrictions or contraindications may apply. DOACs are not sufficiently effective in high-thrombotic risk conditions such as antiphospholipid syndrome and mechanical heart valves. Patients with cancer-associated thrombosis may benefit from DOACs, but the bleeding risk, particularly in those with gastrointestinal or urogenital tumors, must be carefully weighed. In patients with frailty, excess body weight, and/or moderate-to-severe chronic kidney disease, DOACs must be cautiously administered and may require laboratory monitoring. Reversal agents have been developed and approved for life-threatening bleeding. In addition, the clinical testing of potentially safer anticoagulants such as factor XI(a) inhibitors is important to further optimize anticoagulant therapy in an increasingly elderly and frail population worldwide.","PeriodicalId":8057,"journal":{"name":"Annual review of pharmacology and toxicology","volume":" ","pages":"551-575"},"PeriodicalIF":12.5,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41091888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial Intelligence for Drug Discovery: Are We There Yet? 用于药物发现的人工智能：我们已经实现了吗？

IF 12.5 1区医学

Annual review of pharmacology and toxicology Pub Date : 2024-01-23 Epub Date: 2023-09-22 DOI: 10.1146/annurev-pharmtox-040323-040828

Catrin Hasselgren, Tudor I Oprea

引用次数: 0

Hear and Now: Ongoing Clinical Trials to Prevent Drug-Induced Hearing Loss. 现在就听：预防药物性听力损失的现行临床试验。

IF 12.5 1区医学

Annual review of pharmacology and toxicology Pub Date : 2024-01-23 Epub Date: 2023-08-10 DOI: 10.1146/annurev-pharmtox-033123-114106

John Lee, Katharine Fernandez, Lisa L Cunningham

引用次数: 0