冷漠与动机:生物基础与药物治疗

IF 11.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Harry Costello, Masud Husain, Jonathan P Roiser
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引用次数: 0

摘要

淡漠是一种致残性综合征,与功能障碍相关,常见于多种神经和精神疾病。目前,还没有专门针对这种病症的成熟疗法,迫切需要安全有效的治疗方法。人们对人类和动物的动机和目标导向行为的认识不断进步,揭示了导致冷漠的认知和神经生物学机制,为开发新的治疗方法奠定了重要基础。在此,我们回顾了冷漠和动机的认知成分、神经回路和药理学,强调了共同的跨诊断机制的趋同证据。虽然目前还没有药物治疗方法获得许可,但我们总结了迄今为止对现有和新型化合物的试验,确定了几种有希望用于临床的候选药物以及未来药物开发的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Apathy and Motivation: Biological Basis and Drug Treatment.

Apathy is a disabling syndrome associated with poor functional outcomes that is common across a broad range of neurological and psychiatric conditions. Currently, there are no established therapies specifically for the condition, and safe and effective treatments are urgently needed. Advances in the understanding of motivation and goal-directed behavior in humans and animals have shed light on the cognitive and neurobiological mechanisms contributing to apathy, providing an important foundation for the development of new treatments. Here, we review the cognitive components, neural circuitry, and pharmacology of apathy and motivation, highlighting converging evidence of shared transdiagnostic mechanisms. Though no pharmacological treatments have yet been licensed, we summarize trials of existing and novel compounds to date, identifying several promising candidates for clinical use and avenues of future drug development.

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来源期刊
CiteScore
27.80
自引率
0.00%
发文量
53
期刊介绍: Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.
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