Mass Spectrometry-Based Proteogenomics: New Therapeutic Opportunities for Precision Medicine.

IF 11.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Sunil K Joshi, Paul Piehowski, Tao Liu, Sara J C Gosline, Jason E McDermott, Brian J Druker, Elie Traer, Jeffrey W Tyner, Anupriya Agarwal, Cristina E Tognon, Karin D Rodland
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引用次数: 0

Abstract

Proteogenomics refers to the integration of comprehensive genomic, transcriptomic, and proteomic measurements from the same samples with the goal of fully understanding the regulatory processes converting genotypes to phenotypes, often with an emphasis on gaining a deeper understanding of disease processes. Although specific genetic mutations have long been known to drive the development of multiple cancers, gene mutations alone do not always predict prognosis or response to targeted therapy. The benefit of proteogenomics research is that information obtained from proteins and their corresponding pathways provides insight into therapeutic targets that can complement genomic information by providing an additional dimension regarding the underlying mechanisms and pathophysiology of tumors. This review describes the novel insights into tumor biology and drug resistance derived from proteogenomic analysis while highlighting the clinical potential of proteogenomic observations and advances in technique and analysis tools.

基于质谱的蛋白质组学:精准医学的新治疗机会。
蛋白质组学是指整合来自相同样本的全面基因组、转录组和蛋白质组学测量,目的是充分了解将基因型转化为表型的调控过程,通常强调对疾病过程有更深入的了解。尽管长期以来已知特定的基因突变会导致多种癌症的发展,但仅凭基因突变并不总能预测预后或对靶向治疗的反应。蛋白基因组学研究的好处是,从蛋白质及其相应途径获得的信息提供了对治疗靶点的深入了解,这些靶点可以通过提供关于肿瘤潜在机制和病理生理学的额外维度来补充基因组信息。这篇综述描述了蛋白基因组分析对肿瘤生物学和耐药性的新见解,同时强调了蛋白基因组观察的临床潜力以及技术和分析工具的进展。《药理学与毒理学年度评论》第64卷预计最终在线出版日期为2024年1月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
27.80
自引率
0.00%
发文量
53
期刊介绍: Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.
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