Hear and Now: Ongoing Clinical Trials to Prevent Drug-Induced Hearing Loss.

IF 11.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY
John Lee, Katharine Fernandez, Lisa L Cunningham
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引用次数: 0

Abstract

Each year over half a million people experience permanent hearing loss caused by treatment with therapeutic drugs with ototoxic side effects. There is a major unmet clinical need for therapies that protect against this hearing loss without reducing the therapeutic efficacy of these lifesaving drugs. At least 17 clinical trials evaluating 10 therapeutics are currently underway for therapies aimed at preventing aminoglycoside- and/or cisplatin-induced ototoxicity. This review describes the preclinical and clinical development of each of these approaches, provides updates on the status of ongoing trials, and highlights the importance of appropriate outcome measures in trial design and the value of reporting criteria in the dissemination of results.

现在就听:预防药物性听力损失的现行临床试验。
每年有 50 多万人因使用具有耳毒性副作用的治疗药物而导致永久性听力损失。目前,临床上急需一种既能防止听力损失,又不会降低这些救命药物疗效的疗法。目前至少有 17 项临床试验正在进行中,评估了 10 种旨在预防氨基糖苷类和/或顺铂诱导的耳毒性的疗法。本综述介绍了每种方法的临床前和临床开发,提供了正在进行的试验的最新情况,并强调了适当的结果测量在试验设计中的重要性以及报告标准在结果传播中的价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
27.80
自引率
0.00%
发文量
53
期刊介绍: Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.
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