Introduction to the Theme "Novel Therapeutics with the Potential to Advance Health Care".

IF 11.2 1区医学 Q1 PHARMACOLOGY & PHARMACY

Annual review of pharmacology and toxicology Pub Date : 2024-09-25 DOI:10.1146/annurev-pharmtox-090324-021727

Paul A Insel, Susan G Amara, Amrita Ahluwalia

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Abstract

The reviews in Volume 65 of the Annual Review of Pharmacology and Toxicology cover a wide variety of topics in pharmacology and toxicology focused upon the pathway from preclinical studies to clinical trials. Many of these reviews discuss the identification and validation of new therapeutic targets and/or novel therapeutic approaches. Examples include reviews that focus on the treatment of obesity, neuropsychiatric disorders, Parkinson's disease, substance use disorders, liver fibrosis, cardiac arrythmias, chronic intestinal inflammation, prostate cancer, immuno-oncology, sickle cell disease, and snakebite envenoming. Other topics include drug discovery of biologics, microphysiological systems, and human induced pluripotent stem cell-derived organoids and organ-on-chip technology integrated with artificial intelligence methodologies. Together, these and other reviews give new insights into the assessment of aspects of toxicology and provide readers a glimpse of advances in pharmacology and toxicology that we believe will advance health care and environmental safety.

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主题 "有可能促进医疗保健的新型疗法 "介绍。

药理学和毒理学年度综述》第 65 卷中的综述涵盖了药理学和毒理学的各种主题，重点关注从临床前研究到临床试验的途径。其中许多综述讨论了新治疗靶点和/或新型治疗方法的鉴定和验证。例如，这些综述关注肥胖症、神经精神障碍、帕金森病、药物使用障碍、肝纤维化、心律失常、慢性肠炎、前列腺癌、免疫肿瘤学、镰状细胞病和蛇咬伤等疾病的治疗。其他主题包括生物制剂的药物发现、微生理系统、人类诱导多能干细胞衍生的器官体以及与人工智能方法相结合的片上器官技术。这些综述和其他综述共同为毒理学各方面的评估提供了新的见解，并为读者提供了药理学和毒理学进展的一瞥，我们相信这些进展将推动医疗保健和环境安全的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual review of pharmacology and toxicology 医学-毒理学

CiteScore

27.80

自引率

0.00%

发文量

期刊介绍： Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.