Annals of Indian Academy of Neurology最新文献_第5页

My Birdsongs in Clinical Neurology. 我在临床神经病学中的鸟鸣。

IF 1.9 4区医学

Annals of Indian Academy of Neurology Pub Date : 2024-09-01 Epub Date: 2024-10-22 DOI: 10.4103/aian.aian_840_24

Satish V Khadilkar

引用次数: 0

Rare Manifestation of ATP1A3 Mutation with Clinical Response to Cannabidiol. 罕见的 ATP1A3 基因突变表现与大麻二酚的临床反应。

IF 1.9 4区医学

Annals of Indian Academy of Neurology Pub Date : 2024-09-01 Epub Date: 2024-10-17 DOI: 10.4103/aian.aian_276_24

Ashique Hamza, Sachin Sureshbabu, N C Krishnadas, Poornima Narayanan, Deep P Pillai, Nikhil Samuel

引用次数: 0

Clopidogrel Resistance in Ischemic Stroke Patients. 缺血性脑卒中患者对氯吡格雷的耐药性

IF 1.9 4区医学

Annals of Indian Academy of Neurology Pub Date : 2024-09-01 Epub Date: 2024-07-24 DOI: 10.4103/aian.aian_79_24

S Lavanya, Dhanashri Babu, D Dheepthi, E Dhinakar, G Vivekanandh

{"title":"Clopidogrel Resistance in Ischemic Stroke Patients.","authors":"S Lavanya, Dhanashri Babu, D Dheepthi, E Dhinakar, G Vivekanandh","doi":"10.4103/aian.aian_79_24","DOIUrl":"10.4103/aian.aian_79_24","url":null,"abstract":"Stroke remained the second leading cause of death globally in 2019. The antiplatelet drug clopidogrel is used to keep blood clots from forming in people who have experienced a stroke. Although most people find clopidogrel to be safe and beneficial, there is inevitably a range in how each patient responds. The review covers about Clopidogrel resistance in stroke patients, their risk factors and the methods to identify it. Clopidogrel resistance is characterized as the drug's inability to prevent the target enzyme from acting. The prognosis of patients with ischemic stroke and the responsiveness to clopidogrel are significantly impacted by the various genetic polymorphism CYP2C19 genotypes. The two primary mutant alleles, CYP2C19 *2 and CYP2C19 *3, have been found to be the most prevalent genotypes. Better mRS scores six months after treatment showed a higher response rate in patients without these CYP2C19 variant alleles. Other factors are drug-drug interaction (proton pump inhibitors), demographics (age, sex, social history), comorbid conditions, etc. Blood samples for testing platelet reactivity were drawn one month after discharge from a peripheral blood sample. Several methods are used to identify the clopidogrel resistance. Some of them are ADP-Induced platelet aggregation, Platelet Reactivity Index VASP, Verify Now Assay, TEG Analyzer, Plasma microRNA-223. Drugs that are not prodrugs and whose metabolism is not dependent upon CYP2C19 can be selected as a superior alternative in case of CR. Ticagrelor is one such effective substitute. Proton pump inhibitors and clopidogrel should only be used concurrently in patients with reliable clinical indications.","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141750864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay Secondary to a Novel Mutation in the SACS Gene. 继发于 SACS 基因新型突变的常染色体隐性遗传性沙勒沃瓦-萨格奈痉挛性共济失调。

IF 1.9 4区医学

Annals of Indian Academy of Neurology Pub Date : 2024-09-01 Epub Date: 2024-08-16 DOI: 10.4103/aian.aian_223_24

Akhil Sahib, Cankatika Choudhury, Rakesh Nagar, Arun Koul

引用次数: 0

Decoding Multiple Antibody Positivity: Lessons from Paraneoplastic Sensory Ataxia. 解码多重抗体阳性：副肿瘤性感觉共济失调的启示

IF 1.9 4区医学

Annals of Indian Academy of Neurology Pub Date : 2024-09-01 Epub Date: 2024-08-21 DOI: 10.4103/aian.aian_307_24

S Sidharth, Ayush Agarwal, Divyani Garg, Anita Mahadevan, Shamim A Shamim, Pranjal Gupta, Divya M Radhakrishnan, Awadh K Pandit, Achal K Srivastava

{"title":"Decoding Multiple Antibody Positivity: Lessons from Paraneoplastic Sensory Ataxia.","authors":"S Sidharth, Ayush Agarwal, Divyani Garg, Anita Mahadevan, Shamim A Shamim, Pranjal Gupta, Divya M Radhakrishnan, Awadh K Pandit, Achal K Srivastava","doi":"10.4103/aian.aian_307_24","DOIUrl":"10.4103/aian.aian_307_24","url":null,"abstract":"Paraneoplastic neurologic syndromes are cancer-associated, immune-mediated neurologic manifestations that may involve any part of the nervous system. They usually present with characteristic neurologic features and should be considered in high-risk phenotypes such as limbic encephalitis, encephalomyelitis, rapidly progressive cerebellar syndrome, opsoclonus-myoclonus, sensory neuronopathy, enteric neuropathy, and Lambert-Eaton myasthenic syndrome. The diagnosis is made by antibody positivity in the serum or cerebrospinal fluid, in the presence of an appropriate clinical phenotype. Findings on antibody testing by immunoblot should always be verified by immunofluorescence. We report a rare case of sensory neuronopathy with triple paraneoplastic antibody positivity (anti-Hu, anti-collapsing response-mediator protein 5, and anti-amphiphysin) on immunoblot but only anti-Hu positivity on immunofluorescence. The presence of lower facial dyskinesias should raise the possibility of an immune-mediated neurologic syndrome in the appropriate clinical context.","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142078917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CADASIL Type 2 ( HTRA1 Cerebral Small Vessel Disease) in an Indian Woman. 一名印度妇女的 CADASIL 2 型（HTRA1 脑小血管病）。

IF 1.9 4区医学

Annals of Indian Academy of Neurology Pub Date : 2024-09-01 Epub Date: 2024-07-12 DOI: 10.4103/aian.aian_174_24

Boby Varkey Maramattom

引用次数: 0

Primary CNS Vasculitis Mimicking Brainstem Encephalitis. 模仿脑干脑炎的原发性中枢神经系统血管炎

IF 1.9 4区医学

Annals of Indian Academy of Neurology Pub Date : 2024-09-01 Epub Date: 2024-07-12 DOI: 10.4103/aian.aian_189_24

Ayush Agarwal, Venugopalan Y Vishnu, Divyani Garg, Ajay Garg, Meher Chand Sharma, Achal K Srivastava, Mv Padma Srivastava

引用次数: 0

Decoding Autoimmune Autonomic Disorders: A Less-Recognized Overlap. 解码自身免疫性自主神经紊乱：鲜为人知的重叠。

IF 1.9 4区医学

Annals of Indian Academy of Neurology Pub Date : 2024-09-01 Epub Date: 2024-10-08 DOI: 10.4103/aian.aian_394_24

Prachi Mohapatra, Ayush Agarwal, Divya M Radhakrishnan, Achal Kumar Srivastava, Divyani Garg

引用次数: 0

Magnetoencephalography Profile of Patients with Drug-Resistant Focal Epilepsy and Normal MRI. 耐药性局灶性癫痫患者的脑磁图特征和正常磁共振成像。

IF 1.9 4区医学

Annals of Indian Academy of Neurology Pub Date : 2024-09-01 Epub Date: 2024-09-30 DOI: 10.4103/aian.aian_251_24

Ajay Asranna, Asheeb Abdulhak, Lakshminarayanapuram Gopal Viswanathan, Ravindranandh Chowdary Mundlamuri, Raghavendra Kenchaiah, Mariyappa Narayanan, Bhargava Gautham, Velumurugan Jayabal, Rose Dawn Bharath, Jitender Saini, Chandana Nagaraj, Sandhya Mangalore, Karthik Kulanthaivelu, Nishanth Sadashiva, A Mahadevan, Jamuna Rajeswaran, Arivazhagan Arimappamagan, Bhaskara Rao Malla, Sanjib Sinha

{"title":"Magnetoencephalography Profile of Patients with Drug-Resistant Focal Epilepsy and Normal MRI.","authors":"Ajay Asranna, Asheeb Abdulhak, Lakshminarayanapuram Gopal Viswanathan, Ravindranandh Chowdary Mundlamuri, Raghavendra Kenchaiah, Mariyappa Narayanan, Bhargava Gautham, Velumurugan Jayabal, Rose Dawn Bharath, Jitender Saini, Chandana Nagaraj, Sandhya Mangalore, Karthik Kulanthaivelu, Nishanth Sadashiva, A Mahadevan, Jamuna Rajeswaran, Arivazhagan Arimappamagan, Bhaskara Rao Malla, Sanjib Sinha","doi":"10.4103/aian.aian_251_24","DOIUrl":"10.4103/aian.aian_251_24","url":null,"abstract":"Background and objectives: Magnetoencephalography (MEG) could be a valuable tool in the presurgical evaluation of drug-resistant epilepsy (DRE), especially when the initial evaluation is inconclusive. In this retrospective study, we describe the profile of MEG in patients with DRE and normal magnetic resonance imaging (MRI).Methods: We included patients with focal epilepsy and normal MRI who underwent presurgical evaluation for DRE. MEG profiles of these patients, including the frequency of spikes, density of clusters, number of clusters, and concordance with video electroencephalography (VEEG), were analyzed.Results: Of the 73 patients included, magnetic source imaging (MSI) provided localizing information in 51 (69.9%) patients. Among patients with localizing MEG findings, localizing information on VEEG too was noted in 42 (57.5% of the whole cohort). Thirty-one (42.5%) patients had concordant findings with region-specific localization, six (8.2%) patients had partial concordance, and five (6.8%) subjects showed discordant findings. There was a moderate agreement for the presumed epileptogenic zone in comparing findings derived from MEG and VEEG (kappa value of 0.451, P < 0.001). The agreement was lower when MEG localized to the frontal lobe (kappa value of 0.379, P = 0.001) than the temporal lobe (kappa value 0.442, P = 0.002).Conclusions: MEG can provide localizing information in most patients with a normal MRI. A moderate degree of agreement between localization by MEG and VEEG was noted. These findings highlight the usefulness of MSI in the presurgical evaluation of MRI-negative DRE.","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uncommon Pediatric Immune-Mediated Epilepsy: Disease Course, Diagnosis, and Outcome - A Series of Three Cases. 不常见的小儿免疫性癫痫：病程、诊断和结果--三例系列病例。

IF 1.9 4区医学

Annals of Indian Academy of Neurology Pub Date : 2024-09-01 Epub Date: 2024-10-08 DOI: 10.4103/aian.aian_149_24

Aakash Mahesan, Aradhana Rohil, Prashant Jauhari, Madhavi Tripathi, Biswaroop Chakrabarty, Atin Kumar, Sheffali Gulati

{"title":"Uncommon Pediatric Immune-Mediated Epilepsy: Disease Course, Diagnosis, and Outcome - A Series of Three Cases.","authors":"Aakash Mahesan, Aradhana Rohil, Prashant Jauhari, Madhavi Tripathi, Biswaroop Chakrabarty, Atin Kumar, Sheffali Gulati","doi":"10.4103/aian.aian_149_24","DOIUrl":"10.4103/aian.aian_149_24","url":null,"abstract":"Immune-mediated epilepsy (IME) constitutes a substantial proportion of drug-refractory epilepsies. Rapid diagnosis and prompt immunosuppression are required along with antiseizure medications (ASMs). Here we report three unrelated children who presented with fever, encephalopathy, and refractory epilepsy and subsequently tested positive for rare intraneuronal and surface receptor antibodies, namely, contactin-associated protein like 2 (CASPR2), glutamic acid decarboxylase (GAD65), and paraneoplastic antigen Ma2 (PNMA2). In all of them, brain magnetic resonance imaging (MRI) was noncontributory. Electroencephalography showed nonspecific interictal epileptic discharges. F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) brain scan revealed abnormality in metabolic pattern with hypermetabolism in basal ganglia, thalami, frontotemporal cortices, and cerebellar hemispheres, consistent with autoimmune encephalitis. Immunosuppression was initiated along with ASMs. Complete seizure freedom was achieved in GAD65 antibody IME and >50% seizure reduction in CASPR2 and PNMA2 antibody IME. A variable degree of behavioral problems persisted in all. Early immunosuppression is warranted in IME, but does not universally guarantee a complete response.","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0