Annals of Indian Academy of Neurology最新文献

{"title":"Myasthenia Gravis and its Rare Association with Castleman's Disease.","authors":"Rindha V Rao, Divya Teja Chowdary, Sireesha Yareeda, Megha S Uppin, Madhur Kumar Srivastava, Surya Prabha Turaga, Reshma Sultana Shaik","doi":"10.4103/aian.aian_793_25","DOIUrl":"10.4103/aian.aian_793_25","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":"288-290"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146028237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Anti-CASPR2 Encephalitis as the Presenting Manifestation of Hepatitis B Virus Infection.","authors":"Sabyasachi Pattnayak, Abinash Swain, Himanshu S Satapathy, Manasi Das, Chitralekha Naik","doi":"10.4103/aian.aian_899_25","DOIUrl":"10.4103/aian.aian_899_25","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":"298-299"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146099570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Bi-Allelic Mutation in the Paired Box 7 Gene Causing Congenital Myopathy 19 in an Indian Family.","authors":"Alvee Saluja, Akhil Sahib, Anul Haque, Vikas Yadav","doi":"10.4103/aian.aian_774_25","DOIUrl":"10.4103/aian.aian_774_25","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":"284-287"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146058980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Electrophysiological Profile of Patients with Functional Hiccups.","authors":"Nitish Kamble, Abhishek Lenka, B C Nagaraju, Shweta Prasad, Chesta Arora, Vikram V Holla, Shyam Sundar Arumugham, Yc Janardhan Reddy, Pramod K Pal","doi":"10.4103/aian.aian_920_25","DOIUrl":"10.4103/aian.aian_920_25","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":"302-305"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146211721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral Neuropathy-Predominant Adult-Onset Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay: Novel Variant in the SACS gene.","authors":"Anil Dash, Farsana Mustafa, Ayush Agarwal, Divyani Garg, Awadh K Pandit, Achal K Srivastava, Divya M Radhakrishnan","doi":"10.4103/aian.aian_934_25","DOIUrl":"10.4103/aian.aian_934_25","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":"305-308"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147353452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscle Magnetic Resonance Imaging Phenotyping and Pattern Recognition in Genetically Confirmed Myopathies: A Large-Cohort Study from the Indian Subcontinent.","authors":"Shariq Ahmad Shah, Venugopalan Y Vishnu, Leve Joseph Devaranjan Sebastian, Ajay Garg","doi":"10.4103/aian.aian_1092_25","DOIUrl":"10.4103/aian.aian_1092_25","url":null,"abstract":"<p><strong>Background and objectives: </strong>Diagnosing myopathy subtypes is challenging due to clinical and genetic heterogeneity. While muscle magnetic resonance imaging (MRI) enables pattern recognition, standardized imaging data from India are lacking. This study aimed to define MRI patterns in myopathies, compare semi-quantitative scores with fat fraction (FF) analysis, and derive a diagnostic algorithm.</p><p><strong>Methods: </strong>In this study, a total of 102 patients with confirmed dystrophic or inflammatory myopathies underwent 3T MRI of the pelvic girdle and lower limbs, combining conventional sequences with Dixon-based fat quantification. Analysis used a modified Mercuri T1 scale and Stramare T2 edema scoring, along with FF measurements across 6,180 muscles. Disease patterns, correlations between imaging and clinical variables, and associations between qualitative and quantitative metrics were analyzed.</p><p><strong>Results: </strong>MRI patterns were distinct for each myopathy. Facioscapulohumeral dystrophy showed hamstring involvement with low asymmetry (5%). Dystrophinopathies exhibited a \"trefoil with single fruit\" sign (68%). Calpainopathy showed symmetrical end-stage involvement of the gluteal, adductor, and hamstring muscles, while dysferlinopathy affected the gluteus minimus and posterior compartment. Glucosamine-N-acetyl Epimerase (GNE) myopathy showed severe involvement of the gluteus minimus, sartorius, gracilis, and tibialis anterior muscles. In inflammatory myopathies, dermatomyositis showed edema (62%) without a fixed pattern, whereas inclusion body myositis affected the gastrocnemius and gluteal muscles. Disease duration correlated with T1 scores (r = 0.3, P = 0.001) and FF (r = 0.4, P = 0.003). A significant association ( P < 0.001) was observed between T1 scores and FF categories.</p><p><strong>Conclusions: </strong>Combined semi-quantitative scoring and FF MRI distinguished myopathy subtypes, correlated with disease duration, and supported the use of MRI as a biomarker. Our muscle atlas defines disease-specific imaging phenotypes and serves as a reference for diagnostic evaluation in diverse populations.</p>","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":"172-179"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147637757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxic Lesions of the Corpus Callosum Patterns and Etiologies: Insights from an Indian Cohort.","authors":"Sagar Badachi, Sonia Shivde, Saikanth Deepalam, Raghunandan Nadig, Mohammed Shakeebuddin Kashif, Grk Sarma, Vishal Chandra Sharma, Shagun Bhardwaj, Gg Sharath Kumar, Thomas Mathew","doi":"10.4103/aian.aian_1196_25","DOIUrl":"10.4103/aian.aian_1196_25","url":null,"abstract":"<p><strong>Background and objectives: </strong>The corpus callosum (CC) is the largest commissural pathway in the brain. The splenium of corpus callosum (SCC) represents the thickest and most posterior portion of the CC. Transient signal alterations in the SCC on magnetic resonance imaging (MRI) have been observed in various neurological and non-neurological conditions, termed cytotoxic lesions of the corpus callosum (CLOCCs). We aim to study the different MRI brain patterns in patients with CLOCCs and correlate probable etiologies with clinical and radiological presentations.</p><p><strong>Methods: </strong>During the study period of 8 years, 10,000 MRI brain scans were reviewed. A total of 127 (1.27%) patients had splenial involvement. Cases of splenial involvement due to stroke and tumors were excluded. Ultimately, 35 patients who had CLOCCs were enrolled in the study. After analyzing splenial lesions with respect to size, shape, involvement of the genu, and involvement of extracallosal sites, CLOCCs were further classified into dot sign, boomerang sign, double boomerang sign, and boomerang plus sign.</p><p><strong>Results: </strong>The dot sign was observed in 19 (54.28%), the boomerang sign in 3 (8.57%), the double boomerang sign in 3 (8.57%) patients, and the boomerang plus sign in 10 (28.57%) patients. The majority of the patients had seizures. The other probable etiologies included infections, hypernatremia, hypoglycemia, and headache.</p><p><strong>Conclusions: </strong>CLOCCs is a clinicoradiological syndrome resulting from a wide variety of causes. MRI brain patterns can range from isolated involvement of the splenium to involvement of extracallosal sites, and these patterns may help identify the probable etiologies.</p>","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":"231-237"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147637778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship between the Contralateral Posterior Cerebral Circulation Stroke and the Ponticulus Posticus Anomaly: First Report of a Hidden Culprit of the Cause of Stroke.","authors":"Omer L Gundogdu, Ayhan Kanat, Bulent Ozdemir, Serdar Durmaz, Cihangir Erturk, Tugba Yemis, Deniz Sirinoglu","doi":"10.4103/aian.aian_739_25","DOIUrl":"10.4103/aian.aian_739_25","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":"279-281"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Anatomical Insights into a Novel Persistent Primitive Olfactory Artery Variant Associated Aneurysmal Subarachnoid Hemorrhage.","authors":"Trilochan Srivastava, Ashok Gandhi, Ashish Pemawat, Pankajkumar Sharma, Neha Patil","doi":"10.4103/aian.aian_711_25","DOIUrl":"https://doi.org/10.4103/aian.aian_711_25","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":"29 2","pages":"276-279"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Standing Corticomedullary Hyperintensities in a Patient with Probable Neuronal Intranuclear Inclusion Disease.","authors":"YoungSeo Kim, HyunYoung Park","doi":"10.4103/aian.aian_718_25","DOIUrl":"10.4103/aian.aian_718_25","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":"250-251"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145931875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}