Annals of Indian Academy of Neurology最新文献

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Tardive Syndromes: A Challenging Multitude of Maladies.
IF 1.9 4区 医学
Annals of Indian Academy of Neurology Pub Date : 2025-01-29 DOI: 10.4103/aian.aian_657_24
Ranjot Kaur, Vaibhav Patil, Ayush Agarwal, Achal K Srivastava, Divyani Garg
{"title":"Tardive Syndromes: A Challenging Multitude of Maladies.","authors":"Ranjot Kaur, Vaibhav Patil, Ayush Agarwal, Achal K Srivastava, Divyani Garg","doi":"10.4103/aian.aian_657_24","DOIUrl":"https://doi.org/10.4103/aian.aian_657_24","url":null,"abstract":"<p><strong>Abstract: </strong>\"Tardive syndrome\" is an umbrella term for a group of drug-induced movement disorders associated with the prolonged use of mainly dopamine receptor blockers and also other medications. Early recognition followed by gradual withdrawal of the incriminating drug may lead to reversal, although not in all patients. Tardive syndromes are usually mixed movement disorders, with specific phenotypes, which may lead to severe disability. The pathophysiology remains incompletely understood. Treatment ranges from medical options, particularly dopamine-depleting agents and chemodenervation (botulinum toxin), to surgical options (deep brain stimulation and lesioning surgeries). Most studies that focused on treatment are limited by small patient numbers. Unfortunately, tardive syndromes often remain under-recognized in clinical practice. This article reviews the historical aspects, epidemiology and risk factors, pathophysiology, diagnostic criteria, clinical phenotypes, and management of tardive syndromes.</p>","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organizing Pneumonia and Immunomediated Colitis Associated with Ocrelizumab Treatment.
IF 1.9 4区 医学
Annals of Indian Academy of Neurology Pub Date : 2025-01-29 DOI: 10.4103/aian.aian_608_24
Daniel A García-Estévez, Coral Tejido-Sandoval, Montserrat Díaz-Gutiérrez, Clara González-Núñez, Elena Otero-Gutiérrez, Lidia Santos-López
{"title":"Organizing Pneumonia and Immunomediated Colitis Associated with Ocrelizumab Treatment.","authors":"Daniel A García-Estévez, Coral Tejido-Sandoval, Montserrat Díaz-Gutiérrez, Clara González-Núñez, Elena Otero-Gutiérrez, Lidia Santos-López","doi":"10.4103/aian.aian_608_24","DOIUrl":"https://doi.org/10.4103/aian.aian_608_24","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MOGAD and Mortality: A Rarity.
IF 1.9 4区 医学
Annals of Indian Academy of Neurology Pub Date : 2025-01-24 DOI: 10.4103/aian.aian_726_24
Uk Kandha Kumar, Pradeep K Gunasekaran, Ashna Kumar, Daisy Khera, Sarbesh Tiwari, Lokesh Saini
{"title":"MOGAD and Mortality: A Rarity.","authors":"Uk Kandha Kumar, Pradeep K Gunasekaran, Ashna Kumar, Daisy Khera, Sarbesh Tiwari, Lokesh Saini","doi":"10.4103/aian.aian_726_24","DOIUrl":"https://doi.org/10.4103/aian.aian_726_24","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neonatal Chikungunya Encephalitis - A Mimic of Leukoencephalopathy.
IF 1.9 4区 医学
Annals of Indian Academy of Neurology Pub Date : 2025-01-24 DOI: 10.4103/aian.aian_806_24
Mahesh Kamate, Basavanagowda Thanuja, Sugata Mahapatra, Manisha Bhandankar, Virupaxi Hattiholi
{"title":"Neonatal Chikungunya Encephalitis - A Mimic of Leukoencephalopathy.","authors":"Mahesh Kamate, Basavanagowda Thanuja, Sugata Mahapatra, Manisha Bhandankar, Virupaxi Hattiholi","doi":"10.4103/aian.aian_806_24","DOIUrl":"https://doi.org/10.4103/aian.aian_806_24","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterizing Parkinson's Disease-Associated Pain in Native Patients with Malayalam Version of the King's Parkinson's Disease Pain Scale. 用马拉雅拉姆版的King’s帕金森病疼痛量表来表征本土患者帕金森病相关疼痛
IF 1.9 4区 医学
Annals of Indian Academy of Neurology Pub Date : 2025-01-18 DOI: 10.4103/aian.aian_701_24
Prabhu Attur Selvaraj, Asish Vijayaraghavan, Vineeth Radhakrishnan, Divya Kalikavil Puthenveedu, Gangadhara Sarma, Sankara P Sarma, Syam Krishnan
{"title":"Characterizing Parkinson's Disease-Associated Pain in Native Patients with Malayalam Version of the King's Parkinson's Disease Pain Scale.","authors":"Prabhu Attur Selvaraj, Asish Vijayaraghavan, Vineeth Radhakrishnan, Divya Kalikavil Puthenveedu, Gangadhara Sarma, Sankara P Sarma, Syam Krishnan","doi":"10.4103/aian.aian_701_24","DOIUrl":"https://doi.org/10.4103/aian.aian_701_24","url":null,"abstract":"<p><strong>Background and objectives: </strong>Pain is an important non-motor symptom in Parkinson's disease (PD) and is often under-recognized. Pain is also a symptom frequently reported by non-PD elderly subjects. The King's Parkinson's Disease Pain Scale (KPPS) is a valid tool to characterize and quantify pain in PD and has been translated into several languages.</p><p><strong>Methods: </strong>We translated KPPS to Malayalam for native patients with PD and examined the pain characteristics in consecutive patients. Correlations with comprehensive disease-specific rating scales, including the Movement Disorder Society-Sponsored Unified Parkinson's Disease Rating Scale (MDS-UPDRS) and the Non-Motor Symptoms Scale (NMSS), were explored. A group of age- and gender-matched subjects without PD were interviewed using KPPS to examine how the pain reported by the non-PD aging population is different from that in PD.</p><p><strong>Results: </strong>In this study, 82% of patients with PD reported at least one type of pain, compared to 31.3% of age- and gender-matched control subjects (P < 0.001). KPPS total scores (18.2 ± 14.0 vs. 1.8 ± 3.2; P < 0.001) and all the individual domain scores were significantly higher in patients. Pain scores correlated with age in control subjects (R = 0.46, P < 0.001), but not in patients; females reported more pain in both groups. Patients' pain scores were higher in the postural instability and gait difficulty subtype and showed significant correlations with MDS-UPDRS and NMSS scores.</p><p><strong>Conclusions: </strong>Pain is a prevalent symptom in PD and differs from the pain reported by a non-PD aging population. The Malayalam version of KPPS is a valid tool to characterize pain in native, Malayalam-speaking patients.</p>","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Isoniazid-Induced Cerebellitis in Diabetic Chronic Kidney Disease. 异烟肼致糖尿病慢性肾病小脑炎1例。
IF 1.9 4区 医学
Annals of Indian Academy of Neurology Pub Date : 2025-01-16 DOI: 10.4103/aian.aian_741_24
Ramakrishna Ganapathiwar, Aumir Moin, Srinivas Nalloor, Shraddha Kedlaya K
{"title":"A Case of Isoniazid-Induced Cerebellitis in Diabetic Chronic Kidney Disease.","authors":"Ramakrishna Ganapathiwar, Aumir Moin, Srinivas Nalloor, Shraddha Kedlaya K","doi":"10.4103/aian.aian_741_24","DOIUrl":"https://doi.org/10.4103/aian.aian_741_24","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
All Tongue Fasciculations are Not Motor Neuron Disease. 并非所有的舌束动都是运动神经元疾病。
IF 1.9 4区 医学
Annals of Indian Academy of Neurology Pub Date : 2025-01-10 DOI: 10.4103/aian.aian_690_24
Pushkar Pazhani, Saranya B Gomathy, Jayaram Saibaba, Manoj Manyem, Ramkumar Sugumaran, Sunil K Narayan
{"title":"All Tongue Fasciculations are Not Motor Neuron Disease.","authors":"Pushkar Pazhani, Saranya B Gomathy, Jayaram Saibaba, Manoj Manyem, Ramkumar Sugumaran, Sunil K Narayan","doi":"10.4103/aian.aian_690_24","DOIUrl":"https://doi.org/10.4103/aian.aian_690_24","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical, Imaging, and Atrial Cardiopathy Markers in Ischemic Stroke Subtypes - Clues to a Cardioembolic Source. 缺血性脑卒中亚型的临床、影像学和心房心脏病标志物——心脏栓塞来源的线索。
IF 1.9 4区 医学
Annals of Indian Academy of Neurology Pub Date : 2025-01-10 DOI: 10.4103/aian.aian_772_24
Sapna Erat Sreedharan, Kakarla Saikiran, S C Chandralekha, C A Athira, P N Sylaja, V T Jissa, Narayanan Namboodiri
{"title":"Clinical, Imaging, and Atrial Cardiopathy Markers in Ischemic Stroke Subtypes - Clues to a Cardioembolic Source.","authors":"Sapna Erat Sreedharan, Kakarla Saikiran, S C Chandralekha, C A Athira, P N Sylaja, V T Jissa, Narayanan Namboodiri","doi":"10.4103/aian.aian_772_24","DOIUrl":"https://doi.org/10.4103/aian.aian_772_24","url":null,"abstract":"<p><strong>Background and objectives: </strong>Cryptogenic strokes account for 20%-25% of all ischemic strokes. Although atrial cardiopathy markers are more prevalent in the cryptogenic embolic stroke of undetermined source (ESUS) subgroup than in the nonembolic stroke subgroup, the utility of individual parameters in predicting cardioembolic sources needs to be studied further. We studied the clinical, imaging, and atrial cardiopathy markers in three ischemic stroke subtypes - large artery atherosclerosis (LAA), cardioembolism (CE), and cryptogenic ESUS - and their role in predicting the source of CE.</p><p><strong>Methods: </strong>This was a prospective observational study of ischemic stroke patients at Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum from April 2021 to December 2022. Clinical and risk factor profiles, imaging details, atrial cardiopathy marker (N-terminal pro-brain natriuretic peptide [NT-pro-BNP]) levels, electrocardiogram (ECG) parameters (P terminal force of V1 [PTFV1], P wave duration, the PR interval), and transthoracic echo parameters (left atrial [LA] diameter and LA volume) were collected. Associations were made between clinical, imaging, and atrial cardiopathy markers and etiological subtypes.</p><p><strong>Results: </strong>We had 255 participants (LAA- 98, CE- 41, and ESUS- 139) with a mean age of 63.53 years. Among the atrial cardiopathy markers, the most prevalent was elevated NT-pro-BNP (43.95%), followed by the ECG markers P wave duration (30.92%) and PTFV1 (28.74%), and LA diameter greater than 37 mm (24.27%) and LA volume greater than 34 ml/m2 (20.31%). Among the atrial cardiopathy markers, NT-pro-BNP and LA enlargement were strongly predictive of CE etiology, when compared to LAA. Chronic non-lacunar infarcts on imaging and elevated NT-pro-BNP showed a strong association with CE, when compared to cryptogenic strokes.</p><p><strong>Conclusions: </strong>The atrial cardiopathy biomarker NT-pro-BNP and chronic non-lacunar infarcts can serve as useful tools for recognizing cardioembolic sources among patients with embolic strokes.</p>","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"Tracing the Lead" - Lead Encephalopathy Mimicking Autoimmune Encephalitis. “追踪铅”-模仿自身免疫性脑炎的铅性脑病。
IF 1.9 4区 医学
Annals of Indian Academy of Neurology Pub Date : 2025-01-09 DOI: 10.4103/aian.aian_902_24
N Manuraj, Asish Vijayaraghavan, Soumya Sundaram, Sajith Sukumaran
{"title":"\"Tracing the Lead\" - Lead Encephalopathy Mimicking Autoimmune Encephalitis.","authors":"N Manuraj, Asish Vijayaraghavan, Soumya Sundaram, Sajith Sukumaran","doi":"10.4103/aian.aian_902_24","DOIUrl":"https://doi.org/10.4103/aian.aian_902_24","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142943177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Young-Onset Cerebral Small Vessel Disease Associated with COLGALT1 Mutation. 与COLGALT1突变相关的年轻起病脑血管病
IF 1.9 4区 医学
Annals of Indian Academy of Neurology Pub Date : 2025-01-09 DOI: 10.4103/aian.aian_734_24
Boby V Maramattom
{"title":"Young-Onset Cerebral Small Vessel Disease Associated with COLGALT1 Mutation.","authors":"Boby V Maramattom","doi":"10.4103/aian.aian_734_24","DOIUrl":"https://doi.org/10.4103/aian.aian_734_24","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142943207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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