Transcranial Doppler Screening in Sickle Cell Disease: Insights from a Regional Study in Karnataka, India.

IF 1.9 4区医学 Q3 CLINICAL NEUROLOGY

Annals of Indian Academy of Neurology Pub Date : 2025-06-04 DOI:10.4103/aian.aian_65_25

Suryanarayana Sharma, Pooja Aggarwal, Meenakshi Gowrishankar, Tanya Seshadri, Vijay K Sharma, Kishore Ramachandraiah, Deepa Bhat

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Abstract

Abstract: Sickle cell disease (SCD), a hereditary blood disorder in India, disproportionately affects Adivasi communities burdened by socio-economic and systemic inequities. Stroke, a severe complication of SCD, is underexplored in Indian populations, especially among Adivasi groups. This pilot study evaluated the feasibility of transcranial Doppler (TCD) screening in a peripheral healthcare setting in Karnataka, focusing on Adivasi SCD patients. Among 39 participants (27 HbSS, three HbSβ0, nine HbAS) from a hemoglobinopathy registry, none exhibited elevated time-averaged maximum mean (TAMM) velocities, but 73.3% of SCD patients showed unusually low middle cerebral artery (MCA) velocities (<70 cm/s). Significant differences in basilar artery (BA) flow velocities were noted between SCD and sickle cell trait (SCT) patients (p<0.05), while MCA parameters were comparable. The findings establish baseline TCD velocities and highlight the need for region-specific stroke prevention guidelines tailored to underserved Adivasi populations.

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镰状细胞病的经颅多普勒筛查：来自印度卡纳塔克邦地区研究的见解。

镰状细胞病（SCD）是印度的一种遗传性血液疾病，严重影响着社会经济和系统不平等的原住民社区。中风是SCD的一种严重并发症，在印度人群中，特别是在阿迪瓦西人群中尚未得到充分的研究。本初步研究评估了经颅多普勒（TCD）筛查在卡纳塔克邦外围医疗机构的可行性，重点是阿迪瓦西SCD患者。在39名参与者（27名HbSS， 3名HbSβ0, 9名HbAS）中，没有人表现出时间平均最大平均（TAMM）速度升高，但73.3%的SCD患者表现出异常低的大脑中动脉（MCA）速度(

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来源期刊

Annals of Indian Academy of Neurology Nervous System Diseases-

CiteScore

2.20

自引率

11.80%

发文量

293

审稿时长

29 weeks

期刊介绍： The journal has a clinical foundation and has been utilized most by clinical neurologists for improving the practice of neurology. While the focus is on neurology in India, the journal publishes manuscripts of high value from all parts of the world. Journal publishes reviews of various types, original articles, short communications, interesting images and case reports. The journal respects the scientific submission of its authors and believes in following an expeditious double-blind peer review process and endeavors to complete the review process within scheduled time frame. A significant effort from the author and the journal perhaps enables to strike an equilibrium to meet the professional expectations of the peers in the world of scientific publication. AIAN believes in safeguarding the privacy rights of human subjects. In order to comply with it, the journal instructs all authors when uploading the manuscript to also add the ethical clearance (human/animals)/ informed consent of subject in the manuscript. This applies to the study/case report that involves animal/human subjects/human specimens e.g. extracted tooth part/soft tissue for biopsy/in vitro analysis.