Annals of Indian Academy of Neurology最新文献

{"title":"Predictors of Impulse Control Disorders in Patients with Parkinson's Disease.","authors":"Mohammed F Ansari, Nitish Kamble, Vikram V Holla, Ravi Yadav, Rohan R Mahale, Pramod K Pal","doi":"10.4103/aian.aian_309_25","DOIUrl":"https://doi.org/10.4103/aian.aian_309_25","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital CD59 Deficiency-A Novel Cause of Relapsing-Remitting Polyneuropathy.","authors":"Leema P Cornelius, Jered Livingston, Neeraj Elango","doi":"10.4103/aian.aian_1084_24","DOIUrl":"https://doi.org/10.4103/aian.aian_1084_24","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triad of Ophthalmoplegia, Facial Palsy, and Cerebellar Ataxia with \"Hot Cross Bun\" Associated with Autoimmune Thyroiditis.","authors":"Farsana Mustafa, K M Thrupthi, Ayush Agarwal, Ajay Garg, Shamim A Shamim, Achal K Srivastava, Divyani Garg","doi":"10.4103/aian.aian_17_25","DOIUrl":"https://doi.org/10.4103/aian.aian_17_25","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hereditary Spastic Paraplegia Type 7 With Early-Onset Parkinsonism Responsive to Subthalamic Deep Brain Stimulation.","authors":"Sayooja Sachithanandan, Krishnakumar Pisharody, Asish Vijayaraghavan, Lokesh V Dasarathan, Divya Kalikavil Puthenveedu, Syam Krishnan","doi":"10.4103/aian.aian_458_25","DOIUrl":"https://doi.org/10.4103/aian.aian_458_25","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of Dorsal Sural Nerve for Clinical Correlation and Detection of Early Diabetic Neuropathy.","authors":"Partisha Gupta, Ajoy Kumar Sodani, Rahul Jain, Ashish Gaur","doi":"10.4103/aian.aian_1121_24","DOIUrl":"https://doi.org/10.4103/aian.aian_1121_24","url":null,"abstract":"<p><strong>Background and objectives: </strong>Monofilament and tuning fork are commonly applied in clinical testing for distal sensory peripheral neuropathy (DSP). However, a dependable diagnosis of DSP requires nerve conduction studies (NCS). In the present study, we emphasize on the utility of dorsal sural sensory nerve action potential (dsSNAP) abnormality over sural sensory nerve action potential (SNAP) abnormality in detecting early DSP. Furthermore, we study the correlation between the clinical findings and sural SNAP and dsSNAP abnormalities.</p><p><strong>Methods: </strong>The study included 101 persons with type 2 diabetes mellitus (T2DM) (PWD; 202 lower extremities [LEs]) aged 18-70 years, with the duration of T2DM being ≥6 months. Normative data was generated from controls (200 LEs). Clinical and electrophysiological findings of the study group were analyzed and discussed in comparison with the normative data. Furthermore, receiver operating characteristic (ROC) curve analysis determined the optimal cut-off for different sensory modalities, and Spearman's correlation tests were applied to analyze the correlation between NCS and clinical parameters.</p><p><strong>Results: </strong>dsSNAP was abnormal in 39.1%, while sural SNAP was abnormal in 9.8% of asymptomatic PWD. Early neuropathy was detectable with subjective losses of 10% in temperature and pain sensations, 20% in touch sensation, and vibration duration <12 sec. Conventionally, the lower limit of normal of SNAP is considered as the cut-off for abnormality in the Electrophysiology (EP) lab. On ROC analysis, we found different optimal cut-offs for different sensory modalities.</p><p><strong>Conclusions: </strong>Incorporating dorsal sural nerve into routine NCS enhances the detection of early DSP. Clinical sensory abnormalities, especially temperature and vibration sensation, showed the highest sensitivity and specificity, respectively, in relation to NCS abnormalities. Relying solely on standard institute-based reference SNAP amplitudes may potentially overlook early DSP.</p>","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral Chromoblastomycosis: A Unique Presentation of Dematiaceous Fungal Infection in an Immunocompromised Patient.","authors":"Norton Stephen, Soundarya Ravi, Srinivas Bheemanathi Hanuman, Vir Singh Negi, Madhavan Sasidharan Gopalakrishnan","doi":"10.4103/aian.aian_747_24","DOIUrl":"10.4103/aian.aian_747_24","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mastoid Signal Change and Acute Cerebral Venous Sinus Thrombosis: Unlocking the Puzzle.","authors":"Ayush Agarwal, Venugopalan Y Vishnu, Meena Chandu, Divyani Garg, Manjari Agarwal, Ranjot Kaur, Maneesh Shakywar, Rohit Bhatia, Achal K Srivastava, Ashish Upadhyay, Ajay Garg, Mv Padma Srivastava","doi":"10.4103/aian.aian_99_25","DOIUrl":"10.4103/aian.aian_99_25","url":null,"abstract":"<p><strong>Abstract: </strong>Mastoid signal changes on magnetic resonance imaging in cerebral venous sinus thrombosis (CVT) patients are often misinterpreted as septic CVT. Studies have revealed mastoid signal changes in CVT patients. We conducted this study to investigate this relationship. Single-center, retrospective, observational study. Patients aged ≥18 years with venography-proven CVT were enrolled, excluding those with sepsis-induced CVT. Mastoid changes and clot burden score (CBS) were calculated. We screened and enrolled 128 and 124 CVT patients, respectively. Seventy per cent of patients had mastoid signal changes. The median mastoid score and CBS were 1 and 3, respectively. CBS was higher in CVT patients with mastoid changes. A higher CBS was associated with a higher mastoid score ( P = 0.003). Logistic regression analysis revealed an odds ratio of 0.67 (95% confidence interval: 0.52-0.87) for this association. The presence of radiological mastoid involvement is not sine qua non of associated middle ear infections and should raise the possibility of CVT.</p>","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patatin-Like Phospholipase Domain-Containing Protein 8 Mutation Associated with Gonadal Dysgenesis, Cerebellar Ataxia, and Peripheral Neuropathy in an Indian Family.","authors":"Alvee Saluja, Shahbaz Anees, Lekharaj H Ghotekar, Vikas Yadav, Anul Haque, Mehar C Sharma","doi":"10.4103/aian.aian_15_25","DOIUrl":"https://doi.org/10.4103/aian.aian_15_25","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shaky Beginnings: A Novel CoQ8A Mutation in Adolescent-Onset Cerebellar Ataxia with Head Tremors.","authors":"Vishnu K Subramanian, Saranya B Gomathy, Shamir Sella Sugan, Ramkumar Sugumaran, Sunil K Narayan","doi":"10.4103/aian.aian_247_25","DOIUrl":"https://doi.org/10.4103/aian.aian_247_25","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uremic Peripheral Neuropathy in Nondiabetic Chronic Hemodialysis Patients.","authors":"Taoufiq Aatif, Narjiss Labioui, Hajjar Laasli, Yassir Zajjari, Driss El Kabbaj","doi":"10.4103/aian.aian_74_25","DOIUrl":"https://doi.org/10.4103/aian.aian_74_25","url":null,"abstract":"<p><strong>Abstract: </strong>Chronic kidney disease is a global public health problem. Emphasis has been placed on uremic peripheral neuropathy (PN) in nondiabetic chronic hemodialysis (HD) patients. This complication could affect the quality of life. We aimed to determine the prevalence and risk factors of PN. This was a cross-sectional study. Evaluation of PN was made by clinical examination and electroneuromyogram. The prevalence of PN was 30.3%. The most common symptoms were paresthesia and burning. Neuropathic pain was symmetrical in the majority of cases and localized to the lower limb (60%). All patients had axonal type PN. In univariate analysis, the risk factors for PN were advanced age (P = 0.012), hypertension (P = 0.007), ischemic heart disease (P = 0.036), high C-reactive protein (microinflammation) (P = 0.002), low urea reduction ratio (P = 0.013), and high ß2 microglobulin (P = 0.002). Since PN is common in nondiabetic chronic HD patients, it becomes necessary to diagnose it and correct its risk factors.</p>","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}