Annals of Indian Academy of Neurology最新文献

{"title":"Atypical Neuroimaging and Ectodermal Features in Infantile Sandhoff Disease.","authors":"Sedat Işıkay","doi":"10.4103/aian.aian_693_26","DOIUrl":"https://doi.org/10.4103/aian.aian_693_26","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Non-invasive Brain Stimulation in Non-migraine Primary Headache Disorders: A Systematic Review and Meta-analysis.","authors":"Mohd Asif, Seetu Palo, Vishakha Jain, Shikha Yadav, Sujith Mathew, Goutham Thumati, Sai Krishna Tikka, Samir Kumar Praharaj","doi":"10.4103/aian.aian_103_26","DOIUrl":"https://doi.org/10.4103/aian.aian_103_26","url":null,"abstract":"<p><strong>Background and objectives: </strong>Non-migraine primary headache disorders such as tension-type headache and cluster headache are often chronic and significantly impair quality of life, with limited effective treatment options. Non-invasive brain stimulation (NIBS) techniques, including repetitive transcranial magnetic stimulation (rTMS) and transcranial electrical stimulation (tES), have emerged as promising neuromodulatory therapies. This systematic review evaluated the effectiveness and safety of NIBS in reducing headache frequency and intensity in non-migraine primary headache disorders.</p><p><strong>Methods: </strong>This review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. A systematic search of PubMed, Embase, Scopus, and Google Scholar was conducted up to February 25, 2025. Randomized controlled trials and non-randomized studies assessing NIBS modalities in non-migraine primary headache disorders were included. Primary outcomes were headache frequency, intensity, and adverse effects. Meta-analysis was performed using a random-effects model, with subgroup analyses and heterogeneity assessed using the I 2 statistic. This review was registered with PROSPERO (CRD420250651461).</p><p><strong>Results: </strong>Of 1,043 records screened, 14 studies ( N = 690) met the inclusion criteria, of which 9 were eligible for meta-analysis. NIBS significantly reduced headache severity [standardized mean difference (SMD) = -1.30; 95% confidence interval (CI): -2.03 to -0.57; P = 0.0005] and disability (SMD = -1.49; 95% CI: -2.41 to -0.57; P = 0.001). Subgroup analysis showed greater efficacy of rTMS compared with tES. Reduction in headache frequency was not statistically significant. Adverse events were mild and infrequent. Most studies had a moderate to high risk of bias.</p><p><strong>Conclusions: </strong>NIBS, particularly rTMS, may be effective in reducing headache severity and disability in non-migraine primary headache disorders. However, further high-quality, large-scale studies are needed to establish its role in routine clinical practice.</p>","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"A Cheeky Diagnosis\": Mumps Encephalitis with Limbic and Basal Ganglia Magnetic Resonance Imaging Abnormalities.","authors":"Bhargavi Korlakunta, Lakshminarayanpuram Gopal Viswanathan, Ashok Munivenkatappa, Doniparthi V Seshagiri, Madhu Nagappa, Jitender Saini, Sanjib Sinha","doi":"10.4103/aian.aian_605_26","DOIUrl":"https://doi.org/10.4103/aian.aian_605_26","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infantile Vanishing White Matter: Expanding the Known Neuroimaging Phenotype.","authors":"Ankit Arora, Rashmi Adiga, Harshith Gowda, H K Anand, Priya Ranganath, Sabha Ahmed","doi":"10.4103/aian.aian_532_26","DOIUrl":"https://doi.org/10.4103/aian.aian_532_26","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vigabatrin-Induced Worsening of Epileptic Spasms - A Clue to GABA-Transaminase Deficiency.","authors":"Leema P Cornelius, Jered L Kanagaraj, Neeraj Elango","doi":"10.4103/aian.aian_664_26","DOIUrl":"https://doi.org/10.4103/aian.aian_664_26","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angiokeratoma, Dysostosis Multiplex, and Hypomyelination in a Child with Developmental Delay: Think of Fucosidosis.","authors":"Vykuntaraju K Gowda, Varunvenkat M Srinivasan, Uddhav V Kinhal, Amena Nayyar","doi":"10.4103/aian.aian_540_26","DOIUrl":"https://doi.org/10.4103/aian.aian_540_26","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fat Wallet Syndrome: A Rare Piriformis Syndrome Mimic Evaluated with Magnetic Resonance Imaging.","authors":"Allen Johnson, Raghavendra Kenchaiah","doi":"10.4103/aian.aian_545_26","DOIUrl":"https://doi.org/10.4103/aian.aian_545_26","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149023535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personality Disorders in Patients with Idiopathic Generalized Epilepsy- An Underrecognized Comorbidity.","authors":"Ankith Bhasi, Gurumurthy Bharanidharan, Aswathy Suresh, Kiren Koshy, Ramshekhar N Menon, Ashalatha Radhakrishnan","doi":"10.4103/aian.aian_331_26","DOIUrl":"https://doi.org/10.4103/aian.aian_331_26","url":null,"abstract":"<p><strong>Background and objectives: </strong>Personality disorders remain an illness in the shadows, with scarce literature on their prevalence in persons with epilepsy. Moreover, personality traits in idiopathic generalized epilepsy (IGE) have not been explored so far, except for a few authors investigating juvenile myoclonic variant alone. We aimed to explore the prevalence and types of personality traits in persons with all IGE subtypes in adults and to compare them with the general population.</p><p><strong>Method: </strong>We included 57 healthy controls and 57 IGE cases who were diagnosed according to the International League Against Epilepsy criteria. The International Personality Disorder Examination-International Classification of Diseases 10 screening questionnaire was employed to investigate personality traits, while the Bear-Fedio inventory (BFI) was utilized to study several behavioral traits.</p><p><strong>Results: </strong>Compared with controls, a higher prevalence of personality traits was noted among patients with IGE (87.72% versus 36.84%, P = <0.001). They were more prevalent in females with IGE than in males (96.97% versus 75%; P = 0.034). Personality traits such as borderline ( P = <0.001), anankastic ( P = <0.001), anxious ( P = <0.001), histrionic ( P = <0.001), and impulsive ( P = 0.002) traits were higher in persons with IGE. Significantly higher scores in BFI were found among cases in all behavioral traits except hypermorality, altered sexual behavior, and dependence traits. On further analysis, no association of personality traits with the number of antiseizure medications or the duration of epilepsy was observed.</p><p><strong>Conclusions: </strong>Deviant personality traits were significantly higher in patients with IGE. Regardless of the subtype of IGE, the existence of a personality disorder makes treatment more challenging. Hence, specific interventions addressing these disorders should be incorporated into patient management.</p>","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intentional Repetitive Slapping (IRS): A Novel Agitation Phenotype in Behavioral-Variant Frontotemporal Dementia.","authors":"Aparna S Thampi, Athira S Thampi, Tom Xavier, Robert Mathew","doi":"10.4103/aian.aian_315_26","DOIUrl":"https://doi.org/10.4103/aian.aian_315_26","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monocular Nystagmus and Bulbar Dysfunction in Alternating Hemiplegia of Infantile Onset: A Novel Phenotype Associated with an ATP1A3 Mutation.","authors":"S Sonia Rosalind Martina, Jered Livingston Kanagaraj, Neeraj Elango, Leema Pauline Cornelius","doi":"10.4103/aian.aian_355_26","DOIUrl":"https://doi.org/10.4103/aian.aian_355_26","url":null,"abstract":"","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}