Annals of Indian Academy of Neurology最新文献_第2页

Atypical Bilateral Posterior Semicircular Canalolithiasis - A Case Series. 非典型双侧后半规管结石--一个病例系列。

IF 1.9 4区医学

Annals of Indian Academy of Neurology Pub Date : 2024-08-01 DOI: 10.4103/aian.aian_387_24

Ajay K Vats, Shreya Vats, Sudhir Kothari, Nishant Aswani

{"title":"Atypical Bilateral Posterior Semicircular Canalolithiasis - A Case Series.","authors":"Ajay K Vats, Shreya Vats, Sudhir Kothari, Nishant Aswani","doi":"10.4103/aian.aian_387_24","DOIUrl":"https://doi.org/10.4103/aian.aian_387_24","url":null,"abstract":"Abstract: Barany Society includes bilateral typical posterior semicircular canal benign paroxysmal positional vertigo (PSC-BPPV) in its classification of multicanal subtype. In the past decade, less-common and atypical subtypes of PSC-BPPV, like short-arm and non-ampullary arm posterior semicircular canalolithiasis, have emerged, requiring the conduct of conventional and auxiliary positional tests on both sides to uncover their bilaterality. Authors hereby report three atypical less-common subtypes of bilateral PSC-BPPV, discussing their clinicodemographic profiles, management by repositioning maneuvers and physical therapy, and follow up. Both Case 2 and Case 3 are precisely tri-canalolithiasis (bilateral ampullary arm posterior semicircular canalolithiasis with co-occurring right non-ampullary arm posterior semicircular canalolithiasis in Case 2 and bilateral short arm with co-occurring left ampullary arm posterior semicircular canalolithiasis in Case 3), which has not been reported previously in the literature. There has been only one previously reported case of bilateral non-ampullary arm semicircular canalolithiasis, and it is now observed in Case 1.","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clopidogrel Resistance in Ischemic Stroke Patients. 缺血性脑卒中患者对氯吡格雷的耐药性

IF 1.9 4区医学

Annals of Indian Academy of Neurology Pub Date : 2024-07-24 DOI: 10.4103/aian.aian_79_24

S Lavanya, Dhanashri Babu, D Dheepthi, E Dhinakar, G Vivekanandh

{"title":"Clopidogrel Resistance in Ischemic Stroke Patients.","authors":"S Lavanya, Dhanashri Babu, D Dheepthi, E Dhinakar, G Vivekanandh","doi":"10.4103/aian.aian_79_24","DOIUrl":"https://doi.org/10.4103/aian.aian_79_24","url":null,"abstract":"Abstract: Stroke remained the second leading cause of death globally in 2019. The antiplatelet drug clopidogrel is used to keep blood clots from forming in people who have experienced a stroke. Although most people find clopidogrel to be safe and beneficial, there is inevitably a range in how each patient responds.The review covers about Clopidogrel resistance in stroke patients, their risk factors and the methods to identify it. Clopidogrel resistance is characterized as the drug's inability to prevent the target enzyme from acting. The prognosis of patients with ischemic stroke and the responsiveness to clopidogrel are significantly impacted by the various genetic polymorphism CYP2C19 genotypes. The two primary mutant alleles, CYP2C19 *2 and CYP2C19 *3, have been found to be the most prevalent genotypes. Better mRS scores six months after treatment showed a higher response rate in patients without these CYP2C19 variant alleles. Other factors are drug-drug interaction (proton pump inhibitors), demographics (age, sex, social history), comorbid conditions, etc. Blood samples for testing platelet reactivity were drawn one month after discharge from a peripheral blood sample. Several methods are used to identify the clopidogrel resistance. Some of them are ADP-Induced platelet aggregation, Platelet Reactivity Index VASP, Verify Now Assay, TEG Analyzer, Plasma microRNA-223. Drugs that are not prodrugs and whose metabolism is not dependent upon CYP2C19 can be selected as a superior alternative in case of CR. Ticagrelor is one such effective substitute. Proton pump inhibitors and clopidogrel should only be used concurrently in patients with reliable clinical indications.","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141750864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CADASIL Type 2 (HTRA1 Cerebral Small Vessel Disease) in an Indian Woman. 一名印度妇女的 CADASIL 2 型（HTRA1 脑小血管病）。

IF 1.9 4区医学

Annals of Indian Academy of Neurology Pub Date : 2024-07-12 DOI: 10.4103/aian.aian_174_24

Boby Varkey Maramattom

引用次数: 0

Primary CNS Vasculitis Mimicking Brainstem Encephalitis. 模仿脑干脑炎的原发性中枢神经系统血管炎

IF 1.9 4区医学

Annals of Indian Academy of Neurology Pub Date : 2024-07-12 DOI: 10.4103/aian.aian_189_24

Ayush Agarwal, Venugopalan Y Vishnu, Divyani Garg, Ajay Garg, Meher Chand Sharma, Achal K Srivastava, M V Padma Srivastava

引用次数: 0

Neurodevelopmental Disorder with Severe Motor Impairment and Absent Language (NEDMIAL) Due to DHX30 Mutations: First Indian Report of Two Cases. DHX30 基因突变导致的严重运动障碍和无语言的神经发育障碍（NEDMIAL）：印度首次报告的两例病例。

IF 1.9 4区医学

Annals of Indian Academy of Neurology Pub Date : 2024-07-01 Epub Date: 2024-08-16 DOI: 10.4103/aian.aian_253_24

Pradeep Kumar Gunasekaran, Yashu Sharma, Vikas Bhatia, Arushi Gahlot Saini

引用次数: 0

Safety and Efficacy of Newer Oral Anticoagulants Versus Vitamin K Antagonists in the Management of Cerebral Venous Thrombosis: A Single-Center Ambispective Study from South India. 新型口服抗凝剂与维生素 K 拮抗剂治疗脑静脉血栓的安全性和有效性：印度南部单中心前瞻性研究》。

IF 1.9 4区医学

Annals of Indian Academy of Neurology Pub Date : 2024-07-01 Epub Date: 2024-06-21 DOI: 10.4103/aian.aian_1096_23

Rithvik Ramesh, Lakshmi Narasimhan Ranganathan, Sriram Raguraman, Kamlesh Jayakumar, Braveen Rajamanoharan, Varun Kishore Loganathan, Philo Hazeena, Sundar Shanmugam, Deepa Avadhani, Karthik Sankar

{"title":"Safety and Efficacy of Newer Oral Anticoagulants Versus Vitamin K Antagonists in the Management of Cerebral Venous Thrombosis: A Single-Center Ambispective Study from South India.","authors":"Rithvik Ramesh, Lakshmi Narasimhan Ranganathan, Sriram Raguraman, Kamlesh Jayakumar, Braveen Rajamanoharan, Varun Kishore Loganathan, Philo Hazeena, Sundar Shanmugam, Deepa Avadhani, Karthik Sankar","doi":"10.4103/aian.aian_1096_23","DOIUrl":"10.4103/aian.aian_1096_23","url":null,"abstract":"Introduction: Cerebral Venous Thrombosis (CVT) poses a rare but life-threatening challenge, warranting meticulous treatment approaches. Traditional therapy involves Vitamin K Antagonists (VKAs), but Newer Oral Anticoagulants (NOACs) offer potential advantages. This study addresses a crucial knowledge gap in the Indian context, analyzing real-world data to guide CVT management decisions.Methods: A single-center, ambispective cohort study included consecutive adult CVT patients. Data collection encompassed demographics, clinical data, imaging, and treatment details. Patients were categorized into VKA and NOAC groups. Outcomes measured recanalization status, functional outcomes, bleeding events, and adverse drug reactions.Results: Among 181 enrolled patients, NOAC-treated (Group B) individuals had significantly higher rates of complete recanalization (58.5% vs. 31.1%) with a similar incidence of adverse events and also displayed better functional outcomes at weeks 8 and 12 compared to VKA-treated (Group A) patients. Recurrent thromboembolic events were absent in both groups during follow-up.Conclusion: This study highlights NOACs' potential advantages in CVT management, including improved functional outcomes, enhanced recanalization, and similar bleeding risk. Adverse events were milder with NOACs. While acknowledging limitations, these findings support NOACs as a promising alternative to VKAs, advancing CVT care and outcomes.","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141431241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cervical Artery Dissection: Clinical Outcomes and Functional Outcome Predictors from a Tertiary Care Center in India. 颈动脉离断：来自印度一家三级医疗中心的临床结果和功能性结果预测指标。

IF 1.9 4区医学

Annals of Indian Academy of Neurology Pub Date : 2024-07-01 Epub Date: 2024-07-18 DOI: 10.4103/aian.aian_134_24

Ayush Agarwal, Ajay Garg, Yamini Antil, Rohit Bhatia, Leve Joseph, Agrata Sharma, Sushant Agarwal, Ashish Upadhyay, Venugopalan Y Vishnu, M V Padma Srivastava

引用次数: 0

LEUDEN Syndrome: A Novel Hypomyelinating Leukoencephalopathy in a 1-Year-Old Girl. LEUDEN 综合征：一名 1 岁女童的新型骨髓抑制性白质脑病

IF 1.9 4区医学

Annals of Indian Academy of Neurology Pub Date : 2024-07-01 Epub Date: 2024-08-16 DOI: 10.4103/aian.aian_257_24

Singanamalla Bhanudeep, Bramhini Bhargavi Koneti

引用次数: 0

Remote Intracerebral Haemorrhage Secondary to Vessel Rupture Following Bridging Intravenous Thrombolysis (Causal or Incidental) with Successful Endovascular Treatment: A Rare Case Report. 静脉溶栓（因果或偶然）与血管内治疗成功衔接后，血管破裂继发远端脑出血：罕见病例报告。

IF 1.9 4区医学

Annals of Indian Academy of Neurology Pub Date : 2024-07-01 Epub Date: 2024-08-23 DOI: 10.4103/aian.aian_285_24

Piyush Ojha, Gaurav Goel, Mandar Waghralkar, Anshu Mahajan

引用次数: 0

Thrombolysis for Ischemic Stroke Despite Recent Ingestion of Direct Oral Anticoagulants - A Growing Dilemma Also in India. 尽管最近服用了直接口服抗凝剂，缺血性脑卒中仍需溶栓治疗--这在印度也是一个日益严重的难题。

IF 1.9 4区医学

Annals of Indian Academy of Neurology Pub Date : 2024-07-01 Epub Date: 2024-08-20 DOI: 10.4103/aian.aian_524_24

Thomas R Meinel, Naveen K Paramasivan, Bijoy K Menon, Urs Fischer, David J Seiffge

{"title":"Thrombolysis for Ischemic Stroke Despite Recent Ingestion of Direct Oral Anticoagulants - A Growing Dilemma Also in India.","authors":"Thomas R Meinel, Naveen K Paramasivan, Bijoy K Menon, Urs Fischer, David J Seiffge","doi":"10.4103/aian.aian_524_24","DOIUrl":"10.4103/aian.aian_524_24","url":null,"abstract":"The administration of intravenous thrombolysis (IVT) for patients with acute ischemic stroke who have recently ingested direct oral anticoagulants (DOACs) presents a clinical challenge due to the perceived increased risk of intracranial hemorrhage (ICH). Traditional guidelines from the US and European authorities advise against IVT within 48 h of last DOAC ingestion, unless specific coagulation tests indicate safety. However, emerging observational studies suggest that IVT might be safe in selected patients. A US stroke registry study and a global multicenter cohort study both reported no significant increase in symptomatic ICH among patients on DOACs compared to those not on anticoagulants. A systematic review of all published observational studies further supported these findings, showing comparable bleeding rates and functional outcomes in DOAC-treated patients. Reversal agents like idarucizumab for dabigatran have demonstrated potential in facilitating safer IVT administration, though logistical and cost-related barriers limit their widespread use. The variability in global guidelines reflects differing approaches to risk assessment and resource availability, highlighting the need for individualized treatment decisions. In India, the increasing prevalence of atrial fibrillation and stroke as well as prescription of DOACs necessitate adapted guidelines that consider local health-care infrastructure. Despite the promising observational data, the lack of randomized controlled trials underscores the need for further research to establish robust evidence for IVT use in this context. Collaborative international efforts and inclusion of diverse patient populations in future studies will be crucial to refine treatment protocols and improve outcomes for stroke patients on DOACs.","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142085949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0