Annals of Indian Academy of Neurology最新文献_第10页

Correspondence: "Long-Term Effects of Deep Brain Stimulation on Non-Motor Symptoms in Patients with Parkinson's Disease". 对应：“脑深部刺激对帕金森病患者非运动症状的长期影响”。

IF 1.8 4区医学

Annals of Indian Academy of Neurology Pub Date : 2026-01-01 Epub Date: 2026-01-22 DOI: 10.4103/aian.aian_947_25

Shayan Sharifi, Alisina Mirzaei

引用次数: 0

Ictal Bruxism - A Sign of Temporal Lobe Ictal Localization: A Case Series. 尖牙磨牙-颞叶尖牙定位的标志：一个病例系列。

IF 1.8 4区医学

Annals of Indian Academy of Neurology Pub Date : 2026-01-01 Epub Date: 2026-01-31 DOI: 10.4103/aian.aian_814_25

Sita Jayalakshmi, Anuja Patil, Dhrumil Shah, Mihir Parekh, Sudhindra Vooturi, Manas Panigrahi

引用次数: 0

Interpeduncular Angle: A Possible Marker to Differentiate Atypical Parkinsonism from Idiopathic Parkinson's Disease. 椎弓根间角：鉴别非典型帕金森病与特发性帕金森病的可能标志。

IF 1.8 4区医学

Annals of Indian Academy of Neurology Pub Date : 2026-01-01 Epub Date: 2025-11-21 DOI: 10.4103/aian.aian_357_25

Tejas Shivarthi, Mahima Sriram, Udit Saraf, Rajesh Kannan, Sudheeran Kannoth, Abish Sudhakar, Vivek Nambiar, Siby Gopinath, Gopikrishnan Unnikrishnan, Anandkumar Anandakuttan

{"title":"Interpeduncular Angle: A Possible Marker to Differentiate Atypical Parkinsonism from Idiopathic Parkinson's Disease.","authors":"Tejas Shivarthi, Mahima Sriram, Udit Saraf, Rajesh Kannan, Sudheeran Kannoth, Abish Sudhakar, Vivek Nambiar, Siby Gopinath, Gopikrishnan Unnikrishnan, Anandkumar Anandakuttan","doi":"10.4103/aian.aian_357_25","DOIUrl":"10.4103/aian.aian_357_25","url":null,"abstract":"Atypical parkinsonian disorders (APD), such as progressive supranuclear palsy (PSP), multiple system atrophy (MSA), corticobasal syndrome (CBS), and Lewy body dementia (LBD) are frequently misdiagnosed, commonly as Parkinson's disease (PD). The study aims to assess the utility of the interpeduncular angle (IPA) in distinguishing APD from PD across age ranges. This retrospective study was conducted with 225 patients (75 with APD, 75 with PD, and 75 healthy controls). Patients were categorized into three age groups: (51-60, 61-70, and 71-80 years). Two independent raters measured the IPA from T1-weighted axial brain magnetic resonance images (MRIs) at a level below the mammillary bodies using standardized measurement techniques. The APD group included 51 (68%) with PSP, 16 (21.33%) with MSA, 5 (6.67%) with LBD, and 3 (4%) with CBS. Bland-Altman analysis for angle measurement suggested good to excellent agreement between raters ( P < 0.001). IPA measurements among the different diagnostic groups showed that PSP was higher than controls ( P < 0.001) and PD ( P < 0.001), and MSA was higher than controls ( P < 0.001) and PD ( P = 0.003). There was no significant association between IPA and age in the APD phenotypes. With increasing age, the significance between APD and IPD groups decreased ( P < 0.001 in 51-60 years to P = 0.686 in 71-80 years). Receiver Operating Characteristic (ROC) analysis revealed increasing IPA thresholds for PSP versus PD (67.66° in 51-60 years to 75.71° in 71-80 years). IPA is not reliable in differentiating APD, particularly PSP and MSA, from PD and controls.","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":"71-75"},"PeriodicalIF":1.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145562473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Presentation and Evolution of Isolated Focal and Segmental Dystonia in Adults - 20 Years' Experience from a Botulinum Toxin Clinic. 成人孤立性局灶性和节段性肌张力障碍的临床表现和演变- 20年肉毒杆菌毒素临床经验。

IF 1.8 4区医学

Annals of Indian Academy of Neurology Pub Date : 2026-01-01 Epub Date: 2026-02-20 DOI: 10.4103/aian.aian_784_25

Asish Vijayaraghavan, Syam Krishnan, Khushboo Subash Patel, Sm Krishna Mohan, Vineeth Radhakrishnan, Anju Sanalkumar, S Gangadhara Sarma, Ajith Cherian, Divya Kalikavil Puthanveedu

{"title":"Clinical Presentation and Evolution of Isolated Focal and Segmental Dystonia in Adults - 20 Years' Experience from a Botulinum Toxin Clinic.","authors":"Asish Vijayaraghavan, Syam Krishnan, Khushboo Subash Patel, Sm Krishna Mohan, Vineeth Radhakrishnan, Anju Sanalkumar, S Gangadhara Sarma, Ajith Cherian, Divya Kalikavil Puthanveedu","doi":"10.4103/aian.aian_784_25","DOIUrl":"10.4103/aian.aian_784_25","url":null,"abstract":"Background and objectives: Isolated dystonia generally occurs due to genetic causes, and the pattern and distribution may change over time. Botulinum toxin is the first-line treatment in those with isolated focal and segmental dystonia. We aimed to describe the clinical profile and evolution of adult patients with isolated focal and segmental dystonia presenting for treatment in our botulinum neurotoxin (BoNT) clinic, and the response to treatment, over 20 years.Methods: We retrospectively reviewed the medical records of patients with isolated focal and segmental dystonia who had at least two visits in our BoNT clinic. The clinical features at presentation and during follow-up, muscles injected for each type of dystonia, the self-reported benefit with BoNT, and adverse effects were analyzed.Results: Five hundred seventy-eight patients with isolated dystonia were injected and had at least one additional follow-up. Five hundred seventeen (89.4%) had focal dystonia, and 61 (10.6%) had segmental dystonia. Cervical dystonia was the most common type. Spread to other regions was seen in 81 (14%) of patients. Those with blepharospasm as initial presentation tended to have the highest occurrence (27.3%) of spread to other parts. The mean response to BoNT was around 68%. The presence of a sensory trick and the absence of tremor were found to be predictors of good outcomes with BoNT.Conclusions: Isolated focal and segmental dystonia in adults has a good prognosis, with the majority responding well to BoNT and the dystonia remaining confined to the initially affected body part. Our study provides evidence for the response to BoNT therapy in a real-world scenario, outside of a clinical trial setting.","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":"28-34"},"PeriodicalIF":1.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146257195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Authors' reply- Letter Regarding the Article Entitled "Prevalence, Risk Factors, and Psychosocial Impact of Restless Legs Syndrome in End-Stage Renal Disease Patients Undergoing Hemodialysis". 作者关于《终末期肾病血液透析患者不宁腿综合征的患病率、危险因素和社会心理影响》一文的回复。

IF 1.8 4区医学

Annals of Indian Academy of Neurology Pub Date : 2026-01-01 Epub Date: 2026-02-18 DOI: 10.4103/aian.aian_1075_25

Alamanda V Anupama, Anish Mehta, Mahendra Javali, E Mahesh, Pradeep Rangaiah, Purushottam Acharya

引用次数: 0

Fulminant Intracranial Hypertension Secondary to Multiple Cavernomas: A Rare Association. 多发海绵状瘤继发暴发性颅内高压：一种罕见的关联。

IF 1.8 4区医学

Annals of Indian Academy of Neurology Pub Date : 2026-01-01 Epub Date: 2025-11-28 DOI: 10.4103/aian.aian_845_25

Vaibhav Bhandari, Savyasachi Jain, Ayush Agarwal, Divyani Garg, Shailesh B Gaikwad, Achal K Srivastava

引用次数: 0

Robot-Assisted Gait Therapy in the Subacute Phase of Ischemic Stroke: A Randomized Controlled Trial. 机器人辅助步态治疗缺血性中风亚急性期：一项随机对照试验。

IF 1.8 4区医学

Annals of Indian Academy of Neurology Pub Date : 2026-01-01 Epub Date: 2025-11-28 DOI: 10.4103/aian.aian_526_25

Iva Fiedorova, Sarka Banikova, Tomas Adamec, Adela Konde, Pavla Hanzlikova, Aravind Ganesh, Michal Bar, Ondrej Volny

{"title":"Robot-Assisted Gait Therapy in the Subacute Phase of Ischemic Stroke: A Randomized Controlled Trial.","authors":"Iva Fiedorova, Sarka Banikova, Tomas Adamec, Adela Konde, Pavla Hanzlikova, Aravind Ganesh, Michal Bar, Ondrej Volny","doi":"10.4103/aian.aian_526_25","DOIUrl":"10.4103/aian.aian_526_25","url":null,"abstract":"Background and objectives: Robot-assisted gait training (RAGT) constitutes a modern neurorehabilitation approach. However, limited data are available regarding the efficacy of RAGT when combined with conventional rehabilitation in the early subacute phase of stroke. This pilot study assessed the additive impact of protocol-defined RAGT on functional ambulation categories (FACs), walking abilities, and balance.Methods: This randomized controlled trial used a 1:1 Prospective Randomized Open Blinded End-point design (NCT04910217), comparing two groups: conventional rehabilitation and the RAGT group. All participants received protocol-defined conventional rehabilitation (15 sessions over 3 weeks). The RAGT group underwent additional sessions using the Lokomat Pro FreeD (15 sessions over 3 weeks). FAC, 10-meter Walk Test (10MWT), Timed Up and Go (TUG), and Berg Balance Scale (BBS) were assessed at 3 weeks and 3 months after randomization. In addition, the modified Rankin Scale was evaluated.Results: Among 184 patients screened between June 1, 2020, and November 30, 2023, 42 were included (19 in the RAGT group and 23 in the conventional group). The median time from stroke to randomization was 13 days (interquartile range [IQR]: 11-16), and the median age was 67 years (IQR: 58-71). Both groups demonstrated improvements in FACs. Significantly, patients in the RAGT group showed better results in the endpoint of FAC improvement by 2 or more points ( P = 0.044). Progress in TUG ( P = 0.034) and BBS ( P = 0.049) during the study period was significantly more favorable in the RAGT group.Conclusions: The addition of RAGT to conventional rehabilitation in the subacute phase of stroke exhibited positive effects on improving gait, walking, and balance.Trial registration number: NCT04910217.","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":"52-58"},"PeriodicalIF":1.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145627507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary Adult Ventriculitis due to Streptococcus pneumoniae with Obstructive Hydrocephalus: Role of Arachnoid Cyst as a Predisposing Factor. 肺炎链球菌合并阻塞性脑积水导致的原发性成人脑室炎：蛛网膜囊肿作为易感因素的作用。

IF 1.8 4区医学

Annals of Indian Academy of Neurology Pub Date : 2026-01-01 Epub Date: 2025-11-26 DOI: 10.4103/aian.aian_406_25

Bhavani Madduluri, Phaninder Ln Madiraju, Surya Prabha Turaga

引用次数: 0

Case Report of Andersen-Tawil Syndrome: Rare Presentation of a Rare Disease. 安徒生-塔威尔综合征病例报告：罕见疾病的罕见表现。

IF 1.8 4区医学

Annals of Indian Academy of Neurology Pub Date : 2026-01-01 Epub Date: 2025-11-18 DOI: 10.4103/aian.aian_498_25

Himanshu Shakya, Shivangi Bhatnagar, Pratik Babel, Suman Kushwaha, Rajinder K Dhamija

引用次数: 0

Subclinical Respiratory Muscle Weakness and Obstructive Sleep Apnea are Common in Glucosamine-UDP-N-acetyl-2-epimerase / N-acetylmannosamine kinase (GNE) Myopathy. 亚临床呼吸肌无力和阻塞性睡眠呼吸暂停在葡萄糖胺- udp - n -乙酰-2- epimase / n -乙酰甘露氨基激酶（GNE）肌病中很常见。

IF 1.8 4区医学

Annals of Indian Academy of Neurology Pub Date : 2026-01-01 Epub Date: 2026-02-03 DOI: 10.4103/aian.aian_725_25

Esen Kiyan, Aylin Pihtili, Hacer Durmus, Yesim Parman

引用次数: 0