发布求助
文献互助 智能选刊 最新文献

Annual review of genetics最新文献

筛选
英文 中文
The Nature and Nurture of Extracellular Vesicle-Mediated Signaling. 细胞外囊泡介导的信号传导的性质和发展。
IF 8.7 1区 生物学
Annual review of genetics Pub Date : 2024-11-01 Epub Date: 2024-11-14 DOI: 10.1146/annurev-genet-111523-102725
Amy H Buck, Esther N M Nolte-'t Hoen
{"title":"The Nature and Nurture of Extracellular Vesicle-Mediated Signaling.","authors":"Amy H Buck, Esther N M Nolte-'t Hoen","doi":"10.1146/annurev-genet-111523-102725","DOIUrl":"10.1146/annurev-genet-111523-102725","url":null,"abstract":"<p><p>In the last decade, it has become clear that extracellular vesicles (EVs) are a ubiquitous component of living systems. These small membrane-enclosed particles can confer diverse functions to the cells that release, capture, or coexist with them in an environment. We use examples across living systems to produce a conceptual framework that classifies three modes by which EVs exert functions: (<i>a</i>) EV release that serves a function for producing cells, (<i>b</i>) EV modification of the extracellular environment, and (<i>c</i>) EV interactions with, and alteration of, receiving cells. We provide an overview of the inherent properties of EVs (i.e., their nature) as well as factors in the environment and receiving cell (i.e., nurture) that determine whether transmission of EV cargo leads to functional cellular responses. This review broadens the context for ruminating on EV functions and highlights the emergent properties of EVs that define their role in biology and will shape their applications in medicine.</p>","PeriodicalId":8035,"journal":{"name":"Annual review of genetics","volume":" ","pages":"409-432"},"PeriodicalIF":8.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142131581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developmental and Genetic Aspects of Desert Crops. 沙漠作物的发育和遗传方面。
IF 8.7 1区 生物学
Annual review of genetics Pub Date : 2024-11-01 DOI: 10.1146/annurev-genet-111523-102338
Wouter Smet, Ikram Blilou
{"title":"Developmental and Genetic Aspects of Desert Crops.","authors":"Wouter Smet, Ikram Blilou","doi":"10.1146/annurev-genet-111523-102338","DOIUrl":"10.1146/annurev-genet-111523-102338","url":null,"abstract":"<p><p>Deserts are hostile environments to plant life due to exposure to abiotic stresses, including high temperature, heat, high light, low water availability, and poor soil quality. Desert plants have evolved to cope with these stresses, and for thousands of years humans have used these plants as sources of food, fiber, and medicine. Due to desertification, the amount of arable land is reduced every year; hence, the usage of these species as substitutes for some crops might become one of the solutions for food production and land remediation. Additionally, increasing our understanding of how these plants have adapted to their environment could aid in the generation of more resistant staple crops. In this review, we examine three desert plant species and discuss their developmental aspects, physiological adaptations, and genetic diversity and the related genomic resources available to date. We also address major environmental challenges and threats faced by these species as well as their potential use for improving food security through stimulating stress resistance in crops.</p>","PeriodicalId":8035,"journal":{"name":"Annual review of genetics","volume":"58 1","pages":"91-112"},"PeriodicalIF":8.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meiotic Drive and Speciation. 减数分裂驱动与物种繁衍
IF 8.7 1区 生物学
Annual review of genetics Pub Date : 2024-11-01 DOI: 10.1146/annurev-genet-111523-102603
Jeremy B Searle, Fernando Pardo-Manuel de Villena
{"title":"Meiotic Drive and Speciation.","authors":"Jeremy B Searle, Fernando Pardo-Manuel de Villena","doi":"10.1146/annurev-genet-111523-102603","DOIUrl":"10.1146/annurev-genet-111523-102603","url":null,"abstract":"<p><p>Meiotic drive is the biased transmission of alleles from heterozygotes, contrary to Mendel's laws, and reflects intragenomic conflict rather than organism-level Darwinian selection. Theory has been developed as to how centromeric properties can promote female meiotic drive and how conflict between the X and Y chromosomes in males can promote male meiotic drive. There are empirical data that fit both the centromere drive and sex chromosome drive models. Sex chromosome drive may have relevance to speciation through the buildup of Dobzhansky-Muller incompatibilities involving drive and suppressor systems, studied particularly in <i>Drosophila</i>. Centromere drive may promote fixation of chromosomal rearrangements involving the centromere, and those fixed rearrangements may contribute to reproductive isolation, studied particularly in the house mouse. Genome-wide tests suggest that meiotic drive promotes allele fixation with regularity, and those studying the genomics of speciation need to be aware of the potential impact of such fixations on reproductive isolation. New species can originate in many different ways (including multiple factors acting together), and a substantial body of work on meiotic drive point to it being one of the processes involved.</p>","PeriodicalId":8035,"journal":{"name":"Annual review of genetics","volume":"58 1","pages":"341-363"},"PeriodicalIF":8.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recombination Rate Variation in Social Insects: An Adaptive Perspective. 社会性昆虫的重组率变异：适应性视角。
IF 8.7 1区 生物学
Annual review of genetics Pub Date : 2024-11-01 Epub Date: 2024-11-14 DOI: 10.1146/annurev-genet-111523-102550
Timothy J DeLory, Jonathan Romiguier, Olav Rueppell, Karen M Kapheim
{"title":"Recombination Rate Variation in Social Insects: An Adaptive Perspective.","authors":"Timothy J DeLory, Jonathan Romiguier, Olav Rueppell, Karen M Kapheim","doi":"10.1146/annurev-genet-111523-102550","DOIUrl":"10.1146/annurev-genet-111523-102550","url":null,"abstract":"<p><p>Social insects have the highest rates of meiotic recombination among Metazoa, but there is considerable variation within the Hymenoptera. We synthesize the literature to investigate several hypotheses for these elevated recombination rates. We reexamine the long-standing Red Queen hypothesis, considering how social aspects of immunity could lead to increases in recombination. We examine the possibility of positive feedback between gene duplication and recombination rate in the context of caste specialization. We introduce a novel hypothesis that recombination rate may be driven up by direct selection on recombination activity in response to increases in lifespan. Finally, we find that the role of population size in recombination rate evolution remains opaque, despite the long-standing popularity of this hypothesis. Moreover, our review emphasizes how the varied life histories of social insect species provide an effective framework for advancing a broader understanding of adaptively driven variation in recombination rates.</p>","PeriodicalId":8035,"journal":{"name":"Annual review of genetics","volume":" ","pages":"159-181"},"PeriodicalIF":8.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141578834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Apoptotic and Nonapoptotic Cell Death in Caenorhabditis elegans Development. 草履虫发育过程中的细胞凋亡与非凋亡
IF 8.7 1区 生物学
Annual review of genetics Pub Date : 2024-11-01 Epub Date: 2024-11-14 DOI: 10.1146/annurev-genet-111523-102051
Lauren Bayer Horowitz, Shai Shaham
{"title":"Apoptotic and Nonapoptotic Cell Death in <i>Caenorhabditis elegans</i> Development.","authors":"Lauren Bayer Horowitz, Shai Shaham","doi":"10.1146/annurev-genet-111523-102051","DOIUrl":"10.1146/annurev-genet-111523-102051","url":null,"abstract":"<p><p>Programmed cell death (PCD) is an essential component of animal development, and aberrant cell death underlies many disorders. Understanding mechanisms that govern PCD during development can provide insight into cell death programs that are disrupted in disease. Key steps mediating apoptosis, a highly conserved cell death program employing caspase proteases, were first uncovered in the nematode <i>Caenorhabditis elegans</i>, a powerful model system for PCD research. Recent studies in <i>C. elegans</i> also unearthed conserved nonapoptotic caspase-independent cell death programs that function during development. Here, we discuss recent advances in understanding cell death during <i>C. elegans</i> development. We review insights expanding the molecular palette behind the execution of apoptotic and nonapoptotic cell death, as well as new discoveries revealing the mechanistic underpinnings of dying cell engulfment and clearance. A number of open questions are also discussed that will continue to propel the field over the coming years.</p>","PeriodicalId":8035,"journal":{"name":"Annual review of genetics","volume":" ","pages":"113-134"},"PeriodicalIF":8.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141490586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Mammals to Insects: Exploring the Genetic and Neural Basis of Eating Behavior. 从哺乳动物到昆虫：探索进食行为的遗传和神经基础。
IF 8.7 1区 生物学
Annual review of genetics Pub Date : 2024-11-01 DOI: 10.1146/annurev-genet-111523-102202
Deepthi Mahishi, Naman Agrawal, Wenshuai Jiang, Nilay Yapici
{"title":"From Mammals to Insects: Exploring the Genetic and Neural Basis of Eating Behavior.","authors":"Deepthi Mahishi, Naman Agrawal, Wenshuai Jiang, Nilay Yapici","doi":"10.1146/annurev-genet-111523-102202","DOIUrl":"10.1146/annurev-genet-111523-102202","url":null,"abstract":"<p><p>Obesity and anorexia are life-threatening diseases that are still poorly understood at the genetic and neuronal levels. Patients suffering from these conditions experience disrupted regulation of food consumption, leading to extreme weight gain or loss and, in severe situations, death from metabolic dysfunction. Despite the development of various behavioral and pharmacological interventions, current treatments often yield limited and short-lived success. To address this, a deeper understanding of the genetic and neural mechanisms underlying food perception and appetite regulation is essential for identifying new drug targets and developing more effective treatment methods. This review summarizes the progress of past research in understanding the genetic and neural mechanisms controlling food consumption and appetite regulation, focusing on two key model organisms: the fruit fly <i>Drosophila melanogaster</i> and the mouse <i>Mus musculus</i>. These studies investigate how the brain senses energy and nutrient deficiency, how sensory signals trigger appetitive behaviors, and how food intake is regulated through interconnected neural circuits in the brain.</p>","PeriodicalId":8035,"journal":{"name":"Annual review of genetics","volume":"58 1","pages":"455-485"},"PeriodicalIF":8.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cellular, Molecular, and Genetic Mechanisms of Avian Beak Development and Evolution. 鸟喙发育和进化的细胞、分子和遗传机制。
IF 8.7 1区 生物学
Annual review of genetics Pub Date : 2024-11-01 Epub Date: 2024-11-14 DOI: 10.1146/annurev-genet-111523-101929
Richard A Schneider
{"title":"Cellular, Molecular, and Genetic Mechanisms of Avian Beak Development and Evolution.","authors":"Richard A Schneider","doi":"10.1146/annurev-genet-111523-101929","DOIUrl":"10.1146/annurev-genet-111523-101929","url":null,"abstract":"<p><p>Diverse research programs employing complementary strategies have been uncovering cellular, molecular, and genetic mechanisms essential to avian beak development and evolution. In reviewing these discoveries, I offer an interdisciplinary perspective on bird beaks that spans their derivation from jaws of dinosaurian reptiles, their anatomical and ecological diversification across major taxonomic groups, their common embryonic origins, their intrinsic patterning processes, and their structural integration. I describe how descriptive and experimental approaches, including gene expression and cell lineage analyses, tissue recombinations, surgical transplants, gain- and loss-of-function methods, geometric morphometrics, comparative genomics, and genome-wide association studies, have identified key constituent parts and putative genes regulating beak morphogenesis and evolution. I focus throughout on neural crest mesenchyme, which generates the beak skeleton and other components, and describe how these embryonic progenitor cells mediate species-specific pattern and link form and function as revealed by 20 years of research using chimeras between quail and duck embryos.</p>","PeriodicalId":8035,"journal":{"name":"Annual review of genetics","volume":" ","pages":"433-454"},"PeriodicalIF":8.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11777486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142124630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Prokaryotic Roots of Eukaryotic Immune Systems 真核生物免疫系统的原核根源
IF 11.1 1区 生物学
Annual review of genetics Pub Date : 2024-09-12 DOI: 10.1146/annurev-genet-111523-102448
L. Aravind, Gianlucca G. Nicastro, Lakshminarayan M. Iyer, A. Maxwell Burroughs
{"title":"The Prokaryotic Roots of Eukaryotic Immune Systems","authors":"L. Aravind, Gianlucca G. Nicastro, Lakshminarayan M. Iyer, A. Maxwell Burroughs","doi":"10.1146/annurev-genet-111523-102448","DOIUrl":"https://doi.org/10.1146/annurev-genet-111523-102448","url":null,"abstract":"Over the past two decades, studies have revealed profound evolutionary connections between prokaryotic and eukaryotic immune systems, challenging the notion of their unrelatedness. Immune systems across the tree of life share an operational framework, shaping their biochemical logic and evolutionary trajectories. The diversification of immune genes in the prokaryotic superkingdoms, followed by lateral transfer to eukaryotes, was central to the emergence of innate immunity in the latter. These include protein domains related to nucleotide second messenger–dependent systems, NAD+/nucleotide degradation, and P-loop NTPase domains of the STAND and GTPase clades playing pivotal roles in eukaryotic immunity and inflammation. Moreover, several domains orchestrating programmed cell death, ultimately of prokaryotic provenance, suggest an intimate link between immunity and the emergence of multicellularity in eukaryotes such as animals. While eukaryotes directly adopted some proteins from bacterial immune systems, they repurposed others for new immune functions from bacterial interorganismal conflict systems. These emerging immune components hold substantial biotechnological potential.","PeriodicalId":8035,"journal":{"name":"Annual review of genetics","volume":"21 1","pages":""},"PeriodicalIF":11.1,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142209789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paramecium Genetics, Genomics, and Evolution. 草履虫遗传学、基因组学和进化。
IF 8.7 1区 生物学
Annual review of genetics Pub Date : 2023-11-27 DOI: 10.1146/annurev-genet-071819-104035
Hongan Long, Parul Johri, Jean-Francois Gout, Jiahao Ni, Yue Hao, Timothy Licknack, Yaohai Wang, Jiao Pan, Berenice Jiménez-Marín, Michael Lynch
{"title":"<i>Paramecium</i> Genetics, Genomics, and Evolution.","authors":"Hongan Long, Parul Johri, Jean-Francois Gout, Jiahao Ni, Yue Hao, Timothy Licknack, Yaohai Wang, Jiao Pan, Berenice Jiménez-Marín, Michael Lynch","doi":"10.1146/annurev-genet-071819-104035","DOIUrl":"10.1146/annurev-genet-071819-104035","url":null,"abstract":"<p><p>The ciliate genus <i>Paramecium</i> served as one of the first model systems in microbial eukaryotic genetics, contributing much to the early understanding of phenomena as diverse as genome rearrangement, cryptic speciation, cytoplasmic inheritance, and endosymbiosis, as well as more recently to the evolution of mating types, introns, and roles of small RNAs in DNA processing. Substantial progress has recently been made in the area of comparative and population genomics. <i>Paramecium</i> species combine some of the lowest known mutation rates with some of the largest known effective populations, along with likely very high recombination rates, thereby harboring a population-genetic environment that promotes an exceptionally efficient capacity for selection. As a consequence, the genomes are extraordinarily streamlined, with very small intergenic regions combined with small numbers of tiny introns. The subject of the bulk of <i>Paramecium</i> research, the ancient <i>Paramecium aurelia</i> species complex, is descended from two whole-genome duplication events that retain high degrees of synteny, thereby providing an exceptional platform for studying the fates of duplicate genes. Despite having a common ancestor dating to several hundred million years ago, the known descendant species are morphologically indistinguishable, raising significant questions about the common view that gene duplications lead to the origins of evolutionary novelties.</p>","PeriodicalId":8035,"journal":{"name":"Annual review of genetics","volume":"57 ","pages":"391-410"},"PeriodicalIF":8.7,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11334263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138443646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms Underlying the Formation and Evolution of Vertebrate Color Patterns. 脊椎动物颜色模式形成和进化的机制。
IF 8.7 1区 生物学
Annual review of genetics Pub Date : 2023-11-27 Epub Date: 2023-07-24 DOI: 10.1146/annurev-genet-031423-120918
Claudius F Kratochwil, Ricardo Mallarino
{"title":"Mechanisms Underlying the Formation and Evolution of Vertebrate Color Patterns.","authors":"Claudius F Kratochwil, Ricardo Mallarino","doi":"10.1146/annurev-genet-031423-120918","DOIUrl":"10.1146/annurev-genet-031423-120918","url":null,"abstract":"<p><p>Vertebrates exhibit a wide range of color patterns, which play critical roles in mediating intra- and interspecific communication. Because of their diversity and visual accessibility, color patterns offer a unique and fascinating window into the processes underlying biological organization. In this review, we focus on describing many of the general principles governing the formation and evolution of color patterns in different vertebrate groups. We characterize the types of patterns, review the molecular and developmental mechanisms by which they originate, and discuss their role in constraining or facilitating evolutionary change. Lastly, we outline outstanding questions in the field and discuss different approaches that can be used to address them. Overall, we provide a unifying conceptual framework among vertebrate systems that may guide research into naturally evolved mechanisms underlying color pattern formation and evolution.</p>","PeriodicalId":8035,"journal":{"name":"Annual review of genetics","volume":" ","pages":"135-156"},"PeriodicalIF":8.7,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10805968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9864966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信