发布求助
文献互助 智能选刊 最新文献

Annual review of genetics最新文献

筛选
英文 中文
The Red Queen and the Timescale of Antagonistic Coevolution: Parasite Selection for Genetic Diversity. 红皇后与拮抗协同进化的时间尺度：遗传多样性的寄生虫选择。
IF 8.6 1区 生物学
Annual review of genetics Pub Date : 2025-11-01 Epub Date: 2025-08-06 DOI: 10.1146/annurev-genet-112024-091229
Dieter Ebert
{"title":"The Red Queen and the Timescale of Antagonistic Coevolution: Parasite Selection for Genetic Diversity.","authors":"Dieter Ebert","doi":"10.1146/annurev-genet-112024-091229","DOIUrl":"10.1146/annurev-genet-112024-091229","url":null,"abstract":"<p><p>The Red Queen model of antagonistic coevolution has been the preferred explanation for certain biological phenomena, such as extreme genetic diversity and <i>trans</i>-species polymorphisms in disease genes. This model has been studied on diverse timescales using direct observations (covering days to a few years), archived material (several decades), postglacial processes (about 10,000 years), and phylogeographic and phylogenetic methods (millions of years). Here, I review the evidence for specific antagonistic coevolution in the host-parasite <i>Daphnia</i>-<i>Pasteuria</i> model system, paying particular attention to the timescales addressed by different approaches. Microevolutionary studies of the coevolutionary process are congruent with macroevolutionary patterns observed in phylogeographic contexts and deep time. This evidence strongly supports the Red Queen model, providing a powerful explanation for the extraordinary genetic diversity seen in host and parasite disease genes.</p>","PeriodicalId":8035,"journal":{"name":"Annual review of genetics","volume":" ","pages":"215-236"},"PeriodicalIF":8.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating Selective Quality Control in Mammalian Oogenesis: Evidence and Opportunities. 评估哺乳动物卵子发生的选择性质量控制：证据和机会。
IF 9.1 1区 生物学
Annual review of genetics Pub Date : 2025-11-01 Epub Date: 2025-08-08 DOI: 10.1146/annurev-genet-021925-093551
Jay W Zussman, Dominic J Skinner, Daniel E Wagner, Stanislav Y Shvartsman, Diana J Laird
{"title":"Evaluating Selective Quality Control in Mammalian Oogenesis: Evidence and Opportunities.","authors":"Jay W Zussman, Dominic J Skinner, Daniel E Wagner, Stanislav Y Shvartsman, Diana J Laird","doi":"10.1146/annurev-genet-021925-093551","DOIUrl":"10.1146/annurev-genet-021925-093551","url":null,"abstract":"<p><p>The formation and maintenance of the finite mammalian ovarian reserve are critical for fertility and species survival. Genetic and developmental studies have uncovered various mechanisms underlying oocyte development and maturation, revealing two curious features of the ovarian germline: (<i>a</i>) The establishment of the follicle reserve involves an initial massive overproduction of oocyte precursors, and (<i>b</i>) the total number of ovulated oocytes across an animal's fertile lifetime is a very small proportion of the initial ovarian reserve. Many have proposed that this indicates the existence of selective quality control to ensure gamete fitness. Here, we review the findings underlying the hypotheses for germline quality control during prepubertal development, homeostatic fertility, and reproductive aging. We evaluate whether the existing evidence base distinguishes the active selection of specific germ cell subsets from neutral dynamics. Throughout, we discuss strategies for applying statistical frameworks to evaluate selection in oogenesis and the implications of neutrality versus selection at various points in oocyte development.</p>","PeriodicalId":8035,"journal":{"name":"Annual review of genetics","volume":" ","pages":"237-270"},"PeriodicalIF":9.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Biology of Nucleus-Forming Jumbo Phages. 巨核噬菌体的生物学研究。
IF 8.6 1区 生物学
Annual review of genetics Pub Date : 2025-11-01 DOI: 10.1146/annurev-genet-111523-102019
Erica A Birkholz, Emily G Armbruster, Joe Pogliano
{"title":"The Biology of Nucleus-Forming Jumbo Phages.","authors":"Erica A Birkholz, Emily G Armbruster, Joe Pogliano","doi":"10.1146/annurev-genet-111523-102019","DOIUrl":"10.1146/annurev-genet-111523-102019","url":null,"abstract":"<p><p>Nucleus-forming jumbo bacteriophages display a surprisingly intricate replication cycle inside of bacterial host cells, challenging the long-standing paradigm of prokaryotic simplicity. The phage nucleus encloses phage DNA in a protein shell, strictly uncouples transcription from translation, and facilitates selective protein import and messenger RNA (mRNA) export, serving the same major functions as the eukaryotic nucleus. Infection of host cells by these phages begins with the formation of a transcriptionally active membrane-bound early phage infection vesicle, demonstrating that these phages are capable of constructing subcellular compartments composed of lipids and proteins. Here, we review the current body of literature revealing the complexities of nucleus-forming phages and the history of the major discoveries. Studies of these phages are revealing new insights into basic principles of subcellular organization, viral speciation, and intracellular viral competition.</p>","PeriodicalId":8035,"journal":{"name":"Annual review of genetics","volume":"59 1","pages":"51-68"},"PeriodicalIF":8.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12908238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145601664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Forming a Complex: Turbocharging BMP Signal Activation by Heterodimeric Ligands and Heteromeric Receptor Complexes. 形成复合物：异二聚体配体和异二聚体受体复合物涡轮增压BMP信号激活。
IF 8.6 1区 生物学
Annual review of genetics Pub Date : 2025-11-01 Epub Date: 2025-08-07 DOI: 10.1146/annurev-genet-032425-094606
Jeet H Patel, Mary C Mullins
{"title":"Forming a Complex: Turbocharging BMP Signal Activation by Heterodimeric Ligands and Heteromeric Receptor Complexes.","authors":"Jeet H Patel, Mary C Mullins","doi":"10.1146/annurev-genet-032425-094606","DOIUrl":"10.1146/annurev-genet-032425-094606","url":null,"abstract":"<p><p>Bone morphogenetic protein (BMP) signaling functions in a vast range of biological contexts. The basic signaling mechanism of this pathway is well-defined, with BMP ligand dimers recruiting tetrameric receptor complexes that phosphorylate Smads to regulate gene expression. Research has found that the mechanism of BMP signal activation may not be as simple as this linear relay, specifically in considering signal activation by ligand homodi-mers versus heterodimers. Focusing largely on in vivo vertebrate contexts, we discuss how BMP heterodimers exhibit enhanced or exclusive signaling over homodimers, demonstrating that not all signal inputs are functionally equivalent. Challenging the notion that ligand-receptor binding affinity is the primary driver of signal activation, we highlight evidence that some receptors do not signal even when high-affinity ligands are present. Further, not all receptors in the signaling complex are equal, with the kinase activity of some being dispensable while others are obligatory. These observations shift the focus of BMP signal activation to mechanisms by which heterodimeric ligands with specific receptor combinations facilitate signal outcomes in different contexts.</p>","PeriodicalId":8035,"journal":{"name":"Annual review of genetics","volume":" ","pages":"271-288"},"PeriodicalIF":8.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic and Genomic Insights into Planarian Biology. 涡虫生物学的遗传和基因组学见解。
IF 9.1 1区 生物学
Annual review of genetics Pub Date : 2025-11-01 Epub Date: 2025-08-19 DOI: 10.1146/annurev-genet-011725-091634
Longhua Guo
{"title":"Genetic and Genomic Insights into Planarian Biology.","authors":"Longhua Guo","doi":"10.1146/annurev-genet-011725-091634","DOIUrl":"10.1146/annurev-genet-011725-091634","url":null,"abstract":"<p><p>Species such as planarians expand our horizons of imagination and fuel innovation. The ability to regenerate any tissues lost to injury has fascinated many generations of biologists studying regenerative biology. Recent experimental data have shown that regeneration in older planarians can reverse age-associated physiological decline, effectively rejuvenating the animals and making them biologically younger. The remarkable biology manifested by planarians, encompassing whole-body regeneration and rejuvenation, intersects with some of the most critical topics of twenty-first-century research, including stem cell function, lifespan regulation, and healthspan improvement, despite being viewed by some as an evolutionary oddity. Here, we discuss how advances in next-generation sequencing technologies and the advent of genomic approaches over the past two decades have revolutionized planarian research. The results of these studies have transformed our understanding of regeneration, tissue patterning, germ cell development, chromosome evolution, aging, and age reversal (rejuvenation). We anticipate that genetic and genomic tools will drive groundbreaking discoveries in the fundamental mechanisms of regeneration, aging, and rejuvenation in the coming decades.</p>","PeriodicalId":8035,"journal":{"name":"Annual review of genetics","volume":" ","pages":"315-340"},"PeriodicalIF":9.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene Editing Applications as Future Cardiovascular Therapies. 基因编辑在未来心血管治疗中的应用
IF 9.1 1区 生物学
Annual review of genetics Pub Date : 2025-11-01 Epub Date: 2025-07-16 DOI: 10.1146/annurev-genet-011725-094039
Tomonori Tadokoro, Eric N Olson, Ning Liu
{"title":"Gene Editing Applications as Future Cardiovascular Therapies.","authors":"Tomonori Tadokoro, Eric N Olson, Ning Liu","doi":"10.1146/annurev-genet-011725-094039","DOIUrl":"10.1146/annurev-genet-011725-094039","url":null,"abstract":"<p><p>Cardiovascular disease is the leading cause of global morbidity and mortality, despite advances in pharmacological and surgical interventions. The emergence of CRISPR-Cas9 genome editing technology offers promising approaches for correcting genetic causes of hereditary cardiovascular disorders and modulating pathogenic signaling pathways implicated in various heart diseases. However, several challenges with respect to in vivo delivery of gene editing components, as well as important safety considerations, remain to be addressed in the path toward possible clinical application. We review current gene editing strategies, their potential therapeutic applications in the context of a variety of cardiovascular disorders, and their respective merits, limitations, and regulatory considerations. The rapid advances in this field combined with the many opportunities for deploying gene editing therapies for cardiovascular disorders augur well for the future of this transformative technology.</p>","PeriodicalId":8035,"journal":{"name":"Annual review of genetics","volume":" ","pages":"119-145"},"PeriodicalIF":9.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12919758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Somatic Impact on Inheritance and the Germline Control of the Soma. 体细胞对遗传的影响及体细胞系控制。
IF 8.6 1区 生物学
Annual review of genetics Pub Date : 2025-11-01 Epub Date: 2025-07-16 DOI: 10.1146/annurev-genet-020325-040022
Shoma Ishikawa, Björn Schumacher
{"title":"The Somatic Impact on Inheritance and the Germline Control of the Soma.","authors":"Shoma Ishikawa, Björn Schumacher","doi":"10.1146/annurev-genet-020325-040022","DOIUrl":"10.1146/annurev-genet-020325-040022","url":null,"abstract":"<p><p>The faithful transmission of genomic DNA over succeeding generations is an essential prerequisite for species maintenance. The germplasm theory by August Weismann has been foundational for the current understanding of heredity; it proposed that genetic inheritance is exclusively mediated by germ cells while they are protecting heritable germline genomes from the phylogenetic influences of an individual's life history. However, recent studies on the inheritance of epigenetic variation have challenged the traditional dogma of heredity and opened new perspectives on molecular mechanisms of inheritance. This review highlights the current knowledge about heritable memories of the ancestral lifestyle and discusses emerging frontiers in soma-germline circuits with a focus on the control of the integrity of heritable genomes as well as their implications for somatic and reproductive aging.</p>","PeriodicalId":8035,"journal":{"name":"Annual review of genetics","volume":" ","pages":"91-117"},"PeriodicalIF":8.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Human to Mouse and Back Again: Genetic and Genomic Ta(i)les of Islet Dysfunction in Type 2 Diabetes. 从人类到小鼠再到小鼠：2型糖尿病胰岛功能障碍的遗传和基因组基因(1)。
IF 9.1 1区 生物学
Annual review of genetics Pub Date : 2025-11-01 Epub Date: 2025-08-13 DOI: 10.1146/annurev-genet-020525-114513
Romy Kursawe, Khushdeep Bandesh, Sai Nivedita Krishnan, Kevin S Liu, Redwan M Bhuiyan, Michael L Stitzel
{"title":"From Human to Mouse and Back Again: Genetic and Genomic Ta(i)les of Islet Dysfunction in Type 2 Diabetes.","authors":"Romy Kursawe, Khushdeep Bandesh, Sai Nivedita Krishnan, Kevin S Liu, Redwan M Bhuiyan, Michael L Stitzel","doi":"10.1146/annurev-genet-020525-114513","DOIUrl":"10.1146/annurev-genet-020525-114513","url":null,"abstract":"<p><p>Type 2 diabetes (T2D) is a complex genetic disease with substantial environmental inputs leading to glucose homeostasis defects. Insulin production is central to proper glucose control, and islet cell dysfunction and death lie at the nexus of T2D genetics and pathophysiology. Comprehensive identification of genes and pathways contributing to these processes is essential for mechanistic understanding and therapeutic targeting. Here, we summarize the latest human and mouse T2D genetic and genomic studies and assess how these parallel variant-to-function efforts and associated data contribute convergent or complementary insights and new opportunities to dissect T2D islet (dys)function. We distill mechanistic and phenotypic studies of candidate T2D effector genes into prevailing themes by which these T2D risk genes likely contribute to islet dysfunction. We assess how recent molecular and metabolic studies in genetically diverse mice (i.e., Collabo-rative Cross, Diversity Outbred) help to nominate new putative T2D effector genes and processes for future exploration and provide examples where these studies illuminate potential limitations of studies using inbred mice. Finally, we discuss opportunities to address knowledge gaps and modeling challenges to translate T2D genetic associations into molecular and pathophysiologic understanding.</p>","PeriodicalId":8035,"journal":{"name":"Annual review of genetics","volume":" ","pages":"289-314"},"PeriodicalIF":9.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12687576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144844187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell Death, Compensatory Proliferation, and Cell Competition. 细胞死亡、代偿性增殖和细胞竞争。
IF 9.1 1区 生物学
Annual review of genetics Pub Date : 2025-11-01 Epub Date: 2025-07-17 DOI: 10.1146/annurev-genet-012125-083359
Andreas Bergmann
{"title":"Cell Death, Compensatory Proliferation, and Cell Competition.","authors":"Andreas Bergmann","doi":"10.1146/annurev-genet-012125-083359","DOIUrl":"10.1146/annurev-genet-012125-083359","url":null,"abstract":"<p><p>Cell death, compensatory proliferation, and cell competition are fundamental interconnected processes that shape how tissues develop, maintain homeostasis, and regenerate. In this review, I highlight how cell death (apoptosis) not only eliminates excess and damaged cells but can also initiate compensatory proliferation, an adaptive response that occurs following cell loss. I examine cell competition, a quality-control mechanism that removes less fit loser cells in favor of healthier winner neighbors. Cell competition is intricately linked to cell death and compensatory proliferation. I present the history of these processes, discuss the most important examples, and reveal the key molecular mechanisms that underlie them. I incorporate findings from <i>Caenorhabditis elegans</i>, <i>Drosophila melanogaster</i>, vertebrates, and other models to underscore the conservation of the key molecular signaling events. I also discuss how misregulation of these processes can contribute to pathological conditions, including cancer.</p>","PeriodicalId":8035,"journal":{"name":"Annual review of genetics","volume":" ","pages":"165-187"},"PeriodicalIF":9.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12810938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic Mechanisms of Experience-Dependent Neuronal Plasticity. 经验依赖性神经元可塑性的遗传机制。
IF 9.1 1区 生物学
Annual review of genetics Pub Date : 2025-11-01 Epub Date: 2025-09-17 DOI: 10.1146/annurev-genet-020325-103824
Anne E West
{"title":"Genetic Mechanisms of Experience-Dependent Neuronal Plasticity.","authors":"Anne E West","doi":"10.1146/annurev-genet-020325-103824","DOIUrl":"10.1146/annurev-genet-020325-103824","url":null,"abstract":"<p><p>The brain has a remarkable ability to adapt its function in response to both environmental and internal cues. The cellular composition of the brain is largely static after birth; thus, persistent experience-dependent changes in brain function depend on altered programs of gene expression that result in the plasticity of circuit connectivity and network function. High-throughput sequencing studies have comprehensively cataloged stimulus-dependent programs of gene expression in the brain. The current challenge is to integrate this information in the context of specific cells and circuits to understand the mechanisms by which transcriptional regulation coordinates adaptive plasticity of the brain and behavior. Here, I review molecular genetics studies that reveal how neuronal activity-regulated gene products orchestrate intricate cellular and intercellular adaptations in response to changes in patterns of brain activity. I also discuss examples of genetic mutations that impair experience-dependent transcriptional plasticity in the context of neurodevelopmental disorders.</p>","PeriodicalId":8035,"journal":{"name":"Annual review of genetics","volume":" ","pages":"435-459"},"PeriodicalIF":9.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12795507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书