Annals of Medicine and Surgery最新文献

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Surgical decision-making in the digital age: the role of telemedicine - a narrative review. 数字时代的外科决策:远程医疗的作用——叙述性回顾。
IF 1.7
Annals of Medicine and Surgery Pub Date : 2025-01-09 eCollection Date: 2025-01-01 DOI: 10.1097/MS9.0000000000002874
Shehla Parveen, Maryam Amjad, Sameer Abdul Rauf, Shahdil Arbab, Syed Abdan Jamalvi, Shah Emaad-Ur-Rehman Saleem, Syed Khizar Ali, Jaiwanti Bai, Maria Mustansir, Fnu Danish, Muhammad Asif Khalil, Md Ariful Haque
{"title":"Surgical decision-making in the digital age: the role of telemedicine - a narrative review.","authors":"Shehla Parveen, Maryam Amjad, Sameer Abdul Rauf, Shahdil Arbab, Syed Abdan Jamalvi, Shah Emaad-Ur-Rehman Saleem, Syed Khizar Ali, Jaiwanti Bai, Maria Mustansir, Fnu Danish, Muhammad Asif Khalil, Md Ariful Haque","doi":"10.1097/MS9.0000000000002874","DOIUrl":"10.1097/MS9.0000000000002874","url":null,"abstract":"<p><p>This narrative review delves into the transformative role of telemedicine in the realm of surgical decision-making. Telemedicine, a significant innovation in healthcare services, leverages electronic information and communication technologies to provide healthcare services when distance separates the participants. It addresses the challenges of increased healthcare demands, an aging population, and budget constraints. Telemedicine technologies are employed for pre- and postoperative consultations, monitoring, and international surgical teleconferencing and education. They enhance healthcare access, particularly in remote areas, and facilitate knowledge sharing among healthcare professionals. The review also provides a historical context and discusses the technological advancements in telemedicine, including the rise of digital health technologies and the integration of artificial intelligence and machine learning in healthcare. It delves into the details of telemedicine technologies such as telesurgery, telerobotics, telepathology, teleimaging, remote patient monitoring, and virtual and augmented reality. Despite the numerous benefits, the implementation of telemedicine is often hindered by various complex and diverse ethical and legal concerns, including privacy and data security. The review highlights the need for further evidence on health outcomes and cost savings, bridging the digital divide, and enacting policies to support telemedicine reimbursement. It also emphasizes the need for incorporating telemedicine modules in medical education. It recommends that policy-making bodies consider utilizing telemedicine to address healthcare coverage gaps, particularly in rural areas.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 1","pages":"242-249"},"PeriodicalIF":1.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute urinary retention in an adolescent female with Herlyn-Werner-Wunderlich syndrome. 青春期女性herlin - werner - wunderlich综合征急性尿潴留1例。
IF 1.7
Annals of Medicine and Surgery Pub Date : 2025-01-09 eCollection Date: 2025-01-01 DOI: 10.1097/MS9.0000000000002752
Pradeep Shrestha, Bibek Shrestha, Amit K Mishra, Neeta Katuwal
{"title":"Acute urinary retention in an adolescent female with Herlyn-Werner-Wunderlich syndrome.","authors":"Pradeep Shrestha, Bibek Shrestha, Amit K Mishra, Neeta Katuwal","doi":"10.1097/MS9.0000000000002752","DOIUrl":"10.1097/MS9.0000000000002752","url":null,"abstract":"<p><strong>Introduction and importance: </strong>Herlyn-Werner-Wunderlich syndrome (HWWS) is a rare congenital anomaly characterized by the triad of uterus didelphys, unilateral obstructed hemivagina, and ipsilateral renal agenesis. However, atypical presentations such as acute urinary retention are uncommon and pose diagnostic challenges. Early identification and treatment are crucial to prevent long-term complications like endometriosis and infertility.</p><p><strong>Case presentation: </strong>A 12-year-old female presented with the unusual symptom of acute urinary retention, which was likely caused by compression of the bladder neck due to hematocolpos. Imaging via ultrasound and MRI confirmed the presence of uterus didelphys, obstructed hemivagina, and ipsilateral renal agenesis, consistent with HWWS. Surgical excision of the vaginal septum was performed to relieve the hematocolpos, with the patient experiencing a full recovery.</p><p><strong>Clinical discussion: </strong>Congenital abnormalities of Mullerian Duct are rare, and atypical presentations such as acute urinary retention, vaginal discharge, and even pyocolpos or hematosalpinx have been reported. MRI played a crucial role in confirming the diagnosis and guiding treatment. The importance of early detection and long-term monitoring is highlighted, though limitations exist due to the inability to assess future reproductive outcomes.</p><p><strong>Conclusion: </strong>This case emphasizes the importance of recognizing atypical presentations of HWWS, such as acute urinary retention. Timely diagnosis and appropriate surgical intervention are critical for preventing complications and restoring normal function. Early recognition of this rare syndrome, especially in patients with unusual symptoms such as urine retention, is essential for ensuring optimal clinical outcomes.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 1","pages":"331-334"},"PeriodicalIF":1.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of being lateral and sitting position for spinal anesthesia administration on maternal hemodynamic variability and the timing of hypotension among cesarean section patients in a resource-constrained area: a prospective observational cohort study. 资源受限地区剖宫产患者侧位和坐位对产妇血流动力学变异性和低血压时间的影响:一项前瞻性观察队列研究
IF 1.7
Annals of Medicine and Surgery Pub Date : 2025-01-09 eCollection Date: 2025-01-01 DOI: 10.1097/MS9.0000000000002754
Sintayehu Samuel, Blen Kasahun, Tsegaye Demeke, Seleman Reshad, Nesredin Shemsu, Abdulkadir Kedir, Astemamagn Achule, Temesgen Mamo, Getahun Dendir, Sinishaw Genetu, Yisehak Wolde
{"title":"Impact of being lateral and sitting position for spinal anesthesia administration on maternal hemodynamic variability and the timing of hypotension among cesarean section patients in a resource-constrained area: a prospective observational cohort study.","authors":"Sintayehu Samuel, Blen Kasahun, Tsegaye Demeke, Seleman Reshad, Nesredin Shemsu, Abdulkadir Kedir, Astemamagn Achule, Temesgen Mamo, Getahun Dendir, Sinishaw Genetu, Yisehak Wolde","doi":"10.1097/MS9.0000000000002754","DOIUrl":"10.1097/MS9.0000000000002754","url":null,"abstract":"<p><strong>Background: </strong>Type of anesthesia used for cesarean section can be general, spinal, or epidural. However, peripheral nerve blocks, such as the lower and upper extremity nerve blocks, can be referred to as other types of anesthesia. Spinal anesthesia is the most frequently used method because of its ease, dependability, and rapidity in attaining proper anesthesia. The purpose of this study was to determine the effects of spinal anesthesia induction position on maternal hemodynamics and the timing of hypotension.</p><p><strong>Method: </strong>A prospective observational cohort study design was employed. A simple random sampling technique was used. A total of 190 patients received spinal anesthesia, with 95 in the lateral and 95 in the sitting position in each group. The data were entered into Epi Data version 4.6 and then exported to SPSS version 26 for analysis. Independent sample <i>t</i>-tests and chi-square (<i>χ</i> <sup>2</sup>) tests were performed. Kaplan-Meier survival analysis and log-rank test were used and <i>P</i> value ≤0.05 considered significant.</p><p><strong>Results: </strong>The overall incidence rates of hypotension in the lateral and sitting groups were 54.6% [95% CI, 52.3-72.1] and 73.8% [95% CI, 69.8-87.2], respectively (<i>P</i> = 0.025). The timing of first hypotension was 8.86 minute [95% CI, 8.690-13.272] and 15.75 minute [95% CI, 14.569-19.372] (<i>P</i> = 0.001) for sitting and lateral, respectively.</p><p><strong>Conclusion and recommendation: </strong>In this study, we found a significant difference between the lateral and sitting groups with different measurement parameters, such as blood pressure, intraoperative adverse events, and onset of hypotension. The incidence of hypotension, intraoperative adverse effects of spinal anesthesia, and fluid consumption were lower in the lateral groups. Nonetheless, instead of being technically challenging during spinal anesthesia induction, the lateral position results in better hemodynamics and onset of hypotension than in the sitting posture.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 1","pages":"62-69"},"PeriodicalIF":1.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain tumors and induced pluripotent stem cell technology: a systematic review of the literature. 脑肿瘤和诱导多能干细胞技术:文献系统综述。
IF 1.7
Annals of Medicine and Surgery Pub Date : 2025-01-09 eCollection Date: 2025-01-01 DOI: 10.1097/MS9.0000000000002760
Monir Shayestehfar, Tina Taherkhani, Pardis Jahandideh, Amir A Hamidieh, Mahsa Faramarzpour, Amirhossein Memari
{"title":"Brain tumors and induced pluripotent stem cell technology: a systematic review of the literature.","authors":"Monir Shayestehfar, Tina Taherkhani, Pardis Jahandideh, Amir A Hamidieh, Mahsa Faramarzpour, Amirhossein Memari","doi":"10.1097/MS9.0000000000002760","DOIUrl":"10.1097/MS9.0000000000002760","url":null,"abstract":"<p><strong>Background: </strong>Induced pluripotent stem cells (iPSCs) provide a novel approach to studying the pathophysiology of brain tumors and assessing various therapeutic techniques with greater precision. This study aims to systematically review the existing literature to critically analyze and synthesize current research findings. The objective is to evaluate the role of iPSCs in understanding brain tumors and in the development of innovative treatment strategies.</p><p><strong>Methods: </strong>We systematically reviewed existing articles that utilized iPSC technology to assess either the pathophysiology of brain tumors or therapeutic techniques, following the standards of Preferred Reporting Items for Systematic review and Meta-Analysis guidelines. Key terms were comprehensively searched in electronic databases, including PubMed, EMBASE, and Scopus. Articles were screened based on specific inclusion and exclusion criteria. Ultimately, 22 relevant articles were chosen, and their data were extracted.</p><p><strong>Results: </strong>The summary of findings for each selected article was organized into two general categories: \"Methods of Generating iPSCs\" and \"Applications of iPSCs.\" The methods of iPSC generation, including transfection and transduction, as well as the types of viral or non-viral vectors used, were extracted and reported for each study. Additionally, the main aims of the selected studies, whether modeling or therapeutic approaches, were gathered and reported in the results section.</p><p><strong>Conclusion: </strong>iPSC technology is a novel vehicle that brings new solutions to overcome difficulties in brain tumor studies. In vivo and in vitro models generated from iPSCs provide suitable platforms to investigate the pathophysiology of brain tumors more precisely. Also, iPSCs have been utilized in various studies to examine how different antitumor agents may affect the target cells.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 1","pages":"250-264"},"PeriodicalIF":1.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chandipura virus outbreak: a growing public health crisis that demands immediate action. 昌迪普拉病毒爆发:需要立即采取行动的日益严重的公共卫生危机。
IF 1.7
Annals of Medicine and Surgery Pub Date : 2025-01-09 eCollection Date: 2025-01-01 DOI: 10.1097/MS9.0000000000002841
Huda Adnan, Izere Salomon, Maryam Ahmed
{"title":"Chandipura virus outbreak: a growing public health crisis that demands immediate action.","authors":"Huda Adnan, Izere Salomon, Maryam Ahmed","doi":"10.1097/MS9.0000000000002841","DOIUrl":"10.1097/MS9.0000000000002841","url":null,"abstract":"","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 1","pages":"24-26"},"PeriodicalIF":1.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic challenges of tailgut cysts: a case report on an occult perianal mass. 尾肠囊肿的诊断挑战:一例隐性肛周肿块报告。
IF 1.7
Annals of Medicine and Surgery Pub Date : 2025-01-09 eCollection Date: 2025-01-01 DOI: 10.1097/MS9.0000000000002880
Faraz Khalid, Haris Naveed, Masab Ali, Muhammad Saad Ansari, Muhammad Sajjad Shafiq, Muhammad Husnain Ahmad
{"title":"Diagnostic challenges of tailgut cysts: a case report on an occult perianal mass.","authors":"Faraz Khalid, Haris Naveed, Masab Ali, Muhammad Saad Ansari, Muhammad Sajjad Shafiq, Muhammad Husnain Ahmad","doi":"10.1097/MS9.0000000000002880","DOIUrl":"10.1097/MS9.0000000000002880","url":null,"abstract":"<p><strong>Introduction: </strong>Tailgut cysts, or retro-rectal cystic hamartomas, are rare congenital lesions arising from embryonic hindgut remnants, typically located in the retro-rectal area. These cysts present some diagnostic challenges due to vague symptoms and potential for malignancy.</p><p><strong>Case presentation: </strong>A 25-year-old female presented with a 5-year history of perianal swelling. MRI revealed a T2 hyperintense, multiseptated cystic lesion suggestive of a tailgut cyst. The cyst was surgically excised via a trans-sacral approach, and the specimen was sent for histopathological analysis.</p><p><strong>Clinical discussion: </strong>The MRI findings were confirmed by histopathology, identifying a benign tailgut cyst. The patient had an uneventful recovery and was symptom-free at the 2-month follow-up.</p><p><strong>Conclusion: </strong>Tailgut cysts can mimic other perianal masses, complicating diagnosis. Accurate diagnosis and successful treatment rely on clinical vigilance, advanced imaging, and histopathological confirmation. Early surgical resection is crucial to prevent complications, including malignancy.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 1","pages":"421-424"},"PeriodicalIF":1.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of topical treatment with urea in ichthyosis, atopic dermatitis, psoriasis, and other skin conditions-a systematic review. 尿素局部治疗鱼鳞病、特应性皮炎、牛皮癣和其他皮肤病的效果——系统综述。
IF 1.7
Annals of Medicine and Surgery Pub Date : 2025-01-09 eCollection Date: 2025-01-01 DOI: 10.1097/MS9.0000000000002797
Inshal Jawed, Muhammad Umair Abdul Qadir, Umm E Farwa, Farah Alam, Fasiha Bakhtawar Fatima, Hina Khan, Vikash Kumar Karmani, Maham Javaid, Sandesh Raja, Muhammad Khuzzaim Khan, Adarsh Raja, Anuva Khanal
{"title":"Effect of topical treatment with urea in ichthyosis, atopic dermatitis, psoriasis, and other skin conditions-a systematic review.","authors":"Inshal Jawed, Muhammad Umair Abdul Qadir, Umm E Farwa, Farah Alam, Fasiha Bakhtawar Fatima, Hina Khan, Vikash Kumar Karmani, Maham Javaid, Sandesh Raja, Muhammad Khuzzaim Khan, Adarsh Raja, Anuva Khanal","doi":"10.1097/MS9.0000000000002797","DOIUrl":"10.1097/MS9.0000000000002797","url":null,"abstract":"<p><strong>Introduction: </strong>The urea composition has a profound effect on skin disorders, specifically xerosis, desquamation, and scaling, which are some of the main concerns of the current health industry. The application of urea is relatable and more bioactive than alternate treatments. The objective of this systematic review was to evaluate the effectiveness of topically applied urea in the treatment of ichthyosis, psoriasis, and other dermatologic conditions.</p><p><strong>Data and sources: </strong>Research articles were retrieved through electronic databases, including Google Scholar, PubMed, EMBASE, Elsevier, and Sage, selected based on the provision of online free literature from its inception till November 2023. The significant findings were skin dryness, transepidermal water loss (TEWL), and eczema.</p><p><strong>Study selection: </strong>A total of 1826 studies have been found, of which 31 were selected based on inclusion criteria. The primary reason for the exclusion of the studies was the application of urea as a control. All in vivo studies disclosed the effectiveness of urea treatment separately or in addition to another compound on skin conditions. The selected studies have reported findings related to the improvement in xerosis, erythema, scaling, and reduction in TEWL.</p><p><strong>Conclusion: </strong>According to the in-depth review of the research articles, the application of urea has a tremendous effect on different skin diseases. Still, its role as monotherapy is overlooked due to the presence of more susceptible alternate products that need to be addressed. However, in the future, the evaluation of the effects of treatment containing urea with antibiotics on skin diseases would be more beneficial for practical knowledge.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 1","pages":"276-284"},"PeriodicalIF":1.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of ultrasonic bone dissector in diffuse idiopathic skeletal hyperostosis involving the cervical spine. 超声解剖在颈椎弥漫性特发性骨肥大症中的应用。
IF 1.7
Annals of Medicine and Surgery Pub Date : 2025-01-09 eCollection Date: 2025-01-01 DOI: 10.1097/MS9.0000000000002846
Gianluca Scalia, Massimiliano Giuffrida, Giancarlo Ponzo, Massimo Furnari, Bipin Chaurasia, Giuseppe E Umana, Giovanni F Nicoletti
{"title":"Use of ultrasonic bone dissector in diffuse idiopathic skeletal hyperostosis involving the cervical spine.","authors":"Gianluca Scalia, Massimiliano Giuffrida, Giancarlo Ponzo, Massimo Furnari, Bipin Chaurasia, Giuseppe E Umana, Giovanni F Nicoletti","doi":"10.1097/MS9.0000000000002846","DOIUrl":"10.1097/MS9.0000000000002846","url":null,"abstract":"<p><strong>Introduction and importance: </strong>Diffuse idiopathic skeletal hyperostosis (DISH), or Forestier's disease, is characterized by ligament and enthesis calcification, mainly in the thoracic spine. Cervical involvement can cause dysphagia due to soft tissue compression, necessitating surgical intervention when conservative measures fail. We assess the efficacy of anterior cervical osteophytectomy with an ultrasonic bone dissector in relieving symptoms and improving outcomes.</p><p><strong>Case presentation: </strong>A 73-year-old male presented with progressive neck pain and dysphagia caused by DISH in the cervical spine. Conservative treatment was ineffective, requiring anterior cervical osteophytectomy using an ultrasonic bone dissector. Postoperative imaging confirmed spinal cord decompression, and the patient experienced significant symptom relief. The ultrasonic bone dissector enabled precise bone resection, facilitating resolution of dysphagia and improving quality of life.</p><p><strong>Clinical discussion: </strong>This case highlights the effectiveness of ultrasonic bone dissection for cervical DISH. The device ensures precise bone removal with minimal soft tissue trauma, reducing complications and promoting recovery. While initial outcomes are promising, long-term studies are needed to compare this method with other interventions.</p><p><strong>Conclusion: </strong>Surgical intervention, particularly anterior cervical osteophytectomy with ultrasonic bone dissection, is effective when conservative treatments fail. Advanced surgical techniques improve patient outcomes and warrant further investigation to establish their role in managing cervical DISH.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 1","pages":"398-402"},"PeriodicalIF":1.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cyclophosphamide-induced atrial fibrillation in the context of ANCA-associated vasculitis: a case report. 环磷酰胺诱发心房颤动在anca相关血管炎的背景下:一个病例报告。
IF 1.7
Annals of Medicine and Surgery Pub Date : 2025-01-09 eCollection Date: 2025-01-01 DOI: 10.1097/MS9.0000000000002809
Sakar Pandey, Aayusha Dhakal, Roshan Singh, Rahul Shakya, Sweta Dhakal, Sagar Bhandari
{"title":"Cyclophosphamide-induced atrial fibrillation in the context of ANCA-associated vasculitis: a case report.","authors":"Sakar Pandey, Aayusha Dhakal, Roshan Singh, Rahul Shakya, Sweta Dhakal, Sagar Bhandari","doi":"10.1097/MS9.0000000000002809","DOIUrl":"10.1097/MS9.0000000000002809","url":null,"abstract":"<p><strong>Introduction and importance: </strong>Cyclophosphamide is a widely used immunosuppressant for inducing remission in various immune-mediated conditions. However, its potential for cardiotoxicity is well documented. One of the earliest possible manifestations of this cardiotoxicity following cyclophosphamide infusion is atrial fibrillation (AF), which typically presents within 48 h of the infusion.</p><p><strong>Case presentation: </strong>The authors present a case of a 58-year-old male with anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis who presented to the emergency department with clinical features of acute kidney injury. Following subsequent assessment and evaluation, the patient was managed in the intensive care unit with hemodialysis and intravenous corticosteroids. He was aimed at inducing remission with cyclophosphamide infusion. However, a few hours following induction with cyclophosphamide infusion, the patient developed palpitation, sweating, and tachycardia with a heart rate of 140-180/min. The electrocardiogram showed an irregular QRS complex with an absent p-wave. AF was diagnosed and managed with amiodarone infusion for 24 h followed by oral maintenance dosing. No further episode of AF occurred following cessation of cyclophosphamide and switching to rituximab for the treatment of ANCA-associated vasculitis.</p><p><strong>Clinical discussion: </strong>Cyclophosphamide, even at lower dosages, can cause cardiotoxicity in patients with renal impairment due to the delayed elimination of its toxic metabolites. In addition, patients who receive CYP 450 inducers, such as prednisone, may experience the accelerated build-up of its toxic metabolites, thereby raising the risk for cardiotoxicity.</p><p><strong>Conclusion: </strong>The cardiotoxic manifestation of cyclophosphamide can arise from its use in several immune-mediated conditions. Given its potential for cardiotoxicity, careful cardiac monitoring during and after cyclophosphamide infusion is essential to ensure timely intervention, if needed.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 1","pages":"376-379"},"PeriodicalIF":1.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cystic parathyroid lesion: case report of rare entity. 囊性甲状旁腺病变1例。
IF 1.7
Annals of Medicine and Surgery Pub Date : 2025-01-09 eCollection Date: 2025-01-01 DOI: 10.1097/MS9.0000000000002869
Pietro Princi, Ludovica Di Fede, Serena Elisa Tempera, Giulia Salvi, Maria De Ninno, Miriam Veleno, Casimiro Nigro
{"title":"Cystic parathyroid lesion: case report of rare entity.","authors":"Pietro Princi, Ludovica Di Fede, Serena Elisa Tempera, Giulia Salvi, Maria De Ninno, Miriam Veleno, Casimiro Nigro","doi":"10.1097/MS9.0000000000002869","DOIUrl":"10.1097/MS9.0000000000002869","url":null,"abstract":"<p><strong>Introduction and importance: </strong>Parathyroid cysts are rarely encountered in neck surgery and often misdiagnosed. We review the case incidence and treatment of parathyroid cystic lesions among all neck procedure in two single institutions operated on by a single surgeon.</p><p><strong>Case presentation: </strong>We report two female patients presenting with neck swallowing, dysphagia, choking and occasional dysphonia. Ultrasound US (ultrasound) imaging revealed two neck masses of 66 × 44 mm and 44 × 25 × 23 mm; serum iPTH (intact Parathyroid Hormone) levels were 238 and 699 ng/mL respectively and sestamibi scintiscan results were negative for both masses. Intra-cystic fluid evaluation of PTH showed elevated value (>5000 ng/ml). Both patients underwent parathyroidectomy along with total thyroidectomy and thyroid lobectomy. Post-operatively I-PTH and serum calcium levels became normal. Final histology confirmed a benign parathyroid cystic adenoma with concomitant benign thyroid disease.</p><p><strong>Clinical discussion: </strong>Parathyroid cyst is of rare entity and a diagnostic challenge.</p><p><strong>Conclusions: </strong>This case report demonstrates that fine needle aspiration (FNA) fluid with intra-cystic parathyroid analysis shows to be fundamental and supports surgery for hyperparathyroidism resolution.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 1","pages":"413-416"},"PeriodicalIF":1.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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