Annals of Medicine and Surgery最新文献

{"title":"Acute intestinal obstruction revealing an undiagnosed jejunal sarcoidosis in a 59-year-old female.","authors":"Yumna Njoum, Mohammed Hinnawi, Khaled Alshawwa, Hamza A Abdul-Hafez, Omar AbuZaydeh, Bashar Jaber","doi":"10.1097/MS9.0000000000003085","DOIUrl":"https://doi.org/10.1097/MS9.0000000000003085","url":null,"abstract":"<p><strong>Background: </strong>Sarcoidosis is a granulomatous illness with no known cause, defined histopathologically by noncaseating granulomas. While 90% of cases involve the lungs and mediastinal lymph nodes, clinically recognizable gastrointestinal sarcoidosis occurs in only 0.1-0.9% of patients, with small bowel involvement occurring in as few as 0.03% of all cases, and when it does occur, it is usually late in the disease course in patients with multisystem disease.</p><p><strong>Case presentation: </strong>Herein, we report a case of 59-year-old patient who presented with a picture of complete jejunal obstruction and gastrointestinal bleeding. Imaging revealed jejunal thickening and mesenteric lymphadenopathy. Later, intra-operatively, it be found caused by a jejunal stricture and enlarged mesenteric lymph nodes secondary to an undiagnosed sarcoidosis. Postoperative complications included hepatic hematoma and gastrointestinal bleeding. She stabilized after multidisciplinary management. A 1-year follow-up showed mediastinal lymphadenopathy without pulmonary involvement.</p><p><strong>Discussion: </strong>To provide individualized therapeutic care and follow-up, gastrointestinal sarcoidosis is a complex, possibly lethal condition that requires a multidisciplinary approach and early clinical suspicion. Without a prior diagnosis, sarcoidosis must be taken into account as a possible cause of acute intestinal blockage.</p><p><strong>Conclusion: </strong>Our case of jejunal sarcoidosis is unique for the rarity of disease location, the lack of pre-existing diagnosed sarcoidosis, and the necrotized jejunal resected segment indicating bowel ischemia.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 5","pages":"2996-3001"},"PeriodicalIF":1.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effectiveness of intra-arterial thrombolysis vs. mechanical thrombectomy: a literature review.","authors":"Bisrat Abate Bekele, Olivier Uwishema, Abel Haileyesus Adam, Abdi Degefu Gashu, Charbel Kachouh, Sarah Mshaymesh, Jack Wellington","doi":"10.1097/MS9.0000000000003139","DOIUrl":"https://doi.org/10.1097/MS9.0000000000003139","url":null,"abstract":"<p><strong>Background: </strong>Acute ischemic stroke (AIS) remains one of the leading causes of morbidity and mortality worldwide. Time is the single most critical factor in the management of patients presenting with AIS, where re-opening of occluded blood vessels is paramount. Intra-arterial thrombolysis (IAT) and mechanical thrombectomy (MT) are two such therapies employed to reestablish cerebrovascular blood flow in patients with AIS. This review compares both IAT and MT according to their efficacy, safety profiles, recanalization rates, clinical outcomes, and adverse procedural events.</p><p><strong>Methods: </strong>Study abstraction from electronic search databases comprising PubMed/MEDLINE, ResearchGate, and the National Library of Medicine was used. Screening and selection of relevant articles were comprehensively conducted for this review. Direct comparisons between IAT and MT in terms of variables including recanalization rates, clinical outcomes, and adverse procedural events were warranted for study inclusion. Research determined to exhibit insufficient data or without comparable groups were subsequently excluded.</p><p><strong>Results: </strong>MT was prompter when executing procedures than IAT, achieving greater rates of recanalization. Both interventions displayed similar results regarding rates of symptomatic intracranial hemorrhage (sICH) and mortality. Despite current available data indicating MT to demonstrate more efficiency as a procedure, further research is needed to examine IAT in light of specific patient demographics, clinical presentation, and circumstances.</p><p><strong>Conclusion: </strong>This review elucidated that MT often takes less time peri-procedurally, achieving greater success in revascularization compared with that of IAT. Regarding mortality and sICH rates, IAT and MT comparison showed equivocal results. Thus, while making therapeutic decisions, it is important to consider the unique clinical features of each patient as well as the timing of interventions in order to maximize treatment outcomes.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 5","pages":"2749-2757"},"PeriodicalIF":1.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noncardiac surgery for severe pulmonary hypertension: two surgeries in one patient and a review of the literature.","authors":"Maciej Wiewiora, Alicja Nowowiejska-Wiewiora, Mariusz Gasior, Jerzy Piecuch","doi":"10.1097/MS9.0000000000002828","DOIUrl":"https://doi.org/10.1097/MS9.0000000000002828","url":null,"abstract":"<p><strong>Introduction and importance: </strong>We present an analysis of the use of the multimodality approach for the treatment of patients with severe pulmonary arterial hypertension (PAH) who underwent surgery due to recurrent jaundice in the course of biliary obstruction and three years after surgery for breast cancer.</p><p><strong>Case presentation: </strong>A 66-year-old woman with a 5-year documented history of associated PAH related to scleroderomia. Because of cholangitis, she underwent endoscopic stenting of the common bile duct. At the time of the operation, she underwent three rounds of endoscopic removal of the prosthesis from the choledochal duct and restenting procedures due to recurrent jaundice during biliary obstruction. She underwent surgery via epidural thoracic anesthesia with intravenous sedation. Three years later, the patient was diagnosed with breast cancer. She underwent surgery via regional neuraxial blocks with intravenous sedation, and mastectomy with axillary lymphadenectomy was performed.</p><p><strong>Clinical discussion: </strong>According to the Guidelines for the Diagnosis and Treatment of Pulmonary Hypertension, a general recommendation before surgery cannot be made. The perioperative optimization of pulmonary hypertension (PH) therapy should include assessments of functional status, severity of disease and comorbidities. The optimal specific treatment of PH by a cardiologist before the planned surgery of a patient and the selection of the optimal surgery time were crucial. The second very important element was the selection of the type of anesthesia.</p><p><strong>Conclusion: </strong>Our patient underwent high-risk surgery because, first, a large abdominal procedure was performed, and second, the operation was performed without the possibility of special preoperative modification therapy. The third, PH severity was very advanced, with higher pulmonary artery pressure than systemic blood pressure. Patients with advanced PH could experience a relatively smooth intra-operative course in non-cardiac surgery when managed with current operative and anesthetic strategies, as in the case described.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 5","pages":"2963-2969"},"PeriodicalIF":1.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can supplementation with antioxidants improve cognitive functions in patients with multiple sclerosis? A literature review.","authors":"Ali Rezaei, Majid Hamidi, Homa Seyedmirzaei, Abdorreza Naser Moghadasi","doi":"10.1097/MS9.0000000000003124","DOIUrl":"https://doi.org/10.1097/MS9.0000000000003124","url":null,"abstract":"<p><p>Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative disease of the central nervous system (CNS) with a complex and multifactorial pathophysiology. Although these mechanisms are not yet fully elucidated, it is established that oxidative stress (OS) plays a key role in driving neurodegeneration in MS. These pathological mechanisms contribute to a wide range of symptoms, including motor and sensory deficits, as well as cognitive impairment. The impairments in cognitive functions can cause a major burden for these patients and significantly affect their quality of life. For example, memory is one of the most frequently impaired cognitive domains in MS. These deficits often correlate with biomarkers of neurodegeneration and disease progression. Despite the substantial burden of cognitive impairment in MS, no established treatments currently exist to prevent or mitigate cognitive decline in these patients, aside from the disease-modifying treatments. Several clinical trials have investigated the potential of antioxidant supplementation to improve cognitive outcomes in MS patients. However, their findings are often controversial. This review discusses trials evaluating the effects of supplementation with various antioxidants, including <i>Ginkgo biloba</i>, melatonin, omega-3 fatty acids, vitamins A, N-acetylcysteine, lipoic acid, xanthophylls, and crocin, on cognitive performance. We discuss the findings of these studies, highlight methodological limitations, and explore the underlying mechanisms by which these compounds may modulate cognition. These mechanisms range from mitigating OS, inflammation, and glutamate-induced neurotoxicity in the CNS to addressing secondary symptoms such as depression and fatigue, which are often linked to cognitive decline. By reviewing the current evidence, this review not only underscores the therapeutic potential and limitations of antioxidant supplementation but also provides guidance for future research to optimize study design and advance our understanding of cognitive preservation strategies in MS.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 5","pages":"2736-2748"},"PeriodicalIF":1.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A large occipital meningioma with minimal symptoms in a 40-year old female: a rare case report from Syria.","authors":"Ahmad Bahjat Alhamsho, Mohammad Ali Abshi, Alia Mouaz Zindaki, Batoul Dibbane, Nour Dayyoub, Hanan Al Omar, Bilal Sleiay, Amer Al Tawekji, Houssein Al Kannass","doi":"10.1097/MS9.0000000000003249","DOIUrl":"10.1097/MS9.0000000000003249","url":null,"abstract":"<p><strong>Introduction: </strong>Meningiomas, the most common primary intracranial tumors, are typically benign. They can cause significant challenges and neurological symptoms, particularly when affecting visual processing areas.</p><p><strong>Case presentation: </strong>A 40-year-old female with a 2-year history of chronic headaches, worsening recently and accompanied by right eye opacity, was admitted for neurosurgery. She had no prior neurological disorders or relevant family history. MRI revealed a 5 large sacral meningioma measuring (5 × 5 × 5) cm, which was fully resected. Post-surgery, the patient was stable and monitored, displaying awareness and stable biomarkers. Preventive antibiotics were started, and she was advised to maintain a 45-degree sitting position during recovery.</p><p><strong>Clinical discussion: </strong>Large occipital meningiomas can present minimal symptoms, emphasizing the need for advanced imaging like MRI and CT for accurate diagnosis, surgical planning, and effective multidisciplinary management to optimize patient outcomes. Individualized treatment plans are crucial for balancing risks and benefits in surgery while preserving neurological function.</p><p><strong>Conclusion: </strong>This case emphasizes how occipital meningiomas, while less common, significantly affect quality of life due to their visual processing role, sometimes remaining asymptomatic despite size, creating diagnostic challenges for clinicians.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 6","pages":"3870-3873"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival outcomes and prognostic factors in glassy cell carcinoma: a retrospective analysis of the SEER database from 1992 to 2021.","authors":"Akef Obeidat, Tarek Ziad Arabi, Nida Mariyam, Mohammed Hady Albitar, Alwalid Hejazi, Marwan Alaswad, Belal Nedal Sabbah, Abdulrahim Comert","doi":"10.1097/MS9.0000000000003298","DOIUrl":"10.1097/MS9.0000000000003298","url":null,"abstract":"<p><p>Glassy cell carcinoma (GCC) is a rare, highly aggressive subtype of poorly differentiated adenocarcinoma, primarily affecting the cervix but also reported in other anatomical sites such as the lung, pancreas, and uterus. Due to its rarity, little is known about the optimal management and prognostic factors influencing outcomes. This retrospective study utilized the SEER database to analyze 43 confirmed cases of GCC from 1992 to 2021, aiming to clarify demographic, clinical, and treatment-related factors associated with survival. The analysis revealed that GCC primarily affects females (90.7%) with a median age of 43 years, and most commonly arises in the cervix (74.4%). Survival analysis using Kaplan-Meier and Cox proportional hazards models indicated that disease stage at diagnosis and age were significant prognostic factors. Specifically, distant-stage disease (HR = 8.44, <i>P</i> < 0.001) and advanced age (HR = 1.043, <i>P</i> = 0.001) were associated with poorer survival. In contrast, treatment modalities such as chemotherapy and radiotherapy did not significantly impact survival outcomes, suggesting that traditional approaches may be inadequate for this carcinoma type. These findings underscore the need for improved early detection and tailored therapeutic strategies. GCC's unique biological behavior and limited response to conventional treatments highlight the potential value of exploring targeted therapies to enhance patient outcomes in this rare malignancy.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 6","pages":"3113-3117"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress, neutrophils, and immunity: a dynamic interplay.","authors":"Emmanuel Ifeanyi Obeagu","doi":"10.1097/MS9.0000000000003304","DOIUrl":"10.1097/MS9.0000000000003304","url":null,"abstract":"<p><p>Neutrophils, the most abundant type of white blood cells, are pivotal players in the innate immune system, responsible for rapid responses to infection and tissue damage. They engage in various defensive activities, including phagocytosis, degranulation, and the formation of neutrophil extracellular traps (NETs). Stress, encompassing both physiological and psychological forms, significantly influences the immune system, notably impacting neutrophil function. This review delves into the intricate interplay between stress, neutrophils, and immunity, underscoring how stress modulates neutrophil activity and the broader implications for immune health. The body's response to stress involves the activation of the hypothalamic-pituitary-adrenal (HPA) axis and the subsequent release of stress hormones such as cortisol and adrenaline. These hormones can enhance or suppress immune functions, depending on the nature and duration of the stress. Acute stress may temporarily boost neutrophil activity, enhancing the body's immediate defense mechanisms. In contrast, chronic stress typically results in immunosuppression, adversely affecting neutrophil functions and increasing vulnerability to infections and inflammatory diseases. The mechanisms through which stress affects neutrophils include hormonal regulation, neuroimmune interactions, and alterations in the production of inflammatory mediators. The dynamic relationship between stress and neutrophils has significant health implications. While acute stress can enhance immune defenses, chronic stress contributes to a range of health issues, including increased infection risk, autoimmune disorders, and chronic inflammatory conditions such as cardiovascular disease and cancer.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 6","pages":"3573-3585"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uniportal thoracoscopic excision of a bronchogenic cyst impersonating neurogenic tumor: a case report.","authors":"Ranjan Sapkota, Prajjwol Luitel, Manoj Tamang, Asmita Shrestha, Srijana Thapa","doi":"10.1097/MS9.0000000000003273","DOIUrl":"10.1097/MS9.0000000000003273","url":null,"abstract":"<p><strong>Introduction: </strong>Mediastinal bronchogenic cysts (BC) comprise 50%-60% of all mediastinal cysts but are rare in the posterior mediastinum. The infrequent occurrence, unusual features, and atypical locations of posterior BC can result in misdiagnosis before surgery.</p><p><strong>Case presentation: </strong>A 37-year-old male presented with an incidental finding of paravertebral mass during his workup for renal cell carcinoma of the left kidney. Initially, the mass was diagnosed as a neurogenic tumor which after uniportal video-assisted thoracic surgery (uVATS) turned out to be a BC in an ectopic location.</p><p><strong>Discussion: </strong>Surgical resection is recommended for patients with symptoms and is sometimes indicated for asymptomatic patients to confirm diagnosis and prevent possible complications. The mediastinal BC was excised using uVATS, which being minimally invasive reduced the need for postoperative intensive care, minimized scarring, and shortened hospital stays.</p><p><strong>Conclusion: </strong>BC can appear in atypical sites, which can lead to misdiagnosis. Surgical excision is the preferred treatment for these cysts. uVATS presents a safe method for definitive management in such cases.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 6","pages":"3885-3888"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and predictors of survival in 284 patients with recurrent epithelial ovarian cancer: a large-scale retrospective analysis.","authors":"Shahrzad Sheikhhasani, Azam Sadat Moosavi, Setareh Akhavan, Narges Zamani, Elahe Rezayof, Mina Sadat Mosavat","doi":"10.1097/MS9.0000000000003297","DOIUrl":"10.1097/MS9.0000000000003297","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to analyze clinical characteristics, recurrence patterns, and survival predictors in patients with recurrent epithelial ovarian cancer.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 284 patients with recurrent epithelial ovarian cancer treated at our institution between 2012 and 2022. Clinical data, recurrence patterns, treatment modalities, and survival outcomes were evaluated. Kaplan-Meier analysis and Cox proportional hazards models were used to assess survival and identify prognostic factors.</p><p><strong>Results: </strong>The mean age at recurrence was 54.47 years. Multiple site recurrence (50.70%) was the most common, followed by peritoneal (21.47%) and distant metastases (15.84%). Median progression-free survival (PFS) and overall survival (OS) were 5.00 and 23.00 months, respectively. Retroperitoneal recurrence was associated with better survival compared to distant recurrence (median OS 29.00 vs 16.00 months, <i>P</i> = 0.007). Multivariate analysis identified residual disease (HR 2.15, <i>P</i> < 0.001), elevated CA-125 (HR 1.6, <i>P</i> = 0.02), high-grade histology (HR 1.5, <i>P</i> = 0.01), and advanced initial stage (HR 1.7, <i>P</i> = 0.002) as significant predictors of poor survival.</p><p><strong>Conclusion: </strong>Recurrence patterns and timing significantly impact survival in recurrent ovarian cancer. Complete cytoreduction, tumor grade, and initial stage are crucial prognostic factors. These findings emphasize the need for personalized treatment strategies and continued research into novel therapeutic approaches.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 6","pages":"3107-3112"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High resolution computed tomography thorax findings in rheumatoid arthritis and its correlation with spirometry indices - a cross-sectional study.","authors":"Arkadeep Dhali, Dijendra Nath Biswas, Rick Maity, Jyotirmoy Biswas, Hareesha Rishab Bharadwaj, Bharat Kumar, Archana Singh, Ritabrata Mitra, Parasar Ghosh","doi":"10.1097/MS9.0000000000003301","DOIUrl":"10.1097/MS9.0000000000003301","url":null,"abstract":"<p><strong>Background: </strong>Rheumatoid arthritis (RA) is a chronic autoimmune disease primarily affecting joints but also leading to significant extra-articular manifestations. Pulmonary involvement in RA, especially interstitial lung disease (ILD), contributes substantially to morbidity and mortality. This study aims to evaluate the prevalence and pattern of lung involvement in RA patients and correlate these findings with spirometric indices.</p><p><strong>Materials and methods: </strong>In this cross-sectional study, a total of 50 RA patients aged 18-55 years, diagnosed according to ACR-EULAR criteria, were enrolled. All participants underwent spirometry to measure FEV1, FVC, and FEV1/FVC ratios. Additionally, high-resolution computed tomography (HRCT) of the thorax was performed to identify patterns of lung involvement, including ground-glass opacity, honeycombing, interstitial thickening, and fibrosis. Statistical analyses were used to explore associations between disease duration, spirometric indices, and HRCT findings.</p><p><strong>Results: </strong>Lung involvement was observed in 30 (60%) patients, with ground-glass opacities in 16 (32%) and interstitial thickening in 14 (28%) patients. ILD was detected in 13 (26%) patients, with usual interstitial pneumonia being the predominant pattern in 9 (69.2%) cases. A significant correlation was found between longer disease duration (>5 years) and the presence of abnormal spirometry findings (odds ratio [OR] = 16.0, 95% CI: 3.527-72.583, <i>P</i> = 0.000326; 63.2%, <i>n</i> = 12) as well as abnormal HRCT findings (OR = 6.476, 95% CI: 1.563-26.836, <i>P</i> = 0.01; 84.2%, <i>n</i> = 16). Patients with abnormal spirometry had significantly higher odds of showing abnormal HRCT findings (OR = 35.0, 95% CI: 7.629-160.719, <i>P</i> = 0.000084).</p><p><strong>Conclusion: </strong>Abnormal HRCT findings and spirometry patterns correlate significantly with longer disease duration in RA. Early detection and management of pulmonary complications in RA may improve patient outcomes, particularly in those with long-standing disease. Furthermore, longitudinal studies are required to fully comprehend ILD progression in RA and its impact on patient prognosis.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 6","pages":"3178-3182"},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}