Annals of Medicine and Surgery最新文献

{"title":"Surgical decision-making in the digital age: the role of telemedicine - a narrative review.","authors":"Shehla Parveen, Maryam Amjad, Sameer Abdul Rauf, Shahdil Arbab, Syed Abdan Jamalvi, Shah Emaad-Ur-Rehman Saleem, Syed Khizar Ali, Jaiwanti Bai, Maria Mustansir, Fnu Danish, Muhammad Asif Khalil, Md Ariful Haque","doi":"10.1097/MS9.0000000000002874","DOIUrl":"10.1097/MS9.0000000000002874","url":null,"abstract":"<p><p>This narrative review delves into the transformative role of telemedicine in the realm of surgical decision-making. Telemedicine, a significant innovation in healthcare services, leverages electronic information and communication technologies to provide healthcare services when distance separates the participants. It addresses the challenges of increased healthcare demands, an aging population, and budget constraints. Telemedicine technologies are employed for pre- and postoperative consultations, monitoring, and international surgical teleconferencing and education. They enhance healthcare access, particularly in remote areas, and facilitate knowledge sharing among healthcare professionals. The review also provides a historical context and discusses the technological advancements in telemedicine, including the rise of digital health technologies and the integration of artificial intelligence and machine learning in healthcare. It delves into the details of telemedicine technologies such as telesurgery, telerobotics, telepathology, teleimaging, remote patient monitoring, and virtual and augmented reality. Despite the numerous benefits, the implementation of telemedicine is often hindered by various complex and diverse ethical and legal concerns, including privacy and data security. The review highlights the need for further evidence on health outcomes and cost savings, bridging the digital divide, and enacting policies to support telemedicine reimbursement. It also emphasizes the need for incorporating telemedicine modules in medical education. It recommends that policy-making bodies consider utilizing telemedicine to address healthcare coverage gaps, particularly in rural areas.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 1","pages":"242-249"},"PeriodicalIF":1.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cyclophosphamide-induced atrial fibrillation in the context of ANCA-associated vasculitis: a case report.","authors":"Sakar Pandey, Aayusha Dhakal, Roshan Singh, Rahul Shakya, Sweta Dhakal, Sagar Bhandari","doi":"10.1097/MS9.0000000000002809","DOIUrl":"10.1097/MS9.0000000000002809","url":null,"abstract":"<p><strong>Introduction and importance: </strong>Cyclophosphamide is a widely used immunosuppressant for inducing remission in various immune-mediated conditions. However, its potential for cardiotoxicity is well documented. One of the earliest possible manifestations of this cardiotoxicity following cyclophosphamide infusion is atrial fibrillation (AF), which typically presents within 48 h of the infusion.</p><p><strong>Case presentation: </strong>The authors present a case of a 58-year-old male with anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis who presented to the emergency department with clinical features of acute kidney injury. Following subsequent assessment and evaluation, the patient was managed in the intensive care unit with hemodialysis and intravenous corticosteroids. He was aimed at inducing remission with cyclophosphamide infusion. However, a few hours following induction with cyclophosphamide infusion, the patient developed palpitation, sweating, and tachycardia with a heart rate of 140-180/min. The electrocardiogram showed an irregular QRS complex with an absent p-wave. AF was diagnosed and managed with amiodarone infusion for 24 h followed by oral maintenance dosing. No further episode of AF occurred following cessation of cyclophosphamide and switching to rituximab for the treatment of ANCA-associated vasculitis.</p><p><strong>Clinical discussion: </strong>Cyclophosphamide, even at lower dosages, can cause cardiotoxicity in patients with renal impairment due to the delayed elimination of its toxic metabolites. In addition, patients who receive CYP 450 inducers, such as prednisone, may experience the accelerated build-up of its toxic metabolites, thereby raising the risk for cardiotoxicity.</p><p><strong>Conclusion: </strong>The cardiotoxic manifestation of cyclophosphamide can arise from its use in several immune-mediated conditions. Given its potential for cardiotoxicity, careful cardiac monitoring during and after cyclophosphamide infusion is essential to ensure timely intervention, if needed.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 1","pages":"376-379"},"PeriodicalIF":1.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cystic parathyroid lesion: case report of rare entity.","authors":"Pietro Princi, Ludovica Di Fede, Serena Elisa Tempera, Giulia Salvi, Maria De Ninno, Miriam Veleno, Casimiro Nigro","doi":"10.1097/MS9.0000000000002869","DOIUrl":"10.1097/MS9.0000000000002869","url":null,"abstract":"<p><strong>Introduction and importance: </strong>Parathyroid cysts are rarely encountered in neck surgery and often misdiagnosed. We review the case incidence and treatment of parathyroid cystic lesions among all neck procedure in two single institutions operated on by a single surgeon.</p><p><strong>Case presentation: </strong>We report two female patients presenting with neck swallowing, dysphagia, choking and occasional dysphonia. Ultrasound US (ultrasound) imaging revealed two neck masses of 66 × 44 mm and 44 × 25 × 23 mm; serum iPTH (intact Parathyroid Hormone) levels were 238 and 699 ng/mL respectively and sestamibi scintiscan results were negative for both masses. Intra-cystic fluid evaluation of PTH showed elevated value (>5000 ng/ml). Both patients underwent parathyroidectomy along with total thyroidectomy and thyroid lobectomy. Post-operatively I-PTH and serum calcium levels became normal. Final histology confirmed a benign parathyroid cystic adenoma with concomitant benign thyroid disease.</p><p><strong>Clinical discussion: </strong>Parathyroid cyst is of rare entity and a diagnostic challenge.</p><p><strong>Conclusions: </strong>This case report demonstrates that fine needle aspiration (FNA) fluid with intra-cystic parathyroid analysis shows to be fundamental and supports surgery for hyperparathyroidism resolution.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 1","pages":"413-416"},"PeriodicalIF":1.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic challenges of tailgut cysts: a case report on an occult perianal mass.","authors":"Faraz Khalid, Haris Naveed, Masab Ali, Muhammad Saad Ansari, Muhammad Sajjad Shafiq, Muhammad Husnain Ahmad","doi":"10.1097/MS9.0000000000002880","DOIUrl":"10.1097/MS9.0000000000002880","url":null,"abstract":"<p><strong>Introduction: </strong>Tailgut cysts, or retro-rectal cystic hamartomas, are rare congenital lesions arising from embryonic hindgut remnants, typically located in the retro-rectal area. These cysts present some diagnostic challenges due to vague symptoms and potential for malignancy.</p><p><strong>Case presentation: </strong>A 25-year-old female presented with a 5-year history of perianal swelling. MRI revealed a T2 hyperintense, multiseptated cystic lesion suggestive of a tailgut cyst. The cyst was surgically excised via a trans-sacral approach, and the specimen was sent for histopathological analysis.</p><p><strong>Clinical discussion: </strong>The MRI findings were confirmed by histopathology, identifying a benign tailgut cyst. The patient had an uneventful recovery and was symptom-free at the 2-month follow-up.</p><p><strong>Conclusion: </strong>Tailgut cysts can mimic other perianal masses, complicating diagnosis. Accurate diagnosis and successful treatment rely on clinical vigilance, advanced imaging, and histopathological confirmation. Early surgical resection is crucial to prevent complications, including malignancy.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 1","pages":"421-424"},"PeriodicalIF":1.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of topical treatment with urea in ichthyosis, atopic dermatitis, psoriasis, and other skin conditions-a systematic review.","authors":"Inshal Jawed, Muhammad Umair Abdul Qadir, Umm E Farwa, Farah Alam, Fasiha Bakhtawar Fatima, Hina Khan, Vikash Kumar Karmani, Maham Javaid, Sandesh Raja, Muhammad Khuzzaim Khan, Adarsh Raja, Anuva Khanal","doi":"10.1097/MS9.0000000000002797","DOIUrl":"10.1097/MS9.0000000000002797","url":null,"abstract":"<p><strong>Introduction: </strong>The urea composition has a profound effect on skin disorders, specifically xerosis, desquamation, and scaling, which are some of the main concerns of the current health industry. The application of urea is relatable and more bioactive than alternate treatments. The objective of this systematic review was to evaluate the effectiveness of topically applied urea in the treatment of ichthyosis, psoriasis, and other dermatologic conditions.</p><p><strong>Data and sources: </strong>Research articles were retrieved through electronic databases, including Google Scholar, PubMed, EMBASE, Elsevier, and Sage, selected based on the provision of online free literature from its inception till November 2023. The significant findings were skin dryness, transepidermal water loss (TEWL), and eczema.</p><p><strong>Study selection: </strong>A total of 1826 studies have been found, of which 31 were selected based on inclusion criteria. The primary reason for the exclusion of the studies was the application of urea as a control. All in vivo studies disclosed the effectiveness of urea treatment separately or in addition to another compound on skin conditions. The selected studies have reported findings related to the improvement in xerosis, erythema, scaling, and reduction in TEWL.</p><p><strong>Conclusion: </strong>According to the in-depth review of the research articles, the application of urea has a tremendous effect on different skin diseases. Still, its role as monotherapy is overlooked due to the presence of more susceptible alternate products that need to be addressed. However, in the future, the evaluation of the effects of treatment containing urea with antibiotics on skin diseases would be more beneficial for practical knowledge.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 1","pages":"276-284"},"PeriodicalIF":1.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of being lateral and sitting position for spinal anesthesia administration on maternal hemodynamic variability and the timing of hypotension among cesarean section patients in a resource-constrained area: a prospective observational cohort study.","authors":"Sintayehu Samuel, Blen Kasahun, Tsegaye Demeke, Seleman Reshad, Nesredin Shemsu, Abdulkadir Kedir, Astemamagn Achule, Temesgen Mamo, Getahun Dendir, Sinishaw Genetu, Yisehak Wolde","doi":"10.1097/MS9.0000000000002754","DOIUrl":"10.1097/MS9.0000000000002754","url":null,"abstract":"<p><strong>Background: </strong>Type of anesthesia used for cesarean section can be general, spinal, or epidural. However, peripheral nerve blocks, such as the lower and upper extremity nerve blocks, can be referred to as other types of anesthesia. Spinal anesthesia is the most frequently used method because of its ease, dependability, and rapidity in attaining proper anesthesia. The purpose of this study was to determine the effects of spinal anesthesia induction position on maternal hemodynamics and the timing of hypotension.</p><p><strong>Method: </strong>A prospective observational cohort study design was employed. A simple random sampling technique was used. A total of 190 patients received spinal anesthesia, with 95 in the lateral and 95 in the sitting position in each group. The data were entered into Epi Data version 4.6 and then exported to SPSS version 26 for analysis. Independent sample <i>t</i>-tests and chi-square (<i>χ</i> ²) tests were performed. Kaplan-Meier survival analysis and log-rank test were used and <i>P</i> value ≤0.05 considered significant.</p><p><strong>Results: </strong>The overall incidence rates of hypotension in the lateral and sitting groups were 54.6% [95% CI, 52.3-72.1] and 73.8% [95% CI, 69.8-87.2], respectively (<i>P</i> = 0.025). The timing of first hypotension was 8.86 minute [95% CI, 8.690-13.272] and 15.75 minute [95% CI, 14.569-19.372] (<i>P</i> = 0.001) for sitting and lateral, respectively.</p><p><strong>Conclusion and recommendation: </strong>In this study, we found a significant difference between the lateral and sitting groups with different measurement parameters, such as blood pressure, intraoperative adverse events, and onset of hypotension. The incidence of hypotension, intraoperative adverse effects of spinal anesthesia, and fluid consumption were lower in the lateral groups. Nonetheless, instead of being technically challenging during spinal anesthesia induction, the lateral position results in better hemodynamics and onset of hypotension than in the sitting posture.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 1","pages":"62-69"},"PeriodicalIF":1.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transitioning to oral therapy compared to IV in <i>Staphylococcus aureus</i> bloodstream infections: a systematic review and meta-analysis.","authors":"Omme Salma, Mohammed Abdul Samee, Muhammad Saqlain Mustafa, Abdul Haseeb, Wing Lam Ho, Hin Ming Chan, Andrea Gómez Pons, Muhammad Ashir Shafique, Syed Muhammad Sinaan Ali, Abdul Raheem, Tagwa Kalool Fadlalla Ahmad","doi":"10.1097/MS9.0000000000002742","DOIUrl":"10.1097/MS9.0000000000002742","url":null,"abstract":"<p><strong>Background and objective: </strong><i>Staphylococcus aureus</i> bloodstream infections pose a significant threat to public health and necessitate substantial healthcare resources. The optimal antimicrobial therapy for these infections remains a subject of debate. This systematic review and meta-analysis evaluated the efficacy and safety of early transition to oral antimicrobial therapy compared with continued intravenous (IV) therapy in patients with MRSA and MSSA bloodstream infections.</p><p><strong>Method: </strong>A PRISMA-guided systematic review and meta-analysis compared the early transition from intravenous to oral antibiotics with continued intravenous therapy in patients with <i>S. aureus</i> infections, utilizing relevant studies from the PubMed, Embase, Scopus, and Web of Science databases from August 2003 to June 2024.</p><p><strong>Results: </strong>This meta-analysis of 11 studies (N = 54-220, primarily male, age: mid-30s to early 70s) revealed a 71.6% higher risk of all-cause mortality for patients transitioned to early oral therapy than for those who continued IV therapy (RR: 1.716; 95% CI: 1.039-2.836; <i>P</i> = 0.035; I² = 44%). Treatment failure, rehospitalization rates, adverse events, and hospital stay lengths did not differ significantly between groups.</p><p><strong>Conclusion: </strong>Early oral antimicrobial therapy for <i>S. aureus</i> bloodstream infections significantly reduces mortality compared to prolonged intravenous treatment, without increasing the incidence of adverse events or the risk of rehospitalization, suggesting its safety and efficacy as an alternative therapeutic approach; however, further randomized controlled trials are necessary to corroborate these findings.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 1","pages":"265-275"},"PeriodicalIF":1.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of ultrasonic bone dissector in diffuse idiopathic skeletal hyperostosis involving the cervical spine.","authors":"Gianluca Scalia, Massimiliano Giuffrida, Giancarlo Ponzo, Massimo Furnari, Bipin Chaurasia, Giuseppe E Umana, Giovanni F Nicoletti","doi":"10.1097/MS9.0000000000002846","DOIUrl":"10.1097/MS9.0000000000002846","url":null,"abstract":"<p><strong>Introduction and importance: </strong>Diffuse idiopathic skeletal hyperostosis (DISH), or Forestier's disease, is characterized by ligament and enthesis calcification, mainly in the thoracic spine. Cervical involvement can cause dysphagia due to soft tissue compression, necessitating surgical intervention when conservative measures fail. We assess the efficacy of anterior cervical osteophytectomy with an ultrasonic bone dissector in relieving symptoms and improving outcomes.</p><p><strong>Case presentation: </strong>A 73-year-old male presented with progressive neck pain and dysphagia caused by DISH in the cervical spine. Conservative treatment was ineffective, requiring anterior cervical osteophytectomy using an ultrasonic bone dissector. Postoperative imaging confirmed spinal cord decompression, and the patient experienced significant symptom relief. The ultrasonic bone dissector enabled precise bone resection, facilitating resolution of dysphagia and improving quality of life.</p><p><strong>Clinical discussion: </strong>This case highlights the effectiveness of ultrasonic bone dissection for cervical DISH. The device ensures precise bone removal with minimal soft tissue trauma, reducing complications and promoting recovery. While initial outcomes are promising, long-term studies are needed to compare this method with other interventions.</p><p><strong>Conclusion: </strong>Surgical intervention, particularly anterior cervical osteophytectomy with ultrasonic bone dissection, is effective when conservative treatments fail. Advanced surgical techniques improve patient outcomes and warrant further investigation to establish their role in managing cervical DISH.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 1","pages":"398-402"},"PeriodicalIF":1.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute urinary retention in an adolescent female with Herlyn-Werner-Wunderlich syndrome.","authors":"Pradeep Shrestha, Bibek Shrestha, Amit K Mishra, Neeta Katuwal","doi":"10.1097/MS9.0000000000002752","DOIUrl":"10.1097/MS9.0000000000002752","url":null,"abstract":"<p><strong>Introduction and importance: </strong>Herlyn-Werner-Wunderlich syndrome (HWWS) is a rare congenital anomaly characterized by the triad of uterus didelphys, unilateral obstructed hemivagina, and ipsilateral renal agenesis. However, atypical presentations such as acute urinary retention are uncommon and pose diagnostic challenges. Early identification and treatment are crucial to prevent long-term complications like endometriosis and infertility.</p><p><strong>Case presentation: </strong>A 12-year-old female presented with the unusual symptom of acute urinary retention, which was likely caused by compression of the bladder neck due to hematocolpos. Imaging via ultrasound and MRI confirmed the presence of uterus didelphys, obstructed hemivagina, and ipsilateral renal agenesis, consistent with HWWS. Surgical excision of the vaginal septum was performed to relieve the hematocolpos, with the patient experiencing a full recovery.</p><p><strong>Clinical discussion: </strong>Congenital abnormalities of Mullerian Duct are rare, and atypical presentations such as acute urinary retention, vaginal discharge, and even pyocolpos or hematosalpinx have been reported. MRI played a crucial role in confirming the diagnosis and guiding treatment. The importance of early detection and long-term monitoring is highlighted, though limitations exist due to the inability to assess future reproductive outcomes.</p><p><strong>Conclusion: </strong>This case emphasizes the importance of recognizing atypical presentations of HWWS, such as acute urinary retention. Timely diagnosis and appropriate surgical intervention are critical for preventing complications and restoring normal function. Early recognition of this rare syndrome, especially in patients with unusual symptoms such as urine retention, is essential for ensuring optimal clinical outcomes.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 1","pages":"331-334"},"PeriodicalIF":1.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain tumors and induced pluripotent stem cell technology: a systematic review of the literature.","authors":"Monir Shayestehfar, Tina Taherkhani, Pardis Jahandideh, Amir A Hamidieh, Mahsa Faramarzpour, Amirhossein Memari","doi":"10.1097/MS9.0000000000002760","DOIUrl":"10.1097/MS9.0000000000002760","url":null,"abstract":"<p><strong>Background: </strong>Induced pluripotent stem cells (iPSCs) provide a novel approach to studying the pathophysiology of brain tumors and assessing various therapeutic techniques with greater precision. This study aims to systematically review the existing literature to critically analyze and synthesize current research findings. The objective is to evaluate the role of iPSCs in understanding brain tumors and in the development of innovative treatment strategies.</p><p><strong>Methods: </strong>We systematically reviewed existing articles that utilized iPSC technology to assess either the pathophysiology of brain tumors or therapeutic techniques, following the standards of Preferred Reporting Items for Systematic review and Meta-Analysis guidelines. Key terms were comprehensively searched in electronic databases, including PubMed, EMBASE, and Scopus. Articles were screened based on specific inclusion and exclusion criteria. Ultimately, 22 relevant articles were chosen, and their data were extracted.</p><p><strong>Results: </strong>The summary of findings for each selected article was organized into two general categories: \"Methods of Generating iPSCs\" and \"Applications of iPSCs.\" The methods of iPSC generation, including transfection and transduction, as well as the types of viral or non-viral vectors used, were extracted and reported for each study. Additionally, the main aims of the selected studies, whether modeling or therapeutic approaches, were gathered and reported in the results section.</p><p><strong>Conclusion: </strong>iPSC technology is a novel vehicle that brings new solutions to overcome difficulties in brain tumor studies. In vivo and in vitro models generated from iPSCs provide suitable platforms to investigate the pathophysiology of brain tumors more precisely. Also, iPSCs have been utilized in various studies to examine how different antitumor agents may affect the target cells.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"87 1","pages":"250-264"},"PeriodicalIF":1.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11918708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}