Annals of Medicine and Surgery最新文献

{"title":"Assessment of chemotherapy-associated sarcopenia using SARC-F and handgrip strength: a cross-sectional analysis.","authors":"Nabil Almouaalamy","doi":"10.1097/MS9.0000000000005251","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005251","url":null,"abstract":"<p><strong>Background: </strong>Sarcopenia is a significant health concern among patients with cancer who receive chemotherapy due to its potential impacts on treatment tolerance and functional status.</p><p><strong>Objectives: </strong>To explore the association between chemotherapeutic agents and practical sarcopenia markers, including SARC-F scores and grip strength, among oncology outpatients with advanced cancer, and to explore the relationship between chemotherapy exposure (cycle number) and functional muscle decline.</p><p><strong>Methods: </strong>A secondary analysis of a primary cross-sectional dataset of 324 patients who attended outpatient clinics at Princess Noorah Oncology Center, Jeddah. Sarcopenia was assessed via the SARC-F questionnaire and digital grip strength measurement. Associations between chemotherapeutic agents and sarcopenia markers were evaluated using inferential analyses, and agents showing significant bivariate associations were further analyzed using multiple linear regression.</p><p><strong>Results: </strong>Among chemotherapeutic agents, paclitaxel was independently associated with higher SARC-F scores (<i>β</i> = 1.19, 95% CI: 0.26-2.12, <i>P</i> = 0.013) and significantly lower grip strength (median: 28.1 kg vs. 41.3 kg, <i>P</i> < 0.001). Vinblastine showed a negative association with SARC-F in unadjusted analysis (<i>P</i> = 0.025), but not after adjustment (<i>P</i> = 0.269). No significant correlations were found between the number of chemotherapy cycles and either grip strength (R = 0.099, <i>P</i> = 0.212) or SARC-F score (R = 0.066, <i>P</i> = 0.405).</p><p><strong>Conclusion: </strong>Paclitaxel use is an independent predictor of functional decline in cancer patients, highlighting the need for early sarcopenia screening and tailored supportive care during taxane-based chemotherapy.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6249-6257"},"PeriodicalIF":1.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of depressive symptoms in surrogate mothers following child relinquishment: a systematic review and meta-analysis.","authors":"Pegah Rashidian, Ehsan Amini-Salehi, Mohammad Haddadi, Seyyed Amirhossein Salehi, Sepide Javankiani, Shiva Abedinzadeh, Shaghayegh Karami, Mohammadamin Parsaei, Marjan Ghaemi, Sedigheh Hantoushzadeh","doi":"10.1097/MS9.0000000000005539","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005539","url":null,"abstract":"<p><strong>Background: </strong>Surrogacy is a common assisted reproductive practice, yet its psychological impact on surrogate mothers remains a topic of concern. Understanding the prevalence of depressive symptoms among surrogate mothers is crucial for ensuring adequate mental health support. This systematic review and meta-analysis aimed to assess the prevalence of depressive symptoms among surrogate mothers.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across PubMed, Web of Science, Scopus, and Embase for studies published between 1 January 1990 and 31 December 2025. Reference lists of eligible articles were also screened. Studies examining rates of depressive symptoms in surrogate mothers within 1 year postpartum were included in the meta-analysis. A random-effects model was employed to estimate the pooled prevalence of depressive symptoms.</p><p><strong>Results: </strong>Eleven studies encompassing 637 surrogate mothers met the inclusion criteria, with six studies qualifying for meta-analysis. The pooled prevalence of depressive symptoms was 3% (95% CI: 0-16%). Subgroup analyses revealed a higher prevalence in India (27.3%) compared to studies from the UK and USA (0%). Additionally, studies with a low risk of bias reported a higher prevalence (9%) than those with a moderate risk (0%). No significant publication bias was detected.</p><p><strong>Conclusions: </strong>The overall prevalence of depressive symptoms among surrogate mothers following child relinquishment appears low; however, these findings should be interpreted cautiously and considered exploratory in light of the limited underlying evidence. Further well-designed studies are needed to clarify contextual factors influencing mental health outcomes in surrogacy.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6631-6640"},"PeriodicalIF":1.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D deficiency among Ethiopian adults: current evidence, determinants, and policy implications.","authors":"Binyam M Habte, Yoseph M Habte, Makida M Habte, Selamawit G Jima, Esimael M Abdu, Biruk W Fantu","doi":"10.1097/MS9.0000000000005594","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005594","url":null,"abstract":"<p><p>Vitamin D deficiency, commonly defined as a serum 25-hydroxyvitamin D [25(OH)D] level below 20 ng/mL (50 nmol/L), is a hidden but potentially high-impact public health problem in Ethiopian adults, despite the country's abundant year-round sunlight. Emerging studies indicate that certain populations, including pregnant women, patients with tuberculosis or HIV, and urban residents, experience high rates of deficiency, yet nationally representative data are virtually nonexistent. The lack of robust prevalence data, combined with limited laboratory capacity and low clinical awareness, has left this issue largely invisible in Ethiopia's health policy agenda. This narrative review synthesizes the existing evidence on vitamin D deficiency among Ethiopian adults through a literature search of PubMed/PMC, Web of Science, Google Scholar, and African Journals Online (AJOL). It identifies key determinants, including reduced sun exposure, dietary insufficiency, and dark skin pigmentation, and examines potential health consequences, such as impaired bone health, increased fracture risk, and altered immune and metabolic function. Drawing on successful fortification and supplementation programs from other sub-Saharan African countries, the review also outlines feasible, context-specific strategies for Ethiopia, including staple food fortification, targeted supplementation for high-risk groups, and public health campaigns promoting safe sun exposure. The review also highlights important evidence gaps, particularly the need for population-based surveys, standardized vitamin D assays, and longitudinal studies to better define the burden of deficiency and inform national policy. These findings provide an evidence-informed foundation for future research, clinical practice, and public health planning in Ethiopia.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6662-6669"},"PeriodicalIF":1.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison between operative management versus non-operative management in patients with solid organ blunt abdominal injury in the National Trauma Registry of Iran.","authors":"Sara Mirzamohamadi, Mohammad Navid HajiAbbasi, Somayeh Ghorbani, Payman Salamati, Mohammadreza Zafarghandi, Vafa Rahimi-Movaghar, Esmaeil Fakharian, Seyed Houssein Saeed-Banadaky, Vahid Hoseinpour, Mehdi Nasr Isfahani, Amir Ghadiphasha, Sobhan Pourmasjedi, Seyed Mohammad Piri, Khatereh Naghdi, Seyed Amir Miratashi Yazdi","doi":"10.1097/MS9.0000000000005467","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005467","url":null,"abstract":"<p><strong>Background: </strong>Trauma is one of the leading causes of death worldwide. Severe abdominal injuries cause one-fifth of injury mortality. Non-operative management (NOM) or operative management (OM) is a primary challenge in abdominal injuries. In this study, we aimed to compare NOM and OM outcomes in patients with solid organ blunt abdominal injuries in the National Trauma Registry of Iran (NTRI).</p><p><strong>Method: </strong>This cross-sectional study was conducted with data from the NTRI from 24 July 2016 to 21 May 2023. All patients with a solid organ abdominal injury by road traffic crash, falls, hit or bodily force, and assault with blunt objects were admitted to trauma registry member hospitals across the country, according to the NTRI criteria included in this study.</p><p><strong>Results: </strong>Among 358 patients, liver, spleen, and kidney single-organ injuries were managed non-operative more than operative. Among multi-organ abdomen injuries, kidney injuries alongside spleen or liver injuries are managed non-operative more than operative. In the multiple regression model on the matched cohort (102 NOM with 102 OM), moderate or severe Glasgow Coma Scale (GCS) had 16.79 times more chance of Intensive Care Unit (ICU) admission than mild GCS [OR: 16.79, 95% CI (2.06, 137.22), <i>P</i> = 0.008]. Also, hypovolemia increased the chance of death 12.9 times [OR: 12.90, 95% CI (2.20, 75.53), <i>P</i> = 0.005]. In addition, for every 1-year increase in age, the odds of the death occurring increased 1.07 [OR: 1.07, 95% CI (1.02, 1.12), <i>P</i> = 0.005].</p><p><strong>Conclusion: </strong>We observed the non-inferiority of NOM than OM due to the outcomes. Although the liver, spleen, and kidney are mainly managed by non-operatives.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6296-6303"},"PeriodicalIF":1.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in pharmacologic management of obesity: oral semaglutide for weight management.","authors":"Fnu Zainab, Abdul Haseeb Hasan","doi":"10.1097/MS9.0000000000005161","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005161","url":null,"abstract":"<p><p>Obesity is a chronic, multifactorial disease characterized by excessive adiposity and associated with an increased risk of cardiovascular disease, type 2 diabetes, and reduced quality of life. Despite the widespread adoption of lifestyle interventions, long-term weight maintenance remains challenging, highlighting the need for effective pharmacologic therapies. Recent advances, including the US Food and Drug Administration approval of oral semaglutide, offer new opportunities for patient-centered obesity management. Evidence from the OASIS 1 and OASIS 4 trials demonstrates that oral semaglutide, combined with lifestyle intervention, produces clinically meaningful weight loss in adults with overweight or obesity without type 2 diabetes, while improving physical function and cardiometabolic risk markers, such as waist circumference, lipids, and inflammatory parameters. These trials further underscore the benefits of an oral formulation in improving accessibility and adherence compared with injectable therapies. Collectively, oral semaglutide represents a significant advancement in obesity pharmacotherapy, complementing lifestyle interventions and providing both metabolic and functional benefits. Future studies addressing long-term efficacy, cardiovascular outcomes, comparative effectiveness with other agents, and real-world implementation will be essential to fully define its role in comprehensive, individualized obesity care.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6244-6248"},"PeriodicalIF":1.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The case for transitioning to living systematic reviews in rapidly evolving clinical fields.","authors":"Zohaib Hassan, Ayesha Tariq, Sabeen Tahir, Rejina Chhetri, Janu Chhetri, Marina Kc","doi":"10.1097/MS9.0000000000005645","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005645","url":null,"abstract":"","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6918-6919"},"PeriodicalIF":1.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholecystocolonic fistula with ruptured cystic artery pseudoaneurysm presenting as massive per rectal bleeding: a case report.","authors":"Uttam Chaulagain, Kapil Khanal, Naveen Gautam, Kailash Mani Pokhrel, Bishal Gaurav, Sushil Gyawali, Rima Thapa, Abinash Oli","doi":"10.1097/MS9.0000000000005490","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005490","url":null,"abstract":"<p><strong>Introduction and importance: </strong>Cholecystocolonic fistula and cystic artery pseudoaneurysm are rare complications of gallbladder disease. Their coexistence with massive lower gastrointestinal bleeding is extremely rare and potentially fatal.</p><p><strong>Case presentation: </strong>A 47-year-old male presented with severe acute cholecystitis, followed by massive per rectal bleeding and hypovolemic shock. Contrast enhanced CT revealed a cholecystocolonic fistula with a cystic pseudoaneurysm. The patient underwent emergency open cholecystectomy, primary colon repair, and diversion ileostomy. Postoperative histopathology confirmed chronic cholecystitis without malignancy. The ileostomy was successfully closed 8 weeks later, and the patient recovered well.</p><p><strong>Clinical discussion: </strong>This rare bleeding mechanism may lead to diagnostic delays. Contrast-enhanced CT is crucial for identifying the source of bleeding, while surgery remains the definitive treatment for patients with cholecystoenteric fistulas.</p><p><strong>Conclusion: </strong>This case describes a rare cause of lower GI bleeding. Early identification and timely surgery are crucial to avoiding fatal outcomes.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6763-6767"},"PeriodicalIF":1.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term mortality trends of COPD and respiratory failure among adults aged ≥25 years in the United States: an analysis of CDC WONDER data (1999-2023).","authors":"Affaf Mahmood, Farah Latif, Abdul Haseeb Hasan","doi":"10.1097/MS9.0000000000005658","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005658","url":null,"abstract":"<p><p>Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality in the United States and frequently associated with advanced stages complicated by respiratory failure (RF), a major terminal event that has been epidemiologically associated with significantly higher mortality risk among COPD patients. Despite this, long-term population-level trends in COPD-related mortality complicated by RF remain insufficiently characterized. We aimed to quantify long-term mortality trends of COPD and RF among adults aged 25 years or older in the United States from 1999 to 2023 by analyzing age-adjusted mortality rates (AAMRs), annual percent changes (APCs), and demographic and geographic variations using the CDC Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) database. Using national multiple-cause-of-death data from 1999 to 2023, we identified deaths in which COPD and respiratory failure were co-listed using ICD-10 codes. Mortality trends were assessed using Joinpoint regression analysis to estimate APC, along with 95% confidence intervals (CIs) and statistical significance testing (<i>P</i> < 0.05). AAMRs were calculated per 100 000 population using the direct standardization method based on the 2000 U.S. standard population. CDC WONDER is a publicly available, population-based mortality database maintained by the Centers for Disease Control and Prevention, which provides de-identified national death certificate data. A total of 1 393 458 adults aged 25 years or older died from COPD and RF between 1999 and 2023. The overall AAMR was 24.9 per 100 000 (95% CI: 24.8-24.9) with a significant increasing trend (APC: 0.88%, 95% CI: 0.41-1.38, <i>P</i> < 0.0008). Men had higher mortality than women (29.1 vs 22.1 per 100 000), while women showed a faster increase (APC: 1.27% vs 0.29%). White adults had the highest mortality rate (26.3 per 100 000), while Asian or Pacific Islanders had the lowest (8.7 per 100 000). The Midwest showed the steepest rising trend (APC: 2.25%, <i>P</i> < 0.000001), while other regions showed lower or non-significant changes. West Virginia had the highest state-level mortality, and Hawaii the lowest. Targeted public health strategies focusing on smoking cessation, early screening of high-risk populations, improved access to pulmonary care, and reduction of regional healthcare disparities may help address factors associated with COPD- and respiratory failure-related mortality in the United States. These findings represent population-level associations and should not be interpreted as causal relationships.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6430-6440"},"PeriodicalIF":1.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomy of corpus callosum and lateral ventricle: a fiber dissection study.","authors":"Yash Aneesh Gangal, Dattatraya Prakash Muzumdar","doi":"10.1097/MS9.0000000000005528","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005528","url":null,"abstract":"<p><strong>Objective: </strong>This fiber dissection study aimed to explore the anatomy of the fibers of corpus callosum. In addition, the authors sought to explore the interior of the lateral ventricle by opening the window created by incisions made on ventral callosal radiations and transverse callosal fibers.</p><p><strong>Methods: </strong>Blunt fiber dissection of eight formalin fixed normal adult human cadaveric brains was performed. The primary dissection tools were blunt wooden spatulas. Specimens were photographed at progressive steps of dissection.</p><p><strong>Results: </strong>The course of fibers of the corpus callosum and their relationships with the lateral ventricle were demonstrated. Incisions were made on the callosal fibers to create a window to access the lateral ventricle and its interior was studied.</p><p><strong>Conclusions: </strong>Corpus callosum is an elaborate structure composed of fibers originating from (and terminating in) virtually every region of the cerebral cortex. Fibers of the corpus callosum contribute to the composition of walls of the lateral ventricle and fiber dissection is an excellent method to demonstrate this anatomy. A detailed understanding of anatomy of corpus callosum and the lateral ventricles is essential for neurosurgeons for performing surgery of intraventricular tumors as well as disconnective epilepsy surgery procedures. Three-dimensional understanding of this anatomy can be developed by performing fiber dissections.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6272-6282"},"PeriodicalIF":1.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical thrombectomy for superior sagittal sinus thrombosis in early pregnancy: a case report.","authors":"Safal Bogati, Bishal Pradhan, Naresh Kharbuja","doi":"10.1097/MS9.0000000000005639","DOIUrl":"https://doi.org/10.1097/MS9.0000000000005639","url":null,"abstract":"<p><strong>Introduction: </strong>Cerebral venous sinus thrombosis is a rare but life-threatening cause of stroke in pregnancy, typically occurring in the third trimester or postpartum. First-trimester presentations are exceptionally uncommon. We report a case of superior sagittal sinus thrombosis at 6 weeks of gestation successfully managed with mechanical thrombectomy and anticoagulation.</p><p><strong>Case presentation: </strong>A 20-year-old primigravida at 6 weeks of gestation with no significant history and family history of cerebrovascular event, presented with a three-day history of vomiting followed by generalized seizures and a headache. Neurological examination revealed a Glasgow Coma Scale of 14/15 and right lower limb paresis (3/5). Neuroimaging (MRI/MRV) confirmed superior sagittal sinus thrombosis with multiple venous infarcts and hemorrhagic transformation.</p><p><strong>Investigations and management: </strong>Autoimmune and antiphospholipid workup was negative. A multidisciplinary team of neurologists, obstetricians, and interventional radiologists initiated therapeutic low-molecular-weight heparin at 1 mg/kg twice daily and cerebral oedema control. Due to extensive clot burden and neurological deficits, mechanical thrombectomy was performed, retrieving a 25 cm thrombus and achieving successful recanalization. The patient showed complete neurological recovery at a 2-week follow-up. Following patient counselling regarding maternal-fetal risks and the unplanned nature of the pregnancy, a medical termination was later performed.</p><p><strong>Conclusions: </strong>Cerebral venous sinus thrombosis should be considered in pregnant women presenting with seizures or focal deficits, even in early gestation. While low-molecular-weight heparin is the gold standard, this case demonstrates that mechanical thrombectomy is a feasible and effective escalation of care for patients with extensive thrombosis and neurological deterioration, even during the first trimester.</p>","PeriodicalId":8025,"journal":{"name":"Annals of Medicine and Surgery","volume":"88 10","pages":"6841-6845"},"PeriodicalIF":1.6,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}