Annals of Nuclear Medicine最新文献

{"title":"Phenotype-specific metabolic patterns in Posterior cortical atrophy and early-onset typical Alzheimer’s disease","authors":"Jiaying Lu,&nbsp;Keliang Chen,&nbsp;Huamei Lin,&nbsp;Zizhao Ju,&nbsp;Jingjie Ge,&nbsp;Jie Lu,&nbsp;Yihui Guan,&nbsp;Qihao Guo,&nbsp;Shuguang Chu,&nbsp;Qianhua Zhao,&nbsp;Chuantao Zuo,&nbsp;Ping Wu,&nbsp;for the Shanghai Memory Study","doi":"10.1007/s12149-025-02025-8","DOIUrl":"10.1007/s12149-025-02025-8","url":null,"abstract":"<div><h3>Objective</h3><p>Posterior cortical atrophy (PCA) is generally considered an atypical variant of Alzheimer's disease (AD) and is an important component of early-onset AD. Symptomatologic heterogeneity has led to a high rate of misdiagnosis or delayed diagnosis of early-onset AD. We sought to establish the phenotypic-specific metabolic patterns of PCA and early-onset typical AD (tAD) and to assess whether phenotype-specific neuroimaging biomarkers are more valuable for disease recognition.</p><h3>Methods</h3><p>Patients accepting ¹⁸F-FDG PET with an onset age younger than 65 years (PCA, <i>n</i> = 40; early-onset tAD, <i>n</i> = 37; behavioral variant frontotemporal dementia (bv-FTD), <i>n</i> = 35) and healthy controls (HCs, <i>n</i> = 30) were enrolled and divided into two cohorts for pattern establishment and validation, respectively. Similarities and differences between patterns were assessed by pattern topography, expression, classification performance and correlation with clinical severity.</p><h3>Results</h3><p>PCA-related pattern (PCARP) was characterized by extensively relative hypometabolism in the parietal lobe, occipital lobe, temporal lobe, cingulate gyrus, and relative hypermetabolism mainly in vermis, thalamus. Early-onset tAD-related pattern (EOtADRP) was characterized by relative hypometabolism mainly in the middle frontal gyrus, angular gyrus, precuneus, middle temporal gyrus, cingulate gyrus, caudate, and relative hypermetabolism mainly in vermis, thalamus, postcentral gyrus. PCARP and EOtADRP were closely related in topography (<i>r</i> = 0.909, <i>P</i> &lt; 0.001) and expression (<i>r</i> = 0.862, <i>P</i> &lt; 0.001). High accuracies in distinguishing corresponding patient group from HC were found in both, while only PCARP was capable of phenotype discrimination (PCA <i>versus</i> early-onset tAD; area under the receiver operating characteristic curve [AUC] = 0.84–0.88 for PCARP, AUC = 0.57–0.62 for EOtADRP) and distinguishment between PCA/early-onset tAD and bv-FTD (AUC = 1.00/0.91 for PCARP, AUC = 0.73/0.62 for EOtADRP). PCARP showed great potential in detecting clinical severity in both phenotypes whereas EOtADRP only worked in early-onset tAD.</p><h3>Conclusion</h3><p>PCARP outperformed EOtADRP in phenotype discrimination with better potential in severity assessment.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 5","pages":"506 - 517"},"PeriodicalIF":2.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there any effect of hcc location on selective internal radiation therapy with 90yttrium response?","authors":"Elife Akgun,&nbsp;Cagrı Erdim,&nbsp;Burcu Ibicioglu,&nbsp;Tevfik Guzelbey,&nbsp;Burcu Esen Akkas,&nbsp;Ozgur Kılıckesmez","doi":"10.1007/s12149-025-02028-5","DOIUrl":"10.1007/s12149-025-02028-5","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;p&gt;We planned this retrospective study to evaluate the effect of the central vs peripheral location effect on the success of selective internal radiation therapy (SIRT) with &lt;sup&gt;90&lt;/sup&gt;Yttrium-90 (&lt;sup&gt;90&lt;/sup&gt;Y) glass microspheres in hepatocellular carcinomas (HCC).&lt;/p&gt;&lt;h3&gt;Material and methods&lt;/h3&gt;&lt;p&gt;Thirty-eight patients diagnosed with HCC who were eligible for SIRT with &lt;sup&gt;90&lt;/sup&gt;Y glass microspheres were included in this study. The location being central versus peripheral was defined as explained: Straight lines through the bifurcation of the right and left branches of the portal vein to the center of the HCC and the peripheral surface of the liver were traced on the same plane. The coefficient was determined as a ratio of the center of the HCC to the distance from the hilum of the liver at the portal vein bifurcation. Value under ½ accepted as central location (Group 1, &lt;i&gt;n&lt;/i&gt; = 17), over ½ values are accepted as peripheral location (Group 2, &lt;i&gt;n&lt;/i&gt; = 21). Treatment responses were analyzed after 2 months of the treatment with magnetic resonance imaging, and 2-deoxy-2-[&lt;sup&gt;18&lt;/sup&gt;F]fluoro-D-glucose positron emission tomography/computed tomography ([&lt;sup&gt;18&lt;/sup&gt;F]FDG PET/CT) for FDG-avid ones. Differences in treatment responses rates, treatment approach, the absorbed doses and the volumes of each liver segments between groups were investigated.&lt;/p&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;In Group 1; mean age was 67. In 5 cases split infusion, in 10 cases tumor selective treatment approach were applied. According to PERCIST/mRECIST criteria treatment responses categories: complete response in 2/1 cases, partial response in 7/9 cases, stable disease in 3/4 cases, progressive diseases in 2/3 cases; respectively. AFP value decreased in 2 cases, increased in 7 cases, and was stable in 1 case. Mean absorbed doses were 347.9 Gy for tumor, 140.6 Gy for perfused normal tissue, and 26.1 Gy for the normal liver. In Group 2; the mean age was 71.5. In 5 cases split infusion, and in 1 case non-selective treatment approach were applied. According to PERCIST/mRECIST criteria treatment responses categories: complete response in 7/6 cases, partial response in 7/10 cases, stable disease in 2/2 cases, and progressive diseases in 3/3 cases; respectively. AFP value decreased in 9 cases, increased in 2 cases, and was stable in 2 cases. Mean absorbed doses were 495.9 Gy for tumor, 134 Gy for perfused normal tissue, and 17.3 Gy for the normal liver.There is no statistically significant difference in terms of gender, treatment response rates, tumor volumes, perfuse tissue volumes between 2 groups. However, tumor-selective approach and absorbed doses of the perfused normal tissue and the tumor were significantly higher in Group 2 (&lt;i&gt;p&lt;/i&gt; = 0.007, 0.04, and 0.02; respectively).&lt;/p&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;p&gt;Contrary to expectation, centrally located HCCs could be treated as successfully as peripherally located HCCs. However, the complete response rate in the p","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 5","pages":"527 - 534"},"PeriodicalIF":2.5,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12149-025-02028-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy analysis of radioactive iodine therapy for familial non-medullary thyroid cancer in the era of personalized medicine: a cohort study and a meta-analysis","authors":"Jingjia Cao,&nbsp;Xiang Li,&nbsp;Huazhen Liang,&nbsp;Yang Li,&nbsp;Fei Zhao,&nbsp;Aiqiang Dong","doi":"10.1007/s12149-025-02029-4","DOIUrl":"10.1007/s12149-025-02029-4","url":null,"abstract":"<div><h3>Objective</h3><p>Compared with those of sporadic differentiated thyroid cancer (SDTC), the tumor characteristics of familial nonmedullary thyroid cancer (FNMTC) remain debatable. In addition, there is a paucity of data suggesting that their response to radioactive iodine (RAI) therapy differs from that of SDTC. We aimed to determine whether FNMTC is a homogenous biological entity that differs from SDTC in RAI therapy.</p><h3>Methods</h3><p>We retrospectively analyzed patients who underwent adjuvant ablative iodine radiotherapy between July 2016 and March 2020. We compared the differences in clinicopathological features and prognoses between the FNMTC and SDTC groups. The endpoint of the study was the rate of therapeutic response after 1 and 3 years of follow-up after first-line treatment. The response to therapy was classified into four categories: excellent response (ER), biochemical incomplete response (BIR), structural incomplete response (SIR) and indeterminate response (IDR). In addition, we conducted a meta-analysis of cohort studies to investigate the clinical outcomes.</p><h3>Results</h3><p>Of all the patients (<i>n</i> = 1758), 109 (6.2%) were classified as having FNMTC, whereas the remaining 1649 (93.8%) had SDTC. A greater proportion of FNMTC patients presented with extrathyroidal extension, capsular invasion, and multifocality (<i>P</i> = 0.01). In addition, patients with FNMTC were more likely to have advanced primary tumor stage and lymph node metastasis, but the differences were not statistically significant. At the end of follow-up (median follow-up of 3 years), the response to RAI therapy was significantly different between the two groups (ER: 66.1% <i>vs</i> 74.3%; IDR: 9.2% <i>vs</i> 12.1%; SIR: 14.7% <i>vs</i> 7.1%; BIR: 10.1% <i>vs</i> 6.5%). Moreover, patients with FNMTC more frequently presented evidence of disease than patients with SDTC did. However, the disease-free survival of patients with FNMTC was not shorter than that of patients with SDTC (<i>P</i> ≥ 0.05).</p><h3>Conclusion</h3><p>Patients with FNMTC more often have aggressive characteristics at presentation and relatively worse clinical outcomes after RAI therapy. However, there was no statistically significant difference in the recurrence rate in the short-term follow-up. Considering that, FNMTC patients may be required more aggressive treatment approaches and closer postoperative monitoring.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 6","pages":"535 - 545"},"PeriodicalIF":2.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognostic role of staging [18F]PSMA-1007 PET/CT volumetric and dissemination features in prostate cancer","authors":"Domenico Albano,&nbsp;Alessandro Temponi,&nbsp;Francesco Bertagna,&nbsp;Nazareno Suardi,&nbsp;Anna Talin,&nbsp;Marco Lorenzo Bonù,&nbsp;Luca Triggiani","doi":"10.1007/s12149-025-02026-7","DOIUrl":"10.1007/s12149-025-02026-7","url":null,"abstract":"<div><h3>Background</h3><p>This study aimed the role of volumetric and dissemination features of staging [18F]PSMA-1007 PET/CT in predicting progression‐free survival (PFS) in patients with prostate cancer (PCa) and their relationship with the main clinical data (ISUP grade groups, number of lesions, PSA).</p><h3>Methods</h3><p>We included 164 patients with high-risk PCa who underwent baseline [18F]PSMA-1007 PET/CT. With the help of LIFEx version 7.7, the main volumetric and dissemination PET parameters were semi-automatically extracted: PSMA-prostate tumor volume (PSMA-TV), PSMA-prostate total lesion (PSMA-TL), PSMA total TV (PSMA-TTV), PSMA total TL (PSMA-TTL) and Dmax corrected for body-surface-area (Dmax_bsa). Spearman rank correlations between semiquantitative PET features and the clinical variables were analyzed. PFS estimates were plotted with the Kaplan–Meier method.</p><h3>Results</h3><p>A high correlation was seen between the number of lesions and both PSMA-TTL (r 0.725), and Dmaxbsa (r 0.935). A moderate correlation was registered between PSA and PSMA-TTV (r 0.333), PSMA-TTL (r 0.441), Dmax_bsa (r 0.333), as well as between number of lesions and PSMA-TTV (r 0.342).</p><p>After a median follow-up of 17 months (range 2–45), relapse/progression happened in 17 patients (10%). PSA level, presence of distant metastases at staging, PSMA-TV, PSMA-TL, PSMA-TTL and Dmax_bsa were significantly associated with PFS at univariate analysis, but only the presence of distant metastases, PSMA-TTL and Dmax_bsa were confirmed to be independent prognostic factors.</p><h3>Conclusion</h3><p>Volumetric and dissemination features derived by staging [18F]PSMA-1007 PET/CT were significantly correlated with PSA and number of lesions. The combination of PSMA-TTL and Dmax_bsa was the best predictor of PFS and may help to better stratify PCa patients.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 5","pages":"518 - 526"},"PeriodicalIF":2.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12149-025-02026-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the diagnostic accuracy of VSBONE BSI versions for detecting bone metastases in breast and prostate carcinoma patients using conventional and CZT detector gamma cameras","authors":"Akiko Oya,&nbsp;Michihiro Nakayama,&nbsp;Takahiro Uno,&nbsp;Haruka Ueda,&nbsp;Ippei Yoshida,&nbsp;Atsushi Fujiya,&nbsp;Yurina Nomura,&nbsp;Atsutaka Okizaki","doi":"10.1007/s12149-025-02020-z","DOIUrl":"10.1007/s12149-025-02020-z","url":null,"abstract":"<div><h3>Objective</h3><p>Bone scintigraphy is widely employed for detecting bone metastases, with the bone scan index (BSI) gaining traction as a quantitative tool in this domain. VSBONE BSI, an automated image analysis software, identifies abnormal hyperaccumulation areas in bone scintigraphy and computes BSI scores. The software, originally developed using data from conventional gamma cameras (C-Camera), has undergone two upgrades. This study hypothesized that the upgrades enhance the diagnostic accuracy for bone metastases and assessed the software’s applicability to images obtained using a cadmium–zinc–telluride detector gamma camera (CZT-Camera). The aim was to compare the diagnostic accuracy of VSBONE BSI across software versions using both conventional and CZT detectors and to evaluate its utility.</p><h3>Methods</h3><p>A total of 287 patients with breast or prostate carcinoma who underwent whole-body bone scintigraphy were included. VSBONE BSI automatically analyzed and calculated the BSI. The analysis results were compared with the presence or absence of metastases for each software version by using detector type of camera. The diagnostic agreement was evaluated.</p><h3>Results</h3><p>Receiver operating characteristic analysis showed an area under the curve (AUC) exceeding 0.7 across all groups, indicating good diagnostic performance. AUC values significantly increased with version upgrades for all patients and for breast carcinoma patients. In metastasis-negative cases, BSI values decreased with each software version upgrade, with the reduction being more pronounced in breast carcinoma patients scanned with the CZT-Camera.</p><h3>Conclusions</h3><p>Using the VSBONE BSI, version 2 or 3 had a higher rate of diagnostic concordance with the clinical prognosis than version 1. In metastasis-negative patients, newer software versions yielded lower BSI values, especially for breast carcinoma patients scanned using the CZT-Camera, highlighting the improved diagnostic accuracy of the updated software.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 5","pages":"466 - 475"},"PeriodicalIF":2.5,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathologic and metabolic variables from 18F-FDG PET/CT in the prediction of recurrence pattern in stage I–III non-small cell lung cancer after curative surgery","authors":"G. A. Jimenez Londoño,&nbsp;J. Pérez-Beteta,&nbsp;M. Amo-Salas,&nbsp;A. F. Honguero-Martinez,&nbsp;V. M. Pérez-García,&nbsp;C. Lucas Lucas,&nbsp;A. M. Soriano Castrejón,&nbsp;A. M. García Vicente","doi":"10.1007/s12149-025-02021-y","DOIUrl":"10.1007/s12149-025-02021-y","url":null,"abstract":"<div><h3>Aim</h3><p>This study aimed to analyze the clinicopathologic and metabolic parameters derived from staging ¹⁸F-FDG PET/CT that can predict recurrence patterns in non-small-cell lung cancer (NSCLC) after curative surgery.</p><h3>Material and methods</h3><p>Retrospective study included stage I–III NSCLC patients with a baseline ¹⁸F-FDG PET/CT scan. Relapse patterns were analyzed based on location, lesion, and organ-specific recurrence. Clinicopathologic variables were recorded. Three distinct categories of variables were obtained: standardized uptake value (SUV)-based metrics, heterogeneity parameters, and morphological features. The relation of relapse patterns with clinicopathologic and metabolic parameters was analyzed using the uni–multivariate logistic regression.</p><h3>Results</h3><p>Out of 173 patients, 104 experienced recurrences, with 66% presenting distant involvement and 56.7% exhibiting polymetastatic disease at initial recurrence. Patient age, pathologic lymphovascular invasion, and normalized SUVmax perimeter distance (nSPD) were considered as risk factors for early recurrence. Adenocarcinoma histology was identified as an independent variable for distant recurrence. Patient age, number of metastatic mediastinal lymph nodes at staging (nN), sphericity, normalized SUVpeak to centroid distance (nSCD), entropy, low gray-level run emphasis, and high gray-level run emphasis were independent variables for polymetastatic disease. Certain variables were correlated with organ-specific recurrence. Bone recurrence was related to nN and SUVmean. Brain recurrence was related to adenocarcinoma histology. Lung recurrence was associated with coefficient of variation and nSPD.</p><h3>Conclusion</h3><p>The metabolic profile of lung primary tumors obtained from ¹⁸F-FDG PET/CT seems to be predictive of recurrence patterns that are closely linked to the overall survival of NSCLC patients. These findings could help in the development of personalized follow-up strategies based on an individual’s recurrence pattern.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 5","pages":"476 - 505"},"PeriodicalIF":2.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Generative AI and large language models in nuclear medicine: current status and future prospects","authors":"Kenji Hirata,&nbsp;Yusuke Matsui,&nbsp;Akira Yamada,&nbsp;Tomoyuki Fujioka,&nbsp;Masahiro Yanagawa,&nbsp;Takeshi Nakaura,&nbsp;Rintaro Ito,&nbsp;Daiju Ueda,&nbsp;Shohei Fujita,&nbsp;Fuminari Tatsugami,&nbsp;Yasutaka Fushimi,&nbsp;Takahiro Tsuboyama,&nbsp;Koji Kamagata,&nbsp;Taiki Nozaki,&nbsp;Noriyuki Fujima,&nbsp;Mariko Kawamura,&nbsp;Shinji Naganawa","doi":"10.1007/s12149-025-02024-9","DOIUrl":"10.1007/s12149-025-02024-9","url":null,"abstract":"","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 4","pages":"404 - 405"},"PeriodicalIF":2.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12149-025-02024-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specific molecular imaging of BALB/c model mice with Graves’ ophthalmopathy based on high expression of insulin-like growth factor 1 receptor","authors":"Zhiting Zhang,&nbsp;Ziyu Ma,&nbsp;Xuan Wang,&nbsp;Yaqian Zhou,&nbsp;Ruixin Wu,&nbsp;Yiming Shen,&nbsp;Ning Li,&nbsp;Qiang Jia,&nbsp;Hong Zhang,&nbsp;Wei Li,&nbsp;Wei Zheng","doi":"10.1007/s12149-024-02013-4","DOIUrl":"10.1007/s12149-024-02013-4","url":null,"abstract":"<div><h3>Objective</h3><p>At present, most of the targeted imaging based on insulin-like growth factor 1 receptor (IGF-1R) is for tumor research, and there is no IGF-1R-targeted imaging for Graves’ ophthalmopathy(GO). This study aims to develop a peptide probe, ^99mTc-Z_IGF1R:4551-GGGC, targeting the IGF-1R, and to achieve specific imaging in Graves’ disease (GD) animal models exhibiting GO.</p><h3>Methods</h3><p>99mTc-ZIGF1R:4551-GGGC probe was synthesized using a direct labeling method and its labeling efficiency assessed via instant thin-layer chromatography (ITLC). Western blot analysis confirmed the overexpression of IGF-1R in malignant melanoma B16F10 cells. Subsequent SPECT/CT whole-body imaging of B16F10 tumor-bearing mice evaluated the probe’s targeting accuracy. In addition, a GO model was established using an electroporation immunoassay, followed by serological and histopathological examinations. The GO models then underwent 99mTc-ZIGF1R:4551-GGGC SPECT/CT imaging to assess eye-targeted imaging capabilities.</p><h3>Results</h3><p>The peptide probe exhibited a labeling efficiency exceeding 90%. Both GD and GO models were effectively created via electroporation immunoassay. Imaging results indicated significant accumulation and retention of the peptide probes in the tumors of B16F10 tumor-bearing mice. In the GO models, probe uptake was predominantly observed in retrobulbar tissues, contrasting with primary accumulation in the lungs and gastrointestinal tract in normal mice, where only minimal tracer was observed in retrobulbar tissues. Notably, GO mice demonstrated higher probe uptake and prolonged retention.</p><h3>Conclusion</h3><p>This study successfully established GD and GO models, reducing the duration of the immune cycle. Moreover, a peptide probe targeting IGF-1R was synthesized, enabling specific imaging of retrobulbar tissues in GO models.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 4","pages":"388 - 397"},"PeriodicalIF":2.5,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12149-024-02013-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Estimation of liver standardized uptake value in F18-FDG PET/CT scanning: impact of different malignancies, blood glucose level, body weight normalization, and imaging systems","authors":"Mohamed S. Abd-Elkader,&nbsp;Sherif M. Elmaghraby,&nbsp;Mohamed A. Abdel-Mohsen,&nbsp;Magdy M. Khalil","doi":"10.1007/s12149-025-02019-6","DOIUrl":"10.1007/s12149-025-02019-6","url":null,"abstract":"","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 3","pages":"313 - 313"},"PeriodicalIF":2.5,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12149-025-02019-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congratulations on the 60th anniversary of the Japanese Society of Nuclear Medicine","authors":"Seigo Kinuya","doi":"10.1007/s12149-024-02008-1","DOIUrl":"10.1007/s12149-024-02008-1","url":null,"abstract":"<div><p>The Japanese Society of Nuclear Medicine (JSNM) celebrates its 60th anniversary this year. JSNM has been contributing a lot to the development of nuclear medicine, leading a number of international activities. New procedures both in diagnosis and treatment have been continuously developed. JSNM will work hard for the better management of patients.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 3","pages":"229 - 230"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12149-024-02008-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}