The prognostic role of staging [18F]PSMA-1007 PET/CT volumetric and dissemination features in prostate cancer

IF 2.5 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Annals of Nuclear Medicine Pub Date : 2025-02-17 DOI:10.1007/s12149-025-02026-7

Domenico Albano, Alessandro Temponi, Francesco Bertagna, Nazareno Suardi, Anna Talin, Marco Lorenzo Bonù, Luca Triggiani

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引用次数: 0

Abstract

Background

This study aimed the role of volumetric and dissemination features of staging [18F]PSMA-1007 PET/CT in predicting progression‐free survival (PFS) in patients with prostate cancer (PCa) and their relationship with the main clinical data (ISUP grade groups, number of lesions, PSA).

Methods

We included 164 patients with high-risk PCa who underwent baseline [18F]PSMA-1007 PET/CT. With the help of LIFEx version 7.7, the main volumetric and dissemination PET parameters were semi-automatically extracted: PSMA-prostate tumor volume (PSMA-TV), PSMA-prostate total lesion (PSMA-TL), PSMA total TV (PSMA-TTV), PSMA total TL (PSMA-TTL) and Dmax corrected for body-surface-area (Dmax_bsa). Spearman rank correlations between semiquantitative PET features and the clinical variables were analyzed. PFS estimates were plotted with the Kaplan–Meier method.

Results

A high correlation was seen between the number of lesions and both PSMA-TTL (r 0.725), and Dmaxbsa (r 0.935). A moderate correlation was registered between PSA and PSMA-TTV (r 0.333), PSMA-TTL (r 0.441), Dmax_bsa (r 0.333), as well as between number of lesions and PSMA-TTV (r 0.342).

After a median follow-up of 17 months (range 2–45), relapse/progression happened in 17 patients (10%). PSA level, presence of distant metastases at staging, PSMA-TV, PSMA-TL, PSMA-TTL and Dmax_bsa were significantly associated with PFS at univariate analysis, but only the presence of distant metastases, PSMA-TTL and Dmax_bsa were confirmed to be independent prognostic factors.

Conclusion

Volumetric and dissemination features derived by staging [18F]PSMA-1007 PET/CT were significantly correlated with PSA and number of lesions. The combination of PSMA-TTL and Dmax_bsa was the best predictor of PFS and may help to better stratify PCa patients.

查看原文本刊更多论文

PSMA-1007 PET/CT体积和播散特征在前列腺癌分期中的预后作用[18F]。

背景：本研究旨在探讨分期[18F]PSMA-1007 PET/CT的体积和传播特征在预测前列腺癌（PCa）患者无进展生存（PFS）中的作用及其与主要临床数据（ISUP分级分组、病变数量、PSA）的关系。方法：我们纳入164例高危PCa患者，他们接受了基线[18F]PSMA-1007 PET/CT检查。在LIFEx version 7.7的帮助下，半自动提取主要的体积和散布PET参数：PSMA-前列腺肿瘤体积（PSMA-TV）、PSMA-前列腺总病变（PSMA-TL）、PSMA总TV （PSMA- ttv）、PSMA总TL （PSMA- ttl）和体表面积校正后的Dmax （Dmaxbsa）。分析半定量PET特征与临床变量的Spearman秩相关性。PFS估计用Kaplan-Meier方法绘制。结果：病变数量与PSMA-TTL （r = 0.725）、Dmaxbsa （r = 0.935）均呈高度相关。PSA与PSMA-TTV （r 0.333）、PSMA-TTL （r 0.441）、Dmaxbsa （r 0.333）以及病变数量与PSMA-TTV （r 0.342）之间存在中度相关性。中位随访17个月（2-45个月）后，17名患者（10%）出现复发/进展。单因素分析显示，PSA水平、分期时是否存在远处转移、PSMA-TV、PSMA-TL、PSMA-TTL和Dmaxbsa与PFS有显著相关性，但只有远处转移、PSMA-TTL和Dmaxbsa被证实为独立的预后因素。结论：由分期[18F]PSMA-1007 PET/CT得出的体积和播散特征与PSA和病变数量显著相关。PSMA-TTL和Dmaxbsa的结合是PFS的最佳预测指标，可能有助于更好地对PCa患者进行分层。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Nuclear Medicine 医学-核医学

CiteScore

4.90

自引率

7.70%

发文量

111

审稿时长

4-8 weeks

期刊介绍： Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine. The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.