Annals of Nuclear Medicine最新文献

{"title":"Comment on the impact of anti-HER2 therapy on the accuracy of 68 Ga-HER2-affibody PET/CT imaging in metastatic breast cancer.","authors":"Song Jiaming, Ye Jiani","doi":"10.1007/s12149-025-02111-x","DOIUrl":"10.1007/s12149-025-02111-x","url":null,"abstract":"","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to \"Beyond glucose uptake: rethinking PET/CT and hematologic markers for immune profiling in early breast cancer\".","authors":"Romain-David Seban, Laurence Champion, Irene Buvat","doi":"10.1007/s12149-025-02115-7","DOIUrl":"https://doi.org/10.1007/s12149-025-02115-7","url":null,"abstract":"","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative analysis of striatal subregional asymmetry on ^99mTc-TRODAT-1 SPECT and clinical correlations with UPDRS subscales in Parkinson's disease.","authors":"Danping Wu, Quanfu Jiang, Guoping Shen, Xinting Gao, Chunyi Liu, Wanzhong Ye","doi":"10.1007/s12149-025-02112-w","DOIUrl":"https://doi.org/10.1007/s12149-025-02112-w","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationship between striatal asymmetry indices-namely the High/Low Ratio and Asymmetry Index (AI)-derived from dopamine transporter single-photon emission computed tomography (DAT-SPECT) using ^99mTc-TRODAT-1, and the subscale scores of the Unified Parkinson's Disease Rating Scale (UPDRS), with the aim of evaluating their utility in clinical phenotyping and symptom assessment in Parkinson's disease (PD).</p><p><strong>Methods: </strong>Fifty-six patients with clinically diagnosed PD underwent ^99mTc-TRODAT-1 SPECT imaging and UPDRS evaluation. Radiotracer uptake in the caudate nucleus, putamen, and whole striatum was quantified bilaterally, and corresponding High/Low Ratios and AIs were calculated. These asymmetry measures were analyzed in relation to UPDRS subscale scores and Hoehn-Yahr stages.</p><p><strong>Results: </strong>Putaminal asymmetry was significantly greater in early-stage PD patients (Hoehn-Yahr ≤ 2; p = 0.010), suggesting early lateralized dopaminergic degeneration. The AI of the caudate nucleus was strongly correlated with UPDRS Part I (non-motor symptoms; r = 0.690, p < 0.001), while putaminal asymmetry was significantly associated with UPDRS Part III (motor symptoms; r = 0.497, p < 0.001).</p><p><strong>Conclusion: </strong>Region-specific DAT-SPECT asymmetry shows domain-specific correlations in PD (caudate-non-motor; putamen-motor). These findings may support the use of TRODAT-1-based imaging biomarkers for precision assessment and individualized management; however, they are hypothesis-generating and require confirmation in larger, better-balanced prospective cohorts.</p>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond glucose uptake: rethinking PET/CT and hematologic markers for ımmune profiling in early breast cancer.","authors":"Kadri Altundag","doi":"10.1007/s12149-025-02114-8","DOIUrl":"10.1007/s12149-025-02114-8","url":null,"abstract":"","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the comment on the impact of anti-HER2 therapy on the accuracy of 68 Ga-HER2-affibody PET/CT imaging in metastatic breast cancer.","authors":"Cheng Liu, Shaoli Song","doi":"10.1007/s12149-025-02110-y","DOIUrl":"https://doi.org/10.1007/s12149-025-02110-y","url":null,"abstract":"","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between technetium-99 m albumin scintigraphy-based severity of protein-losing enteropathy and patient characteristics and laboratory data.","authors":"Takahiro Hosokawa, Mayuki Uchiyama, Sakie Namba, Yutaka Tanami, Yumiko Sato, Yasuharu Wakabayashi, Eiji Oguma","doi":"10.1007/s12149-025-02109-5","DOIUrl":"https://doi.org/10.1007/s12149-025-02109-5","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to demonstrate the differences in Technetium-99 m albumin scintigraphy findings for patients with protein-losing enteropathy (PLE) associated with their characteristics and laboratory data.</p><p><strong>Methods: </strong>Eighteen patients with PLE were grouped into two based on two mechanisms: direct mucosal damage and failed lymph drainage. Scintigraphy images were divided based on the timing of acquisition: images obtained at 1, 2, 4, 6, and 24 h after starting the examination. The intensity of tracer uptake was graded as follows: 3 (marked uptake equal to or greater than the liver level), 2 (moderate uptake less than liver and greater than kidney levels), 1 (mild uptake less than kidney level), and 0 (negative). The grades at each timepoint for the two groups were compared using the Mann-Whitney U test. The associations between the grades and fecal alpha-1-antitrypsin and serum total protein concentrations were evaluated using Pearson correlation coefficients.</p><p><strong>Results: </strong>Of 18 patients, 7 had PLE due to failed lymph drainage. The direct mucosal damage and failed lymph drainage groups had significantly different fecal alpha-1-antitrypsin concentrations [43.5 ± 29.6 (range 11-115) vs. 208.7 ± 66.0 (range 124-311), respectively; P < 0.001] and scintigraphy-based severity at 24 h [1.2 ± 0.8 (range 1-3) vs. 2.8 ± 0.4 (range 2-3), respectively; P = 0.007]. The fecal alpha-1-antitrypsin concentration was positively correlated with the scintigraphy-based severity at 6 h (r = 0.499, P = 0.049) and 24 h (r = 0.747, P = 0.002). However, the serum protein concentration was negatively correlated with the scintigraphy-based severity at 6 h (r = - 0.587, P = 0.017).</p><p><strong>Conclusions: </strong>The scintigraphy-based severity at 6 and 24 h and the fecal alpha-1-antitrypsin concentrations were higher for patients with PLE due to failed lymph drainage mechanisms than for those with PLE due to direct mucosal damage. Scintigraphy can help localize the leakage point and determine disease severity to guide PLE management.</p>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognostic value of ¹⁸F-FDG PET-derived whole-body feature in patients with lung adenocarcinoma treated with EGFR-targeted therapy.","authors":"Kun-Han Lue, Yung-Hsuan Wang, Yu-Hung Chen, Sung-Chao Chu, Chih-Bin Lin, Shu-Hsin Liu","doi":"10.1007/s12149-025-02108-6","DOIUrl":"https://doi.org/10.1007/s12149-025-02108-6","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the prognostic values of ¹⁸F-FDG PET-derived whole-body imaging features in patients with metastatic lung adenocarcinoma treated with EGFR-targeted therapies.</p><p><strong>Methods: </strong>We retrospectively analyzed 249 patients with lung adenocarcinoma who underwent pre-treatment ¹⁸F-FDG PET and were treated with EGFR-targeted agents. The patients were divided into analog (n = 150) and digital (n = 99) PET cohorts. Whole-body and primary tumor respiratory-stable imaging features were extracted. The prognostic values of the study variables for progression-free (PFS) and overall survival (OS) were assessed using univariate and multivariate Cox regression analyses across the analog and digital PET cohorts.</p><p><strong>Results: </strong>Total sphericity and primary tumor inverse difference normalized were independent predictors of both PFS and OS. The total metabolic tumor volume was another independent predictor of OS. Combined models integrating these imaging biomarkers with clinical variables outperformed the traditional staging system (c-indices for PFS: 0.649 versus 0.550 for analog and 0.668 versus 0.583 for digital PET cohorts; for OS: 0.694 versus 0.562 for analog and 0.728 versus 0.579 for digital PET cohorts). Our models showed consistent predictive values across subgroups based on sex, EGFR mutation subtype, and clinical stage.</p><p><strong>Conclusions: </strong>Our results indicate that models integrating whole-body ¹⁸F-FDG PET features with traditional variables can enhance survival prediction and may support personalized treatment strategies for patients with lung adenocarcinoma treated with EGFR-targeted therapies.</p>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of body weight on arterial partition coefficient estimation in ¹²³I-IMP SPECT: a comparison between ARG and no-arterial sampling methods.","authors":"Masamichi Imai, Yusuke Ochiai, Yuki Kosaka, Kazuaki Mori","doi":"10.1007/s12149-025-02104-w","DOIUrl":"https://doi.org/10.1007/s12149-025-02104-w","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the impact of body weight on the estimation of the arterial blood-to-whole-body partition coefficient in 123I-iodoamphetamine (IMP) SPECT using a no-arterial sampling method (validation method) and to compare it with the autoradiographic (ARG) method.</p><p><strong>Methods: </strong>A total of 172 123I-IMP SPECT scans from clinical patients were retrospectively analyzed. To investigate systematic differences between the partition coefficients obtained by the ARG method and those estimated by the validation method in the QSPECT/DTARG package, a Bland-Altman plot was used. The distribution of differences was further visualized across body weights. Observing a trend related to body weight, we then performed regression analysis using body weight as a predictor of the difference between the two methods. The improvement in fit achieved by incorporating body weight was evaluated using the residual sum of squares (RSS).</p><p><strong>Results: </strong>The validation method systematically underestimated the partition coefficient when the actual value by the ARG method is high, and overestimated it when the true value is low. On the Bland-Altman plot, samples with light body weight were more likely to fall into the region of lower partition coefficients, whereas samples with heavy body weight tended to fall into the region of higher partition coefficients. After correction of body weight, the distribution of partition coefficients more closely approximated an ideal pattern across all body weight groups. Regression analysis revealed that the weight-corrected model provided a significantly better fit than the assumption of a constant partition coefficient (F = 51.36, p < 0.001). The RSS was reduced by 25% following weight correction, supporting the utility of this adjustment.</p><p><strong>Conclusions: </strong>The assumption of a constant arterial partition coefficient in the validation method may not be valid for individuals with light or heavy body weight. Incorporating body weight into the estimation process significantly improves even without arterial sampling. The validation method adding body weight correction may reduce variability in cerebral blood flow (CBF) estimates derived from these coefficients, which may improve the accuracy of CBF quantification even without arterial sampling.</p>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interobserver and intraobserver agreement for equivocal lesions in Ga-68 PSMA PET/CT according to PSMA-RADS 2.0 criteria.","authors":"Khanim Niftaliyeva, Selin Kesim, Nuh Filizoglu, Zeynep Ceren Balaban Genc, Salih Ozguven, Feyza Cagliyan, Tunc Ones, Fuat Dede, Halil Turgut Turoglu, Tanju Yusuf Erdil","doi":"10.1007/s12149-025-02103-x","DOIUrl":"https://doi.org/10.1007/s12149-025-02103-x","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to systematically evaluate the inter- and intra-observer agreement regarding lesions with uncertain malignancy potential in Ga-68 PSMA PET/CT imaging of prostate cancer patients, utilizing the PSMA-RADS 2.0 classification system, and to emphasize the malignancy evidence associated with these lesions.</p><p><strong>Methods: </strong>We retrospectively reviewed Ga-68 PSMA PET/CT images of patients diagnosed with prostate cancer via histopathology between December 2016 and November 2023. Seventy-six patients and 98 target lesions, classified with PSMA-RADS scores 3A-3D by an experienced nuclear medicine specialist, were included. Three observers (two experienced and one less experienced nuclear medicine physician) evaluated the lesions at two different time points, three months apart, in a blinded manner. Intra-observer agreement was assessed using Cohen's kappa, while inter-observer agreement was analyzed using Fleiss' kappa.</p><p><strong>Results: </strong>All observers demonstrated significant intra-observer agreement, with percentages ranging from 67.3 to 80.6% and kappa values between 0.62 and 0.76. The highest intra-observer agreement was noted for bone lesions, while non-regional lymph nodes exhibited the lowest agreement. For inter-observer assessments, moderate agreement was observed across all lesions (Fleiss k = 0.51), with the highest agreement in regional lymph nodes and the lowest in non-regional lymph nodes and bone lesions. Follow-up results indicated malignancy detection rates of 63.4% for 3A, 47% for 3B, 44.5% for 3C, and 41.4% for 3D scored lesions.</p><p><strong>Conclusions: </strong>The PSMA-RADS classification system demonstrated substantial intra-observer agreement and moderate inter-observer agreement for lesions with uncertain malignancy potential, supporting its clinical applicability. However, notable variability and limitations in reporting bone lesions, non-regional lymph nodes, and lung lesions were observed among readers. The ambiguous nature and management of PSMA-RADS 3 lesions underscore the need for further research to enhance risk stratification.</p>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of National Diagnostic Reference Levels 2025 for nuclear medicine in Japan","authors":"Koichiro Abe,&nbsp;Shingo Baba,&nbsp;Reo Etani,&nbsp;Takahiro Fujimto,&nbsp;Makoto Hosono,&nbsp;Takashi Iimori,&nbsp;Anri Inaki,&nbsp;Masanobu Ishiguro,&nbsp;Noriaki Miyaji,&nbsp;Atsutaka Okizaki,&nbsp;Takeshi Sasaki,&nbsp;Hiroyuki Tsushima,&nbsp;Hiroshi Watanabe,&nbsp;Masanori Watanabe,&nbsp;Nobuhiro Yada","doi":"10.1007/s12149-025-02102-y","DOIUrl":"10.1007/s12149-025-02102-y","url":null,"abstract":"<div><p>Diagnostic reference levels (DRLs) are practical benchmarks for optimizing patient radiation exposure in medical imaging. In Japan, national DRLs, including those for nuclear medicine together and other radiological procedures, were first established in 2015 and revised in 2020. In this study, we revised the DRL values of nuclear medicine for the establishment of DRLs2025, based on data collected from institutions nationwide throughout Japan. Data were collected via an online survey from facilities performing nuclear medicine procedures, including SPECT, PET, and hybrid CT imaging. Information on dose activity of the administered radiopharmaceuticals and CT parameters (CTDIvol and DLP) were collected. DRL values were determined through analysis of the submitted data, supplemented by panel discussions among experts taking into account the clinical appropriateness of the values and various technological factors. Overall, the newly established DRLs2025 demonstrated a decreasing trend in administered radiopharmaceutical activities, CTDIvol, and DLP compared with the previous surveys. This trend reflects ongoing efforts toward the optimization of radiation exposure and radiopharmaceutical dose reduction, likely driven by the introduction of image reconstruction methods based on newer technologies. However, substantial interfacility variations were observed, particularly in the CT parameters, suggesting disparities in equipment, imaging protocols, and the balance between image quality and radiation dose. The establishment of DRLs2025 underscores continued progress in optimizing radiation exposure in nuclear medicine practice in Japan. Although issues regarding data variability and quality remain, DRLs continue to be a key tool in radiation protection and quality assurance. Ongoing efforts to improve data collection systems and to align procedures with international standards are essential for the future refinement of DRLs.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 10","pages":"1027 - 1036"},"PeriodicalIF":2.5,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12149-025-02102-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}