Annals of Nuclear Medicine最新文献

{"title":"Response to the comment on “Kinetic and quantitative analysis of [18F]SMBT-1 PET imaging for monoamine oxidase B”","authors":"Kotaro Hiraoka","doi":"10.1007/s12149-026-02214-z","DOIUrl":"10.1007/s12149-026-02214-z","url":null,"abstract":"","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"40 8","pages":"1012 - 1012"},"PeriodicalIF":2.4,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the letter regarding “Long-term efficacy and safety of peptide receptor radionuclide therapy in Japanese patients with unresectable neuroendocrine tumor: extension of the Japanese phase I and phase I/II study”","authors":"Noritoshi Kobayashi","doi":"10.1007/s12149-026-02216-x","DOIUrl":"10.1007/s12149-026-02216-x","url":null,"abstract":"","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"40 6","pages":"733 - 734"},"PeriodicalIF":2.5,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: [18F]SMBT-1 PET quantification – methodological considerations and future directions","authors":"Qing Song, Mengxing Li","doi":"10.1007/s12149-026-02203-2","DOIUrl":"10.1007/s12149-026-02203-2","url":null,"abstract":"","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"40 8","pages":"1010 - 1011"},"PeriodicalIF":2.4,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12149-026-02203-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147715697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semi-quantitative evaluation of early phase 99mTc-DPD scintigraphy in patients with suspected cardiac amyloidosis","authors":"Lukas Kessler,&nbsp;Leon Ferber,&nbsp;Christoph Rischpler,&nbsp;Stephan Settelmeier,&nbsp;Tugce Telli,&nbsp;Zohreh Varasteh,&nbsp;Clemens P. Spielvogel,&nbsp;Tim Hagenacker,&nbsp;Wolfgang P. Fendler,&nbsp;Alexander Carpinteiro,&nbsp;Lars Michel,&nbsp;Ken Herrmann,&nbsp;Tienush Rassaf,&nbsp;Miriam Sraieb,&nbsp;David Kersting","doi":"10.1007/s12149-026-02209-w","DOIUrl":"10.1007/s12149-026-02209-w","url":null,"abstract":"<div><h3>Background</h3><p>Scintigraphy using bone-avid tracers like ^99mTc-diphosphono-propanodicarboxylic acid (^99mTc-DPD), ^99mTc-hydroxymethylene-diphosphonate (^99mTc-HMDP), or ^99mTc-pyrophosphate (^99mTc-PYP) is a widely available and non-invasive imaging tool for diagnosis of cardiac amyloidosis. Visual evaluation and semi-quantitative image analyses reach excellent sensitivity and specificity results. For ^99mTc-HMDP, high accuracy of early semi-quantitative parameters derived from imaging 10 min after tracer injection was described but never validated for other tracers. The aim of this study was to evaluate early semi-quantitative parameters in ^99mTc-DPD scintigraphy.</p><h3>Methods</h3><p>122 patients (78 male / 44 female) with suspected cardiac amyloidosis who underwent ^99mTc-DPD scintigraphy were retrospectively analysed. Early and late planar whole-body scintigraphy images were acquired 10 min (+ 5 min) and 2.5–3.5 h after tracer injection. Early cardiac ^99mTc-DPD uptake was evaluated using the Heart/whole-body rectangular (H/WBr), Heart/whole-body profile (H/WBp), Heart/Skull (H/S), Heart/Mediastinum (H/M), Heart/Contralateral Lung (H/CL), Heart/Liver (H/L), and Heart/Pelvis (H/P) ratios.</p><h3>\u0000 <b>Results</b>\u0000 </h3><p>H/L was not correlated to the other parameters.Best results for prediction of Perugini ≥1 were achieved for H/M (sensitivity 69.6%, specificity 84.4%, accuracy 77.5%), best results for prediction of ATTR-CA for H/L (sensitivity 65.9%, specificity 88.6%, accuracy 80.8%). Adding the H/L to other parameters increased accuracy and specificity (best results for H/L+H/S: accuracy 83.3%, sensitivity 63.4%, specificity 93.7% to predict CA).</p><h3>\u0000 <b>Conclusion</b>\u0000 </h3><p>Previous results for^99mTc-HMDP were not confirmed; diagnostic precision of early ^99mTc-DPD is not sufficient to replace late imaging in clinical routine. Early H/L is a novel, independent, and specific parameter which may be added to imaging protocols to increase the accuracy in combination with other imaging biomarkers</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"40 8","pages":"949 - 960"},"PeriodicalIF":2.4,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12149-026-02209-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visceral technetium-99 m-labeled pyrophosphate uptake in patients with wild-type transthyretin cardiac amyloidosis","authors":"Koji Takahashi,&nbsp;Shuhei Yamamoto,&nbsp;Daisuke Sasaki,&nbsp;Takaaki Iwamura,&nbsp;Yoshiyasu Hiratsuka,&nbsp;Sohei Kitazawa,&nbsp;Nobuhisa Yamamura,&nbsp;Mitsuharu Ueda,&nbsp;Yushi Utsunomiya,&nbsp;Hiroe Morioka,&nbsp;Shigeki Uemura,&nbsp;Tomoki Sakaue,&nbsp;Katsuji Inoue","doi":"10.1007/s12149-026-02174-4","DOIUrl":"10.1007/s12149-026-02174-4","url":null,"abstract":"<div><h3>Objectives</h3><p>Technetium-99 m-labeled pyrophosphate (Tc-99 m-PYP) scintigraphy can image tracer uptake in the myocardium, subcutaneous fat, and skeletal muscles of patients with wild-type amyloid transthyretin (ATTRwt) cardiac amyloidosis (CA), which indicates ATTR deposition. However, there are few reports of visceral Tc-99 m-PYP uptake in patients with ATTRwt-CA. This study was conducted to determine whether Tc-99 m-PYP scintigraphy can image ATTR deposition in the viscera, particularly the liver, spleen, and gastrointestinal tract.</p><h3>Methods</h3><p>Chest- and abdomen-centered Tc-99 m-PYP scintigraphy with single-photon emission computed tomography-computed tomography fusion images were acquired 2 h after patients with clinically suspected CA were intravenously injected with 20 mCi of the tracer. The participants were divided into two groups: ATTR-CA and non-ATTR-CA groups. Semi-quantitative visual grade of hepatic tracer uptake and mean standardized uptake values in the liver (SUV_mean-L) were investigated. The presence or absence of tracer uptake in the spleen and alimentary tract (stomach, small intestine, and colon, excluding the rectum and anus) was also investigated.</p><h3>Results</h3><p>Of 209 participants (median age, 85 years; range, 79–90 years; 56.5% male), 72 patients, all of whom had ATTRwt-CA, were assigned to the ATTR-CA group, whereas 137 were assigned to the non-ATTR-CA group. Semi-quantitative visual grade of hepatic tracer uptake, SUV_mean-L, and the rate of splenic tracer uptake did not vary between both groups (<i>p</i> = 0.100, <i>p</i> = 0.904, and <i>p</i> = 0.356, respectively). However, the ATTR-CA group showed a higher rate of tracer uptake in the alimentary tract than the non-ATTR-CA group (<i>p</i> &lt; 0.001). Within the digestive tract, the tracer uptake rates in the small intestine and colon were significantly higher in the ATTR-CA group than in the non-ATTR-CA group (<i>p</i> &lt; 0.001 and <i>p</i> &lt; 0.001, respectively); however, no significant difference was observed in gastric accumulation between the two groups (<i>p</i> = 0.305).</p><h3>Conclusions</h3><p>Tc-99 m-PYP scintigraphy may image ATTR deposition in the small intestine and colon of patients with ATTRwt-CA. In contrast, Tc-99 m-PYP uptake likely reflects blood pool activity rather than ATTR deposition in the liver, spleen, and stomach.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"40 6","pages":"707 - 722"},"PeriodicalIF":2.5,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to “Methodological and clinical considerations on predicting PSMA-positive metastatic disease in early biochemical failure after radical prostatectomy: comment on Santo et al.”","authors":"Giulia Santo,&nbsp;Francesco Grillone,&nbsp;Giuseppe Lucio Cascini,&nbsp;Francesco Cicone","doi":"10.1007/s12149-026-02215-y","DOIUrl":"10.1007/s12149-026-02215-y","url":null,"abstract":"","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"40 7","pages":"842 - 843"},"PeriodicalIF":2.4,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PSMA PET/CT imaging for biochemical recurrence in prostate cancer: can it replace conventional imaging and guide salvage therapy?","authors":"Efrah Ahmed Ibrahim","doi":"10.1007/s12149-026-02192-2","DOIUrl":"10.1007/s12149-026-02192-2","url":null,"abstract":"<div>\u0000 \u0000 <p>Biochemical recurrence (BCR) after primary treatment for prostate cancer presents a significant clinical challenge. Conventional imaging modalities have limited sensitivity for detecting sites of recurrence, particularly at low prostate specific antigen (PSA) levels. Prostate specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) has emerged as a promising diagnostic tool that may transform the management paradigm for recurrent prostate cancer. To systematically evaluate the diagnostic performance of PSMA PET/CT in patients with biochemical recurrence of prostate cancer, compare it with conventional imaging modalities, and assess its impact on salvage therapy decisions. A systematic review was conducted following the PRISMA guidelines. PubMed/MEDLINE, Embase, Cochrane Library, and Web of Science were searched for studies published between 2020 and 2025. Studies evaluating PSMA PET/CT in patients with biochemical recurrence after primary treatment were included. The primary outcomes were detection rates stratified by PSA levels, diagnostic accuracy compared to conventional imaging, and the impact on management decisions. PSMA PET/CT demonstrated superior detection rates compared to conventional imaging across all PSA levels, with detection rates ranging from 36.2% to 96.7% for PSA levels below 0.5 ng/mL and above 5 ng/mL, respectively. In patients with negative conventional imaging, PSMA PET/CT identified true positive lesions in 64% of cases (95% CI, 56.7%-71.5%). Among patients with high-risk biochemically recurrent prostate cancer and negative conventional imaging, PSMA PET/CT detected distant metastatic disease (M1) in 46% of patients. Management plans were altered in 54-76% of cases based on PSMA PET/CT findings, with significant implications for salvage therapy targeting. PSMA PET/CT significantly outperforms conventional imaging in detecting sites of recurrence across all PSA levels, with particularly notable advantages at low PSA values. The high detection rates and accuracy of PSMA PET/CT in patients with negative conventional imaging support its role as a replacement for or complement to standard imaging protocols, while acknowledging current limitations in availability, cost, and long-term outcome data. PSMA PET/CT findings frequently alter management decisions, enabling more precise targeting of salvage therapies and potentially improving oncological outcomes.</p>\u0000 </div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"40 5","pages":"469 - 479"},"PeriodicalIF":2.5,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12149-026-02192-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of CT-guided spatial normalization for semi-quantification of dopamine transporter SPECT and detection of nigrostriatal degeneration","authors":"Alae Eddine El Barkaoui,&nbsp;Christian Scheiber,&nbsp;Stephane Thobois,&nbsp;Ralph Buchert,&nbsp;Marc Janier,&nbsp;Thomas Grenier,&nbsp;Anthime Flaus","doi":"10.1007/s12149-026-02204-1","DOIUrl":"10.1007/s12149-026-02204-1","url":null,"abstract":"<div><h3>Objective</h3><p>The present study aims to assess the performance of a CT-guided spatial normalization method (CT-method) for the anatomical region-of-interest (ROI)-based semi-quantification of dopamine transporter (DAT) single photon emission computed tomography (SPECT) images and the detection of nigrostriatal degeneration as compared to an effective SPECT template-based method (MSPECT-method) and visual analysis performed by an expert reader.</p><h3>Methods</h3><p>Patients who underwent [¹²³I]FP-CIT SPECT/CT in the <i>Hospices Civils de Lyon</i> between 2008 and 2018 for clinically uncertain parkinsonian syndromes were included. The proposed CT-method aimed to spatially normalize the jointly acquired CT scans and apply the deformation fields to the coregistered SPECT images. It was compared to an effective SPECT template-based method using multiple templates as target for the spatial normalization (MSPECT-method). The distribution of specific binding ratios (SBR) was compared between both methods and the SBR classifications were compared to an expert’s visual classification of the scans, which served as the reference.</p><h3>Results</h3><p>Overall, 1156 patients (mean age ± SD = 68.7 ± 11.5; 52.6% male) were included. The CT-method provided a good separation between the normal and reduced SBR, with a higher effect size of the distance between the Gaussians (3.31 vs 3.11) and smaller overlap (6.44% vs 8.96%) compared to the MSPECT-method. Both the CT-method and MSPECT-method demonstrated high classification accuracy (96.7%, 95% CI: 95.7-97.7% vs. 94.6%, 95% CI: 93.3-95.9%), sensitivity (96.0%, CI: 94.3-97.7% vs. 89.7%, CI: 87.1-92.3%), and specificity (97.3%, CI: 96.1-98.6% vs. 98.7%, CI: 97.9-99.6%), respectively.</p><h3>Conclusions</h3><p>The proposed CT-guided spatial normalization method for automated semi-quantitative [¹²³I]FP-CIT SPECT analysis is a viable option when CT images are available. It offers objective spatial normalization and provides high accuracy for the detection of nigrostriatal degeneration, closely aligning with an expert’s visual interpretation.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"40 8","pages":"926 - 936"},"PeriodicalIF":2.4,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12149-026-02204-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 68Ga-PSMA-11 PET/CT PRIMARY score for predicting pathological upgrading in ISUP grade group 1 prostate cancer: Methodological considerations and future directions","authors":"Tian Ruan","doi":"10.1007/s12149-026-02207-y","DOIUrl":"10.1007/s12149-026-02207-y","url":null,"abstract":"","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"40 7","pages":"840 - 841"},"PeriodicalIF":2.4,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Long-term efficacy and safety of peptide receptor radionuclide therapy in Japanese patients with unresectable neuroendocrine tumor: extension of the Japanese phase I and phase I/II study”","authors":"Kotina Shridevi,&nbsp;Megha Doiphode,&nbsp;Rakhi Mishra,&nbsp;Archana Dhyani","doi":"10.1007/s12149-026-02206-z","DOIUrl":"10.1007/s12149-026-02206-z","url":null,"abstract":"","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"40 6","pages":"731 - 732"},"PeriodicalIF":2.5,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}