Annals of Nuclear Medicine最新文献

{"title":"Voxel-based dosimetry with integrated Y-90 PET/MRI and prediction of response of primary and metastatic liver tumors to radioembolization with Y-90 glass microspheres","authors":"Burak Demir,&nbsp;Cigdem Soydal,&nbsp;Nuriye Ozlem Kucuk,&nbsp;Emre Can Celebioglu,&nbsp;Mehmet Sadık Bilgic,&nbsp;Digdem Kuru Oz,&nbsp;Atilla Halil Elhan,&nbsp;Kemal Metin Kir","doi":"10.1007/s12149-024-01974-w","DOIUrl":"10.1007/s12149-024-01974-w","url":null,"abstract":"<div><h3>Purpose</h3><p>In this study, we aimed to evaluate the response of the primary and metastatic liver tumors to radioembolization with ⁹⁰Y glass microspheres and investigate its correlations with dosimetric variables calculated with ⁹⁰Y PET/MRI.</p><h3>Methods</h3><p>In this ambispective study, 44 patients treated with ⁹⁰Y glass microspheres and imaged with ⁹⁰Y PET/MRI were included for analysis. Dosimetric analysis was performed for every perfused lesion using dose–volume histograms. Response was assessed by comparing pre-treatment and follow-up total lesion glycolysis (TLG) values derived from ¹⁸F-FDG PET imaging. The relationship between ΔTLG and log-transformed dosimetric variables was analyzed with linear mixed effects regression models. ROC analyses were performed to compare discriminatory power of the variables in predicting response and complete response.</p><h3>Results</h3><p>Regression and ROC analyses demonstrated that mean tumor dose and almost all D values were statistically significant predictors of treatment response and complete treatment response. Specifically, D60, D70 and D80 values exhibited significantly higher discriminatory power for predicting treatment response compared to the mean dose (<i>D</i>_mean) delivered to tumor. High specificity cut-off values to predict response were determined as 160.75 Gy for <i>D</i>_mean, 95.50 Gy for D60, 89 Gy for D70, and 59.50 Gy for D80. Similarly, high-specificity cut-off values to predict complete response were 262.75 Gy for D_mean, 173 Gy for D70, 140.5 Gy for D80, and 100 Gy for D90.</p><h3>Conclusion</h3><p>In this study, we demonstrated that voxel-based dosimetry with post-treatment ⁹⁰Y PET/MRI can predict response to treatment. D60, D70 and D80 variables also did have greater discriminatory power compared to <i>D</i>_mean in prediction of response. In addition, we present high-specificity cut-offs to predict response (CR + PR) and complete response (CR) for both <i>D</i>_mean and several <i>D</i> variables derived from dose–volume histograms.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 1","pages":"31 - 46"},"PeriodicalIF":2.5,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical assessment and striatal dopaminergic activity in healthy controls and patients with Parkinson’s disease: a Bayesian approach","authors":"Seunghyeon Shin,&nbsp;Hyun-Yeol Nam,&nbsp;Keunyoung Kim,&nbsp;Jihyun Kim,&nbsp;Myung Jun Lee,&nbsp;Kyoungjune Pak","doi":"10.1007/s12149-024-01972-y","DOIUrl":"10.1007/s12149-024-01972-y","url":null,"abstract":"<div><h3>Objectives</h3><p>We aimed to evaluate correlations between striatal dopamine transporter (DAT) uptake and clinical assessments in both patients with Parkinson’s disease (PD) and healthy controls.</p><h3>Methods</h3><p>This study enrolled 193 healthy controls, and 581 patients with PD. They underwent various clinical assessments and ¹²³I-FP-CIT SPECT scans. After reconstruction, attenuation correction, and normalization of SPECT images, counts were measured from the bilateral caudate and putamen, and the occipital cortex for reference. Count densities for each region were extracted and used to calculate striatal binding ratios (SBRs) for each striatal region. SBR is calculated as (target region/reference region)—1. After logarithmic transformation of striatal SBRs, we analyzed the effects of clinical assessments on striatal SBRs using Bayesian hierarchical modeling.</p><h3>Results</h3><p>MDS-UPDRS total score, part I, part II, part III, Epworth Sleepiness Scale, REM sleep behavior disorder screening questionnaire, SCOPA-AUT total score were negatively associated with striatal SBR in patients with PD. Also, HVLT recognition discrimination was positively associated with striatal SBR in both healthy controls and patients with PD. In healthy control, MDS-UPDRS part II, MOCA, SCOPA-AUT total score were positively associated with striatal SBR.</p><h3>Conclusion</h3><p>We demonstrated that motor symptom, sleep disturbance, autonomic symptom, and cognition of patients with PD were associated with striatal dopaminergic activity. In healthy controls, motor symptoms, autonomic symptom, and cognition were associated with striatal dopaminergic activity, some of which showing the opposite direction with patients with PD. This result might provide new insight to underlying mechanism of dopamine system with motor and non-motor assessments.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"38 12","pages":"989 - 998"},"PeriodicalIF":2.5,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142071801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of myocardial injury by SPECT myocardial perfusion imaging in patients with COVID-19 infection in a single center after lifting the restrictions in China","authors":"Keke Xin,&nbsp;Xinghong Ma,&nbsp;Xiaoli Meng,&nbsp;Xiao Zhang,&nbsp;Weidong Yang,&nbsp;Taoqi Ma,&nbsp;Cheng Zhou,&nbsp;Jing Wang,&nbsp;Guoquan Li","doi":"10.1007/s12149-024-01970-0","DOIUrl":"10.1007/s12149-024-01970-0","url":null,"abstract":"<div><h3>Purpose</h3><p>To assess myocardial injury using rest single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) in patients with COVID-19 and to evaluate whether myocardial injury detected by rest MPI predict the prognosis of symptoms after 6 months follow-up.</p><h3>Methods</h3><p>Patients suspected of myocarditis between December 2022 and March 2023, after the lifting of COVID-19 pandemic restrictions, and between December 2018 and March 2019, prior to the pandemic, were referred to our study. All patients underwent rest MPI. One hundred and sixty four patients with COVID-19 infection after the lifting of pandemic restrictions and 101 patients before the pandemic were included as the study and control groups, respectively. One hundred and fifty three patients of the study group and 83 of the control group presented symptoms when they initially visit to our department. Compare the parameters of myocardial injury detected by rest SPECT MPI between the two groups and then investigate the association between myocardial injury and symptom prognosis in symptomatic patients of both groups.</p><h3>Results</h3><p>Total perfusion defect (TPD) (4.2% ± 3.3% vs. 2.3% ± 2.2%, <i>P</i> &lt; 0.001), summed rest score (SRS) (5.3 ± 5.4 vs. 2.7 ± 2.0, <i>P</i> &lt; 0.001), the proportion of patients with TPD &gt; 4% (43.3% vs. 17.8%, <i>P</i> &lt; 0.001), TPD &gt; 10% (6.71% vs 0, <i>P</i> &lt; 0.001), SRS &gt; 4 (40.2% vs 15.8%, <i>P</i> &lt; 0.001), SRS &gt; 10 (12.8% vs 0, <i>P</i> &lt; 0.001), the number of abnormal perfusion segments (3.9 ± 3.1 vs. 2.4 ± 1.7, <i>P</i> &lt; 0.001) were all significantly higher in the study group. All the parameters of rest MPI were not associated with the prognosis of symptoms in symptomatic patients of both groups after 6 months follow-up.</p><h3>Conclusion</h3><p>Myocardial injury in COVID-19 patients could be assessed by rest SPECT MPI. The COVID-19 patients could exhibited a higher frequency and greater severity of myocardial injury than uninfected control patients. Myocardial injury assessed by rest MPI did not predict for the prognosis of symptoms in symptomatic patients of both COVID-19 patients and uninfected patients.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"38 12","pages":"971 - 979"},"PeriodicalIF":2.5,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142054730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How anatomical impairments found on CT affect perfusion percentage assessed by SPECT/CT scan?","authors":"Daniel M. Seraphim,&nbsp;Katia H. Koga,&nbsp;Antoine Vacavant,&nbsp;Diana R. de Pina","doi":"10.1007/s12149-024-01969-7","DOIUrl":"10.1007/s12149-024-01969-7","url":null,"abstract":"<div><h3>Aim</h3><p>CT images can identify structural and opacity alterations of the lungs while nuclear medicine’s lung perfusion studies show the homogeneity (or lack of) of blood perfusion on the organ. Therefore, the use of SPECT/CT in lung perfusion scintigraphies can help physicians to assess anatomical and functional alterations of the lungs and to differentiate between acute and chronic disease.</p><h3>Objective</h3><p>To develop a computer-aided methodology to quantify the total global perfusion of the lungs via SPECT/CT images and to compare these results with parenchymal alterations obtained in CT images.</p><h3>Methods</h3><p>39 perfusion SPECT/CT images collected retrospectively from the Nuclear Medicine Facility of Botucatu Medical School’s Clinics Hospital in São Paulo, Brazil, were analyzed. Anatomical lung impairments (emphysema, collapsed and infiltrated tissue) and the functional percentage of the lungs (blood perfusion) were quantified from CT and SPECT images, with the aid of the free, open-source software 3D Slicer. The results obtained with 3D Slicer (3D-TGP) were also compared to the total global perfusion of each patient’s found on their medical report, obtained from visual inspection of planar images (2D-TGP).</p><h3>Results</h3><p>This research developed a novel and practical methodology for obtaining lungs’ total global perfusion from SPECT/CT images in a semiautomatic manner. 3D-TGP versus 2D-TGP showed a bias of 7% with a variation up to 67% between the two methods. Perfusion percentage showed a weak positive correlation with infiltration (<i>p</i> = 0.0070 and <i>ρ</i> = 0.43) and collapsed parenchyma (<i>p</i> = 0.040 and <i>ρ</i> = 0.33).</p><h3>Conclusions</h3><p>This research brings meaningful contributions to the scientific community because it used a free open-source software to quantify the lungs blood perfusion via SPECT/CT images and pointed that the relationship between parenchyma alterations and the organ’s perfusion capability might not be so direct, given compensatory mechanisms.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"38 12","pages":"960 - 970"},"PeriodicalIF":2.5,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative evaluation of striatal uptake ratios using an adaptive template registration method for 123I-ioflupane dopamine transporter SPECT","authors":"Sunao Mizumura,&nbsp;Naoyuki Tamamura,&nbsp;Junya Ebina,&nbsp;Hikaru Watanabe,&nbsp;Masaaki Hori","doi":"10.1007/s12149-024-01968-8","DOIUrl":"10.1007/s12149-024-01968-8","url":null,"abstract":"<div><h3>Introduction</h3><p>¹²³I-FP-CIT (¹²³I-Ioflupane) SPECT shows strong accumulation in the striatum, but morphological standardization is challenging due to low accumulation outside the striatum, particularly in subjects with marked striatal decline. In this study, morphological standardization without MRI was achieved using the adaptive template registration (ATR) method to create a subject-specific optimized template with weighted images of normal-type and egg-shape-type templates. The accuracy of a quantitative method for calculating the ratio with nonspecific accumulation in the occipital lobe was evaluated by placing voxels-of-interest (VOI) on standardized images, particularly targeting the striatum.</p><h3>Methods</h3><p>The average images of eight subjects, demonstrating normal-type and egg-shape-type tracer accumulation in ¹²³I-Ioflupane SPECT, were utilized as normal and disease templates, respectively. The study included 300 subjects that underwent both ¹²³I-Ioflupane SPECT and MRI for the diagnosis of suspected Parkinson's disease or for exclusion diagnosis. Morphological standardization of SPECT images using structural MRI (MRI-based method) was considered the standard of truth (SOT). Three morphological standardizations without MRI were conducted. The first involved conventional morphological standardization using a normal template (fixed template method), the second employed the ATR method, with a weighted template, and the third used the split-ATR method, processing the left and right striatum separately to address asymmetrical accumulation. VOIs were set on the striatum, caudate, putamen as regions of specific accumulation, and on the occipital lobe as a reference region for nonspecific accumulation.</p><h3>Results</h3><p>Results showed significant and robust linearity in the striatal accumulation ratios for all templates when compared with the occipital lobe accumulation ratio when using the MRI-based method. Comparing intra-class correlations for different linearities, the ATR method and split-ATR method demonstrated higher linearity in the striatum, caudate, and putamen. The split-ATR method showed similar improvements, although more linearity than some of the ATR methods; the effectiveness of the Split-ATR method may vary by image quality, and further validation of its effectiveness in diverse asymmetric accumulation cases seemed warranted.</p><h3>Conclusion</h3><p>The use of optimized templates, such as the ATR and split-ATR methods, improved reproducibility in fully automated processing and demonstrated superior linearity compared to that of MRI-based method, in the ratio to the occipital lobe. The ATR method, which enables morphological standardization when using SPECT images only, proved highly reproducible for clinical quantitative analysis of striatal accumulation, facilitating its clinical use.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"38 12","pages":"943 - 959"},"PeriodicalIF":2.5,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12149-024-01968-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SPECT/CT imaging: quantifying 99mTc-MDP concentration in the spine and pelvis","authors":"Xiaoguang Hou,&nbsp;Yibo He,&nbsp;Guobing Liu,&nbsp;Shuguang Chen,&nbsp;Hongcheng Shi","doi":"10.1007/s12149-024-01967-9","DOIUrl":"10.1007/s12149-024-01967-9","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to identify a relatively robust SUV for guiding clinical practice through quantitative measurement and comparison of various normalization methods based on the SUV of ^99mTc-MDP in the normal spine and pelvis using an integrated SPECT/CT scanner.</p><h3>Methods</h3><p>Between June 2017 and September 2019, a total of 500 oncology patients (mean age, 60.9; men, 66.0%) who underwent bone SPECT/CT scans with ^99mTc-MDP were enrolled in this retrospective study. The mean SUV (SUV_mean) of 4962 spinal and pelvic bones was calculated based on the patients’ body weight (BW), lean body mass (LBM), bone mineral content (BMC), body surface area (BSA), and body mass index (BMI), defined as SUV_bw, SUV_lbm, SUV_bmc, SUV_bsa, and SUV_bmi, respectively. The coefficients of variation (CoVs) of the aforementioned parameters were compared, and the correlation and multiple linear regression analyses were used to compare the extent to which these parameters were affected by sex, age, height, weight, BMI, and CT values.</p><h3>Results</h3><p>The average SUVs in the normal spine and pelvis displayed a relatively wide variability: 4.573 ± 1.972 for SUV_bw, 3.555 ± 1.517 for SUV_lbm, 0.163 ± 0.071 for SUV_bmc, 0.124 ± 0.052 for SUV_bsa, and 1.668 ± 0.732 for SUV_bmi. In general, SUV_bsa had relatively lowest CoV (42.1%) in all vertebrae and pelvis compared with other SUVs. For correlation analyses, all SUVs displayed weak but significant correlations with age and CT values. For regression analyses, SUV_bsa was influenced only by age, BMI, and CT values independently. The effects of these variables on SUV_bsa were all smaller than those on conventional SUV_bw.</p><h3>Conclusions</h3><p>The SUVs of ^99mTc-MDP in normal bone derived from quantitative bone SPECT/CT could serve as a reference for evaluating tumor bone metastasis, but it should be assessed on a site-specific basis. SUV_bsa exhibited superior robustness among all the SUV normalization variations, indicating potential clinical applications.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"38 12","pages":"933 - 942"},"PeriodicalIF":2.5,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of net influx constant based on FDG PET/CT dynamic imaging in the differential diagnosis of metastatic from non-metastatic lymph nodes in lung cancer","authors":"Xieraili Wumener,&nbsp;Yarong Zhang,&nbsp;Zihan Zang,&nbsp;Xiaoxing Ye,&nbsp;Jiuhui Zhao,&nbsp;Jun Zhao,&nbsp;Ying Liang","doi":"10.1007/s12149-024-01964-y","DOIUrl":"10.1007/s12149-024-01964-y","url":null,"abstract":"<div><h3>Objectives</h3><p>This study aims to evaluate the value of the dynamic and static quantitative metabolic parameters derived from ¹⁸F-fluorodeoxyglucose (FDG)–positron emission tomography/CT (PET/CT) in the differential diagnosis of metastatic from non-metastatic lymph nodes (LNs) in lung cancer and to validate them based on the results of a previous study.</p><h3>Methods</h3><p>One hundred and twenty-one patients with lung nodules or masses detected on chest CT scan underwent ¹⁸F-FDG PET/CT dynamic + static imaging with informed consent. A retrospective collection of 126 LNs in 37 patients with lung cancer was pathologically confirmed. Static image analysis parameters include LN-SUV_max and LN-SUV_max/primary tumor SUV_max (LN-SUV_max/PT-SUV_max). Dynamic metabolic parameters including the net influx rate (<i>K</i>_i) and the surrogate of perfusion (<i>K</i>₁) and of each LN were obtained by applying the irreversible two-tissue compartment model using in-house Matlab software. <i>K</i>_i/<i>K</i>₁ was then calculated as a separate marker. Based on the pathological findings, we divided into a metastatic group and a non-metastatic group. The <i>χ</i>² test was used to evaluate the agreement of the individual and combined diagnosis of each metabolic parameter with the gold standard. The receiver-operating characteristic (ROC) analysis was performed for each parameter to determine the diagnostic efficacy in differentiating non-metastatic from metastatic LNs with high FDG-avid. <i>P</i> &lt; 0.05 was considered statistically significant.</p><h3>Results</h3><p>Among the 126 FDG-avid LNs confirmed by pathology, 70 LNs were metastatic, and 56 LNs were non-metastatic. For ROC analysis, in separate assays, the dynamic metabolic parameter <i>K</i>_i [sensitivity (SEN) of 84.30%, specificity (SPE) of 94.60%, accuracy of 88.89%, and AUC of 0.895] had a better diagnostic value than the static metabolic parameter SUV_max (SEN of 82.90%, SPE of 62.50%, accuracy of 74.60%, and AUC of 0.727) in differentiating between metastatic from non-metastatic LNs groups, respectively. In the combined diagnosis group, the combined SUV_max + <i>K</i>_i diagnosis had a better diagnostic value in the differential diagnosis of metastatic from non-metastatic LNs, with SEN, SPE, accuracy, and AUC of 84.3%, 94.6%, 88.89%, and 0.907, respectively.</p><h3>Conclusions</h3><p>When the cutoff value of <i>K</i>_i was 0.022 ml/g/min, it had a high diagnostic value in the differential diagnosis between metastasis and non-metastasis in FDG-avid LNs of lung cancer, especially in improving the specificity. The combination of SUV_max and <i>K</i>_i is expected to be a reliable metabolic parameter for N-staging of lung cancer.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"38 11","pages":"904 - 912"},"PeriodicalIF":2.5,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12149-024-01964-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141791749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of 1 cm dose-equivalent rate on the day after administration of 177Lu-DOTATATE from 111In-somatostatine receptor scintigraphy prior to treatment","authors":"Go Takai,&nbsp;Kohei Hanaoka,&nbsp;Keiji Nagano,&nbsp;Tsutomu Okada,&nbsp;Maya Honda,&nbsp;Izumi Komoto","doi":"10.1007/s12149-024-01962-0","DOIUrl":"10.1007/s12149-024-01962-0","url":null,"abstract":"<div><h3>Objective</h3><p>When patients administered ¹⁷⁷Lu-DOTATATE are released or discharged from rooms where radiopharmaceuticals are used, the time required for release or discharge varies across patients. This study investigated whether the amount of radioactivity accumulated on ¹¹¹In-somatostatine receptor scintigraphy (¹¹¹In-SRS) performed prior to treatment can predict the 1 cm dose-equivalent rate at a distance of 1 m from the patient on the day after ¹⁷⁷Lu-DOTATATE administration.</p><h3>Methods</h3><p>Whole-body planar ¹¹¹In-SRS images were acquired for 21 patients. Pixel values within whole-body and abdominal (35 × 25 cm) regions of interest (ROIs) were converted to radioactivity dose (MBq). The 1 cm dose-equivalent rate (µSv/h) at a distance of 1 m from the patient 18.3 ± 0.5 h after administration of ¹⁷⁷Lu-DOTATATE was measured using an ionization survey meter.</p><h3>Results</h3><p>The following relationships were observed between the radioactivity on ¹¹¹In-SRS and the 1 cm dose-equivalent rate on the day after administration of ¹⁷⁷Lu-DOTATATE: whole-body ROI: <i>y</i> = 0.16<i>x</i> + 5.01 (<i>r</i> = 0.56, <i>p</i> = 0.009), abdominal ROI: <i>y</i> = 0.27<i>x</i> + 5.13 (<i>r</i> = 0.63, <i>p</i> = 0.002). The regression equations indicate that patients cannot be released or discharged from the radiopharmaceutical room the day after ¹⁷⁷Lu-DOTATATE administration if the whole-body and abdominal ROI doses are greater than 81 and 48 MBq, respectively, on ¹¹¹In-SRS.</p><h3>Conclusions</h3><p>The amount of radioactivity accumulated on ¹¹¹In-SRS may be a predictor of release criteria for patients receiving ¹⁷⁷Lu-DOTATATE.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"38 11","pages":"927 - 932"},"PeriodicalIF":2.5,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141764997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tubarial salivary glands show a low relative contribution to functional salivary gland tissue mass","authors":"Sui wai Ling,&nbsp;Astrid van der Veldt,&nbsp;Marcel Segbers,&nbsp;Henk Luiting,&nbsp;Tessa Brabander,&nbsp;Frederik Verburg","doi":"10.1007/s12149-024-01965-x","DOIUrl":"10.1007/s12149-024-01965-x","url":null,"abstract":"<div><h3>Background</h3><p>In 2021, the tubarial salivary glands (TSGs) were newly identified on prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) as macroscopic glands in the nasopharyngeal wall. However, the relative contribution of the TSGs to the total salivary gland function, and consequently on the development of xerostomia after external beam radiotherapy (EBRT) or PSMA-targeted radionuclide therapy (RNT) is not known. Therefore, we aimed to determine the presence of the TSGs and to quantify uptake in the TSGs on PSMA PET.</p><h3>Methods</h3><p>Qualitative and quantitative analyses were performed on ⁶⁸Ga-PSMA-11 PET/CT scans of 100 patients with prostate cancer. The mean and maximum standardized uptake value (SUVmean and SUVmax) in the TSGs were measured and compared to the parotid, submandibular and sublingual salivary glands (PSGs, SMSGs and SLSGs, respectively). Furthermore, proportional function of the TSGs was compared to the PSGs, SMSGs and SLSGs based on the total organ PSMA (TO-PSMA).</p><h3>Results</h3><p>The TSGs were visible on 95% of the ⁶⁸Ga-PSMA-11 PET/CT scans. The normalized median SUVmean and SUVmax was significantly higher for the PSGs (<i>p</i> &lt; 0.001) and SMSGs (<i>p</i> &lt; 0.001) compared to the TSGs, but not for the SLSGs (<i>p</i> = 0.242 and <i>p</i> = 0.300, respectively). The normalized median TO-PSMA was significantly higher for the PSGs (<i>p</i> &lt; 0.001) and SMSGs (<i>p</i> &lt; 0.001), and significant lower for the SLSGs (<i>p</i> &lt; 0.001) compared the TSGs.</p><h3>Conclusions</h3><p>The SUVmean, SUVmax and TO-PSMA of the TSGs were most comparable to the SLSGs. However, the measured PSMA uptake may be disproportional towards the saliva production. Therefore, future studies should focus on the relation between PSMA uptake and salivary function before and after PSMA therapy.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"38 11","pages":"913 - 918"},"PeriodicalIF":2.5,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12149-024-01965-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141764998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the selection and timing of postoperative radioiodine treatment in patients with differentiated thyroid carcinoma","authors":"Xin Dai,&nbsp;Xinyi Ren,&nbsp;Jinyu Zhang,&nbsp;Yuxin Zheng,&nbsp;Zhengjie Wang,&nbsp;Gang Cheng","doi":"10.1007/s12149-024-01963-z","DOIUrl":"10.1007/s12149-024-01963-z","url":null,"abstract":"<div><p>Differentiated thyroid cancer (DTC) is the most common endocrine malignancy. Patients who receive systematic care typically have a better prognosis. RAI treatment plays a key role in eradicating any remaining thyroid lesions in DTC patients, hence decreasing the risk of distant metastases and cancer recurrence. As research continues to advance, RAI treatment is becoming more and more individualized. Because of the excellent prognosis for DTC patients, there is a relatively broad window for RAI treatment, making it easy to overlook when to receive RAI treatment. However, research on this issue can help patients with varying recurrence risk stratification make better decisions about when to begin RAI treatment following surgery, and physicians can schedule patients based on the severity of their disease. This will improve patient prognosis and lessen needless anxiety in addition to helping solve the problems of unjust healthcare resource distribution. In this review, we will mainly discuss the target population of RAI treatment as well as studies that examine the impact of RAI treatment timing on patient outcomes. In an effort to discourage DTC patients and physicians from selecting RAI therapy at random, we also review the possible negative effects of this treatment.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"38 9","pages":"688 - 699"},"PeriodicalIF":2.5,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141750860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}