Annals of Nuclear Medicine最新文献

{"title":"Next day sentinel node biopsy for melanoma after lymphoscintigraphy using 99mTc-labelled nanocolloid does not adversely affect long-term outcomes","authors":"Amit Roshan,&nbsp;Terouz Pasha,&nbsp;Georgios Kounidas,&nbsp;Suzanne Murphy,&nbsp;Luigi Aloj,&nbsp;John Buscombe,&nbsp;Animesh Patel,&nbsp;Amer Durrani","doi":"10.1007/s12149-024-01980-y","DOIUrl":"10.1007/s12149-024-01980-y","url":null,"abstract":"<div><h3>Objective</h3><p>Sentinel Lymph Node Biopsy (SLNB) is an important management tool for early-stage melanoma. Different radiopharmaceuticals are used internationally to localise the sentinel node using lymphoscintigraphy (LSG) before surgery. Recent reports have suggested that a delayed interval between LSG and SLNB using ^99mTc-labelled nanocolloid tracer has an adverse survival impact, but not with ^99mTc-labelled antimony sulphide colloid. This study aims to analyse survival outcome in a prospective cohort of melanoma patients undergoing same day or next day SLNB after LSG using ^99mTc-labelled nanocolloid.</p><h3>Methods</h3><p>Outcome data were reviewed for patients undergoing SLNB, stratified by time interval between LSG and SLNB at a single UK academic centre. Kaplan–Meier survival analysis was used to assess overall survival (OS), melanoma-specific survival (MSS) and progression-free survival (PFS). Cox multivariable regression analysis identified independent risk factors.</p><h3>Results</h3><p>925 patients had LSG using the ^99mTc-nanocolloid tracer between 2009 and 2019, with a median follow-up of 6.36 years. No difference was seen on univariate analysis in OS, MSS, PFS, or nodal recurrence between patients undergoing same day or next day SLNB (Log-rank <i>P</i> = 0.437, 0.293, 0.587, 0.342 respectively). In addition, nodal recurrence as first site or anytime site of recurrence in SLNB negative patients was similar between the groups (Log-rank <i>P</i> = 0.093 and 0.457 respectively). Stratified analysis of time did not demonstrate an outcome difference (MSS Log-rank <i>P</i> = 0.938). Cox multivariable regression did not show time interval to independently influence OS, MSS or PFS.</p><h3>Conclusions</h3><p>We do not find a significant effect on long-term outcomes when SLNB is performed the day after LSG with ^99mTc-labelled nanocolloid tracer. We infer that tracer migration is not clinically significant within 24 h of injection based on long term clinical outcome data.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 1","pages":"77 - 85"},"PeriodicalIF":2.5,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12149-024-01980-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142265860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood-pool SUV analysis of 99mTc-galactosyl human serum albumin (99mTc-GSA) normalized by blood volume for prediction of short-term survival in severe liver failure: preliminary report","authors":"Naoya Yama,&nbsp;Hiroomi Tatsumi,&nbsp;Masayuki Akatsuka,&nbsp;Masamitsu Hatakenaka","doi":"10.1007/s12149-024-01975-9","DOIUrl":"10.1007/s12149-024-01975-9","url":null,"abstract":"<div><h3>Purpose</h3><p>This study evaluated the usefulness of SUV analysis of 99mTc-galactosyl human serum albumin (99mTc-GSA) scintigraphy including SUV analysis of the cardiac blood pool normalized by blood volume as a predictor of short-term survival in severe liver failure.</p><h3>Patients and methods</h3><p>We enrolled 24 patients with severe liver failure who underwent 99mTc-GSA scintigraphy and were admitted to the intensive care unit. Patients were divided into survival and non-survival groups at 7, 14, and 28 days from the performance of 99mTc-GSA scintigraphy. From SPECT images we calculated SUVs of the cardiac blood pool, performing normalization for body weight, lean body weight, Japanese lean body weight, and blood volume and we calculated SUVs of the liver, normalizing by body weight, lean body weight, and Japanese lean body weight. We also calculated the uptake ratio of the heart at 15 min to that at 3 min (HH15) and the uptake ratio of the liver at 15 min to the liver plus the heart at 15 min (LHL15) from planar images of 99mTc-GSA scintigraphy.</p><h3>Results</h3><p>There were significant differences between the 7 day survival and non-survival groups for all SUVs of the heart and the liver and HH15, for 14 day survival groups in SUVs of the heart normalized by Japanese lean body weight and blood volume, and no significant differences between 28 day survival groups for any SUVs, HH15, or LHL15. Although the difference was not significant, SUV analysis of the heart normalized by blood volume showed the highest value for the area under the receiver-operating-characteristics curve for both 7 day and 14 day survival.</p><h3>Conclusion</h3><p>SUV analysis of 99mTc-GSA including SUV analysis of cardiac blood pool normalized by blood volume is of value for prediction of short-term survival in cases with severe liver failure.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 1","pages":"58 - 67"},"PeriodicalIF":2.5,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142176624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of transient ischemic dilatation by 13N-ammonia PET MPI for short-term outcomes in patients with non-obstructive CAD","authors":"Yanni jia,&nbsp;Yingqi Hu,&nbsp;Lihong Yang,&nbsp;Xin Diao,&nbsp;Yuanyuan Li,&nbsp;Yanhui Wang,&nbsp;Ruonan Wang,&nbsp;Jianbo Cao,&nbsp;Sijin Li","doi":"10.1007/s12149-024-01976-8","DOIUrl":"10.1007/s12149-024-01976-8","url":null,"abstract":"<div><h3>Objective</h3><p>Transient ischaemic dilatation (TID) had incremental diagnostic and prognostic value in obstructive coronary artery disease (CAD), but its clinical significance in patients with non-obstructive CAD remains unknown. We aimed to explore the prognostic value of TID in patients with non-obstructive CAD by ¹³N-ammonia PET imaging.</p><h3>Methods</h3><p>We retrospectively studied 131 consecutive patients with non-obstructive CAD undergoing one-day rest-stress ¹³N-ammonia PET myocardial perfusion imaging (MPI). TID was automatically generated using CardIQ Physio software. The receiver operative characteristic (ROC) curve was used to determine the optimal threshold of TID. The follow-up outcome was major adverse cardiac events (MACE), a composite of re-hospitalization for heart failure or unstable angina, late revascularization, non-fatal myocardial infarction, and cardiac death. Cardiac event-free survivals for normal and abnormal TID were compared using Kaplan–Meier plots and log-rank tests.</p><h3>Results</h3><p>During a median follow-up of 42.08 ± 17.67 months, 22 (16.7%) patients occurred MACE. The optimal cut-off value of TID was 1.03 based on MACE. Our preliminary outcome analysis suggests that TID-abnormal subjects had a lower overall survival probability. Furthermore, our multivariate analysis reveals abnormal TID was the only independent predictor for MACE in non-obstructive CAD. In the subgroup analysis, an abnormal TID was an independent predictor for MACE in patients with abnormal perfusion patterns.</p><h3>Conclusion</h3><p>Among patients with non-obstructive CAD, PET-derived TID ≥ 1.03 may identify those with a high risk of subsequent MACE independently. It was also an independent risk factor for poor prognosis in patients with abnormal perfusion.</p><h3>Graphical abstract</h3><p> <i>CAD</i> coronary artery disease,<i> PET</i> positron emission tomography, <i>MPI</i> myocardial perfusion imaging, <i>TID</i> transient ischaemic dilatation,<i> MACE</i> major adverse cardiac events, <i>ROC</i> receiver operative characteristic.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 1","pages":"47 - 57"},"PeriodicalIF":2.5,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12149-024-01976-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142176623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of advanced hybrid SPECT/CT system using dynamic anthropomorphic cardiac phantom","authors":"Elad Gelbart,&nbsp;Alexander Krakovich,&nbsp;Yigal Sherm,&nbsp;Gilad Rabin,&nbsp;Hagit Ratner,&nbsp;Mickey Scheinowitz,&nbsp;Ronen Goldkorn","doi":"10.1007/s12149-024-01966-w","DOIUrl":"10.1007/s12149-024-01966-w","url":null,"abstract":"<div><h3>Objective</h3><p>Myocardial blood flow (MBF) assessment can provide incremental diagnostic and prognostic information and thus the validation of dynamic SPECT is of high importance. We recently developed a novel cardiac phantom for dynamic SPECT validation and compared its performance against the GE Discovery NM 530c. We now report its use for validation of a new hybrid SPECT/CT System featuring advanced cadmium zinc telluride (CZT) technology in a ring array detector design (StarGuide™, GE HealthCare).</p><h3>Methods</h3><p>Our recently developed cardiac phantom with injected technetium-99m radiotracer was used to create physiological time activity curves (TACs) for the left ventricular (LV) cavity and the myocardium. The TACs allow the calculation of uptake rate (K1) and MBF. The StarGuide system was used to acquire and process the TACs, and these were compared to the TACs produced by the phantom and its mathematical model. Fifteen (15) experiments with different doses representing various MBF values were conducted, and a standard statistic tool was applied for significance.</p><h3>Results</h3><p>The TACs produced by the StarGuide system had a significant correlation (<i>p</i> &lt; 0.001) with the reference TACs generated by the phantom both for the LV (r = 0.94) and for the myocardium (r = 0.89). The calculated MBF difference between the system and the phantom was 0.14 ± 0.16 ml/min/g and the average relative absolute difference was 13.2 ± 8.1%. A coefficient of variance of ≤ 11% was observed for all MBF subranges. The regional uptake rate values were similar to the global one with a maximum difference of 5%.</p><h3>Conclusions</h3><p>Our newly developed dynamic cardiac phantom was used for validation of the dynamic hybrid SPECT/CT CZT-based system (StarGuide™, GE). The accuracy and precision of the system for assessing MBF values were high. The new StarGuide system can reliably perform dynamic SPECT acquisitions over a wide range of myocardial perfusion flow rates.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"38 11","pages":"919 - 926"},"PeriodicalIF":2.5,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12149-024-01966-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phantom test procedures for a new neuro-oncological amino acid PET tracer: [18F]fluciclovine","authors":"Kaede Tsuzura,&nbsp;Kei Wagatsuma,&nbsp;Yuto Kamitaka,&nbsp;Kenta Miwa,&nbsp;Noriaki Miyaji,&nbsp;Takashi Kamiya,&nbsp;Noriyo Yokotsuka,&nbsp;Kenji Ishii","doi":"10.1007/s12149-024-01973-x","DOIUrl":"10.1007/s12149-024-01973-x","url":null,"abstract":"<div><h3>Objective</h3><p>Amino acid positron emission tomography (PET) examinations using anti-1-amino-3-[¹⁸F]-fluorocyclobutane-1-carboxylic acid ([¹⁸F]FACBC) were allowed for routine clinical use in July 2024. However, phantom test procedures for [¹⁸F]FACBC reconstruction parameters have not yet been established. The present study aimed to establish new phantom test procedures for [¹⁸F]FACBC brain PET imaging to determine optimal reconstruction parameters.</p><h3>Methods</h3><p>Background (BG) activity as well as hot sphere and target-to-background ratios (TBRs) of [¹⁸F]FACBC were estimated based on brain activity and tumor-to-normal tissue ratios (TNR) in a Japanese clinical trial of [¹⁸F]FACBC. Phantom experiments proceeded under [¹⁸F]FACBC or L-[methyl-¹¹C]-methionine ([¹¹C]MET) conditions. The number of iterations and the Gaussian filter parameters were determined from the reconstruction parameters %contrast_mean and coefficients of variation (CVs) in ordered subset expectation maximization (OSEM) and time-of-flight (TOF) with or without point-spread-function (PSF) correction.</p><h3>Results</h3><p>The amounts of activity in the hot spheres and BG were 1.1 and 5.5 kBq/mL, respectively, and the TBR was 5.0 at the start of acquisition. The %contrast_mean of all hot spheres was higher with [¹⁸F]FACBC than [¹¹C]MET, and %contrast_mean converged between 4 and 6 iterations in hot spheres with diameters &lt; 10 mm. We used four iterations for OSEM + TOF and five for OSEM + TOF + PSF correction for [¹⁸F]FACBC and [¹¹C]MET images. The CV was higher for [¹⁸F]FACBC than [¹¹C]MET. The optimal sizes of Gaussian filters for OSEM + TOF and OSEM + TOF + PSF correction of image reconstruction were 5 mm for [¹⁸F]FACBC, and 4 and 3 mm, respectively, for [¹¹C]MET images.</p><h3>Conclusions</h3><p>We estimated phantom activity and TBR based on brain activity in a Japanese clinical trial and established new phantom test procedures for [¹⁸F]FACBC. We recommend that the optimal reconstruction parameters for [¹⁸F]FACBC should be set to the same number of iterations as [¹¹C]MET and that the FWHM of Gaussian filter should have a few mm higher than [¹¹C]MET to reduce image noise from brain normal tissue.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 1","pages":"21 - 30"},"PeriodicalIF":2.5,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel algorithm developed using machine learning and a J-ACCESS database can estimate defect scores from myocardial perfusion single-photon emission tomography images","authors":"Keisuke Kiso,&nbsp;Kenichi Nakajima,&nbsp;Yukitaka Nimura,&nbsp;Tsunehiko Nishimura","doi":"10.1007/s12149-024-01971-z","DOIUrl":"10.1007/s12149-024-01971-z","url":null,"abstract":"<div><h3>Background</h3><p>Stress myocardial perfusion single-photon emission computed tomography (SPECT) imaging (MPI) has been used to diagnose and predict the prognoses of patients with coronary artery disease (CAD). An ongoing multicenter collaboration established a Japanese database (J-ACCESS) in 2001 that includes a risk model and expert interpretations. The present study aimed to develop a novel algorithm using machine learning (ML) and resources from the J-ACCESS database to aid SPECT image interpretation.</p><h3>Methods</h3><p>We analyzed data from 1288 patients in J-ACCESS 3 and 4 databases. Three-dimensional (3D) stereoscopic images of left ventricular myocardial perfusion were reconstructed with linear transformation from the original short-axis data. Segments were extracted from U-Net, then features were extracted from each segment during the ML process. We estimated segmental scores based on weighted features obtained from fully connected layers. Correlations between segment scores interpreted by nuclear cardiology experts and estimated by ML were evaluated using a 17-segment model, summed stress (SSS), summed rest (SRS), and summed difference (SDS) scores, and ratios (%) of summed different scores (%SDS).</p><h3>Results</h3><p>The complete concordance rate of scores assessed by the experts and estimated by ML was 79.6%. The underestimated and overestimated rates were 10.3% and 10.0%, respectively. Associations between defect scores assessed by experts and ML were close, with correlation coefficients (<i>r</i>) of 0.923, 0.917, 0.842 and 0.853 for SSS, SRS, SDS, %SDS, respectively (<i>p</i> &lt; 0.0001 for all).</p><h3>Conclusions</h3><p>We created a new algorithm to estimate MPI scores using ML and the J-ACCESS database. This algorithm should provide accurate MPI interpretation even in facilities without specialist nuclear cardiologists, and might facilitate therapeutic decision-making and predict prognoses.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"38 12","pages":"980 - 988"},"PeriodicalIF":2.5,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12149-024-01971-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Voxel-based dosimetry with integrated Y-90 PET/MRI and prediction of response of primary and metastatic liver tumors to radioembolization with Y-90 glass microspheres","authors":"Burak Demir,&nbsp;Cigdem Soydal,&nbsp;Nuriye Ozlem Kucuk,&nbsp;Emre Can Celebioglu,&nbsp;Mehmet Sadık Bilgic,&nbsp;Digdem Kuru Oz,&nbsp;Atilla Halil Elhan,&nbsp;Kemal Metin Kir","doi":"10.1007/s12149-024-01974-w","DOIUrl":"10.1007/s12149-024-01974-w","url":null,"abstract":"<div><h3>Purpose</h3><p>In this study, we aimed to evaluate the response of the primary and metastatic liver tumors to radioembolization with ⁹⁰Y glass microspheres and investigate its correlations with dosimetric variables calculated with ⁹⁰Y PET/MRI.</p><h3>Methods</h3><p>In this ambispective study, 44 patients treated with ⁹⁰Y glass microspheres and imaged with ⁹⁰Y PET/MRI were included for analysis. Dosimetric analysis was performed for every perfused lesion using dose–volume histograms. Response was assessed by comparing pre-treatment and follow-up total lesion glycolysis (TLG) values derived from ¹⁸F-FDG PET imaging. The relationship between ΔTLG and log-transformed dosimetric variables was analyzed with linear mixed effects regression models. ROC analyses were performed to compare discriminatory power of the variables in predicting response and complete response.</p><h3>Results</h3><p>Regression and ROC analyses demonstrated that mean tumor dose and almost all D values were statistically significant predictors of treatment response and complete treatment response. Specifically, D60, D70 and D80 values exhibited significantly higher discriminatory power for predicting treatment response compared to the mean dose (<i>D</i>_mean) delivered to tumor. High specificity cut-off values to predict response were determined as 160.75 Gy for <i>D</i>_mean, 95.50 Gy for D60, 89 Gy for D70, and 59.50 Gy for D80. Similarly, high-specificity cut-off values to predict complete response were 262.75 Gy for D_mean, 173 Gy for D70, 140.5 Gy for D80, and 100 Gy for D90.</p><h3>Conclusion</h3><p>In this study, we demonstrated that voxel-based dosimetry with post-treatment ⁹⁰Y PET/MRI can predict response to treatment. D60, D70 and D80 variables also did have greater discriminatory power compared to <i>D</i>_mean in prediction of response. In addition, we present high-specificity cut-offs to predict response (CR + PR) and complete response (CR) for both <i>D</i>_mean and several <i>D</i> variables derived from dose–volume histograms.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 1","pages":"31 - 46"},"PeriodicalIF":2.5,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical assessment and striatal dopaminergic activity in healthy controls and patients with Parkinson’s disease: a Bayesian approach","authors":"Seunghyeon Shin,&nbsp;Hyun-Yeol Nam,&nbsp;Keunyoung Kim,&nbsp;Jihyun Kim,&nbsp;Myung Jun Lee,&nbsp;Kyoungjune Pak","doi":"10.1007/s12149-024-01972-y","DOIUrl":"10.1007/s12149-024-01972-y","url":null,"abstract":"<div><h3>Objectives</h3><p>We aimed to evaluate correlations between striatal dopamine transporter (DAT) uptake and clinical assessments in both patients with Parkinson’s disease (PD) and healthy controls.</p><h3>Methods</h3><p>This study enrolled 193 healthy controls, and 581 patients with PD. They underwent various clinical assessments and ¹²³I-FP-CIT SPECT scans. After reconstruction, attenuation correction, and normalization of SPECT images, counts were measured from the bilateral caudate and putamen, and the occipital cortex for reference. Count densities for each region were extracted and used to calculate striatal binding ratios (SBRs) for each striatal region. SBR is calculated as (target region/reference region)—1. After logarithmic transformation of striatal SBRs, we analyzed the effects of clinical assessments on striatal SBRs using Bayesian hierarchical modeling.</p><h3>Results</h3><p>MDS-UPDRS total score, part I, part II, part III, Epworth Sleepiness Scale, REM sleep behavior disorder screening questionnaire, SCOPA-AUT total score were negatively associated with striatal SBR in patients with PD. Also, HVLT recognition discrimination was positively associated with striatal SBR in both healthy controls and patients with PD. In healthy control, MDS-UPDRS part II, MOCA, SCOPA-AUT total score were positively associated with striatal SBR.</p><h3>Conclusion</h3><p>We demonstrated that motor symptom, sleep disturbance, autonomic symptom, and cognition of patients with PD were associated with striatal dopaminergic activity. In healthy controls, motor symptoms, autonomic symptom, and cognition were associated with striatal dopaminergic activity, some of which showing the opposite direction with patients with PD. This result might provide new insight to underlying mechanism of dopamine system with motor and non-motor assessments.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"38 12","pages":"989 - 998"},"PeriodicalIF":2.5,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142071801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of myocardial injury by SPECT myocardial perfusion imaging in patients with COVID-19 infection in a single center after lifting the restrictions in China","authors":"Keke Xin,&nbsp;Xinghong Ma,&nbsp;Xiaoli Meng,&nbsp;Xiao Zhang,&nbsp;Weidong Yang,&nbsp;Taoqi Ma,&nbsp;Cheng Zhou,&nbsp;Jing Wang,&nbsp;Guoquan Li","doi":"10.1007/s12149-024-01970-0","DOIUrl":"10.1007/s12149-024-01970-0","url":null,"abstract":"<div><h3>Purpose</h3><p>To assess myocardial injury using rest single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) in patients with COVID-19 and to evaluate whether myocardial injury detected by rest MPI predict the prognosis of symptoms after 6 months follow-up.</p><h3>Methods</h3><p>Patients suspected of myocarditis between December 2022 and March 2023, after the lifting of COVID-19 pandemic restrictions, and between December 2018 and March 2019, prior to the pandemic, were referred to our study. All patients underwent rest MPI. One hundred and sixty four patients with COVID-19 infection after the lifting of pandemic restrictions and 101 patients before the pandemic were included as the study and control groups, respectively. One hundred and fifty three patients of the study group and 83 of the control group presented symptoms when they initially visit to our department. Compare the parameters of myocardial injury detected by rest SPECT MPI between the two groups and then investigate the association between myocardial injury and symptom prognosis in symptomatic patients of both groups.</p><h3>Results</h3><p>Total perfusion defect (TPD) (4.2% ± 3.3% vs. 2.3% ± 2.2%, <i>P</i> &lt; 0.001), summed rest score (SRS) (5.3 ± 5.4 vs. 2.7 ± 2.0, <i>P</i> &lt; 0.001), the proportion of patients with TPD &gt; 4% (43.3% vs. 17.8%, <i>P</i> &lt; 0.001), TPD &gt; 10% (6.71% vs 0, <i>P</i> &lt; 0.001), SRS &gt; 4 (40.2% vs 15.8%, <i>P</i> &lt; 0.001), SRS &gt; 10 (12.8% vs 0, <i>P</i> &lt; 0.001), the number of abnormal perfusion segments (3.9 ± 3.1 vs. 2.4 ± 1.7, <i>P</i> &lt; 0.001) were all significantly higher in the study group. All the parameters of rest MPI were not associated with the prognosis of symptoms in symptomatic patients of both groups after 6 months follow-up.</p><h3>Conclusion</h3><p>Myocardial injury in COVID-19 patients could be assessed by rest SPECT MPI. The COVID-19 patients could exhibited a higher frequency and greater severity of myocardial injury than uninfected control patients. Myocardial injury assessed by rest MPI did not predict for the prognosis of symptoms in symptomatic patients of both COVID-19 patients and uninfected patients.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"38 12","pages":"971 - 979"},"PeriodicalIF":2.5,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142054730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How anatomical impairments found on CT affect perfusion percentage assessed by SPECT/CT scan?","authors":"Daniel M. Seraphim,&nbsp;Katia H. Koga,&nbsp;Antoine Vacavant,&nbsp;Diana R. de Pina","doi":"10.1007/s12149-024-01969-7","DOIUrl":"10.1007/s12149-024-01969-7","url":null,"abstract":"<div><h3>Aim</h3><p>CT images can identify structural and opacity alterations of the lungs while nuclear medicine’s lung perfusion studies show the homogeneity (or lack of) of blood perfusion on the organ. Therefore, the use of SPECT/CT in lung perfusion scintigraphies can help physicians to assess anatomical and functional alterations of the lungs and to differentiate between acute and chronic disease.</p><h3>Objective</h3><p>To develop a computer-aided methodology to quantify the total global perfusion of the lungs via SPECT/CT images and to compare these results with parenchymal alterations obtained in CT images.</p><h3>Methods</h3><p>39 perfusion SPECT/CT images collected retrospectively from the Nuclear Medicine Facility of Botucatu Medical School’s Clinics Hospital in São Paulo, Brazil, were analyzed. Anatomical lung impairments (emphysema, collapsed and infiltrated tissue) and the functional percentage of the lungs (blood perfusion) were quantified from CT and SPECT images, with the aid of the free, open-source software 3D Slicer. The results obtained with 3D Slicer (3D-TGP) were also compared to the total global perfusion of each patient’s found on their medical report, obtained from visual inspection of planar images (2D-TGP).</p><h3>Results</h3><p>This research developed a novel and practical methodology for obtaining lungs’ total global perfusion from SPECT/CT images in a semiautomatic manner. 3D-TGP versus 2D-TGP showed a bias of 7% with a variation up to 67% between the two methods. Perfusion percentage showed a weak positive correlation with infiltration (<i>p</i> = 0.0070 and <i>ρ</i> = 0.43) and collapsed parenchyma (<i>p</i> = 0.040 and <i>ρ</i> = 0.33).</p><h3>Conclusions</h3><p>This research brings meaningful contributions to the scientific community because it used a free open-source software to quantify the lungs blood perfusion via SPECT/CT images and pointed that the relationship between parenchyma alterations and the organ’s perfusion capability might not be so direct, given compensatory mechanisms.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"38 12","pages":"960 - 970"},"PeriodicalIF":2.5,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}