Annals of Nuclear Medicine最新文献

{"title":"Evaluation of two-dimensional total bone uptake (2D-TBU) and bone scan index (BSI) extracted from active bone metastatic burden on the bone scintigraphy in patients with radium-223 treatment","authors":"Shohei Fukai,&nbsp;Hiromitsu Daisaki,&nbsp;Takuro Umeda,&nbsp;Naoki Shimada,&nbsp;Takashi Terauchi,&nbsp;Mitsuru Koizumi","doi":"10.1007/s12149-024-01918-4","DOIUrl":"10.1007/s12149-024-01918-4","url":null,"abstract":"<div><h3>Objective</h3><p>Radium-223 is a first alpha-emitting radionuclide treatment for metastatic castration-resistant prostate cancer (mCRPC) patients with bone metastases. Although the spread-based bone scan index (BSI) and novel index of the intensity-based two-dimensional total bone uptake (2D-TBU) from bone scintigraphy may provide useful input in radium-223 treatment, they have not been evaluated in detail yet. This study aimed to fill this gap by evaluating BSI and 2D-TBU in patients treated with radium-223.</p><h3>Methods</h3><p>Twenty-seven Japanese patients with mCRPC treated with radium-223 were retrospectively analyzed. The patients were evaluated via blood tests and bone scans at baseline and 3 cycles intervals of treatment. BSI and 2D-TBU were analyzed via VSBONE BSI in terms of correlations, response to radium-223 treatment, association with treatment completion, and the Kaplan–Meier survival analysis was performed.</p><h3>Results</h3><p>Nineteen patients (70.4%) completed six cycles of radium-223 treatment, whereas eight patients (29.6%) did not complete the treatment regimen. A significant difference in baseline BSI and 2D-TBU was observed between these groups of patients. Both BSI and 2D-TBU were highly correlated (r = 0.96, <i>p</i> &lt; 0.001). Univariate analysis showed an association between radium-223 completion in median BSI and 2D-TBU values (<i>p</i> = 0.015) and completion percentage differences (91.7% vs. 45.5%; <i>p</i> = 0.027). The Kaplan–Meier product limit estimator showed that the median overall survival was 25.2 months (95% CI 14.0–33.6 months) in the completion group and 7.5 months (95% CI 3.3–14.2 months) in the without completion group (<i>p</i> &lt; 0.001). The overall survival based on median cutoff levels showed a significant difference in 2D-TBU (<i>p</i> = 0.007), but not in BSI (<i>p</i> = 0.15).</p><h3>Conclusions</h3><p>The 2D-TBU may offer advantages over BSI in classifying patients towards radium-223 treatment based on the degree of progression of bone metastases. This study supports the importance of preliminary assessment of bone metastasis status using BSI and 2D-TBU extracted from VSBONE BSI for radium-223 treatment decisions.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"38 6","pages":"450 - 459"},"PeriodicalIF":2.5,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140189402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of consistency in centiloid scale among different analytical methods in amyloid PET: the CapAIBL, VIZCalc, and Amyquant methods","authors":"Cong Shang,&nbsp;Keita Sakurai,&nbsp;Takashi Nihashi,&nbsp;Yutaka Arahata,&nbsp;Akinori Takeda,&nbsp;Kazunari Ishii,&nbsp;Kenji Ishii,&nbsp;Hiroshi Matsuda,&nbsp;Kengo Ito,&nbsp;Takashi Kato,&nbsp;Hiroshi Toyama,&nbsp;Akinori Nakamura,&nbsp;BATON Study Group","doi":"10.1007/s12149-024-01919-3","DOIUrl":"10.1007/s12149-024-01919-3","url":null,"abstract":"<div><h3>Objective</h3><p>The Centiloid (CL) scale is a standardized measure for quantifying amyloid deposition in amyloid positron emission tomography (PET) imaging. We aimed to assess the agreement among 3 CL calculation methods: CapAIBL, VIZCalc, and Amyquant.</p><h3>Methods</h3><p>This study included 192 participants (mean age: 71.5 years, range: 50–87 years), comprising 55 with Alzheimer’s disease, 65 with mild cognitive impairment, 13 with non-Alzheimer's dementia, and 59 cognitively normal participants. All the participants were assessed using the three CL calculation methods. Spearman’s rank correlation, linear regression, Friedman tests, Wilcoxon signed-rank tests, and Bland–Altman analysis were employed to assess data correlations, linear associations, method differences, and systematic bias, respectively.</p><h3>Results</h3><p>Strong correlations (rho = 0.99, <i>p</i> &lt; .001) were observed among the CL values calculated using the three methods. Scatter plots and regression lines visually confirmed these strong correlations and met the validation criteria. Despite the robust correlations, a significant difference in CL value between CapAIBL and Amyquant was observed (36.1 ± 39.7 vs. 34.9 ± 39.4; <i>p</i> &lt; .001). In contrast, no significant differences were found between CapAIBL and VIZCalc or between VIZCalc and Amyquant. The Bland–Altman analysis showed no observable systematic bias between the methods.</p><h3>Conclusions</h3><p>The study demonstrated strong agreement among the three methods for calculating CL values. Despite minor variations in the absolute values of the Centiloid scores obtained using these methods, the overall agreement suggests that they are interchangeable.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"38 6","pages":"460 - 467"},"PeriodicalIF":2.5,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11108942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140183509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel indices representing heterogeneous distributions of myocardial perfusion imaging","authors":"Misato Chimura,&nbsp;Tomohito Ohtani,&nbsp;Fusako Sera,&nbsp;Rie Higuchi,&nbsp;Kenji Kajitani,&nbsp;Kenichi Nakajima,&nbsp;Yasushi Sakata","doi":"10.1007/s12149-024-01920-w","DOIUrl":"10.1007/s12149-024-01920-w","url":null,"abstract":"<div><h3>Introduction</h3><p>Heterogeneous distribution in myocardial perfusion images (MPI) obtained by scintigraphy is often observed in cardiac diseases with normal myocardial perfusion. However, quantitative assessments of such heterogeneity have not been established. We hypothesized that the heterogeneity in MPI can be quantitatively evaluated through histogram analysis, calculating the standard deviation (SD), the 95% bandwidth (BW95%), and entropy.</p><h3>Methods</h3><p>We examined resting ^99mTc-MIBI images in 20 healthy subjects and 29 patients with cardiac disease who had none or very-mild reduced myocardial perfusion evaluated as a low summed rest score (0 to 4, the range of the studied healthy subjects). Two nuclear medicine specialists blindly divided them into two groups: non-heterogeneity or heterogeneity group, based solely on their visual assessments of heterogeneity on splash and polar maps generated from single-photon emission computed tomography (SPECT) images. The %uptake was determined by dividing the tracer count of each pixel by the tracer count of the pixel with the highest value in the LV myocardium. SD, BW95%, and entropy from histogram patterns were analyzed from the polar map data array of each %uptake. We investigated whether heterogeneity could be assessed using SD, BW95, and entropy in two groups classified by visual assessments. Additionally, we evaluated the area under the curve (AUC) to identify heterogeneity in the receiver operating characteristic curve analysis.</p><h3>Results</h3><p>Based solely on visual assessments, 11 (22%) and 38 (78%) cases were classified into the non-heterogeneity and heterogeneity groups, respectively. The non-heterogeneity group consisted of only healthy subjects, and all patients with cardiac disease were classified into the heterogeneity group. The cases in the heterogeneity group had significantly higher values of heterogeneity indices (SD, BW95%, and entropy) in %uptake than those in the non-heterogeneity group (<i>p</i> &lt; 0.05 for all). The AUCs of the heterogeneity indices were sufficiently high (AUCs &gt; 0.90 for all) in distinguishing cases with visually heterogeneous distribution or patients with cardiac disease.</p><h3>Conclusions</h3><p>Heterogeneity in MPI can be evaluated using SD, BW95%, and entropy through histogram analysis. These novel indices may help identify patients with subtle myocardial changes, even in images that show preserved perfusion (345/350).</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"38 6","pages":"468 - 474"},"PeriodicalIF":2.5,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12149-024-01920-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140172905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of left ventricular mechanical dyssynchrony indices derived from gated myocardial perfusion SPECT in coronary artery disease: a systematic review and meta-analysis","authors":"Koeun Lee,&nbsp;Sangwon Han,&nbsp;Jeongryul Ryu,&nbsp;Sang-Geon Cho,&nbsp;Dae Hyuk Moon","doi":"10.1007/s12149-024-01915-7","DOIUrl":"10.1007/s12149-024-01915-7","url":null,"abstract":"<div><h3>Purpose</h3><p>Left ventricular mechanical dyssynchrony (LVMD) is an important prognostic factor in coronary artery disease. A growing body of evidence indicates that LVMD parameters derived from phase analysis of gated myocardial SPECT may allow risk stratification for future cardiac events. We performed a systematic review and meta-analysis on the prognostic value of LVMD on gated SPECT in patients with coronary artery disease.</p><h3>Methods</h3><p>PubMed, Embase, and the Cochrane library were searched until August 25, 2022, for studies reporting the prognostic value of LVMD on gated SPECT for outcomes of all-cause death, cardiac death, or major adverse cardiovascular event (MACE) in patients with coronary artery disease. Hazard ratios (HRs) and their 95% confidence intervals (CIs) were meta-analytically pooled using a random-effects model.</p><h3>Results</h3><p>Nine studies (26,750 patients) were included in a qualitative synthesis. Among the SPECT LVMD parameters used in various studies, high phase standard deviation, phase bandwidth, and phase entropy were widely evaluated and reported to be associated with high rates of all-cause death, cardiac death, or MACE. For five studies (23,973 patients) in the quantitative synthesis, the pooled HR of LVMD for predicting MACE was 2.81 (95% CI 2.03–3.88). Studies using combined phase parameters to define LVMD showed higher HRs than a study using phase entropy (<i>p</i> = 0.0180).</p><h3>Conclusion</h3><p>LVMD from gated myocardial SPECT is a significant prognostic factor for coronary artery disease. Phase analysis of gated SPECT may be useful for accurate risk stratification and could be applied for clinical decision-making in such patients.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"38 6","pages":"441 - 449"},"PeriodicalIF":2.5,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140152038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement in the estimation of perfusable tissue fraction and myocardial flow reserve in the ischemic myocardial lesions using ECG-gated dynamic myocardial PET with 15O-water","authors":"Ayaka Maruo,&nbsp;Keiichi Magota,&nbsp;Yamato Munakata,&nbsp;Kenji Hirata,&nbsp;Chietsugu Katoh","doi":"10.1007/s12149-024-01913-9","DOIUrl":"10.1007/s12149-024-01913-9","url":null,"abstract":"<div><h3>Objective</h3><p>Perfusable tissue fraction (PTF) and myocardial flow reserve (MFR) from ¹⁵O-water dynamic positron emission tomography (PET) are parameters of myocardial viability. However, myocardial motion causes errors in these values. We aimed to develop accurate estimation of PTF and MFR in ischemic lesions using an electro-cardiogram (ECG)-gated dynamic myocardial PET with ¹⁵O-water.</p><h3>Methods</h3><p>Twenty-seven patients with ischemic heart disease were enrolled. All patients underwent percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). List mode 3D PET data and ECG signals were acquired using Philips Gemini TF64 instrument. For each scan, 500 MBq of ¹⁵O-water was infused slowly for 2 min, and the dynamic data were scanned for 6 min. Both non-gated dynamic images and ECG-gated diastolic dynamic images were reconstructed. On the myocardial PET images of each patient, the entire myocardial region of interest (ROI) was set and divided into 17 segments. Myocardial blood flow in the resting state (rest MBF), hyperemic state (stress MBF), PTF, and MFR in each segment were estimated from both non-gated and ECG-gated dynamic PET images. Coronary arteriograms were obtained for all patients. In total, 128 normal segments without stenosis and 50 ischemic segments with &gt; 90% stenosis were evaluated.</p><h3>Results</h3><p>In the ischemic myocardial segments, the PTF with ECG-gated PET was estimated as significantly lower than that with non-gated PET (0.63 ± 0.09 vs. 0.72 ± 0.08 [mL/mL], p &lt; 0.001). The ECG-gated PET estimated a significantly lower PTF in the ischemic segments than in the normal segments (0.63 ± 0.09 vs. 0.67 ± 0.07 [mL/mL], p &lt; 0.01). In the normal segments, the ECG-gated PET detected no significant difference in MFR compared with those from the non-gated PET (2.15 ± 0.76 vs. 2.24 ± 0.79, p = 0.28). However, in the ischemic myocardial segments, the MFR with ECG-gated PET was estimated as significantly lower than that with the non-gated PET (1.23 ± 0.29 vs. 1.69 ± 0.71, p &lt; 0.001). The ECG-gated PET presented a significantly higher inter-observer reproducibility of PTF and rest MBF than the non-gated PET (p &lt; 0.01). Neither stress MBF nor MFR yielded significant differences in inter-observer reproducibility between the ECG-gated and non-gated PET.</p><h3>Conclusions</h3><p>The ECG-gated dynamic ¹⁵O-water PET suppressed the myocardial motion effect and resulted in a lower PTF and MFR in ischemic myocardial lesions than the non-gated PET. The ECG-gated PET seemed to be better than the conventional non-gated dynamic PET for the detection of ischemic myocardial lesion.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"38 5","pages":"369 - 381"},"PeriodicalIF":2.5,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140118609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flare phenomenon visualized by 99mTc-bone scintigraphy has prognostic value for patients with metastatic castration-resistant prostate cancer","authors":"Xue Zhang,&nbsp;Kenichi Nakajima,&nbsp;Atsushi Mizokami,&nbsp;Hiroyuki Horikoshi,&nbsp;Koshiro Nishimoto,&nbsp;Katsuyoshi Hashine,&nbsp;Hideyasu Matsuyama,&nbsp;Satoru Takahashi,&nbsp;Hiroshi Wakabayashi,&nbsp;Seigo Kinuya","doi":"10.1007/s12149-024-01914-8","DOIUrl":"10.1007/s12149-024-01914-8","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to determine the prognostic value of the flare phenomenon in patients with metastatic castration-resistant prostate cancer (mCRPC) using the bone scan index (BSI) derived from ^99mTc-methylenediphosphonate (MDP) bone scintigraphy images.</p><h3>Methods</h3><p>We categorized 72 patients from the PROSTAT-BSI registry with mCRPC who were followed-up for 2 years after starting docetaxel chemotherapy to groups based on pre-chemotherapy BSI values of &lt; 1, 1–4, and &gt; 4. We assessed the effects of the flare phenomenon (defined as a &gt; 10% increase in the BSI within 3 months of starting chemotherapy, followed by &gt; 10% improvement within the next 3 months) on survival using Kaplan–Meier curves and Cox proportional hazard analyses.</p><h3>Results</h3><p>The flare phenomenon was found in 26 (36%) of the 72 patients. Prostate-specific antigen (PSA), alkaline phosphatase (ALP), and hemoglobin (Hb) levels steadily increased, then deteriorated in patients with and without flare, respectively. Elevated BSI and PSA values at 3 months after starting therapy and the absence of abiraterone or/and enzalutamide therapy led to poor 2-year overall survival (OS) in the group without flare. In contrast, no influence was noticeable in the group with flare. The results of multivariable analyses that included only factors associated with PSA and BSI showed that increased baseline BSI (hazard ratio [HR], 1.39; 95% confidence interval [CI], 1.04–1.86; <i>P</i> = 0.023) and PSA (HR, 7.15; 95% CI 2.13–24.04; <i>P</i> = 0.0015) values could be independent risk factors for patients with mCRPC without flare. However, these factors lost significance during flare. The risk for all-cause death was significantly higher among patients with BSI &gt; 4 without, than with flare. The results of univariable analyses indicated that flare positively impacted survival (HR, 0.24; 95% CI 0.06‒0.91; <i>P</i> = 0.035). Multivariable analysis did not identify any factors that could predict outcomes.</p><h3>Conclusion</h3><p>Favorable prognosis, with fewer disturbances from other factors such as the use of abiraterone or/and enzalutamide, PSA changes, and BSI, was attainable in cases when the mCRPC patient demonstrated flare phenomenon. Follow-up bone scintigraphy at least every 3 months could help to determine the prognosis of patients with bone metastasis of mCRPC.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"38 6","pages":"428 - 440"},"PeriodicalIF":2.5,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11108890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140118597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative analysis of abdominal aortic blood flow by 99mTc-DTPA renal scintigraphy in patients with heart failure","authors":"Yue Li,&nbsp;Zhiqiang Yang,&nbsp;Pei Yin,&nbsp;Xian Gao,&nbsp;Lizhuo Li,&nbsp;Qingzhen Zhao,&nbsp;Yuzhi Zhen,&nbsp;Yu Wang,&nbsp;Chao Liu","doi":"10.1007/s12149-024-01912-w","DOIUrl":"10.1007/s12149-024-01912-w","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to explore the characteristics of abdominal aortic blood flow in patients with heart failure (HF) using ^99mTc-diethylenetriaminepentaacetic acid (DTPA) renal scintigraphy. We investigated the ability of renal scintigraphy to measure the cardiopulmonary transit time and assessed whether the time-to-peak of the abdominal aorta (TTPa) can distinguish between individuals with and without HF.</p><h3>Methods</h3><p>We conducted a retrospective study that included 304 and 37 patients with and without HF (controls), respectively. All participants underwent ^99mTc-DTPA renal scintigraphy. The time to peak from the abdominal aorta’s first-pass time–activity curve was noted and compared between the groups. The diagnostic significance of TTPa for HF was ascertained through receiver operating characteristic (ROC) analysis and logistic regression. Factors influencing the TTPa were assessed using ordered logistic regression.</p><h3>Results</h3><p>The HF group displayed a significantly prolonged TTPa than controls (18.5 [14, 27] s vs. 11 [11, 13] s). Among the HF categories, HF with reduced ejection fraction (HFrEF) exhibited the longest TTPa compared with HF with mildly reduced (HFmrEF) and preserved EF (HFpEF) (25 [17, 36.5] s vs. 17 [15, 23] s vs. 15 [11, 17] s) (<i>P</i> &lt; 0.001). The ROC analysis had an area under the curve of 0.831, which underscored TTPa’s independent diagnostic relevance for HF. The diagnostic precision was enhanced as left ventricular ejection fraction (LVEF) declined and HF worsened. Independent factors for TTPa included the left atrium diameter, LVEF, right atrium diameter, velocity of tricuspid regurgitation, and moderate to severe aortic regurgitation.</p><h3>Conclusions</h3><p>Based on ^99mTc-DTPA renal scintigraphy, TTPa may be used as a straightforward and non-invasive tool that can effectively distinguish patients with and without HF.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"38 6","pages":"418 - 427"},"PeriodicalIF":2.5,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140100906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of [11C]methionine PET with Bayesian penalized likelihood reconstruction on glioma grades based on new WHO 2021 classification","authors":"Kei Wagatsuma,&nbsp;Kensuke Ikemoto,&nbsp;Motoki Inaji,&nbsp;Yuto Kamitaka,&nbsp;Shoko Hara,&nbsp;Kaoru Tamura,&nbsp;Kenta Miwa,&nbsp;Kaede Tsuzura,&nbsp;Taisei Tsuruki,&nbsp;Noriaki Miyaji,&nbsp;Kenji Ishibashi,&nbsp;Kenji Ishii","doi":"10.1007/s12149-024-01911-x","DOIUrl":"10.1007/s12149-024-01911-x","url":null,"abstract":"<div><h3>Objective</h3><p>The uptake of [¹¹C]methionine in positron emission tomography (PET) imaging overlapped in earlier images of tumors. Bayesian penalized likelihood (BPL) reconstruction increases the quantitative values of tumors compared with conventional ordered subset-expectation maximization (OSEM). The present study aimed to grade glioma malignancy based on the new WHO 2021 classification using [¹¹C]methionine PET images reconstructed using BPL.</p><h3>Methods</h3><p>We categorized 32 gliomas in 28 patients as grades 2/3 (<i>n</i> = 15) and 4 (<i>n</i> = 17) based on the WHO 2021 classification. All [¹¹C]methionine images were reconstructed using OSEM + time-of-flight (TOF) and BPL + TOF (<i>β = </i>200). Maximum standardized uptake value (SUV_max) and tumor-to-normal tissue ratio (T/N_max) were measured at each lesion.</p><h3>Results</h3><p>The mean SUV_max was 4.65 and 4.93 in grade 2/3 and 6.38 and 7.11 in grade 4, and the mean T/N_max was 7.08 and 7.22 in grade 2/3 and 9.30 and 10.19 in grade 4 for OSEM and BPL, respectively. The BPL significantly increased these values in grade 4 gliomas. The area under the receiver operator characteristic (ROC) curve (AUC) for SUV_max was the highest (0.792) using BPL.</p><h3>Conclusions</h3><p>The BPL increased mean SUV_max and mean T/N_max in lesions with higher contrast such as grade 4 glioma. The discrimination power between grades 2/3 and 4 in SUV_max was also increased using [¹¹C]methionine PET images reconstructed with BPL.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"38 5","pages":"400 - 407"},"PeriodicalIF":2.5,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140100905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Radiation dosimetry and pharmacokinetics of the tau PET tracer florzolotau (18F) in healthy Japanese subjects","authors":"Masaomi Miyamoto,&nbsp;Chio Okuyama,&nbsp;Shinya Kagawa,&nbsp;Kuninori Kusano,&nbsp;Masaaki Takahashi,&nbsp;Keisuke Takahata,&nbsp;Ming-Kuei Jang,&nbsp;Hiroshi Yamauchi","doi":"10.1007/s12149-024-01917-5","DOIUrl":"10.1007/s12149-024-01917-5","url":null,"abstract":"","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"38 4","pages":"328 - 328"},"PeriodicalIF":2.5,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10955007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140048580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The active papillary muscle sign in 18F-FDG PET/CT cardiac sarcoidosis exams and its relationship with myocardial suppression","authors":"Can Özütemiz,&nbsp;Yasemin Koksel,&nbsp;Jerry W. Froelich,&nbsp;Nathan Rubin,&nbsp;Maneesh Bhargava,&nbsp;Henri Roukoz,&nbsp;Rebecca Cogswell,&nbsp;Jeremy Markowitz,&nbsp;David M. Perlman,&nbsp;Daniel Steinberger","doi":"10.1007/s12149-024-01910-y","DOIUrl":"10.1007/s12149-024-01910-y","url":null,"abstract":"<div><h3>Objective</h3><p>Papillary muscle (PM) activity may demonstrate true active cardiac sarcoidosis (CS) or mimic CS in ¹⁸FDG-PET/CT if adequate myocardial suppression (MS) is not achieved. We aim to examine whether PM uptake can be used as a marker of failed MS and measure the rate of PM activity presence in active CS with different dietary preparations.</p><h3>Materials and methods</h3><p>We retrospectively reviewed PET/CTs obtained with three different dietary preparations. Diet-A: 24-h ketogenic diet with overnight fasting (<i>n</i> = 94); Diet-B: 18-h fasting (<i>n</i> = 44); and Diet-C: 72-h daytime ketogenic diet with 3-day overnight fasting (<i>n</i> = 98). Each case was evaluated regarding CS diagnosis (negative, positive, and indeterminant) and presence of PM activity. MaxSUV was measured from bloodpool, liver, and the most suppressed normal myocardium. Linear mixed-effects models were used to compare these factors between those with PM activity and those without.</p><h3>Results</h3><p>PM activity was markedly lower in the Diet-C group compared with others: Diet-C: 6 (6.1%), Diet-A: 36 (38.3%), and Diet-B: 26 (59.1%) (<i>p</i> &lt; <i>0.001).</i> Myocardium_MaxSUV was higher, and Myocardium_maxSUV/Bloodpool_maxSUV, Myocardium_maxSUV/Liver_maxSUV ratios were significantly higher in the cases with PM activity (<i>p</i> &lt; <i>0.001).</i> Among cases that used Diet-C and had PM activity, 66.7% were positive and 16.7% were indeterminate. If Diet-A or Diet-B was used, those with PM activity had a higher proportion of indeterminate cases (Diet-A: 61.1%, Diet-B: 61.5%) than positive cases (Diet-A: 36.1%, Diet-B: 38.5%).</p><h3>Conclusion</h3><p>Lack of PM activity can be a sign of appropriate MS. PM activity is less common with a specific dietary preparation (72-h daytime ketogenic diet with 3-day overnight fasting), and if it is present with this particular preparation, the likelihood that the case being true active CS might be higher than the other traditional dietary preparations.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"38 5","pages":"391 - 399"},"PeriodicalIF":2.5,"publicationDate":"2024-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140011998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}