G. A. Jimenez Londoño, J. Pérez-Beteta, M. Amo-Salas, A. F. Honguero-Martinez, V. M. Pérez-García, C. Lucas Lucas, A. M. Soriano Castrejón, A. M. García Vicente
{"title":"来自18F-FDG PET/CT的临床病理和代谢变量预测I-III期非小细胞肺癌根治性手术后复发模式","authors":"G. A. Jimenez Londoño, J. Pérez-Beteta, M. Amo-Salas, A. F. Honguero-Martinez, V. M. Pérez-García, C. Lucas Lucas, A. M. Soriano Castrejón, A. M. García Vicente","doi":"10.1007/s12149-025-02021-y","DOIUrl":null,"url":null,"abstract":"<div><h3>Aim</h3><p>This study aimed to analyze the clinicopathologic and metabolic parameters derived from staging <sup>18</sup>F-FDG PET/CT that can predict recurrence patterns in non-small-cell lung cancer (NSCLC) after curative surgery.</p><h3>Material and methods</h3><p>Retrospective study included stage I–III NSCLC patients with a baseline <sup>18</sup>F-FDG PET/CT scan. Relapse patterns were analyzed based on location, lesion, and organ-specific recurrence. Clinicopathologic variables were recorded. Three distinct categories of variables were obtained: standardized uptake value (SUV)-based metrics, heterogeneity parameters, and morphological features. The relation of relapse patterns with clinicopathologic and metabolic parameters was analyzed using the uni–multivariate logistic regression.</p><h3>Results</h3><p>Out of 173 patients, 104 experienced recurrences, with 66% presenting distant involvement and 56.7% exhibiting polymetastatic disease at initial recurrence. Patient age, pathologic lymphovascular invasion, and normalized SUVmax perimeter distance (nSPD) were considered as risk factors for early recurrence. Adenocarcinoma histology was identified as an independent variable for distant recurrence. Patient age, number of metastatic mediastinal lymph nodes at staging (nN), sphericity, normalized SUVpeak to centroid distance (nSCD), entropy, low gray-level run emphasis, and high gray-level run emphasis were independent variables for polymetastatic disease. Certain variables were correlated with organ-specific recurrence. Bone recurrence was related to nN and SUVmean. Brain recurrence was related to adenocarcinoma histology. Lung recurrence was associated with coefficient of variation and nSPD.</p><h3>Conclusion</h3><p>The metabolic profile of lung primary tumors obtained from <sup>18</sup>F-FDG PET/CT seems to be predictive of recurrence patterns that are closely linked to the overall survival of NSCLC patients. These findings could help in the development of personalized follow-up strategies based on an individual’s recurrence pattern.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 5","pages":"476 - 505"},"PeriodicalIF":2.5000,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clinicopathologic and metabolic variables from 18F-FDG PET/CT in the prediction of recurrence pattern in stage I–III non-small cell lung cancer after curative surgery\",\"authors\":\"G. A. Jimenez Londoño, J. Pérez-Beteta, M. Amo-Salas, A. F. Honguero-Martinez, V. M. Pérez-García, C. Lucas Lucas, A. M. Soriano Castrejón, A. M. García Vicente\",\"doi\":\"10.1007/s12149-025-02021-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Aim</h3><p>This study aimed to analyze the clinicopathologic and metabolic parameters derived from staging <sup>18</sup>F-FDG PET/CT that can predict recurrence patterns in non-small-cell lung cancer (NSCLC) after curative surgery.</p><h3>Material and methods</h3><p>Retrospective study included stage I–III NSCLC patients with a baseline <sup>18</sup>F-FDG PET/CT scan. Relapse patterns were analyzed based on location, lesion, and organ-specific recurrence. Clinicopathologic variables were recorded. Three distinct categories of variables were obtained: standardized uptake value (SUV)-based metrics, heterogeneity parameters, and morphological features. The relation of relapse patterns with clinicopathologic and metabolic parameters was analyzed using the uni–multivariate logistic regression.</p><h3>Results</h3><p>Out of 173 patients, 104 experienced recurrences, with 66% presenting distant involvement and 56.7% exhibiting polymetastatic disease at initial recurrence. Patient age, pathologic lymphovascular invasion, and normalized SUVmax perimeter distance (nSPD) were considered as risk factors for early recurrence. Adenocarcinoma histology was identified as an independent variable for distant recurrence. Patient age, number of metastatic mediastinal lymph nodes at staging (nN), sphericity, normalized SUVpeak to centroid distance (nSCD), entropy, low gray-level run emphasis, and high gray-level run emphasis were independent variables for polymetastatic disease. Certain variables were correlated with organ-specific recurrence. Bone recurrence was related to nN and SUVmean. Brain recurrence was related to adenocarcinoma histology. Lung recurrence was associated with coefficient of variation and nSPD.</p><h3>Conclusion</h3><p>The metabolic profile of lung primary tumors obtained from <sup>18</sup>F-FDG PET/CT seems to be predictive of recurrence patterns that are closely linked to the overall survival of NSCLC patients. These findings could help in the development of personalized follow-up strategies based on an individual’s recurrence pattern.</p></div>\",\"PeriodicalId\":8007,\"journal\":{\"name\":\"Annals of Nuclear Medicine\",\"volume\":\"39 5\",\"pages\":\"476 - 505\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-02-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Nuclear Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s12149-025-02021-y\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Nuclear Medicine","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s12149-025-02021-y","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Clinicopathologic and metabolic variables from 18F-FDG PET/CT in the prediction of recurrence pattern in stage I–III non-small cell lung cancer after curative surgery
Aim
This study aimed to analyze the clinicopathologic and metabolic parameters derived from staging 18F-FDG PET/CT that can predict recurrence patterns in non-small-cell lung cancer (NSCLC) after curative surgery.
Material and methods
Retrospective study included stage I–III NSCLC patients with a baseline 18F-FDG PET/CT scan. Relapse patterns were analyzed based on location, lesion, and organ-specific recurrence. Clinicopathologic variables were recorded. Three distinct categories of variables were obtained: standardized uptake value (SUV)-based metrics, heterogeneity parameters, and morphological features. The relation of relapse patterns with clinicopathologic and metabolic parameters was analyzed using the uni–multivariate logistic regression.
Results
Out of 173 patients, 104 experienced recurrences, with 66% presenting distant involvement and 56.7% exhibiting polymetastatic disease at initial recurrence. Patient age, pathologic lymphovascular invasion, and normalized SUVmax perimeter distance (nSPD) were considered as risk factors for early recurrence. Adenocarcinoma histology was identified as an independent variable for distant recurrence. Patient age, number of metastatic mediastinal lymph nodes at staging (nN), sphericity, normalized SUVpeak to centroid distance (nSCD), entropy, low gray-level run emphasis, and high gray-level run emphasis were independent variables for polymetastatic disease. Certain variables were correlated with organ-specific recurrence. Bone recurrence was related to nN and SUVmean. Brain recurrence was related to adenocarcinoma histology. Lung recurrence was associated with coefficient of variation and nSPD.
Conclusion
The metabolic profile of lung primary tumors obtained from 18F-FDG PET/CT seems to be predictive of recurrence patterns that are closely linked to the overall survival of NSCLC patients. These findings could help in the development of personalized follow-up strategies based on an individual’s recurrence pattern.
期刊介绍：
Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine.
The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.
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