Annals of Nuclear Medicine最新文献

{"title":"The 13th World Federation of Nuclear Medicine and Biology congress (WFNMB 2022): summarize the past half century and discuss the next half century of WFNMB-","authors":"Hirofumi Fujii,&nbsp;Hiroshi Toyama,&nbsp;Daiki Kayano,&nbsp;Kazunari Ishii,&nbsp;Seigo Kinuya","doi":"10.1007/s12149-024-01999-1","DOIUrl":"10.1007/s12149-024-01999-1","url":null,"abstract":"<div><p>The 13th World Federation of Nuclear Medicine and Biology congress (WFNMB 2022) was held in Kyoto and Kanazawa, Japan in September 2022, approximately half a century after the first World Congress of Nuclear Medicine held in Tokyo and Kyoto, Japan. In this paper, we describe the road to hosting another WFNMB congress in Japan, including the historic election for WFNMB 2022, the state of WFNMB 2022 in Kyoto, and the post-congress symposium in Kanazawa. This congress, themed “Summarize the past half century and discuss the next half century of WFNMB,” was successful and strongly encouraged doctors and researchers to develop future research and clinical practice in nuclear medicine.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 2","pages":"87 - 97"},"PeriodicalIF":2.5,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"18F-FET PET/CT can aid in diagnosing patients with indeterminate MRI findings for brain tumors: a prospective study","authors":"Sheng-Chieh Chan,&nbsp;Tsung-Lang Chiu,&nbsp;Shu-Hang Ng,&nbsp;Hung-Wen Kao,&nbsp;Sheng-Tzung Tsai,&nbsp;Shu-Hsin Liu","doi":"10.1007/s12149-024-02005-4","DOIUrl":"10.1007/s12149-024-02005-4","url":null,"abstract":"<div><h3>Objective</h3><p>This prospective study aimed to evaluate the diagnostic value of fluorine-18-labeled fluoroethyltyrosine (¹⁸F-FET) positron emission tomography (PET)/computed tomography (CT) in diagnosing brain tumors within an Asian patient population.</p><h3>Methods</h3><p>Patients suspected of having primary or recurrent brain tumors were prospectively recruited. Each patient underwent ¹⁸F-FET and fluorine-18 fluorodeoxyglucose (¹⁸F-FDG) PET/CT on separate days within 1 week. We calculated the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy to compare the diagnostic performance of the two PET scans. The standardized uptake value (SUV) and tumor-to-background ratio (TBR) of the lesions were determined using static images. Additionally, time–activity curves (TACs) and time-to-peak (TTP) were generated from the dynamic PET images.</p><h3>Results</h3><p>From September 2019 to December 2023, 33 subjects were enrolled for reasons including suspected brain tumors (<i>n</i> = 20) or suspicious glioma recurrence (<i>n</i> = 8) on magnetic resonance imaging (MRI) and restaging for glioma (<i>n</i> = 5). Among the patients with suspected brain tumors or glioma recurrence on MRI, 25% had false-positive results. ¹⁸F-FET PET/CT accurately identified 86% of these false positives. The sensitivity, specificity, PPV, NPV, and accuracy of visual interpretation of ¹⁸F-FET PET/CT were 96.2%, 85.7%, 96.2%, 85.7%, and 93.9%, respectively. The corresponding ¹⁸F-FDG PET/CT values were 73.1%, 71.4%, 90.5%, 41.7%, and 72.7%. ¹⁸F-FET PET/CT demonstrated significantly higher sensitivity and accuracy than ¹⁸F-FDG PET (<i>p</i> = 0.031 and <i>p</i> = 0.030, respectively). Using TBRmean as an adjunct reference index enhanced the diagnostic accuracy of ¹⁸F-FET PET/CT, achieving a sensitivity and NPV of 100%. Wash-out TAC or TTP &lt; 20 min was associated with a PPV of 100% for brain tumors.</p><h3>Conclusions</h3><p>¹⁸F-FET PET/CT appears to be a valuable tool for assessing brain tumors with indeterminate MRI findings in this Asian cohort. ¹⁸F-FET PET/CT offers benefits over ¹⁸F-FDG PET in differentiating brain tumors from nontumor brain lesions, particularly when using semiquantitative analysis with TBR.</p><p>This study was registered on CinicalTrial.gov (NCT06563024).</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 4","pages":"342 - 352"},"PeriodicalIF":2.5,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement of tumor-to-blood ratio of radioimmunoconjugates by poly(ethyleneimine)-containing chelating agent","authors":"Kazuma Nakashima,&nbsp;Hiroki Shimohara,&nbsp;Hiroyuki Watanabe,&nbsp;Masahiro Ono","doi":"10.1007/s12149-024-02003-6","DOIUrl":"10.1007/s12149-024-02003-6","url":null,"abstract":"<div><h3>Objective</h3><p>Monoclonal antibody (mAb)-based radioimmunoconjugates (RICs) exhibit marked tumor uptake in cancer imaging and therapy, although their high blood retention has limited the development of RICs. In our previous study, a trifunctional chelating agent with a cationic poly(ethyleneimine) (PEI) structure of tetraethylenepentamine (PEI4), maleimide-DOTA-PEI4 (MDI4), improved the tumor-to-blood ratio of RICs by increasing tumor retention compared with a conventional bifunctional chelating agent. In this study, we developed a novel chelating agent composed of a maleimide moiety, DOTA derivative, and two PEI4 structures as a PEI4-2 unit, maleimide-DOTA-PEI4-2 (MDI4-2), a design for a highly cationized chelating agent to synthesize RICs. The properties of MDI4-2 were compared with MDI4 to evaluate the effect of the PEI4-2 unit on the pharmacokinetics of RICs.</p><h3>Methods</h3><p>Trastuzumab and ¹¹¹In were selected as a model mAb and radiometal, respectively. Trastuzumab-based RICs were synthesized using MDI4-2 by two-step radiolabeling, wherein conjugation with mAbs is followed by radiolabeling of chelating agents, to obtain trastuzumab-[¹¹¹In]In-MDI4-2 ([¹¹¹In]In-TMDI4-2). The immunoreactivity and residualizing properties of [¹¹¹In]In-TMDI4-2 were evaluated using human epidermal growth factor receptor 2 (HER2)/<i>neu</i>-expressing SK-OV-3 cells. A biodistribution assay using SK-OV-3 tumor-bearing mice was also performed for [¹¹¹In]In-TMDI4-2 and the results were compared with trastuzumab-[¹¹¹In]In-MDI4 ([¹¹¹In]In-TMDI4).</p><h3>Results</h3><p>[¹¹¹In]In-TMDI4-2 was successfully synthesized by two-step radiolabeling at a radiochemical yield of 37.7%. The immunoreactivity of [¹¹¹In]In-TMDI4-2 was determined as 81.7%, suggesting the maintained binding ability through radiolabeling steps. The internalization assay revealed equivalent internalizing properties of [¹¹¹In]In-TMDI4-2 to [¹¹¹In]In-TMDI4. In the biodistribution assay, [¹¹¹In]In-TMDI4-2 exhibited lower blood retention of radioactivity to and comparable tumor uptake with [¹¹¹In]In-TMDI4, resulting in an improved tumor-to-blood ratio. These in vitro and in vivo results indicate that the PEI4-2 unit largely contributed to the decrease in the blood radioactivity of RICs without compromising the tumor uptake.</p><h3>Conclusion</h3><p>MDI4-2 with the PEI4-2 unit exhibited favorable properties for designing RICs with an improved tumor-to-blood ratio.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 4","pages":"323 - 333"},"PeriodicalIF":2.5,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PRIMARY scoring in 68Ga-PSMA PET/CT: correlation with prostate cancer risk groups and its potential impact on active surveillance","authors":"Hatice Uslu,&nbsp;Dilruba Şahin,&nbsp;Ebru İbişoğlu,&nbsp;Mehmet Tarık Tatoğlu","doi":"10.1007/s12149-024-02004-5","DOIUrl":"10.1007/s12149-024-02004-5","url":null,"abstract":"<div><h3>Objective</h3><p>The PRIMARY scoring system is a scale designed to identify clinically significant intraprostatic malignancies on 68Ga-PSMA PET/CT images. Active surveillance is a management method for patients with low-risk prostate cancer. In this study, we aimed to assess the efficacy of PRIMARY scoring in identifying appropriate candidates for active surveillance based on the distribution within prostate cancer risk groups.</p><h3>Methods</h3><p>The data of 134 patients diagnosed with PCa by biopsy who underwent 68Ga-PSMA PET/CT imaging for post-diagnostic staging purposes were retrospectively analyzed. Age, total PSA, ISUP grade, prostate lesion SUVmax values, PI-RADS scores, and PRIMARY scores were recorded. Patients were classified into low-risk and intermediate/high-risk groups.</p><h3>Results</h3><p>In the intermediate/high-risk group, the PRIMARY score was 1–2 in 17.6% and 3–5 in 82.4% of patients. In the low-risk group, the PRIMARY score was 1–2 in 34.7% and 3–5 in 65.3% of patients. None of the patients in the low-risk group had a PRIMARY score of 5. The most frequent PRIMARY score in both groups was 4, and there was a significant difference between the average SUVmax values of the intermediate/high and low-risk groups with a PRIMARY score of 4 (<i>p</i> = 0.018). The sensitivity of PRIMARY scoring in detecting patients in the intermediate/high-risk group was 82.3%, the specificity was 34.6%, and the positive predictive value (PPV) was 68.6%. When a cut-off SUVmax value 5.0 was used for the PRIMARY score of 4, the sensitivity was 67.0%, the specificity was 65.3% and the PPV was 77.0%. In the ROC analysis, the area under the curve was 0.727 for PRIMARY scoring, 0.662 for PI-RADS, and 0.744 for their combined mean.</p><h3>Conclusion</h3><p>The PRIMARY scoring system can complement PI-RADS scoring in mpMRI for selecting patients suitable for active surveillance. Revising the PRIMARY score 4 with an SUVmax cut-off value may increase the specificity.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 4","pages":"334 - 341"},"PeriodicalIF":2.5,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of visual information in multimodal large language model performance: an evaluation using the Japanese nuclear medicine board examination","authors":"Takashi Watanabe,&nbsp;Akira Baba,&nbsp;Takeshi Fukuda,&nbsp;Ken Watanabe,&nbsp;Jun Woo,&nbsp;Hiroya Ojiri","doi":"10.1007/s12149-024-01992-8","DOIUrl":"10.1007/s12149-024-01992-8","url":null,"abstract":"<div><h3>Objectives</h3><p>This study aimed to assess the performance of state-of-the-art multimodal large language models (LLMs), specifically GPT-4o, Claude 3 Opus, and Gemini 1.5 Pro, on Japanese Nuclear Medicine Board Examination (JNMBE) questions and to evaluate the influence of visual information on the decision-making process.</p><h3>Methods</h3><p>This study utilized 92 questions with images from the JNMBE (2019–2023). The LLMs’ responses were assessed under two conditions: providing both text and images and providing only text. Each model answered all questions thrice, and the most frequent answer choice was considered the final answer. The accuracy and agreement rates among the model answers were evaluated using statistical tests.</p><h3>Results</h3><p>GPT-4o, Claude 3 Opus, and Gemini 1.5 Pro exhibited no significant differences in terms of accuracy between the text-and-image and text-only conditions. GPT-4o and Claude 3 Opus demonstrated accuracies of 54.3% (95% CI: 44.2%–64.1%) each when provided with both text and images; however, they selected the same options as in the text-only condition for 71.7% of the questions. Gemini 1.5 Pro performed significantly worse than GPT-4o under text and image conditions. The agreement rates among the model answers ranged from weak to moderate.</p><h3>Conclusion</h3><p>The influence of images on decision-making in nuclear medicine is limited to the latest multimodal LLMs, and their diagnostic ability in this highly specialized field remains insufficient. Improving the utilization of image information and enhancing the answer reproducibility are crucial for the effective application of LLMs in nuclear medicine education and practice. Further advancements in these areas are necessary to harness the potential of LLMs as assistants in nuclear medicine diagnosis.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 2","pages":"217 - 224"},"PeriodicalIF":2.5,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of early and standard 18F-PSMA-11 PET/CT imaging in treatment-naïve patients with prostate cancer","authors":"Xiaolin Sun,&nbsp;Guojin Zhang,&nbsp;Qing Zhang,&nbsp;Hui Yuan,&nbsp;Lei Jiang,&nbsp;Taotao Sun","doi":"10.1007/s12149-024-02000-9","DOIUrl":"10.1007/s12149-024-02000-9","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the diagnostic performance of dual-time-point ¹⁸F-PSMA-11 PET/CT imaging at 30 and 60 min post-injection (p.i.) in treatment-naïve patients with prostate cancer (PCa).</p><h3>Methods</h3><p>Twenty treatment-naïve patients with histology-proven PCa who underwent ¹⁸F-PSMA-11 PET/CT scans at both 30 and 60-min p.i. were retrospectively analyzed. Lesion detection, semi-quantitative analysis of lesion and background, and unspecific bone uptake (UBU) between two time points were evaluated and compared. Besides, interrater reliability was also evaluated.</p><h3>Results</h3><p>Lesion detection was consistent at both 30 and 60-min p.i. imaging of 20 patients (mean age 72 ± 9), identifying 27 primary prostate lesions, 84 lymph node metastases, bone metastases in 8 patients, and other metastases in 2 patients. Primary prostate lesions showed no significant difference in SUVmax and target-to-blood pool (T/B) ratios between the two imaging times, while these parameters significantly increased over time in bone metastases. Lymph node metastases showed no significant difference in SUVmax but higher T/B ratios at 60 min compared to 30 min. A higher frequency of UBU was observed at 60 min (37.3%) compared to 30 min (32.3%), with significantly higher SUVmax and T/B ratios at 60 min. 85.6% UBU was categorized as PSMA-RADS 2 at 60 min, and the others were PSMA-RADS 3 or 4. The most frequent localization was vertebrae, followed by ribs. Interrater reliability was almost perfect for lesion detection at both time points.</p><h3>Conclusion</h3><p>Early 30-min ¹⁸F-PSMA-11 PET/CT imaging provided comparable PCa lesion detection and semi-quantitative analysis with reduced UBU to the standard 60-min imaging.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 3","pages":"295 - 302"},"PeriodicalIF":2.5,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased individual workload for nuclear medicine physicians over the past years: 2008–2023 data from The Netherlands","authors":"Asaad A. H. Amasha,&nbsp;Ömer Kasalak,&nbsp;Andor W. J. M. Glaudemans,&nbsp;Walter Noordzij,&nbsp;Rudi A. J. O. Dierckx,&nbsp;Klaas-Pieter Koopmans,&nbsp;Thomas C. Kwee","doi":"10.1007/s12149-024-01995-5","DOIUrl":"10.1007/s12149-024-01995-5","url":null,"abstract":"<div><h3>Objecive</h3><p>To investigate temporal trends in the individual workload of nuclear medicine physicians at a large tertiary care academic center between 2008 and 2023.</p><h3>Methods</h3><p>This study analyzed the reporting workload of nuclear medicine physicians in a large tertiary care academic center in The Netherlands on 36 unique (randomly sampled) calendar days, for each year between 2008 and 2023. The average daily departmental workload (measured with relative value units) was calculated for each year between 2008 and 2023. The individual workload was calculated by dividing the average daily departmental workload in each year by the available full-time equivalent nuclear medicine physicians in each year. Mann–Kendall tests were used to assess for any temporal monotonic trends in individual workload and types of nuclear medicine procedures performed.</p><h3>Results</h3><p>Individual workload increased significantly between 2008 and 2023 (Mann–Kendall tau of 0.611, <i>P</i> = 0.001). Individual workload in 2023 was 86% higher than in 2008. The use of positron emission tomography (PET) increased significantly (Mann–Kendall tau of 0.912, <i>P</i> &lt; 0.001) between 2008 and 2023. The use of diagnostic scintigraphy decreased significantly in the same period (Mann–Kendall tau of -0.817, <i>P</i> &lt; 0.001). The use of DEXA also showed a significant decrease (Mann–Kendall tau of -0.467, <i>P</i> = 0.013), but this decrease was negligible on a relative scale. The number of therapeutic procedures (Mann–Kendall tau of -0.100, <i>P</i> = 0.626) remained statistically stable in this period.</p><h3>Conclusions</h3><p>Our single-center study showed that the individual workload of nuclear medicine physicians has increased significantly between 2008 and 2023, driven by the rise in PET scans. The demand for both diagnostic and therapeutic nuclear medicine procedures and associated workload is expected to keep on increasing in the foreseeable future. This workload trend should be taken into account by policymakers involved in nuclear medicine staffing planning. A healthy balance between the nuclear medicine workforce and workload is necessary to maintain the quality of care, to be able to perform other important (academic) tasks such as research, educating and training medical students and residents, and management, and to prevent physician burnout and dropout.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 3","pages":"273 - 277"},"PeriodicalIF":2.5,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research trends and hotspots of radioiodine-refractory thyroid cancer treatment in the twenty-first century: a bibliometric analysis","authors":"Yuhang Xue,&nbsp;Yuzhe Zhang,&nbsp;Xintao Ding,&nbsp;Xinyu Wu,&nbsp;Bo Li,&nbsp;Ye Zhang,&nbsp;Yongju Gao","doi":"10.1007/s12149-024-01998-2","DOIUrl":"10.1007/s12149-024-01998-2","url":null,"abstract":"<div><p>The treatment of radioiodine-refractory differentiated thyroid cancer (RAIR-DTC) has made significant advancements in the twenty-first century. This study aimed to assess the current state of research and identify potential new directions by conducting a bibliometric analysis of scientific publications on RAIR-DTC treatment. Publications relevant to RAIR-DTC, published from January 1, 2000, to December 31, 2023, were retrieved from the Web of Science Core Collection. Bibliometric analyses of major keywords, authors, countries, institutions, publications, and journals were conducted using CiteSpace and VOSviewer. A total of 859 papers were included in the analysis. The results demonstrated a rising trend in the number of publications over time. The United States was identified as the leading contributor in terms of publication output, citations, and international collaborations. Gustave Roussy emerged as the top organization in publication productivity, while the journal Thyroid had the highest number of related publications. The research on RAIR treatment was categorized into three key hotspots: clinical trials of targeted therapies, novel therapeutic strategies, and debates surrounding the RAIR-DTC management. RAIR-DTC research is expanding from the clinical trial phase of tyrosine kinase inhibitor monotherapy to a more complex combination therapy strategy, in particular, the synergistic effect of immune checkpoint inhibitors and other therapeutic agents, requiring more high-quality prospective studies to validate the clinical benefits. Moreover, the timely identification of RAIR-DTC patients holds the potential to enable early disease intervention, constituting a pivotal novel research direction in the future.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 1","pages":"9 - 20"},"PeriodicalIF":2.5,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12149-024-01998-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term effect of postoperative radioactive iodine therapy on parathyroid function in patients with differentiated thyroid cancer","authors":"Fatma Avcı Merdin,&nbsp;Asena Gökçay Canpolat,&nbsp;Demet Çorapçıoğlu,&nbsp;Çiğdem Soydal,&nbsp;Mustafa Şahin","doi":"10.1007/s12149-024-01996-4","DOIUrl":"10.1007/s12149-024-01996-4","url":null,"abstract":"<div><h3>Objective</h3><p>The study aimed to assess the impact of postoperative radioactive iodine (RAI) therapy on parathyroid function in patients who underwent total or subtotal thyroidectomy for differentiated thyroid cancer (DTC).</p><h3>Methods</h3><p>Data from 150 patients treated with RAI for DTC and 76 patients with low-risk DTC not receiving RAI were retrospectively analyzed. Clinical characteristics, preoperative and 1-month postoperative biochemical parameters, and adjusted calcium, phosphorus, parathyroid hormone (PTH), and 25-hydroxyvitamin D3 (25-OH-D) levels at 3 months, 1 year, 3 years, and 5 years post-RAI (or in the low-risk group) were recorded.</p><h3>Results</h3><p>A total of 226 DTC patients were included in the study (80.5% female, mean age 42.7 ± 13.2 years). Total thyroidectomy was performed in 97.3% (n = 220) of patients, with central lymph node dissection (CLND) in 41.6% (n = 94). No significant preoperative differences in PTH, aCa, P, Mg, or 25-hydroxyvitamin D3 levels were observed. However, patients receiving ≥ 3.7 GBq (or 100 mCi) RAI (n = 70) had lower calcium and PTH levels at the end of the first year following RAI treatment (p = 0.048, p = 0.032). The non-RAI group showed significantly higher calcium levels at one month postoperatively (p = 0.031) and lower rates of CLND and neck dissection. No significant differences in biochemical parameters were found at the five-year follow-up, except for one patient who developed normocalcemic hyperparathyroidism after RAI.</p><h3>Conclusion</h3><p>High-dose RAI therapy may lead to transient decreases in calcium and PTH levels in the early post-treatment period. However, long-term parathyroid function appears to remain unaffected in DTC patients, regardless of the RAI dose administered. Nonetheless, close monitoring of calcium and PTH levels is recommended, particularly in the early post-treatment period, to promptly manage any potential transient hypoparathyroidism.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 3","pages":"278 - 284"},"PeriodicalIF":2.5,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142574790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of post-pyeloplasty renal drainage in antenatally detected hydronephrosis by 99mTc-L, L-Ethylenedicysteine renal scintigraphy: the importance of delayed imaging","authors":"Piyush Aggarwal,&nbsp;Vinisha Gunasekaran,&nbsp;M. Gowtham,&nbsp;Jai K. Mahajan,&nbsp;Ashwani Sood,&nbsp;Bhagwant R. Mittal,&nbsp;Prema Menon,&nbsp;Nitin James Peters,&nbsp;Muneer A. Malik,&nbsp;Anish Bhattacharya","doi":"10.1007/s12149-024-01994-6","DOIUrl":"10.1007/s12149-024-01994-6","url":null,"abstract":"<div><h3>Objective</h3><p>Diuretic renal scintigraphy is important in diagnosing pelvi-ureteric junction obstruction (PUJO) in antenatally detected hydronephrotic (ANH) kidneys. Early-phase dynamic renal scintigraphy has several pitfalls contributing to the false interpretation of obstructed drainage, especially after pyeloplasty. This study explores the utility of delayed imaging in ^99mTc-L,L-Ethylenedicysteine (EC) diuretic renal scintigraphy to assess post-pyeloplasty renal drainage in ANH.</p><h3>Methods</h3><p>Data from May 2019 to January 2024 was retrospectively studied to identify infants with ANH who underwent surgery for PUJO and pre-and post-surgical assessment of renal drainage using ^99mTc-L,L-EC diuretic renal scintigraphy. Dynamic and post-void static images were analyzed to calculate percentage drainage till 3 h. Pre- and post-operative quantitative parameters were compared. Receiver operator curve analysis was done to calculate the threshold drainage to detect renal obstruction on postvoid images.</p><h3>Results</h3><p>In a cohort of 104 patients with a mean age of 10.1 ± 6.5 months (range 2–36 months) at surgery, 106 renal units (bilateral involvement in two patients) were analyzed. There was no significant difference in the sum of obstructive and equivocal curve patterns (105 vs 79, <i>p</i> = 0.06) and T_1/2 values (105 vs 82, <i>p</i> = 0.093) before and after surgery. However, there was a significant difference between the pre-and post-surgery median 3-h percentage drainage (26 vs 80%, <i>p</i> &lt; 0.001). A drainage threshold of less than 59% at 3 h had 93.4% sensitivity and 92.5% specificity to detect obstructive drainage.</p><h3>Conclusion</h3><p>Delayed images in diuretic renal scintigraphy are crucial in accurately interpreting post-pyeloplasty drainage patterns and help overcome pitfalls of the dynamic study.</p></div>","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":"39 3","pages":"266 - 272"},"PeriodicalIF":2.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}