Animals最新文献

{"title":"Is Canine Prostate-Specific Esterase a Reliable Marker for Benign Prostatic Hyperplasia Progression in Dogs?","authors":"Florin-Petrișor Posastiuc, Nicolae-Tiberiu Constantin, Guillaume Domain, Lotte Spanoghe, Ann Van Soom, Alexandru Ilie Diaconescu, Mario-Darius Codreanu","doi":"10.3390/ani15111614","DOIUrl":"10.3390/ani15111614","url":null,"abstract":"<p><p>Benign prostatic hyperplasia (BPH) is a common condition in intact male dogs, often progressing from subclinical to symptomatic stages with increasing clinical and structural impact. This study evaluated canine prostate-specific esterase (CPSE) as a biomarker for BPH progression, focusing on clinical severity, complexity, and ultrasonographic features. Seventy-one dogs were included: subclinical-BPH (n = 14), clinical-BPH (n = 26), BPH-prostatitis (n = 9), and controls (n = 22). CPSE levels, measured using a canine-specific enzyme-linked immunosorbent assay, were significantly correlated with clinical severity (<i>ρ</i> = 0.800, <i>p</i> ≤ 0.001) and complexity (<i>ρ</i> = 0.818, <i>p</i> ≤ 0.001). CPSE predicted mild (OR = 1.260, B = 0.231, <i>p</i> ≤ 0.001) and moderate severity (OR = 1.300, B = 0.262, <i>p</i> ≤ 0.001), as well as low (OR = 1.225, B = 0.203, <i>p</i> ≤ 0.05), moderate (OR = 1.235, B = 0.211, <i>p</i> ≤ 0.01), and high (OR = 1.346, B = 0.297, <i>p</i> ≤ 0.001) clinical complexity. CPSE showed a trend toward predicting structural alterations (OR = 1.227, B = 0.204, <i>p</i> = 0.069) and was associated with larger stippled areas, increased prostatic volume, and larger cysts/abscesses (all <i>p</i> ≤ 0.001). CPSE appears to be a promising marker for BPH progression.</p>","PeriodicalId":7955,"journal":{"name":"Animals","volume":"15 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil Gelatinase-Associated Lipocalin (NGAL) as a Biomarker of Acute Kidney Injury (AKI) in Dogs with Congestive Heart Failure (CHF) Due to Myxomatous Mitral Valve Disease (MMVD).","authors":"Maria Chiara Sabetti, Sabrina Fasoli, Serena Crosara, Cecilia Quintavalla, Giovanni Romito, Roberta Troìa, Francesca Fidanzio, Chiara Mazzoldi, Erica Monari, Francesco Dondi","doi":"10.3390/ani15111607","DOIUrl":"10.3390/ani15111607","url":null,"abstract":"<p><p>Dogs with acute congestive heart failure (CHF) can develop acute kidney injury (AKI); the prevalence of this condition has not been defined. This study aimed to assess the occurrence of AKI (increase in serum creatinine (sCr) ≥ 0.3 mg/dL) within 48 h from admission in dogs with myxomatous mitral valve disease (MMVD) with acute CHF, and the role of urinary neutrophil gelatinase-associated lipocalin (uNGAL) as a predictive marker of AKI. This was a multicentric, prospective observational study. Thirty dogs were included. The types and dosages of the diuretics administered, as well as the serum and urinary chemistry, including uNGAL and uNGAL, to the urinary creatinine ratio (uNGALC), were determined at admission (T0) and after 24 (T24) and 48 (T48) hours of hospitalization. Nineteen dogs developed AKI. We found no statistically significant differences in sCr, uNGAL, uNGALC, diuretic dosage, or hours of hospitalization between dogs that developed AKI and those that did not. The urinary NGAL and uNGALC values were not statistically significantly different at any time point, while the sCr was higher at T24 and T48 than T0. Our findings suggest that AKI in MMVD dogs with CHF is primarily functional, driven by effective decongestion rather than severe tubular damage, with the benefits of decongestion outweighing transient increases in sCr.</p>","PeriodicalId":7955,"journal":{"name":"Animals","volume":"15 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preserving Biodiversity of Sheep and Goat Farming in the Apulia Region.","authors":"Antonella Santillo, Antonella Della Malva, Marzia Albenzio","doi":"10.3390/ani15111610","DOIUrl":"10.3390/ani15111610","url":null,"abstract":"<p><p>The interconnection between biodiversity loss, food system and climate change is a complex issue with profound implications for global sustainability. Small ruminant farming is a crucial part of addressing these challenges as it contributes to environmental, social, and economic resilience. In Italy, sheep and goat farming is most common in marginal areas with a prevalence of pastoral systems and low mechanization levels. In the Apulia region of Southern Italy, autochthonous small ruminant breeds are at high risk of extinction, due to changing agricultural practices and market pressures. Autochthonous breeds represent valuable genetic resources, adapted to the local environment and capable of producing high-quality products. Apulia boasts an ancient dairy tradition, producing a variety of cheeses from small ruminants, such as Canestrato Pugliese, a Protected Designation of Origin, and four cheeses (Cacioricotta, Pecorino Foggiano, Scamorza di Pecora, and Caprino) recognized as Traditional Agri-Food Products by the Italian Ministry of Agriculture, Food Sovereignty and Forests. These products represent an essential element for biodiversity conservation, encompassing ecosystems, autochthonous breeds, microbial diversity, traditional farming practices, and production systems. This review surveys the main small ruminant native breeds of Apulia region, highlighting their historical significance, distinctive traits, and traditional productions, to help shape strategies for animal biodiversity conservation.</p>","PeriodicalId":7955,"journal":{"name":"Animals","volume":"15 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mare Milk and Foal Plasma Fatty Acid Composition in Foals Born to Mares Fed Either Flax or Fish Oil During Late Gestation.","authors":"Erica A Snyder-Peterson, Nichola Shost, Timber Thomson-Parker, Kayla C Mowry, Kalley K Fikes, Rachelle Smith, Benjamin Corl, Ashley Wagner, Ivan Girard, Jessica K Suagee-Bedore","doi":"10.3390/ani15111612","DOIUrl":"10.3390/ani15111612","url":null,"abstract":"<p><p>Maternal supplementation with omega-3 fatty acids during late gestation has been shown to have a variety of benefits for neonates. The current study utilized 13 mares and their foals, assigned to one of three dietary treatments: an unsupplemented control diet (CON; n = 5), or the addition of either fish oil-derived omega-3 (FO; n = 5) or a flaxseed (FLAX; n = 3) supplement. The mares received treatments beginning on day 310 of gestation through day 5 post-parturition. Samples of plasma were collected from the mares prior to beginning supplementation, on days 0, 5, and 30 post-partum. Milk samples were collected from the mares 12 h post-partum. Plasma samples were collected from the foals at birth and at 5 and 30 d post-partum. The fatty acid compositions of the mare plasma, mare milk, and foal plasma were determined using gas chromatography. The data were analyzed using repeated-measures ANOVA. Foals born to FO mares exhibited increased plasma docosahexaenoic acid (DHA) levels at birth compared with those born to CON mares. Across the treatments, the plasma from foals at birth prior to nursing had the highest DHA content compared with on d 5 and 30. No treatment differences were observed in the mare plasma or milk fatty acid composition for DHA levels. FLAX mares had higher 20:3 n6 plasma proportions than FO or CON mares. Beginning supplementation with fish oil on day 310 of gestation may be sufficient to elevate neonatal foal DHA concentrations.</p>","PeriodicalId":7955,"journal":{"name":"Animals","volume":"15 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NDUFAB1 as a Novel Regulator of NEFA-Induced Metabolic Dysfunction in Bovine Adipocytes.","authors":"Jing Zhou, Tao Tang, Wenqiang Sun, Xianbo Jia, Jie Wang, Hengwei Yu, Songjia Lai","doi":"10.3390/ani15111618","DOIUrl":"10.3390/ani15111618","url":null,"abstract":"<p><p>Elevated non-esterified fatty acid (NEFA) levels are closely associated with metabolic disorders in dairy cattle, yet their direct effects on adipocyte physiology remain poorly understood. In this study, we demonstrate that high NEFA concentrations significantly impair bovine adipocyte function by simultaneously inhibiting proliferation/differentiation (<i>p</i> < 0.01) and promoting pathological lipid deposition. Through integrated transcriptomic and functional analyses, we identified NDUFAB1 as a central metabolic regulator that counteracts NEFA-induced adipocyte dysfunction. Mechanistically, NDUFAB1 activation attenuates the cytotoxic effects of excessive NEFA exposure. These findings provide both fundamental insights into energy metabolism regulation and a potential therapeutic target (NDUFAB1) for preventing bovine metabolic diseases.</p>","PeriodicalId":7955,"journal":{"name":"Animals","volume":"15 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations in the Peritoneal Fluid Proteome of Horses with Colic Attributed to Ischemic and Non-Ischemic Intestinal Disease.","authors":"Rebecca C Bishop, Justine V Arrington, Pamela A Wilkins, Annette M McCoy","doi":"10.3390/ani15111604","DOIUrl":"10.3390/ani15111604","url":null,"abstract":"<p><p>Peritoneal fluid (PF) is intimately associated with the gastrointestinal tract, and changes in the PF may directly reflect abdominal pathology. We aimed to quantify differences in the PF proteome between intestinal lesion type (ischemic vs. non-ischemic) and location (small vs. large intestine). PF samples were collected at hospital admission from horses presenting for abdominal pain (colic). Cases were clinically categorized by lesion type and location after resolution (10 per group). PF proteins were extracted and quantified by label-free liquid chromatography-tandem mass spectroscopy. Data were analyzed in Perseus and R, with functional annotation by UniProtKB and interaction visualization in STRING. Sixteen proteins unique to ischemic lesions and twelve unique to small intestinal lesions had significant network enrichment with functions related to inflammatory and immune responses. Identified proteins related to ischemic and small intestinal lesions included calprotectin, lactotransferrin, alpha 2 macroglobulin, and serine proteases/protease inhibitors, as well as apolipoprotein B and lipid metabolism pathways not previously described in relation to ischemic intestinal disease. While no single biomarker is expected to adequately diagnose or predict the outcome of equine colic, the proteins identified here should be considered as candidates for further study in a larger population.</p>","PeriodicalId":7955,"journal":{"name":"Animals","volume":"15 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scoping Review of Disease Surveillance Practices and Veterinary Care Use in Small-Scale Swine Farms in the United States.","authors":"Rachel A Schambow, Michelle L Schultze, Andres M Perez","doi":"10.3390/ani15111620","DOIUrl":"10.3390/ani15111620","url":null,"abstract":"<p><p>The recent spread of foreign animal diseases (FADs) such as foot-and-mouth disease and African swine fever emphasizes the need to conduct comprehensive surveillance to detect a potential disease introduction as soon as possible. The United States is currently free of many important FADs of swine, and many preparedness initiatives have raised awareness amongst the commercial, intensive swine industry. However, the awareness and engagement of small-scale swine farmers regarding disease surveillance and passive reporting is not well known. This scoping review was conducted to identify and characterize sources of evidence on the practices and attitudes of small-scale swine farmers and owners in the United States regarding pig health and disease management, surveillance, and veterinary care use, and secondarily to characterize information seeking and communication behaviors. Sources of evidence were found through keyword searches of online databases, citation matching, and Sustainable Agriculture Research and Education project reports. Eligibility criteria included being conducted on or with US small-scale (defined in this review as less than 1000 pigs) or non-intensive swine farms and containing information pertinent to the objectives of the review. Seventeen sources were included in the final review. Regular disease monitoring and surveillance practices were not commonly reported, and multiple sources reported little to no incidence of disease occurrence in small-scale swine farms. Reported veterinary use and access was variable, and multiple sources reported that the choice to use veterinary care was affected by its perceived cost, value, and accessibility. Future research and outreach should aim to discern key factors affecting farmer's decisions to use a veterinarian, improve their awareness and prioritization of swine diseases, and develop small-scale appropriate disease surveillance protocols. Ultimately, this will help small-scale swine farmers to protect the health of their pigs and improve FAD surveillance in the US.</p>","PeriodicalId":7955,"journal":{"name":"Animals","volume":"15 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Study on the Differences in Rumen Microbiota-Liver Gluconeogenesis-Mitochondrial Interaction Between Tibetan Sheep and Hu Sheep in the Qinghai-Tibet Plateau.","authors":"Qianling Chen, Yuzhu Sha, Xiu Liu, Min Gao, Xiaowei Chen, Wenxin Yang, Wei Huang, Jiqing Wang, Yapeng He, Xu Gao, Yanyu He","doi":"10.3390/ani15111603","DOIUrl":"10.3390/ani15111603","url":null,"abstract":"&lt;p&gt;&lt;p&gt;As high-quality sheep germplasm resources in China, Hu sheep are characterized by fast growth and development, high fecundity, and tolerance to drought and cold. Tibetan sheep, adapted to high-altitude environments, have developed strong environmental adaptability. To explore the differences in the interaction among rumen microbial flora, hepatic gluconeogenesis, and mitochondrial function between Tibetan sheep and Hu sheep in the Qinghai-Tibet Plateau, this study systematically compared and analyzed the rumen flora density, key enzyme activities related to hepatic gluconeogenesis and mitochondrial function, and the expression levels of related genes in Tibetan sheep and Hu sheep under identical feeding management conditions, followed by correlation analysis. The results showed that Hu sheep had significantly higher densities of &lt;i&gt;Ruminobacteramylophilus&lt;/i&gt; (&lt;i&gt;Ram&lt;/i&gt;) and &lt;i&gt;Fibrobacter succinogenes&lt;/i&gt; (&lt;i&gt;Fs&lt;/i&gt;) associated with starch and protein degradation (&lt;i&gt;p&lt;/i&gt; &lt; 0.01). The expression levels of &lt;i&gt;Forkhead box O1&lt;/i&gt; (&lt;i&gt;FOXO1&lt;/i&gt;), pyruvate carboxylase (PC) activity, and adenosine triphosphate (ATP) content were also significantly higher than those in Tibetan sheep (&lt;i&gt;p&lt;/i&gt; &lt; 0.01). In contrast, Tibetan sheep had higher densities of &lt;i&gt;Butyrivibrio fibrisolvens&lt;/i&gt; (&lt;i&gt;Bf&lt;/i&gt;), &lt;i&gt;Ruminococcus albus&lt;/i&gt; (&lt;i&gt;Ra&lt;/i&gt;), &lt;i&gt;Ruminococcus flavefaciens&lt;/i&gt; (&lt;i&gt;Rf&lt;/i&gt;), etc., related to cellulose degradation (&lt;i&gt;p&lt;/i&gt; &lt; 0.01). The gluconeogenesis-related genes, &lt;i&gt;Glucose-6-phosphatase catalytic subunit 1&lt;/i&gt; (&lt;i&gt;G6PC1&lt;/i&gt;) and &lt;i&gt;phosphoenolpyruvate carboxykinase1&lt;/i&gt; (&lt;i&gt;PCK1&lt;/i&gt;), and the activities of phosphoenolpyruvate carboxykinase (PEPCK) and fructose-1,6-bisphosphatase (FBPase) were significantly higher in Tibetan sheep than in Hu sheep (&lt;i&gt;p&lt;/i&gt; &lt; 0.01). Mitochondrial function-related genes &lt;i&gt;Mitofusin-1&lt;/i&gt; (&lt;i&gt;Mfn1&lt;/i&gt;), &lt;i&gt;Mitofusin-2&lt;/i&gt; (&lt;i&gt;Mfn2&lt;/i&gt;), &lt;i&gt;subunit 6 of ATP synthase&lt;/i&gt; (&lt;i&gt;ATP6&lt;/i&gt;), &lt;i&gt;cytochrome b&lt;/i&gt; (&lt;i&gt;Cytb&lt;/i&gt;), etc., also showed significantly higher expression in Tibetan sheep (&lt;i&gt;p&lt;/i&gt; &lt; 0.01). While no significant differences were observed in the contents of citric acid (CA), pyruvic acid (PA), glucose (Glu), etc. (&lt;i&gt;p&lt;/i&gt; &gt; 0.05). Correlation analysis indicated that rumen flora was associated with the key enzyme activities and gene expressions of hepatic gluconeogenesis and mitochondrial function to varying degrees. In summary, Tibetan sheep exhibit strong fiber degradation capacity, the efficient utilization of gluconeogenic intermediates, and mitochondrial oxidative phosphorylation (OXPHOS) ability, forming adaptive strategies for high-altitude environments. By contrast, Hu sheep show efficient protein and starch degradation capacity, thereby enhancing the supply of gluconeogenic precursors. It is indicated that when introducing Hu sheep to high-altitude areas, dietary intervention can be used to regulate rumen microorganisms, such as increasing fiber-decomposing bacteria or enhancing mitoc","PeriodicalId":7955,"journal":{"name":"Animals","volume":"15 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating Progranulin: A Promising Novel Diagnostic and Prognostic Biomarker in Canine Oncology.","authors":"Keon Kim, Yeong Jun Kim, Chang Hyeon Choi, Yoon Jung Do, Woong Bin Ro, Chang Min Lee","doi":"10.3390/ani15111605","DOIUrl":"10.3390/ani15111605","url":null,"abstract":"<p><p>Progranulin (PGRN) is a pluripotent growth factor that has shown promise as a diagnostic and prognostic biomarker for various neoplastic conditions in humans. This study aims to explore the PGRN as a novel biomarker for diagnosing and predicting the prognosis in canine tumors. Dogs (<i>n</i> = 104) with tumors as the chief complaint were selected and classified based on clinical categorization, malignancy, and metastasis. The control group (<i>n</i> = 30) consisted of healthy dogs with no evidence of neoplastic diseases. Serum PGRN levels were quantified using enzyme-linked immunosorbent assay (ELISA). Dogs with tumors exhibited significantly elevated PGRN levels compared to control dogs (<i>p</i> < 0.0001), with a high sensitivity of 90.91%. Malignant tumors demonstrated markedly higher PGRN levels relative to the control group (<i>p</i> = 0.0012), while no significant difference was found between benign tumors and the control group. Additionally, serum PGRN was identified as a significant marker for differentiating metastatic tumors from non-metastatic ones (<i>p</i> = 0.0264). PGRN exhibited high sensitivity for tumor detection, suggesting that it may serve as a screening biomarker. Prognostically, increased PGRN correlated with unfavorable outcomes, notably linked to malignancy and metastasis. This study underscores the potential of PGRN as a novel biomarker with early diagnostic and prognostic value in canine oncology.</p>","PeriodicalId":7955,"journal":{"name":"Animals","volume":"15 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Epidemiology and Socioecological Dynamics of Hydatid-like Cysts Within a Specific Endemic District.","authors":"Muhammad Irfan Khan, Rahmat Ali, Dejun Ji, Wei Lan, Ahmed A Saleh, Shahab Ur Rehman, Muhammad Shuaib, Shah Zeb Ahmad, Hussain, Xi Wu","doi":"10.3390/ani15111617","DOIUrl":"10.3390/ani15111617","url":null,"abstract":"<p><p>Cystic Echinococcosis (CE) is a significant zoonotic parasitic disease caused by <i>Echinococcus</i> cestode parasites, affecting a variety of animals, including humans and wildlife, with serious implications for public health. In Pakistan, CE continues to pose a considerable public health challenge, impacting the livestock sector and wildlife conservation due to its economic and socio-cultural ramifications. This study aimed to examine the frequency of lesions indicative of <i>Echinococcus</i> cysts in livestock across several slaughterhouses in Khyber Pakhtunkhwa (KP), with the data collection occurring from May 2022 to February 2024. A total of 1120 animals, including 455 buffaloes, 295 cows, 200 sheep, and 170 goats, were assessed. The overall CE prevalence was found to be 5.7% (95% CI: 4.3-7.0%; 63 out of 1120), with the highest frequency in buffaloes (6.6%; 95% CI: 4.3-8.9%) and the lowest in goats (2.9%; 95% CI: 0.4-5.5%). Female animals demonstrated a higher infection rate (6.3%; 95% CI: 4.4-8.1%) compared to males (4.7%; 95% CI: 2.8-6.7%), with the liver being the most frequently affected organ (55.0%; 95% CI: 41.7-66.3%). Additionally, a survey of 200 respondents revealed that 74.5% of farmers were unaware of CE, and only 14.5% were taking preventive measures against parasites. These findings suggest a potential decline in the prevalence of this parasitic disease, likely due to advancements in veterinary services and modern farming practices.</p>","PeriodicalId":7955,"journal":{"name":"Animals","volume":"15 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}