Is Canine Prostate-Specific Esterase a Reliable Marker for Benign Prostatic Hyperplasia Progression in Dogs?

IF 2.7 2区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Animals Pub Date : 2025-05-30 DOI:10.3390/ani15111614

Florin-Petrișor Posastiuc, Nicolae-Tiberiu Constantin, Guillaume Domain, Lotte Spanoghe, Ann Van Soom, Alexandru Ilie Diaconescu, Mario-Darius Codreanu

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Abstract

Benign prostatic hyperplasia (BPH) is a common condition in intact male dogs, often progressing from subclinical to symptomatic stages with increasing clinical and structural impact. This study evaluated canine prostate-specific esterase (CPSE) as a biomarker for BPH progression, focusing on clinical severity, complexity, and ultrasonographic features. Seventy-one dogs were included: subclinical-BPH (n = 14), clinical-BPH (n = 26), BPH-prostatitis (n = 9), and controls (n = 22). CPSE levels, measured using a canine-specific enzyme-linked immunosorbent assay, were significantly correlated with clinical severity (ρ = 0.800, p ≤ 0.001) and complexity (ρ = 0.818, p ≤ 0.001). CPSE predicted mild (OR = 1.260, B = 0.231, p ≤ 0.001) and moderate severity (OR = 1.300, B = 0.262, p ≤ 0.001), as well as low (OR = 1.225, B = 0.203, p ≤ 0.05), moderate (OR = 1.235, B = 0.211, p ≤ 0.01), and high (OR = 1.346, B = 0.297, p ≤ 0.001) clinical complexity. CPSE showed a trend toward predicting structural alterations (OR = 1.227, B = 0.204, p = 0.069) and was associated with larger stippled areas, increased prostatic volume, and larger cysts/abscesses (all p ≤ 0.001). CPSE appears to be a promising marker for BPH progression.

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犬前列腺特异性酯酶是犬良性前列腺增生进展的可靠标志吗？

良性前列腺增生（BPH）是一种常见的状况在完整的雄性狗，往往从亚临床发展到症状阶段，增加临床和结构的影响。本研究评估犬前列腺特异性酯酶（CPSE）作为BPH进展的生物标志物，重点关注临床严重程度、复杂性和超声特征。纳入71只犬：亚临床性bph (n = 14)，临床性bph (n = 26)， bph -前列腺炎（n = 9）和对照组（n = 22）。使用犬特异性酶联免疫吸附试验测量CPSE水平与临床严重程度（ρ = 0.800, p≤0.001）和复杂性（ρ = 0.818, p≤0.001）显著相关。CPSE预测轻度（OR = 1.260, B = 0.231, p≤0.001）、中度（OR = 1.300, B = 0.262, p≤0.001）以及轻度（OR = 1.225, B = 0.203, p≤0.05）、中度（OR = 1.235, B = 0.211, p≤0.01）、重度（OR = 1.346, B = 0.297, p≤0.001）临床复杂性。CPSE有预测结构改变的趋势（OR = 1.227, B = 0.204, p = 0.069），并且与较大的点状区域、增大的前列腺体积和较大的囊肿/脓肿相关（均p≤0.001）。CPSE似乎是BPH进展的一个有希望的标志。

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来源期刊

Animals Agricultural and Biological Sciences-Animal Science and Zoology

CiteScore

4.90

自引率

16.70%

发文量

3015

审稿时长

20.52 days

期刊介绍： Animals (ISSN 2076-2615) is an international and interdisciplinary scholarly open access journal. It publishes original research articles, reviews, communications, and short notes that are relevant to any field of study that involves animals, including zoology, ethnozoology, animal science, animal ethics and animal welfare. However, preference will be given to those articles that provide an understanding of animals within a larger context (i.e., the animals'' interactions with the outside world, including humans). There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental details and/or method of study, must be provided for research articles. Articles submitted that involve subjecting animals to unnecessary pain or suffering will not be accepted, and all articles must be submitted with the necessary ethical approval (please refer to the Ethical Guidelines for more information).