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Annual review of cell and developmental biology最新文献

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Developing Therapies for Neurodegenerative Disorders: Insights from Protein Aggregation and Cellular Stress Responses. 开发治疗神经退行性疾病:从蛋白质聚集和细胞应激反应的见解。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2020-10-06 DOI: 10.1146/annurev-cellbio-040320-120625
Giovanna R Mallucci, David Klenerman, David C Rubinsztein
{"title":"Developing Therapies for Neurodegenerative Disorders: Insights from Protein Aggregation and Cellular Stress Responses.","authors":"Giovanna R Mallucci,&nbsp;David Klenerman,&nbsp;David C Rubinsztein","doi":"10.1146/annurev-cellbio-040320-120625","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-040320-120625","url":null,"abstract":"<p><p>As the world's population ages, neurodegenerative disorders are poised to become the commonest cause of death. Despite this, they remain essentially untreatable. Characterized pathologically both by the aggregation of disease-specific misfolded proteins and by changes in cellular stress responses, to date, therapeutic approaches have focused almost exclusively on reducing misfolded protein load-notably amyloid beta (Aβ) in Alzheimer's disease. The repeated failure of clinical trials has led to despondency over the possibility that these disorders will ever be treated. We argue that this is in fact a time for optimism: Targeting various generic stress responses is emerging as an increasingly promising means of modifying disease progression across these disorders. New treatments are approaching clinical trials, while novel means of targeting aggregates could eventually act preventively in early disease.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"36 ","pages":"165-189"},"PeriodicalIF":11.3,"publicationDate":"2020-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-cellbio-040320-120625","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38463274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 28
The Lineage Before Time: Circadian and Nonclassical Clock Influences on Development. 时间之前的血统：昼夜节律和非经典时钟对发育的影响》（The Lineage Before Time: Circadian and Nonclassical Clock Influences on Development）。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2020-10-06 DOI: 10.1146/annurev-cellbio-100818-125454
Joseph Lewis Bedont, Daniel Maxim Iascone, Amita Sehgal
{"title":"The Lineage Before Time: Circadian and Nonclassical Clock Influences on Development.","authors":"Joseph Lewis Bedont, Daniel Maxim Iascone, Amita Sehgal","doi":"10.1146/annurev-cellbio-100818-125454","DOIUrl":"10.1146/annurev-cellbio-100818-125454","url":null,"abstract":"<p><p>Diverse factors including metabolism, chromatin remodeling, and mitotic kinetics influence development at the cellular level. These factors are well known to interact with the circadian transcriptional-translational feedback loop (TTFL) after its emergence. What is only recently becoming clear, however, is how metabolism, mitosis, and epigenetics may become organized in a coordinated cyclical precursor signaling module in pluripotent cells prior to the onset of TTFL cycling. We propose that both the precursor module and the TTFL module constrain cellular identity when they are active during development, and that the emergence of these modules themselves is a key lineage marker. Here we review the component pathways underlying these ideas; how proliferation, specification, and differentiation decisions in both developmental and adult stem cell populations are or are not regulated by the classical TTFL; and emerging evidence that we propose implies a primordial clock that precedes the classical TTFL and influences early developmental decisions.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"36 ","pages":"469-509"},"PeriodicalIF":11.4,"publicationDate":"2020-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10826104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38463272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combinatorial Control of Plant Specialized Metabolism: Mechanisms, Functions, and Consequences. 植物特殊代谢的组合控制:机制、功能和后果。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2020-10-06 Epub Date: 2020-06-19 DOI: 10.1146/annurev-cellbio-011620-031429
Elia Lacchini, Alain Goossens
{"title":"Combinatorial Control of Plant Specialized Metabolism: Mechanisms, Functions, and Consequences.","authors":"Elia Lacchini,&nbsp;Alain Goossens","doi":"10.1146/annurev-cellbio-011620-031429","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-011620-031429","url":null,"abstract":"<p><p>Plants constantly perceive internal and external cues, many of which they need to address to safeguard their proper development and survival. They respond to these cues by selective activation of specific metabolic pathways involving a plethora of molecular players that act and interact in complex networks. In this review, we illustrate and discuss the complexity in the combinatorial control of plant specialized metabolism. We hereby go beyond the intuitive concept of combinatorial control as exerted by modular-acting complexes of transcription factors that govern expression of specialized metabolism genes. To extend this discussion, we also consider all known hierarchical levels of regulation of plant specialized metabolism and their interfaces by referring to reported regulatory concepts from the plant field. Finally, we speculate on possible yet-to-be-discovered regulatory principles of plant specialized metabolism that are inspired by knowledge from other kingdoms of life and areas of biological research.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"36 ","pages":"291-313"},"PeriodicalIF":11.3,"publicationDate":"2020-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-cellbio-011620-031429","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38066647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
Structural Biology of RNA Polymerase II Transcription: 20 Years On. RNA聚合酶II转录的结构生物学:20年的研究进展。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2020-10-06 Epub Date: 2020-08-21 DOI: 10.1146/annurev-cellbio-042020-021954
Sara Osman, Patrick Cramer
{"title":"Structural Biology of RNA Polymerase II Transcription: 20 Years On.","authors":"Sara Osman,&nbsp;Patrick Cramer","doi":"10.1146/annurev-cellbio-042020-021954","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-042020-021954","url":null,"abstract":"<p><p>Gene transcription by RNA polymerase II (Pol II) is the first step in the expression of the eukaryotic genome and a focal point for cellular regulation during development, differentiation, and responses to the environment. Two decades after the determination of the structure of Pol II, the mechanisms of transcription have been elucidated with studies of Pol II complexes with nucleic acids and associated proteins. Here we provide an overview of the nearly 200 available Pol II complex structures and summarize how these structures have elucidated promoter-dependent transcription initiation, promoter-proximal pausing and release of Pol II into active elongation, and the mechanisms that Pol II uses to navigate obstacles such as nucleosomes and DNA lesions. We predict that future studies will focus on how Pol II transcription is interconnected with chromatin transitions, RNA processing, and DNA repair.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"36 ","pages":"1-34"},"PeriodicalIF":11.3,"publicationDate":"2020-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-cellbio-042020-021954","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38284520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 63
The Source and Dynamics of Adult Hematopoiesis: Insights from Lineage Tracing. 成人造血的来源和动态:来自血统追踪的见解。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2020-10-06 Epub Date: 2020-06-24 DOI: 10.1146/annurev-cellbio-020520-114601
Joseph N Pucella, Samik Upadhaya, Boris Reizis
{"title":"The Source and Dynamics of Adult Hematopoiesis: Insights from Lineage Tracing.","authors":"Joseph N Pucella,&nbsp;Samik Upadhaya,&nbsp;Boris Reizis","doi":"10.1146/annurev-cellbio-020520-114601","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-020520-114601","url":null,"abstract":"<p><p>The generation of all blood cell lineages (hematopoiesis) is sustained throughout the entire life span of adult mammals. Studies using cell transplantation identified the self-renewing, multipotent hematopoietic stem cells (HSCs) as the source of hematopoiesis in adoptive hosts and delineated a hierarchy of HSC-derived progenitors that ultimately yield mature blood cells. However, much less is known about adult hematopoiesis as it occurs in native hosts, i.e., without transplantation. Here we review recent advances in our understanding of native hematopoiesis, focusing in particular on the application of genetic lineage tracing in mice. The emerging evidence has established HSCs as the major source of native hematopoiesis, helped to define the kinetics of HSC differentiation, and begun exploring native hematopoiesis in stress conditions such as aging and inflammation. Major outstanding questions about native hematopoiesis still remain, such as its clonal composition, the nature of lineage commitment, and the dynamics of the process in humans.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"36 ","pages":"529-550"},"PeriodicalIF":11.3,"publicationDate":"2020-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-cellbio-020520-114601","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38080242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
Integrating Chemistry and Mechanics: The Forces Driving Axon Growth. 整合化学和力学:驱动轴突生长的力量。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2020-10-06 Epub Date: 2020-06-30 DOI: 10.1146/annurev-cellbio-100818-125157
Kristian Franze
{"title":"Integrating Chemistry and Mechanics: The Forces Driving Axon Growth.","authors":"Kristian Franze","doi":"10.1146/annurev-cellbio-100818-125157","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-100818-125157","url":null,"abstract":"<p><p>The brain is our most complex organ. During development, neurons extend axons, which may grow over long distances along well-defined pathways to connect to distant targets. Our current understanding of axon pathfinding is largely based on chemical signaling by attractive and repulsive guidance cues. These cues instruct motile growth cones, the leading tips of growing axons, where to turn and where to stop. However, it is not chemical signals that cause motion-motion is driven by forces. Yet our current understanding of the mechanical regulation of axon growth is very limited. In this review, I discuss the origin of the cellular forces controlling axon growth and pathfinding, and how mechanical signals encountered by growing axons may be integrated with chemical signals. This mechanochemical cross talk is an important but often overlooked aspect of cell motility that has major implications for many physiological and pathological processes involving neuronal growth.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"36 ","pages":"61-83"},"PeriodicalIF":11.3,"publicationDate":"2020-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-cellbio-100818-125157","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38099874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 44
Scaling of Subcellular Structures. 亚细胞结构的缩放。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2020-10-06 Epub Date: 2020-06-30 DOI: 10.1146/annurev-cellbio-020520-113246
Wallace F Marshall
{"title":"Scaling of Subcellular Structures.","authors":"Wallace F Marshall","doi":"10.1146/annurev-cellbio-020520-113246","DOIUrl":"10.1146/annurev-cellbio-020520-113246","url":null,"abstract":"<p><p>As cells grow, the size and number of their internal organelles increase in order to keep up with increased metabolic requirements. Abnormal size of organelles is a hallmark of cancer and an important aspect of diagnosis in cytopathology. Most organelles vary in either size or number, or both, as a function of cell size, but the mechanisms that create this variation remain unclear. In some cases, organelle size appears to scale with cell size through processes of relative growth, but in others the size may be set by either active measurement systems or genetic programs that instruct organelle biosynthetic activities to create organelles of a size appropriate to a given cell type.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"36 ","pages":"219-236"},"PeriodicalIF":11.3,"publicationDate":"2020-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-cellbio-020520-113246","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38099875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Synthetic Developmental Biology: Understanding Through Reconstitution. 合成发育生物学：通过重组来理解。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2020-10-06 DOI: 10.1146/annurev-cellbio-020620-090650
Gavin Schlissel, Pulin Li
{"title":"Synthetic Developmental Biology: Understanding Through Reconstitution.","authors":"Gavin Schlissel, Pulin Li","doi":"10.1146/annurev-cellbio-020620-090650","DOIUrl":"10.1146/annurev-cellbio-020620-090650","url":null,"abstract":"<p><p>Reconstitution is an experimental strategy that seeks to recapitulate biological events outside their natural contexts using a reduced set of components. Classically, biochemical reconstitution has been extensively applied to identify the minimal set of molecules sufficient for recreating the basic chemistry of life. By analogy, reconstitution approaches to developmental biology recapitulate aspects of developmental events outside an embryo, with the goal of revealing the basic genetic circuits or physical cues sufficient for recreating developmental decisions. The rapidly growing repertoire of genetic, molecular, microscopic, and bioengineering tools is expanding the complexity and precision of reconstitution experiments. We review the emerging field of synthetic developmental biology, with a focus on the ways in which reconstitution strategies and new biological tools have enhanced our modern understanding of fundamental questions in developmental biology.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"36 ","pages":"339-357"},"PeriodicalIF":11.3,"publicationDate":"2020-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139837/pdf/nihms-1694059.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38463273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shaping Organs: Shared Structural Principles Across Kingdoms. 塑造器官:跨王国共享的结构原则。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2020-10-06 Epub Date: 2020-07-06 DOI: 10.1146/annurev-cellbio-012820-103850
O Hamant, T E Saunders
{"title":"Shaping Organs: Shared Structural Principles Across Kingdoms.","authors":"O Hamant,&nbsp;T E Saunders","doi":"10.1146/annurev-cellbio-012820-103850","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-012820-103850","url":null,"abstract":"<p><p>Development encapsulates the morphogenesis of an organism from a single fertilized cell to a functional adult. A critical part of development is the specification of organ forms. Beyond the molecular control of morphogenesis, shape in essence entails structural constraints and thus mechanics. Revisiting recent results in biophysics and development, and comparing animal and plant model systems, we derive key overarching principles behind the formation of organs across kingdoms. In particular, we highlight how growing organs are active rather than passive systems and how such behavior plays a role in shaping the organ. We discuss the importance of considering different scales in understanding how organs form. Such an integrative view of organ development generates new questions while calling for more cross-fertilization between scientific fields and model system communities.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"36 ","pages":"385-410"},"PeriodicalIF":11.3,"publicationDate":"2020-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-cellbio-012820-103850","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38128472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Foreword. 前言。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2020-10-06 DOI: 10.1146/annurev-cb-36-082620-100001
Ruth Lehmann
{"title":"Foreword.","authors":"Ruth Lehmann","doi":"10.1146/annurev-cb-36-082620-100001","DOIUrl":"https://doi.org/10.1146/annurev-cb-36-082620-100001","url":null,"abstract":"","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"36 ","pages":"v-vi"},"PeriodicalIF":11.3,"publicationDate":"2020-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38463275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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