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Annual review of cell and developmental biology最新文献

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Thymic Mimetic Cells: Ontogeny as Immunology 胸腺模拟细胞：本体免疫学
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2024-04-12 DOI: 10.1146/annurev-cellbio-112122-023316
Daniel A. Michelson, Diane Mathis
{"title":"Thymic Mimetic Cells: Ontogeny as Immunology","authors":"Daniel A. Michelson, Diane Mathis","doi":"10.1146/annurev-cellbio-112122-023316","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-112122-023316","url":null,"abstract":"Medullary thymic epithelial cells (mTECs) generate immunological self-tolerance by ectopically expressing peripheral-tissue antigens (PTAs) within the thymus to preview the peripheral self to maturing T cells. Recent work, drawing inspiration from old histological observations, has shown that subtypes of mTECs, collectively termed mimetic cells, co-opt developmental programs from throughout the organism to express biologically coherent groups of PTAs. Here, we review key aspects of mimetic cells, especially as they relate to the larger contexts of molecular, cellular, developmental, and evolutionary biology. We highlight lineage-defining transcription factors as key regulators of mimetic cells and speculate as to what other factors, including Aire and the chromatin potential of mTECs, permit mimetic cell differentiation and function. Last, we consider what mimetic cells can teach us about not only the thymus but also other tissues.","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"130 1","pages":""},"PeriodicalIF":11.3,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140598067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcription Factor Dynamics: One Molecule at a Time. 转录因子动力学：一次一个分子。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2023-10-16 Epub Date: 2023-08-04 DOI: 10.1146/annurev-cellbio-022823-013847
Kaustubh Wagh, Diana A Stavreva, Arpita Upadhyaya, Gordon L Hager
{"title":"Transcription Factor Dynamics: One Molecule at a Time.","authors":"Kaustubh Wagh, Diana A Stavreva, Arpita Upadhyaya, Gordon L Hager","doi":"10.1146/annurev-cellbio-022823-013847","DOIUrl":"10.1146/annurev-cellbio-022823-013847","url":null,"abstract":"<p><p>Cells must tightly regulate their gene expression programs and yet rapidly respond to acute biochemical and biophysical cues within their environment. This information is transmitted to the nucleus through various signaling cascades, culminating in the activation or repression of target genes. Transcription factors (TFs) are key mediators of these signals, binding to specific regulatory elements within chromatin. While live-cell imaging has conclusively proven that TF-chromatin interactions are highly dynamic, how such transient interactions can have long-term impacts on developmental trajectories and disease progression is still largely unclear. In this review, we summarize our current understanding of the dynamic nature of TF functions, starting with a historical overview of early live-cell experiments. We highlight key factors that govern TF dynamics and how TF dynamics, in turn, affect downstream transcriptional bursting. Finally, we conclude with open challenges and emerging technologies that will further our understanding of transcriptional regulation.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"277-305"},"PeriodicalIF":11.3,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9936367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Following the Birth, Life, and Death of mRNAs in Single Cells. 单细胞中信使核糖核酸的产生、生存和死亡。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2023-10-16 DOI: 10.1146/annurev-cellbio-022723-024045
Bastian T Eichenberger, Esther Griesbach, Jessica Mitchell, Jeffrey A Chao
{"title":"Following the Birth, Life, and Death of mRNAs in Single Cells.","authors":"Bastian T Eichenberger, Esther Griesbach, Jessica Mitchell, Jeffrey A Chao","doi":"10.1146/annurev-cellbio-022723-024045","DOIUrl":"10.1146/annurev-cellbio-022723-024045","url":null,"abstract":"<p><p>Recent advances in single-molecule imaging of mRNAs in fixed and living cells have enabled the lives of mRNAs to be studied with unprecedented spatial and temporal detail. These approaches have moved beyond simply being able to observe specific events and have begun to allow an understanding of how regulation is coupled between steps in the mRNA life cycle. Additionally, these methodologies are now being applied in multicellular systems and animals to provide more nuanced insights into the physiological regulation of RNA metabolism.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"39 ","pages":"253-275"},"PeriodicalIF":11.3,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41231863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cis Interactions of Membrane Receptors and Ligands. 膜受体和配体的顺式半胱氨酸相互作用。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2023-10-16 Epub Date: 2023-06-20 DOI: 10.1146/annurev-cellbio-120420-103941
Enfu Hui
{"title":"<i>Cis</i> Interactions of Membrane Receptors and Ligands.","authors":"Enfu Hui","doi":"10.1146/annurev-cellbio-120420-103941","DOIUrl":"10.1146/annurev-cellbio-120420-103941","url":null,"abstract":"<p><p>Cell-cell communication is critical for the development and function of multicellular organisms. A crucial means by which cells communicate with one another is physical interactions between receptors on one cell and their ligands on a neighboring cell. <i>Trans</i> ligand:receptor interactions activate the receptor, ultimately leading to changes in the fate of the receptor-expressing cells. Such <i>trans</i> signaling is known to be critical for the functions of cells in the nervous and immune systems, among others. Historically, <i>trans</i> interactions are the primary conceptual framework for understanding cell-cell communication. However, cells often coexpress many receptors and ligands, and a subset of these has been reported to interact in <i>cis</i> and profoundly impact cell functions. <i>Cis</i> interactions likely constitute a fundamental, understudied regulatory mechanism in cell biology. Here, I discuss how <i>cis</i> interactions between membrane receptors and ligands regulate immune cell functions, and I also highlight outstanding questions in the field.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"391-408"},"PeriodicalIF":11.4,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10042891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Mexican Tetra, Astyanax mexicanus, as a Model System in Cell and Developmental Biology. 墨西哥毒蜥Astyanax mexicanus，作为细胞和发育生物学的模型系统。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2023-10-16 Epub Date: 2023-07-12 DOI: 10.1146/annurev-cellbio-012023-014003
Pavani Ponnimbaduge Perera, David Perez Guerra, Misty R Riddle
{"title":"The Mexican Tetra, <i>Astyanax mexicanus,</i> as a Model System in Cell and Developmental Biology.","authors":"Pavani Ponnimbaduge Perera, David Perez Guerra, Misty R Riddle","doi":"10.1146/annurev-cellbio-012023-014003","DOIUrl":"10.1146/annurev-cellbio-012023-014003","url":null,"abstract":"<p><p>Our understanding of cell and developmental biology has been greatly aided by a focus on a small number of model organisms. However, we are now in an era where techniques to investigate gene function can be applied across phyla, allowing scientists to explore the diversity and flexibility of developmental mechanisms and gain a deeper understanding of life. Researchers comparing the eyeless cave-adapted Mexican tetra, <i>Astyanax mexicanus</i>, with its river-dwelling counterpart are revealing how the development of the eyes, pigment, brain, cranium, blood, and digestive system evolves as animals adapt to new environments. Breakthroughs in our understanding of the genetic and developmental basis of regressive and constructive trait evolution have come from <i>A. mexicanus</i> research. They include understanding the types of mutations that alter traits, which cellular and developmental processes they affect, and how they lead to pleiotropy. We review recent progress in the field and highlight areas for future investigations that include evolution of sex differentiation, neural crest development, and metabolic regulation of embryogenesis.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"23-44"},"PeriodicalIF":11.3,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10131745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Tubulin Code, from Molecules to Health and Disease. 微管蛋白密码，从分子到健康和疾病。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2023-10-16 DOI: 10.1146/annurev-cellbio-030123-032748
Elizabeth D McKenna, Stephanie L Sarbanes, Steven W Cummings, Antonina Roll-Mecak
{"title":"The Tubulin Code, from Molecules to Health and Disease.","authors":"Elizabeth D McKenna, Stephanie L Sarbanes, Steven W Cummings, Antonina Roll-Mecak","doi":"10.1146/annurev-cellbio-030123-032748","DOIUrl":"10.1146/annurev-cellbio-030123-032748","url":null,"abstract":"<p><p>Microtubules are essential dynamic polymers composed of α/β-tubulin heterodimers. They support intracellular trafficking, cell division, cellular motility, and other essential cellular processes. In many species, both α-tubulin and β-tubulin are encoded by multiple genes with distinct expression profiles and functionality. Microtubules are further diversified through abundant posttranslational modifications, which are added and removed by a suite of enzymes to form complex, stereotyped cellular arrays. The genetic and chemical diversity of tubulin constitute a tubulin code that regulates intrinsic microtubule properties and is read by cellular effectors, such as molecular motors and microtubule-associated proteins, to provide spatial and temporal specificity to microtubules in cells. In this review, we synthesize the rapidly expanding tubulin code literature and highlight limitations and opportunities for the field. As complex microtubule arrays underlie essential physiological processes, a better understanding of how cells employ the tubulin code has important implications for human disease ranging from cancer to neurological disorders.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"39 ","pages":"331-361"},"PeriodicalIF":11.3,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41231866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
tRNA Dysregulation in Neurodevelopmental and Neurodegenerative Diseases. 神经发育和神经退行性疾病中的tRNA失调。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2023-10-16 Epub Date: 2023-06-20 DOI: 10.1146/annurev-cellbio-021623-124009
Robert W Burgess, Erik Storkebaum
{"title":"tRNA Dysregulation in Neurodevelopmental and Neurodegenerative Diseases.","authors":"Robert W Burgess, Erik Storkebaum","doi":"10.1146/annurev-cellbio-021623-124009","DOIUrl":"10.1146/annurev-cellbio-021623-124009","url":null,"abstract":"<p><p>Transfer RNAs (tRNAs) decode messenger RNA codons to peptides at the ribosome. The nuclear genome contains many tRNA genes for each amino acid and even each anticodon. Recent evidence indicates that expression of these tRNAs in neurons is regulated, and they are not functionally redundant. When specific tRNA genes are nonfunctional, this results in an imbalance between codon demand and tRNA availability. Furthermore, tRNAs are spliced, processed, and posttranscriptionally modified. Defects in these processes lead to neurological disorders. Finally, mutations in the aminoacyl tRNA synthetases (aaRSs) also lead to disease. Recessive mutations in several aaRSs cause syndromic disorders, while dominant mutations in a subset of aaRSs lead to peripheral neuropathy, again due to an imbalance between tRNA supply and codon demand. While it is clear that disrupting tRNA biology often leads to neurological disease, additional research is needed to understand the sensitivity of neurons to these changes.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"223-252"},"PeriodicalIF":11.4,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10245835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Control of Tissue Development by Morphogens. 形态发生素对组织发育的控制。
IF 12.5 1区 生物学
Annual review of cell and developmental biology Pub Date : 2023-10-16 Epub Date: 2023-07-07 DOI: 10.1146/annurev-cellbio-020823-011522
Anna Kicheva, James Briscoe
{"title":"Control of Tissue Development by Morphogens.","authors":"Anna Kicheva, James Briscoe","doi":"10.1146/annurev-cellbio-020823-011522","DOIUrl":"10.1146/annurev-cellbio-020823-011522","url":null,"abstract":"<p><p>Intercellular signaling molecules, known as morphogens, act at a long range in developing tissues to provide spatial information and control properties such as cell fate and tissue growth. The production, transport, and removal of morphogens shape their concentration profiles in time and space. Downstream signaling cascades and gene regulatory networks within cells then convert the spatiotemporal morphogen profiles into distinct cellular responses. Current challenges are to understand the diverse molecular and cellular mechanisms underlying morphogen gradient formation, as well as the logic of downstream regulatory circuits involved in morphogen interpretation. This knowledge, combining experimental and theoretical results, is essential to understand emerging properties of morphogen-controlled systems, such as robustness and scaling.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"91-121"},"PeriodicalIF":12.5,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9758247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neofunctionalization of Toll Signaling in Insects: From Immunity to Dorsoventral Patterning. 昆虫Toll信号的新功能化：从免疫到背腔模式。
IF 11.3 1区 生物学
Annual review of cell and developmental biology Pub Date : 2023-10-16 DOI: 10.1146/annurev-cellbio-120319-120223
Siegfried Roth
{"title":"Neofunctionalization of Toll Signaling in Insects: From Immunity to Dorsoventral Patterning.","authors":"Siegfried Roth","doi":"10.1146/annurev-cellbio-120319-120223","DOIUrl":"10.1146/annurev-cellbio-120319-120223","url":null,"abstract":"<p><p>Toll signaling plays a crucial role in pathogen defense throughout the animal kingdom. It was discovered, however, for its function in dorsoventral (DV) axis formation in <i>Drosophila</i>. In all other insects studied so far, but not outside the insects, Toll is also required for DV patterning. However, in insects more distantly related to <i>Drosophila</i>, Toll's patterning role is frequently reduced and substituted by an expanded influence of BMP signaling, the pathway implicated in DV axis formation in all major metazoan lineages. This suggests that Toll was integrated into an ancestral BMP-based patterning system at the base of the insects or during insect evolution. The observation that Toll signaling has an immune function in the extraembryonic serosa, an early differentiating tissue of most insect embryos, suggests a scenario of how Toll was co-opted from an ancestral immune function for its new role in axis formation.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"39 ","pages":"1-22"},"PeriodicalIF":11.3,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41231865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RBG Motif Bridge-Like Lipid Transport Proteins: Structure, Functions, and Open Questions. RBG基序桥状脂质转运蛋白：结构、功能和悬而未决的问题。
IF 11.4 1区 生物学
Annual review of cell and developmental biology Pub Date : 2023-10-16 Epub Date: 2023-07-05 DOI: 10.1146/annurev-cellbio-120420-014634
Michael Hanna, Andrés Guillén-Samander, Pietro De Camilli
{"title":"RBG Motif Bridge-Like Lipid Transport Proteins: Structure, Functions, and Open Questions.","authors":"Michael Hanna, Andrés Guillén-Samander, Pietro De Camilli","doi":"10.1146/annurev-cellbio-120420-014634","DOIUrl":"10.1146/annurev-cellbio-120420-014634","url":null,"abstract":"<p><p>The life of eukaryotic cells requires the transport of lipids between membranes, which are separated by the aqueous environment of the cytosol. Vesicle-mediated traffic along the secretory and endocytic pathways and lipid transfer proteins (LTPs) cooperate in this transport. Until recently, known LTPs were shown to carry one or a few lipids at a time and were thought to mediate transport by shuttle-like mechanisms. Over the last few years, a new family of LTPs has been discovered that is defined by a repeating β-groove (RBG) rod-like structure with a hydrophobic channel running along their entire length. This structure and the localization of these proteins at membrane contact sites suggest a bridge-like mechanism of lipid transport. Mutations in some of these proteins result in neurodegenerative and developmental disorders. Here we review the known properties and well-established or putative physiological roles of these proteins, and we highlight the many questions that remain open about their functions.</p>","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":" ","pages":"409-434"},"PeriodicalIF":11.4,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9746352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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