Mechanical Patterning in Animal Morphogenesis.

IF 3.5 2区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
ACS Chemical Biology Pub Date : 2021-10-06 Epub Date: 2021-07-09 DOI:10.1146/annurev-cellbio-120319-030931
Yonit Maroudas-Sacks, Kinneret Keren
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引用次数: 11

Abstract

Morphogenesis is one of the most remarkable examples of biological pattern formation. Despite substantial progress in the field, we still do not understand the organizational principles responsible for the robust convergence of the morphogenesis process across scales to form viable organisms under variable conditions. Achieving large-scale coordination requires feedback between mechanical and biochemical processes, spanning all levels of organization and relating the emerging patterns with the mechanisms driving their formation. In this review, we highlight the role of mechanics in the patterning process, emphasizing the active and synergistic manner in which mechanical processes participate in developmental patterning rather than merely following a program set by biochemical signals. We discuss the value of applying a coarse-grained approach that considers the large-scale dynamics and feedback and complements the reductionist approach focused on molecular detail. A central challenge in this approach is identifying relevant coarse-grained variables and developing effective theories that can serve as a basis for an integrated framework toward understanding this remarkable pattern-formation process.

动物形态发生中的机械模式。
形态发生是生物模式形成最显著的例子之一。尽管在该领域取得了实质性进展,但我们仍然不了解组织原理,这些组织原理负责跨尺度的形态发生过程的强大收敛,从而在可变条件下形成可存活的生物体。实现大规模协调需要机械和生化过程之间的反馈,跨越组织的所有层面,并将新兴模式与驱动其形成的机制联系起来。在这篇综述中,我们强调力学在模式形成过程中的作用,强调机械过程参与发育模式的积极和协同方式,而不仅仅是遵循生化信号设定的程序。我们讨论了应用考虑大规模动力学和反馈的粗粒度方法的价值,并补充了专注于分子细节的还原论方法。这种方法的核心挑战是确定相关的粗粒度变量,并开发有效的理论,这些理论可以作为理解这一非凡模式形成过程的集成框架的基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Chemical Biology
ACS Chemical Biology 生物-生化与分子生物学
CiteScore
7.50
自引率
5.00%
发文量
353
审稿时长
3.3 months
期刊介绍: ACS Chemical Biology provides an international forum for the rapid communication of research that broadly embraces the interface between chemistry and biology. The journal also serves as a forum to facilitate the communication between biologists and chemists that will translate into new research opportunities and discoveries. Results will be published in which molecular reasoning has been used to probe questions through in vitro investigations, cell biological methods, or organismic studies. We welcome mechanistic studies on proteins, nucleic acids, sugars, lipids, and nonbiological polymers. The journal serves a large scientific community, exploring cellular function from both chemical and biological perspectives. It is understood that submitted work is based upon original results and has not been published previously.
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