Annual review of cell and developmental biology最新文献_第6页

Cellular Mechanisms of NETosis. NETosis的细胞机制。

IF 11.3 1区生物学

Annual review of cell and developmental biology Pub Date : 2020-10-06 Epub Date: 2020-07-14 DOI: 10.1146/annurev-cellbio-020520-111016

Hawa Racine Thiam, Siu Ling Wong, Denisa D Wagner, Clare M Waterman

{"title":"Cellular Mechanisms of NETosis.","authors":"Hawa Racine Thiam, Siu Ling Wong, Denisa D Wagner, Clare M Waterman","doi":"10.1146/annurev-cellbio-020520-111016","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-020520-111016","url":null,"abstract":"Neutrophils are critical to innate immunity, including host defense against bacterial and fungal infections. They achieve their host defense role by phagocytosing pathogens, secreting their granules full of cytotoxic enzymes, or expelling neutrophil extracellular traps (NETs) during the process of NETosis. NETs are weblike DNA structures decorated with histones and antimicrobial proteins released by activated neutrophils. Initially described as a means for neutrophils to neutralize pathogens, NET release also occurs in sterile inflammation, promotes thrombosis, and can mediate tissue damage. To effectively manipulate this double-edged sword to fight a particular disease, researchers must work toward understanding the mechanisms driving NETosis. Such understanding would allow the generation of new drugs to promote or prevent NETosis as needed. While knowledge regarding the (patho)physiological roles of NETosis is accumulating, little is known about the cellular and biophysical bases of this process. In this review, we describe and discuss our current knowledge of the molecular, cellular, and biophysical mechanisms mediating NET release as well as open questions in the field.","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"36 ","pages":"191-218"},"PeriodicalIF":11.3,"publicationDate":"2020-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-cellbio-020520-111016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38151763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 177

B Cell Immunosenescence. B细胞免疫衰老。

IF 11.3 1区生物学

Annual review of cell and developmental biology Pub Date : 2020-10-06 DOI: 10.1146/annurev-cellbio-011620-034148

Daniela Frasca, Alain Diaz, Maria Romero, Denisse Garcia, Bonnie B Blomberg

引用次数: 60

Protein Quality Control and Lipid Droplet Metabolism. 蛋白质质量控制与脂滴代谢。

IF 11.3 1区生物学

Annual review of cell and developmental biology Pub Date : 2020-10-06 DOI: 10.1146/annurev-cellbio-031320-101827

Melissa A Roberts, James A Olzmann

引用次数: 41

Nuclear Membrane Rupture and Its Consequences. 核膜破裂及其后果

IF 11.3 1区生物学

Annual review of cell and developmental biology Pub Date : 2020-10-06 Epub Date: 2020-07-21 DOI: 10.1146/annurev-cellbio-020520-120627

John Maciejowski, Emily M Hatch

{"title":"Nuclear Membrane Rupture and Its Consequences.","authors":"John Maciejowski, Emily M Hatch","doi":"10.1146/annurev-cellbio-020520-120627","DOIUrl":"10.1146/annurev-cellbio-020520-120627","url":null,"abstract":"The nuclear envelope is often depicted as a static barrier that regulates access between the nucleus and the cytosol. However, recent research has identified many conditions in cultured cells and in vivo in which nuclear membrane ruptures cause the loss of nuclear compartmentalization. These conditions include some that are commonly associated with human disease, such as migration of cancer cells through small spaces and expression of nuclear lamin disease mutations in both cultured cells and tissues undergoing nuclear migration. Nuclear membrane ruptures are rapidly repaired in the nucleus but persist in nuclear compartments that form around missegregated chromosomes called micronuclei. This review summarizes what is known about the mechanisms of nuclear membrane rupture and repair in both the main nucleus and micronuclei, and highlights recent work connecting the loss of nuclear integrity to genome instability and innate immune signaling. These connections link nuclear membrane rupture to complex chromosome alterations, tumorigenesis, and laminopathy etiologies.","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"36 ","pages":"85-114"},"PeriodicalIF":11.3,"publicationDate":"2020-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191142/pdf/nihms-1705605.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38175796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Processing Temporal Growth Factor Patterns by an Epidermal Growth Factor Receptor Network Dynamically Established in Space. 空间动态建立的表皮生长因子受体网络对时间生长因子模式的处理。

IF 11.3 1区生物学

Annual review of cell and developmental biology Pub Date : 2020-10-06 Epub Date: 2020-07-21 DOI: 10.1146/annurev-cellbio-013020-103810

Aneta Koseska, Philippe I H Bastiaens

{"title":"Processing Temporal Growth Factor Patterns by an Epidermal Growth Factor Receptor Network Dynamically Established in Space.","authors":"Aneta Koseska, Philippe I H Bastiaens","doi":"10.1146/annurev-cellbio-013020-103810","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-013020-103810","url":null,"abstract":"The proto-oncogenic epidermal growth factor (EGF) receptor (EGFR) is a tyrosine kinase whose sensitivity and response to growth factor signals that vary over time and space determine cellular behavior within a developing tissue. The molecular reorganization of the receptors on the plasma membrane and the enzyme-kinetic mechanisms of phosphorylation are key determinants that couple growth factor binding to EGFR signaling. To enable signal initiation and termination while simultaneously accounting for suppression of aberrant signaling, a coordinated coupling of EGFR kinase and protein tyrosine phosphatase activity is established through space by vesicular dynamics. The dynamical operation mode of this network enables not only time-varying growth factor sensing but also adaptation of the response depending on cellular context. By connecting spatially coupled enzymatic kinase/phosphatase processes and the corresponding dynamical systems description of the EGFR network, we elaborate on the general principles necessary for processing complex growth factor signals.","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"36 ","pages":"359-383"},"PeriodicalIF":11.3,"publicationDate":"2020-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-cellbio-013020-103810","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38175794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

F-Actin Cytoskeleton Network Self-Organization Through Competition and Cooperation. 通过竞争和合作的F-Actin细胞骨架网络自组织。

IF 11.3 1区生物学

Annual review of cell and developmental biology Pub Date : 2020-10-06 DOI: 10.1146/annurev-cellbio-032320-094706

Rachel S Kadzik, Kaitlin E Homa, David R Kovar

{"title":"F-Actin Cytoskeleton Network Self-Organization Through Competition and Cooperation.","authors":"Rachel S Kadzik, Kaitlin E Homa, David R Kovar","doi":"10.1146/annurev-cellbio-032320-094706","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-032320-094706","url":null,"abstract":"Many fundamental cellular processes such as division, polarization, endocytosis, and motility require the assembly, maintenance, and disassembly of filamentous actin (F-actin) networks at specific locations and times within the cell. The particular function of each network is governed by F-actin organization, size, and density as well as by its dynamics. The distinct characteristics of different F-actin networks are determined through the coordinated actions of specific sets of actin-binding proteins (ABPs). Furthermore, a cell typically assembles and uses multiple F-actin networks simultaneously within a common cytoplasm, so these networks must self-organize from a common pool of shared globular actin (G-actin) monomers and overlapping sets of ABPs. Recent advances in multicolor imaging and analysis of ABPs and their associated F-actin networks in cells, as well as the development of sophisticated in vitro reconstitutions of networks with ensembles of ABPs, have allowed the field to start uncovering the underlying principles by which cells self-organize diverse F-actin networks to execute basic cellular functions.","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"36 ","pages":"35-60"},"PeriodicalIF":11.3,"publicationDate":"2020-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-cellbio-032320-094706","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38463271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 39

Mitochondrial Quality Control and Restraining Innate Immunity. 线粒体质量控制与抑制先天免疫。

IF 11.3 1区生物学

Annual review of cell and developmental biology Pub Date : 2020-10-06 DOI: 10.1146/annurev-cellbio-021820-101354

Andrew T Moehlman, Richard J Youle

{"title":"Mitochondrial Quality Control and Restraining Innate Immunity.","authors":"Andrew T Moehlman, Richard J Youle","doi":"10.1146/annurev-cellbio-021820-101354","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-021820-101354","url":null,"abstract":"Maintaining mitochondrial health is essential for the survival and function of eukaryotic organisms. Misfunctioning mitochondria activate stress-responsive pathways to restore mitochondrial network homeostasis, remove damaged or toxic proteins, and eliminate damaged organelles via selective autophagy of mitochondria, a process termed mitophagy. Failure of these quality control pathways is implicated in the pathogenesis of Parkinson's disease and other neurodegenerative diseases. Impairment of mitochondrial quality control has been demonstrated to activate innate immune pathways, including inflammasome-mediated signaling and the antiviral cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING)-regulated interferon response. Immune system malfunction is a common hallmark in many neurodegenerative diseases; however, whether inflammation suppresses or exacerbates disease pathology is still unclear. The goal of this review is to provide a historical overview of the field, describe mechanisms of mitochondrial quality control, and highlight recent advances on the emerging role of mitochondria in innate immunity and inflammation.","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"36 ","pages":"265-289"},"PeriodicalIF":11.3,"publicationDate":"2020-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-cellbio-021820-101354","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38463270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 52

The Role of Immune Factors in Shaping Fetal Neurodevelopment. 免疫因子在塑造胎儿神经发育中的作用。

IF 11.3 1区生物学

Annual review of cell and developmental biology Pub Date : 2020-10-06 Epub Date: 2020-07-28 DOI: 10.1146/annurev-cellbio-021120-033518

Alice Lu-Culligan, Akiko Iwasaki

{"title":"The Role of Immune Factors in Shaping Fetal Neurodevelopment.","authors":"Alice Lu-Culligan, Akiko Iwasaki","doi":"10.1146/annurev-cellbio-021120-033518","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-021120-033518","url":null,"abstract":"Fetal neurodevelopment in utero is profoundly shaped by both systemic maternal immunity and local processes at the maternal-fetal interface. Immune pathways are a critical participant in the normal physiology of pregnancy and perturbations of maternal immunity due to infections during this period have been increasingly linked to a diverse array of poor neurological outcomes, including diseases that manifest much later in postnatal life. While experimental models of maternal immune activation (MIA) have provided groundbreaking characterizations of the maternal pathways underlying pathogenesis, less commonly examined are the immune factors that serve pathogen-independent developmental functions in the embryo and fetus. In this review, we explore what is known about the in vivo role of immune factors in fetal neurodevelopment during normal pregnancy and provide an overview of how MIA perturbs the proper orchestration of this sequence of events. Finally, we discuss how the dysregulation of immune factors may contribute to the manifestation of a variety of neurological disorders.","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"36 ","pages":"441-468"},"PeriodicalIF":11.3,"publicationDate":"2020-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-cellbio-021120-033518","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38210730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Msp1/ATAD1 in Protein Quality Control and Regulation of Synaptic Activities. Msp1/ATAD1在突触活性蛋白质量控制和调控中的作用。

IF 11.3 1区生物学

Annual review of cell and developmental biology Pub Date : 2020-10-06 Epub Date: 2020-09-04 DOI: 10.1146/annurev-cellbio-031220-015840

Lan Wang, Peter Walter

{"title":"Msp1/ATAD1 in Protein Quality Control and Regulation of Synaptic Activities.","authors":"Lan Wang, Peter Walter","doi":"10.1146/annurev-cellbio-031220-015840","DOIUrl":"https://doi.org/10.1146/annurev-cellbio-031220-015840","url":null,"abstract":"Mitochondrial function depends on the efficient import of proteins synthesized in the cytosol. When cells experience stress, the efficiency and faithfulness of the mitochondrial protein import machinery are compromised, leading to homeostatic imbalances and damage to the organelle. Yeast Msp1 (mitochondrial sorting of proteins 1) and mammalian ATAD1 (ATPase family AAA domain-containing 1) are orthologous AAA proteins that, fueled by ATP hydrolysis, recognize and extract mislocalized membrane proteins from the outer mitochondrial membrane. Msp1 also extracts proteins that have become stuck in the import channel. The extracted proteins are targeted for proteasome-dependent degradation or, in the case of mistargeted tail-anchored proteins, are given another chance to be routed correctly. In addition, ATAD1 is implicated in the regulation of synaptic plasticity, mediating the release of neurotransmitter receptors from postsynaptic scaffolds to allow their trafficking. Here we discuss how structural and functional specialization imparts the unique properties that allow Msp1/ATAD1 ATPases to fulfill these diverse functions and also highlight outstanding questions in the field.","PeriodicalId":7944,"journal":{"name":"Annual review of cell and developmental biology","volume":"36 ","pages":"141-164"},"PeriodicalIF":11.3,"publicationDate":"2020-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-cellbio-031220-015840","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38344887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Pediatric Allergic Diseases, Food Allergy, and Oral Tolerance. 儿童过敏性疾病，食物过敏和口腔耐受。

IF 11.3 1区生物学

Annual review of cell and developmental biology Pub Date : 2020-10-06 Epub Date: 2020-07-07 DOI: 10.1146/annurev-cellbio-100818-125346

Kirsty Logan, George Du Toit, Mattia Giovannini, Victor Turcanu, Gideon Lack

引用次数: 12