{"title":"New data confirm that HPV can cause oropharyngeal cancer","authors":"Martina Habeck (Freelance science writer)","doi":"10.1016/S1357-4310(00)01752-4","DOIUrl":"10.1016/S1357-4310(00)01752-4","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 8","pages":"Page 297"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01752-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21745183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stroke recovery: how the computer reprograms itself","authors":"Steven C Cramer MD (Assistant Professor)","doi":"10.1016/S1357-4310(00)01744-5","DOIUrl":"https://doi.org/10.1016/S1357-4310(00)01744-5","url":null,"abstract":"<div><p>Neuronal Plasticity: the key to stroke recovery</p><p>Kananaskis, Alberta, Canada, 19–22 March 2000</p></div>","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 8","pages":"Pages 301-303"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01744-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71787762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yu-Ting Tan (Medical student), Darren J. Tillett PhD (Post-Doctoral Research Fellow), Ian A. McKay PhD (Senior Lecturer)
{"title":"Molecular strategies for overcoming antibiotic resistance in bacteria","authors":"Yu-Ting Tan (Medical student), Darren J. Tillett PhD (Post-Doctoral Research Fellow), Ian A. McKay PhD (Senior Lecturer)","doi":"10.1016/S1357-4310(00)01739-1","DOIUrl":"10.1016/S1357-4310(00)01739-1","url":null,"abstract":"<div><p>Overuse of antibiotics in humans and livestock has led to the rapid evolution of bacteria that are resistant to multiple drugs such that even vancomycin, the drug of last resort, is no longer effective against some strains. Apart from the discovery and exploitation of the natural peptide antimicrobial agents that form part of the innate immune systems of plants and animals, there have been few new antibiotics developed in recent years. Here we review strategies designed to exploit recent advances in molecular biology, including recombinant DNA technology, molecular modelling and genomics to develop new antibacterial agents that overcome antibiotic resistance.</p></div>","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 8","pages":"Pages 309-314"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01739-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21745186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jim L Kelley PhD (Associate Professor, Medicine Director, Lipid Research Laboroatory), David S Chi PhD (Professor of Medicine, Chief, Division of Biomedical Research), Wael Abou-Auda MD (Post-doctoral Fellow, Division of Cardiology), J.Kelly Smith MD, FACP (Professor of Medicine, Chief of Immunology), Guha Krishnaswamy MD, FACP (Associate Professor of Medicine, Chief, Allergy and Immunology James H. Quillen V.A. Medical Center)
{"title":"The molecular role of mast cells in atherosclerotic cardiovascular disease","authors":"Jim L Kelley PhD (Associate Professor, Medicine Director, Lipid Research Laboroatory), David S Chi PhD (Professor of Medicine, Chief, Division of Biomedical Research), Wael Abou-Auda MD (Post-doctoral Fellow, Division of Cardiology), J.Kelly Smith MD, FACP (Professor of Medicine, Chief of Immunology), Guha Krishnaswamy MD, FACP (Associate Professor of Medicine, Chief, Allergy and Immunology James H. Quillen V.A. Medical Center)","doi":"10.1016/S1357-4310(00)01747-0","DOIUrl":"10.1016/S1357-4310(00)01747-0","url":null,"abstract":"<div><p>Human atherosclerosis has many characteristics of an inflammatory disorder. Recent data suggest that mast cells might be important in the pathogenesis of atherosclerotic disease. By secretion of pro-inflammatory cytokines, mast cells can assist in the recruitment of monocytes and lymphocytes into vascular tissue, thereby propagating the inflammatory response. Mast cell enzymes might activate pro-metalloproteinases, thereby destabilizing atheromatous plaques. Mast cells can facilitate foam cell formation by promoting cholesterol accumulation. However, mast cell tryptase could slow thrombus formation at sites of plaque rupture by interfering with coagulation. Therefore, mast cells can modulate coronary artery disease by both facilitatory and inhibitory pathways.</p></div>","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 8","pages":"Pages 304-308"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01747-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21745185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evolution at work in chronic infections","authors":"Colin Michie FRCPCH","doi":"10.1016/S1357-4310(00)01749-4","DOIUrl":"10.1016/S1357-4310(00)01749-4","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 8","pages":"Page 299"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01749-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56514716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nancy L. Carteron MD, FACR (Rheumatology Consultant)
{"title":"Cytokines in rheumatoid arthritis: trials and tribulations","authors":"Nancy L. Carteron MD, FACR (Rheumatology Consultant)","doi":"10.1016/S1357-4310(00)01757-3","DOIUrl":"10.1016/S1357-4310(00)01757-3","url":null,"abstract":"<div><p>Biological agents that inhibit the activity of proinflammatory cytokines are being investigated for use in the treatment of rheumatoid arthritis. Thus far, two of these agents, both of which neutralize tumor necrosis factor α (TNF-α), have received US Food and Drug Administration approval for the treatment of the disease. Etanercept is a bioengineered fusion protein of the p75 soluble TNF receptor, and infliximab is a chimeric monoclonal antibody to TNF-α. Other agents that target proinflammatory cytokines are also being developed. By allowing earlier treatment and better-tolerated long-term therapy, biologics might help slow or prevent disease progression and joint destruction.</p></div>","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 8","pages":"Pages 315-323"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01757-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21745187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Catherine C Park PhD (Research Resident) , Mina J Bissell PhD (Division Director) , Mary Helen Barcellos-Hoff PhD (Group Leader)
{"title":"The influence of the microenvironment on the malignant phenotype","authors":"Catherine C Park PhD (Research Resident) , Mina J Bissell PhD (Division Director) , Mary Helen Barcellos-Hoff PhD (Group Leader)","doi":"10.1016/S1357-4310(00)01756-1","DOIUrl":"10.1016/S1357-4310(00)01756-1","url":null,"abstract":"<div><p>Normal tissue homeostasis is maintained by dynamic interactions between epithelial cells and their microenvironment. As tissue becomes cancerous, there are reciprocal interactions between neoplastic cells, adjacent normal cells such as stroma and endothelium, and their microenvironments. The current dominant paradigm wherein multiple genetic lesions provide both the impetus for, and the Achilles heel of, cancer might be inadequate to understand cancer as a disease process. In the following brief review, we will use selected examples to illustrate the influence of the microenvironment in the evolution of the malignant phenotype. We will also discuss recent studies that suggest novel therapeutic interventions might be derived from focusing on microenvironment and tumor cells interactions.</p></div>","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 8","pages":"Pages 324-329"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01756-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21745188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Persistence of foreign cells: microchimerism in the healthy adult","authors":"Colin Michie FRCPCH","doi":"10.1016/S1357-4310(00)01766-4","DOIUrl":"10.1016/S1357-4310(00)01766-4","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 8","pages":"Page 299"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01766-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56514796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Migraine: more than just a headache","authors":"Kathryn Senior (Freelance science writer)","doi":"10.1016/S1357-4310(00)01751-2","DOIUrl":"10.1016/S1357-4310(00)01751-2","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 8","pages":"Pages 297-298"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01751-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21745184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Genetic basis of psoriasis","authors":"David P. Kelsell PhD","doi":"10.1016/S1357-4310(00)01750-0","DOIUrl":"10.1016/S1357-4310(00)01750-0","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 8","pages":"Page 300"},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01750-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56514727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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