Jim L Kelley PhD (Associate Professor, Medicine Director, Lipid Research Laboroatory), David S Chi PhD (Professor of Medicine, Chief, Division of Biomedical Research), Wael Abou-Auda MD (Post-doctoral Fellow, Division of Cardiology), J.Kelly Smith MD, FACP (Professor of Medicine, Chief of Immunology), Guha Krishnaswamy MD, FACP (Associate Professor of Medicine, Chief, Allergy and Immunology James H. Quillen V.A. Medical Center)
{"title":"肥大细胞在动脉粥样硬化性心血管疾病中的分子作用","authors":"Jim L Kelley PhD (Associate Professor, Medicine Director, Lipid Research Laboroatory), David S Chi PhD (Professor of Medicine, Chief, Division of Biomedical Research), Wael Abou-Auda MD (Post-doctoral Fellow, Division of Cardiology), J.Kelly Smith MD, FACP (Professor of Medicine, Chief of Immunology), Guha Krishnaswamy MD, FACP (Associate Professor of Medicine, Chief, Allergy and Immunology James H. Quillen V.A. Medical Center)","doi":"10.1016/S1357-4310(00)01747-0","DOIUrl":null,"url":null,"abstract":"<div><p>Human atherosclerosis has many characteristics of an inflammatory disorder. Recent data suggest that mast cells might be important in the pathogenesis of atherosclerotic disease. By secretion of pro-inflammatory cytokines, mast cells can assist in the recruitment of monocytes and lymphocytes into vascular tissue, thereby propagating the inflammatory response. Mast cell enzymes might activate pro-metalloproteinases, thereby destabilizing atheromatous plaques. Mast cells can facilitate foam cell formation by promoting cholesterol accumulation. However, mast cell tryptase could slow thrombus formation at sites of plaque rupture by interfering with coagulation. Therefore, mast cells can modulate coronary artery disease by both facilitatory and inhibitory pathways.</p></div>","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 8","pages":"Pages 304-308"},"PeriodicalIF":0.0000,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01747-0","citationCount":"97","resultStr":"{\"title\":\"The molecular role of mast cells in atherosclerotic cardiovascular disease\",\"authors\":\"Jim L Kelley PhD (Associate Professor, Medicine Director, Lipid Research Laboroatory), David S Chi PhD (Professor of Medicine, Chief, Division of Biomedical Research), Wael Abou-Auda MD (Post-doctoral Fellow, Division of Cardiology), J.Kelly Smith MD, FACP (Professor of Medicine, Chief of Immunology), Guha Krishnaswamy MD, FACP (Associate Professor of Medicine, Chief, Allergy and Immunology James H. Quillen V.A. Medical Center)\",\"doi\":\"10.1016/S1357-4310(00)01747-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Human atherosclerosis has many characteristics of an inflammatory disorder. Recent data suggest that mast cells might be important in the pathogenesis of atherosclerotic disease. By secretion of pro-inflammatory cytokines, mast cells can assist in the recruitment of monocytes and lymphocytes into vascular tissue, thereby propagating the inflammatory response. Mast cell enzymes might activate pro-metalloproteinases, thereby destabilizing atheromatous plaques. Mast cells can facilitate foam cell formation by promoting cholesterol accumulation. However, mast cell tryptase could slow thrombus formation at sites of plaque rupture by interfering with coagulation. Therefore, mast cells can modulate coronary artery disease by both facilitatory and inhibitory pathways.</p></div>\",\"PeriodicalId\":79448,\"journal\":{\"name\":\"Molecular medicine today\",\"volume\":\"6 8\",\"pages\":\"Pages 304-308\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01747-0\",\"citationCount\":\"97\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular medicine today\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1357431000017470\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular medicine today","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1357431000017470","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The molecular role of mast cells in atherosclerotic cardiovascular disease
Human atherosclerosis has many characteristics of an inflammatory disorder. Recent data suggest that mast cells might be important in the pathogenesis of atherosclerotic disease. By secretion of pro-inflammatory cytokines, mast cells can assist in the recruitment of monocytes and lymphocytes into vascular tissue, thereby propagating the inflammatory response. Mast cell enzymes might activate pro-metalloproteinases, thereby destabilizing atheromatous plaques. Mast cells can facilitate foam cell formation by promoting cholesterol accumulation. However, mast cell tryptase could slow thrombus formation at sites of plaque rupture by interfering with coagulation. Therefore, mast cells can modulate coronary artery disease by both facilitatory and inhibitory pathways.