{"title":"Chemoprevention of intestinal neoplasia","authors":"Stephen A Bustin","doi":"10.1016/S1357-4310(00)01818-9","DOIUrl":"10.1016/S1357-4310(00)01818-9","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 12","pages":"Page 459"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01818-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21925494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oliver M. Sieber BSc (Graduate student) , Ian P. Tomlinson BM, BCh, MA, PhD (Head of Laboratory) , Hanan Lamlum DPhil (Research Fellow)
{"title":"The adenomatous polyposis coli (APC) tumour suppressor – genetics, function and disease","authors":"Oliver M. Sieber BSc (Graduate student) , Ian P. Tomlinson BM, BCh, MA, PhD (Head of Laboratory) , Hanan Lamlum DPhil (Research Fellow)","doi":"10.1016/S1357-4310(00)01828-1","DOIUrl":"10.1016/S1357-4310(00)01828-1","url":null,"abstract":"<div><p>Mutations in the adenomatous polyposis coli (<em>APC</em>) gene are the basis of familial adenomatous polyposis and the majority of sporadic colorectal cancer. APC is expressed in a wide variety of tissues, interacts with the cytoskeleton, is involved in regulating levels of β-catenin and, most recently, has been shown to bind DNA, suggesting that it may possess a nuclear role. The mutation spectrum implicated in tumorigenesis and its correlation with disease phenotype is well characterized and has contributed to our understanding of important functional domains in APC. Despite these advances, APC continues to provide a fertile subject of research for both colorectal tumorigenesis and cancer in general.</p></div>","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 12","pages":"Pages 462-469"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01828-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21925497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reference standard for gene therapy closer","authors":"Mark Greener (Freelance science writer)","doi":"10.1016/S1357-4310(00)01821-9","DOIUrl":"10.1016/S1357-4310(00)01821-9","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 12","pages":"Page 454"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01821-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21925488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mining bacterial genomes for antimicrobial targets","authors":"Hannes Loferer PhD (Senior Director Microbiology)","doi":"10.1016/S1357-4310(00)01815-3","DOIUrl":"10.1016/S1357-4310(00)01815-3","url":null,"abstract":"<div><p>The elucidation of whole-genome sequences is expected to have a revolutionary impact on the discovery of novel medicines. With the availability of complete genome sequences of more than 30 different species, the field of antimicrobial drug discovery has the opportunity to access a remarkable diversity of genomic information. In this review, I summarize how microbial genomics has changed strategies of drug discovery by applying bioinformatics, novel genetic approaches and genomics-based technologies, including analysis of gene expression using DNA microarrays.</p></div>","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 12","pages":"Pages 470-474"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01815-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21925498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Richard C.G. Pollok BSc, MRCP, DTM&H (Wellcome Trust Research Training Fellow) , Michael J.G. Farthing MD, FRCP (Professor Gastroenterology)
{"title":"Enteric viruses in HIV-related diarrhoea","authors":"Richard C.G. Pollok BSc, MRCP, DTM&H (Wellcome Trust Research Training Fellow) , Michael J.G. Farthing MD, FRCP (Professor Gastroenterology)","doi":"10.1016/S1357-4310(00)01816-5","DOIUrl":"10.1016/S1357-4310(00)01816-5","url":null,"abstract":"<div><p>HIV-related diarrhoea is an important cause of morbidity and mortality in HIV infection. Cytomegalovirus is a well-established cause of diarrhoea, but the role of other enteric viruses is less clear and will be discussed here. The clinical manifestations, disease mechanisms, diagnostic techniques and current treatments for the management of these infections are reviewed.</p></div>","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 12","pages":"Pages 483-487"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01816-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21925500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A new gene involved in mental retardation?","authors":"Robert Brooksbank PhD","doi":"10.1016/S1357-4310(00)01819-0","DOIUrl":"10.1016/S1357-4310(00)01819-0","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 12","pages":"Page 457"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01819-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21925491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Overexpression of CDC25A associated with poor prognosis in breast cancer","authors":"Kathryn L Evans PhD","doi":"10.1016/S1357-4310(00)01824-4","DOIUrl":"10.1016/S1357-4310(00)01824-4","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 12","pages":"Page 459"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01824-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21925495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}