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Chemoprevention of intestinal neoplasia 肠道肿瘤的化学预防
Molecular medicine today Pub Date : 2000-12-01 DOI: 10.1016/S1357-4310(00)01818-9
Stephen A Bustin
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引用次数: 2
The adenomatous polyposis coli (APC) tumour suppressor – genetics, function and disease 腺瘤性大肠息肉病(APC)肿瘤抑制因子的遗传、功能和疾病
Molecular medicine today Pub Date : 2000-12-01 DOI: 10.1016/S1357-4310(00)01828-1
Oliver M. Sieber BSc (Graduate student) , Ian P. Tomlinson BM, BCh, MA, PhD (Head of Laboratory) , Hanan Lamlum DPhil (Research Fellow)
{"title":"The adenomatous polyposis coli (APC) tumour suppressor – genetics, function and disease","authors":"Oliver M. Sieber BSc (Graduate student) ,&nbsp;Ian P. Tomlinson BM, BCh, MA, PhD (Head of Laboratory) ,&nbsp;Hanan Lamlum DPhil (Research Fellow)","doi":"10.1016/S1357-4310(00)01828-1","DOIUrl":"10.1016/S1357-4310(00)01828-1","url":null,"abstract":"<div><p>Mutations in the adenomatous polyposis coli (<em>APC</em>) gene are the basis of familial adenomatous polyposis and the majority of sporadic colorectal cancer. APC is expressed in a wide variety of tissues, interacts with the cytoskeleton, is involved in regulating levels of β-catenin and, most recently, has been shown to bind DNA, suggesting that it may possess a nuclear role. The mutation spectrum implicated in tumorigenesis and its correlation with disease phenotype is well characterized and has contributed to our understanding of important functional domains in APC. Despite these advances, APC continues to provide a fertile subject of research for both colorectal tumorigenesis and cancer in general.</p></div>","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 12","pages":"Pages 462-469"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01828-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21925497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 137
Reference standard for gene therapy closer 基因治疗的参考标准更接近
Molecular medicine today Pub Date : 2000-12-01 DOI: 10.1016/S1357-4310(00)01821-9
Mark Greener (Freelance science writer)
{"title":"Reference standard for gene therapy closer","authors":"Mark Greener (Freelance science writer)","doi":"10.1016/S1357-4310(00)01821-9","DOIUrl":"10.1016/S1357-4310(00)01821-9","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 12","pages":"Page 454"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01821-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21925488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synergism: bioinformatics and biological experimentation 协同作用:生物信息学和生物实验
Molecular medicine today Pub Date : 2000-12-01 DOI: 10.1016/S1357-4310(00)01817-7
Michele Ramsay
{"title":"Synergism: bioinformatics and biological experimentation","authors":"Michele Ramsay","doi":"10.1016/S1357-4310(00)01817-7","DOIUrl":"10.1016/S1357-4310(00)01817-7","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 12","pages":"Page 458"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01817-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21925492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Murine γ-herpesvirus-68: a mouse model for infectious mononucleosis? 小鼠γ-疱疹病毒-68:传染性单核细胞增多症小鼠模型?
Molecular medicine today Pub Date : 2000-12-01 DOI: 10.1016/S1357-4310(00)01813-X
Marcia A. Blackman PhD (Associate Member) , Emilio Flaño PhD (Research Associate) , Edward Usherwood PhD (Research Assistant Member) , David L. Woodland PhD (Associate Member)
{"title":"Murine γ-herpesvirus-68: a mouse model for infectious mononucleosis?","authors":"Marcia A. Blackman PhD (Associate Member) ,&nbsp;Emilio Flaño PhD (Research Associate) ,&nbsp;Edward Usherwood PhD (Research Assistant Member) ,&nbsp;David L. Woodland PhD (Associate Member)","doi":"10.1016/S1357-4310(00)01813-X","DOIUrl":"https://doi.org/10.1016/S1357-4310(00)01813-X","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 12","pages":"Pages 488-490"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01813-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71734311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 39
Mining bacterial genomes for antimicrobial targets 挖掘细菌基因组的抗菌目标
Molecular medicine today Pub Date : 2000-12-01 DOI: 10.1016/S1357-4310(00)01815-3
Hannes Loferer PhD (Senior Director Microbiology)
{"title":"Mining bacterial genomes for antimicrobial targets","authors":"Hannes Loferer PhD (Senior Director Microbiology)","doi":"10.1016/S1357-4310(00)01815-3","DOIUrl":"10.1016/S1357-4310(00)01815-3","url":null,"abstract":"<div><p>The elucidation of whole-genome sequences is expected to have a revolutionary impact on the discovery of novel medicines. With the availability of complete genome sequences of more than 30 different species, the field of antimicrobial drug discovery has the opportunity to access a remarkable diversity of genomic information. In this review, I summarize how microbial genomics has changed strategies of drug discovery by applying bioinformatics, novel genetic approaches and genomics-based technologies, including analysis of gene expression using DNA microarrays.</p></div>","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 12","pages":"Pages 470-474"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01815-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21925498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
Polyglutamine stretches suppress transcription 聚谷氨酰胺拉伸抑制转录
Molecular medicine today Pub Date : 2000-12-01 DOI: 10.1016/S1357-4310(00)01827-X
Lucy R Osborne
{"title":"Polyglutamine stretches suppress transcription","authors":"Lucy R Osborne","doi":"10.1016/S1357-4310(00)01827-X","DOIUrl":"10.1016/S1357-4310(00)01827-X","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 12","pages":"Pages 457-458"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01827-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21925493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Enteric viruses in HIV-related diarrhoea 艾滋病毒相关腹泻中的肠道病毒
Molecular medicine today Pub Date : 2000-12-01 DOI: 10.1016/S1357-4310(00)01816-5
Richard C.G. Pollok BSc, MRCP, DTM&H (Wellcome Trust Research Training Fellow) , Michael J.G. Farthing MD, FRCP (Professor Gastroenterology)
{"title":"Enteric viruses in HIV-related diarrhoea","authors":"Richard C.G. Pollok BSc, MRCP, DTM&H (Wellcome Trust Research Training Fellow) ,&nbsp;Michael J.G. Farthing MD, FRCP (Professor Gastroenterology)","doi":"10.1016/S1357-4310(00)01816-5","DOIUrl":"10.1016/S1357-4310(00)01816-5","url":null,"abstract":"<div><p>HIV-related diarrhoea is an important cause of morbidity and mortality in HIV infection. Cytomegalovirus is a well-established cause of diarrhoea, but the role of other enteric viruses is less clear and will be discussed here. The clinical manifestations, disease mechanisms, diagnostic techniques and current treatments for the management of these infections are reviewed.</p></div>","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 12","pages":"Pages 483-487"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01816-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21925500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
A new gene involved in mental retardation? 与智力迟钝有关的新基因?
Molecular medicine today Pub Date : 2000-12-01 DOI: 10.1016/S1357-4310(00)01819-0
Robert Brooksbank PhD
{"title":"A new gene involved in mental retardation?","authors":"Robert Brooksbank PhD","doi":"10.1016/S1357-4310(00)01819-0","DOIUrl":"10.1016/S1357-4310(00)01819-0","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 12","pages":"Page 457"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01819-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21925491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overexpression of CDC25A associated with poor prognosis in breast cancer CDC25A过表达与乳腺癌预后不良相关
Molecular medicine today Pub Date : 2000-12-01 DOI: 10.1016/S1357-4310(00)01824-4
Kathryn L Evans PhD
{"title":"Overexpression of CDC25A associated with poor prognosis in breast cancer","authors":"Kathryn L Evans PhD","doi":"10.1016/S1357-4310(00)01824-4","DOIUrl":"10.1016/S1357-4310(00)01824-4","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 12","pages":"Page 459"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01824-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21925495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
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