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A new gene transfer vector for the lung 一种新的肺基因转移载体
Molecular medicine today Pub Date : 2000-12-01 Epub Date: 2000-11-27 DOI: 10.1016/S1357-4310(00)01823-2
Natasha J Caplen PhD
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引用次数: 1
Poliovirus replicons for targeting the CNS 针对中枢神经系统的脊髓灰质炎病毒复制子
Molecular medicine today Pub Date : 2000-12-01 Epub Date: 2000-11-27 DOI: 10.1016/S1357-4310(00)01826-8
Sharon Dorrell (Freelance science writer)
{"title":"Poliovirus replicons for targeting the CNS","authors":"Sharon Dorrell (Freelance science writer)","doi":"10.1016/S1357-4310(00)01826-8","DOIUrl":"10.1016/S1357-4310(00)01826-8","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 12","pages":"Pages 454-455"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01826-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21925489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An early start to ill health 早出晚归身体不好
Molecular medicine today Pub Date : 2000-12-01 Epub Date: 2000-11-27 DOI: 10.1016/S1357-4310(00)01825-6
Jane Bradbury (Freelance science writer)
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引用次数: 0
Forty winks: molecular basis of sleep disorders 四十次眨眼:睡眠障碍的分子基础
Molecular medicine today Pub Date : 2000-12-01 Epub Date: 2000-11-27 DOI: 10.1016/S1357-4310(00)01820-7
Claire Sansom (Freelance science writer)
{"title":"Forty winks: molecular basis of sleep disorders","authors":"Claire Sansom (Freelance science writer)","doi":"10.1016/S1357-4310(00)01820-7","DOIUrl":"10.1016/S1357-4310(00)01820-7","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 12","pages":"Page 453"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01820-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21925487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recommendations proposed for adenovirus gene therapy trials in the UK 对英国腺病毒基因治疗试验的建议
Molecular medicine today Pub Date : 2000-12-01 Epub Date: 2000-11-27 DOI: 10.1016/S1357-4310(00)01791-3
Norman C. Nevin MD FFPHM, FRCPath, FRCPEd, FRCP (Professor and Chairman) , Jayne Spink PhD (GTAC Secretariat)
{"title":"Recommendations proposed for adenovirus gene therapy trials in the UK","authors":"Norman C. Nevin MD FFPHM, FRCPath, FRCPEd, FRCP (Professor and Chairman) , Jayne Spink PhD (GTAC Secretariat)","doi":"10.1016/S1357-4310(00)01791-3","DOIUrl":"10.1016/S1357-4310(00)01791-3","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 12","pages":"Page 461"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01791-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56514885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Genetics of drug response to immunosuppressive treatment and prospects for personalized therapy 免疫抑制治疗药物反应的遗传学及个体化治疗的前景
Molecular medicine today Pub Date : 2000-12-01 Epub Date: 2000-11-27 DOI: 10.1016/S1357-4310(00)01822-0
Romano Danesi MD, PhD (Associate Professor of Pharmacology) , Marta Mosca MD (Clinical Research Associate) , Ugo Boggi MD (Assistant Professor of Surgery) , Franco Mosca MD, FACS (Professor of Surgery and Chief) , Mario Del Tacca MD, PharmD (Professor of Pharmacology and Chief)
{"title":"Genetics of drug response to immunosuppressive treatment and prospects for personalized therapy","authors":"Romano Danesi MD, PhD (Associate Professor of Pharmacology) ,&nbsp;Marta Mosca MD (Clinical Research Associate) ,&nbsp;Ugo Boggi MD (Assistant Professor of Surgery) ,&nbsp;Franco Mosca MD, FACS (Professor of Surgery and Chief) ,&nbsp;Mario Del Tacca MD, PharmD (Professor of Pharmacology and Chief)","doi":"10.1016/S1357-4310(00)01822-0","DOIUrl":"10.1016/S1357-4310(00)01822-0","url":null,"abstract":"<div><p>The use of immunosuppressive agents in the treatment of transplant rejection and autoimmune disorders is gaining momentum, with significant improvements of both graft and patient survival. The individual response to drugs, however, is variable and unexpected toxicity, or impaired activity might be seen, as a result of molecular determinants that eventually dictate how the individual will respond to immunosuppressive agents. This review addresses a number of issues related to pharmacogenetics, and discusses how this approach might be used to improve the clinical efficacy and tolerability of therapeutic options for the management of organ transplantation and autoimmune disorders in the next decade.</p></div>","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 12","pages":"Pages 475-482"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01822-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21925499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
An opportune moment to sequence an opportunistic pathogen 这是给机会性病原体排序的好时机
Molecular medicine today Pub Date : 2000-11-01 Epub Date: 2000-12-14 DOI: 10.1016/S1357-4310(00)01809-8
Andrew J Mungall
{"title":"An opportune moment to sequence an opportunistic pathogen","authors":"Andrew J Mungall","doi":"10.1016/S1357-4310(00)01809-8","DOIUrl":"10.1016/S1357-4310(00)01809-8","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 11","pages":"Pages 414-415"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01809-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21900398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Angiogenic wisdom 血管生成的智慧
Molecular medicine today Pub Date : 2000-11-01 Epub Date: 2000-12-14 DOI: 10.1016/S1357-4310(00)01804-9
Jonathan B Weitzman PhD
{"title":"Angiogenic wisdom","authors":"Jonathan B Weitzman PhD","doi":"10.1016/S1357-4310(00)01804-9","DOIUrl":"10.1016/S1357-4310(00)01804-9","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 11","pages":"Page 416"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01804-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21900401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial DNA mutations in the pathogenesis of human disease 线粒体DNA突变在人类疾病发病机制中的作用
Molecular medicine today Pub Date : 2000-11-01 Epub Date: 2000-12-14 DOI: 10.1016/S1357-4310(00)01805-0
Patrick F. Chinnery PhD, MRCP (Lecturer in Neurology) , Douglas M. Turnbull MD, PhD, FRCP (Professor of Neurology)
{"title":"Mitochondrial DNA mutations in the pathogenesis of human disease","authors":"Patrick F. Chinnery PhD, MRCP (Lecturer in Neurology) ,&nbsp;Douglas M. Turnbull MD, PhD, FRCP (Professor of Neurology)","doi":"10.1016/S1357-4310(00)01805-0","DOIUrl":"10.1016/S1357-4310(00)01805-0","url":null,"abstract":"<div><p>The coding sequence for the human mitochondrial genome (mtDNA) was published in 1981. Within a decade, the first pathogenic mtDNA mutations were described in humans with sporadic and maternally inherited disease. The last ten years has seen a profusion of reports describing new pathogenic mutations associated with a diverse range of clinical phenotypes. Although we have seen great advances in our understanding of the molecular mechanisms involved in the pathogenesis of mtDNA disease, we are only just beginning to tackle some of the more difficult questions. In this review we describe recent advances in our understanding of mtDNA disease and highlight ways that this knowledge might lead to novel therapies in the future.</p></div>","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 11","pages":"Pages 425-432"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01805-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21900404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 99
New diagnostic test for lupus 狼疮的新诊断测试
Molecular medicine today Pub Date : 2000-11-01 Epub Date: 2000-12-14 DOI: 10.1016/S1357-4310(00)01806-2
Sharon Dorrell
{"title":"New diagnostic test for lupus","authors":"Sharon Dorrell","doi":"10.1016/S1357-4310(00)01806-2","DOIUrl":"10.1016/S1357-4310(00)01806-2","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 11","pages":"Pages 412-413"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01806-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21900396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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