{"title":"A new gene transfer vector for the lung","authors":"Natasha J Caplen PhD","doi":"10.1016/S1357-4310(00)01823-2","DOIUrl":"10.1016/S1357-4310(00)01823-2","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 12","pages":"Page 460"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01823-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21925496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Poliovirus replicons for targeting the CNS","authors":"Sharon Dorrell (Freelance science writer)","doi":"10.1016/S1357-4310(00)01826-8","DOIUrl":"10.1016/S1357-4310(00)01826-8","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 12","pages":"Pages 454-455"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01826-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21925489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An early start to ill health","authors":"Jane Bradbury (Freelance science writer)","doi":"10.1016/S1357-4310(00)01825-6","DOIUrl":"10.1016/S1357-4310(00)01825-6","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 12","pages":"Pages 455-456"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01825-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21925490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Romano Danesi MD, PhD (Associate Professor of Pharmacology) , Marta Mosca MD (Clinical Research Associate) , Ugo Boggi MD (Assistant Professor of Surgery) , Franco Mosca MD, FACS (Professor of Surgery and Chief) , Mario Del Tacca MD, PharmD (Professor of Pharmacology and Chief)
{"title":"Genetics of drug response to immunosuppressive treatment and prospects for personalized therapy","authors":"Romano Danesi MD, PhD (Associate Professor of Pharmacology) , Marta Mosca MD (Clinical Research Associate) , Ugo Boggi MD (Assistant Professor of Surgery) , Franco Mosca MD, FACS (Professor of Surgery and Chief) , Mario Del Tacca MD, PharmD (Professor of Pharmacology and Chief)","doi":"10.1016/S1357-4310(00)01822-0","DOIUrl":"10.1016/S1357-4310(00)01822-0","url":null,"abstract":"<div><p>The use of immunosuppressive agents in the treatment of transplant rejection and autoimmune disorders is gaining momentum, with significant improvements of both graft and patient survival. The individual response to drugs, however, is variable and unexpected toxicity, or impaired activity might be seen, as a result of molecular determinants that eventually dictate how the individual will respond to immunosuppressive agents. This review addresses a number of issues related to pharmacogenetics, and discusses how this approach might be used to improve the clinical efficacy and tolerability of therapeutic options for the management of organ transplantation and autoimmune disorders in the next decade.</p></div>","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 12","pages":"Pages 475-482"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01822-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21925499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Norman C. Nevin MD FFPHM, FRCPath, FRCPEd, FRCP (Professor and Chairman) , Jayne Spink PhD (GTAC Secretariat)
{"title":"Recommendations proposed for adenovirus gene therapy trials in the UK","authors":"Norman C. Nevin MD FFPHM, FRCPath, FRCPEd, FRCP (Professor and Chairman) , Jayne Spink PhD (GTAC Secretariat)","doi":"10.1016/S1357-4310(00)01791-3","DOIUrl":"10.1016/S1357-4310(00)01791-3","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 12","pages":"Page 461"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01791-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56514885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An opportune moment to sequence an opportunistic pathogen","authors":"Andrew J Mungall","doi":"10.1016/S1357-4310(00)01809-8","DOIUrl":"10.1016/S1357-4310(00)01809-8","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 11","pages":"Pages 414-415"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01809-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21900398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Angiogenic wisdom","authors":"Jonathan B Weitzman PhD","doi":"10.1016/S1357-4310(00)01804-9","DOIUrl":"10.1016/S1357-4310(00)01804-9","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 11","pages":"Page 416"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01804-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21900401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patrick F. Chinnery PhD, MRCP (Lecturer in Neurology) , Douglas M. Turnbull MD, PhD, FRCP (Professor of Neurology)
{"title":"Mitochondrial DNA mutations in the pathogenesis of human disease","authors":"Patrick F. Chinnery PhD, MRCP (Lecturer in Neurology) , Douglas M. Turnbull MD, PhD, FRCP (Professor of Neurology)","doi":"10.1016/S1357-4310(00)01805-0","DOIUrl":"10.1016/S1357-4310(00)01805-0","url":null,"abstract":"<div><p>The coding sequence for the human mitochondrial genome (mtDNA) was published in 1981. Within a decade, the first pathogenic mtDNA mutations were described in humans with sporadic and maternally inherited disease. The last ten years has seen a profusion of reports describing new pathogenic mutations associated with a diverse range of clinical phenotypes. Although we have seen great advances in our understanding of the molecular mechanisms involved in the pathogenesis of mtDNA disease, we are only just beginning to tackle some of the more difficult questions. In this review we describe recent advances in our understanding of mtDNA disease and highlight ways that this knowledge might lead to novel therapies in the future.</p></div>","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 11","pages":"Pages 425-432"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01805-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21900404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"New diagnostic test for lupus","authors":"Sharon Dorrell","doi":"10.1016/S1357-4310(00)01806-2","DOIUrl":"10.1016/S1357-4310(00)01806-2","url":null,"abstract":"","PeriodicalId":79448,"journal":{"name":"Molecular medicine today","volume":"6 11","pages":"Pages 412-413"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1357-4310(00)01806-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21900396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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